Yang, Jie
Primary Appointment
Assistant Professor, Biochemistry and Molecular Genetics
Education
- BS, Biological Sciences, Wuhan University, China
- PhD, Biophysics, Case Western Reserve University. Cleveland, Ohio
- Postdoc, Structural Biology, Scripps Research. La Jolla, CA
Contact Information
Email: wfw7nc@virginia.edu
Website: https://jieyang-lab.com/
Research Disciplines
Alzheimer's Disease, Biochemistry, Biophysics, Biophysics & Structural Biology, Biotechnology, Cancer Biology, Cardiovascular Biology, Cell and Developmental Biology, Computational Biology, Molecular Biology, Structural Biology
Research Interests
Structural biology, Cryo-EM, Mitochondrial stress, Integrated stress response, De novo protein design, Drug development, Neurodegeneration, Heart disease, Cancer
Research Description
Our research seeks to understand how cells detect, integrate, and adapt to stress at the molecular level. We combine cryo-electron microscopy, structural biology, biochemistry, cell biology, and protein engineering to elucidate the molecular architecture and regulatory mechanisms of stress-sensing signaling complexes. Our work focuses on mitochondrial stress signaling and the integrated stress response, with particular emphasis on how these pathways coordinate protein homeostasis, cellular metabolism, signal transduction, and cell fate decisions. By uncovering fundamental mechanisms of stress adaptation, we aim to develop innovative therapeutic strategies for cancer, neurodegenerative diseases, cardiometabolic disorders, and other stress-associated human diseases.