Selected Publications by Anna Cliffe


Cuddy SR, Cliffe AR. The Intersection of Innate Immune Pathways with the Latent Herpes Simplex Virus Genome. J Virol. 2023 May 31;97(5):e0135222. doi: 10.1128/jvi.01352-22. Epub 2023 Apr 27. PMID: 37129520; PMCID: PMC10231182.


Whitford AL, Cliffe AR. Key questions on the epigenetics of herpes simplex virus latency. PLoS Pathog. 2022 Jun 30;18(6):e1010587. doi: 10.1371/journal.ppat.1010587. PMID: 35772067.

Dochnal S, Merchant HY, Schinlever AR, Babnis A, Depledge DP, Wilson AC, Cliffe AR. DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals. J Virol. 2022 Jun 22;96(12):e0050822. doi: 10.1128/jvi.00508-22. Epub 2022 May 24. PMID: 35608347

Whitford AL, Clinton CA, Kennedy EBL, Dochnal SA, Suzich JB, Cliffe AR. Ex Vivo Herpes Simplex Virus Reactivation Involves a Dual Leucine Zipper Kinase-Dependent Wave of Lytic Gene Expression That Is Independent of Histone Demethylase Activity and Viral Genome Synthesis. J Virol. 2022 Jun 22;96(12):e0047522. doi: 10.1128/jvi.00475-22. Epub 2022 May 23. PMID: 35604215.


Dochnal, SA, Francois, AK. Cliffe AR. De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses. Viruses 2021 13(8), 1470. PMID: 34452335.

Suzich JB, Cuddy SR, Baidas H, Dochnal S, Ke E, Schinlever AR, Babnis A, Boutell C, Cliffe AR. PML-NB-dependent type I interferon memory results in a restricted form of HSV latency. EMBO Rep. 2021 Sep 6;22(9):e52547. doi: 10.15252/embr.202152547. Epub 2021 Jul 1. PMID: 34197022.


Cuddy S, Schinlever AR, Dochnal S, Suzich J, Kundu P, Downs TK, Farah M, Desai B, Boutell C, Cliffe AR. Neuronal hyperexcitability is a DLK-dependent trigger of HSV-1 reactivation that can be induced by IL-1. eLife 2020 Dec 22;9:e58037. doi: 10.7554/eLife.58037. PMID: 33350386


Cliffe AR. DNA Damage Meets Neurotrophin Signaling: A Delicate Balancing AKT to Maintain Virus Latency. Molecular Cell. 2019 May 2;74(3):411-413. doi: 10.1016/j.molcel.2019.04.015. PMID 31051136


Suzich JB, Cliffe AR. Strength in diversity: Understanding the pathways to herpes simplex virus reactivation. Virology. 2018 Jul 14;522:81-91. PubMed PMID: 30014861


Cliffe AR, Wilson AC.  Restarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus Reactivation., 2016; Journal of virology. 91(2) . PMID: 27807236 | PMCID: PMC5215350

Pre-2016 Publications

Cliffe AR, Arbuckle JH, Vogel JL, Geden MJ, Rothbart SB, Cusack CL, Strahl BD, Kristie TM, Deshmukh M.  Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation., 2015; Cell host & microbe. 18(6) 649-58. PMID: 26651941 PMCID: PMC4681005

Gama V, Swahari V, Schafer J, Kole AJ, Evans A, Huang Y, Cliffe A, Golitz B, Sciaky N, Pei XH, Xiong Y, Deshmukh M.  The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells., 2014; Science signaling. 7(334) ra67. PMID: 25028717 | PMCID: PMC4182917

Cliffe AR, Coen DM, Knipe DM.  Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection., 2013; mBio. 4(1) . PMID: 23322639 | PMCID: PMC3551550

Cliffe AR, Garber DA, Knipe DM.  Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters., 2009; Journal of virology. 83(16) 8182-90. PMID: 19515781 | PMCID: PMC2715743

Hancock MH, Cliffe AR, Knipe DM, Smiley JR.  Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells., 2009; Journal of virology. 84(3) 1366-75. PMID: 19939931 | PMCID: PMC2812316

Knipe DM, Cliffe A.  Chromatin control of herpes simplex virus lytic and latent infection., 2008; Nature reviews. Microbiology. 6(3) 211-21. PMID: 18264117

Cliffe AR, Knipe DM.  Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection., 2008; Journal of virology. 82(24) 12030-8. PMID: 18842720 | PMCID: PMC2593313