Anne Kenworthy

Balakrishnan, M., & Kenworthy, A. K. (2024). Lipid Peroxidation Drives Liquid-Liquid Phase Separation and Disrupts Raft Protein Partitioning in Biological Membranes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 146(2), 1374-1387. doi:10.1021/jacs.3c10132

Balakrishnan, M., & Kenworthy, A. K. (2023). Lipid peroxidation drives liquid-liquid phase separation and disrupts raft protein partitioning in biological membranes.. bioRxiv. doi:10.1101/2023.09.12.557355

Kenworthy, A. K., Han, B., Ariotti, N., & Parton, R. G. (2023). The Role of Membrane Lipids in the Formation and Function of Caveolae. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 15(9). doi:10.1101/cshperspect.a041413

Kenworthy, A. K. (2023). What's past is prologue: FRAP keeps delivering 50 years later. BIOPHYSICAL JOURNAL, 122(18), 3577-3586. doi:10.1016/j.bpj.2023.05.016

Kenworthy, A. K. (2023). The building blocks of caveolae revealed: caveolins finally take center stage. BIOCHEMICAL SOCIETY TRANSACTIONS, 51(2), 855-869. doi:10.1042/BST20221298

Han, B., Gulsevin, A., Connolly, S., Wang, T., Meyer, B., Porta, J., . . . Kenworthy, A. K. (2023). Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in the assembly of oligomeric complexes. JOURNAL OF BIOLOGICAL CHEMISTRY, 299(4). doi:10.1016/j.jbc.2023.104574

Kenworthy, A. K. (2023). Cellular sinkholes buffer membrane tension. NATURE CELL BIOLOGY, 25(1), 15-16. doi:10.1038/s41556-022-01032-5

Gulsevin, A., Han, B., Porta, J. C., Mchaourab, H. S., Meiler, J., & Kenworthy, A. K. (2023). Template-free prediction of a new monotopic membrane protein fold and assembly by AlphaFold2. BIOPHYSICAL JOURNAL, 122(11), 2041-2052. doi:10.1016/j.bpj.2022.11.011

Ohi, M. D., & Kenworthy, A. K. (2022). Emerging Insights into the Molecular Architecture of Caveolin-1. JOURNAL OF MEMBRANE BIOLOGY, 255(4-5), 375-383. doi:10.1007/s00232-022-00259-5

Porta, J. C., Han, B., Gulsevin, A., Chung, J. M., Peskova, Y., Connolly, S., . . . Ohi, M. D. (2022). Molecular architecture of the human caveolin-1 complex. SCIENCE ADVANCES, 8(19). doi:10.1126/sciadv.abn7232

Fricke, N., Raghunathan, K., Tiwari, A., Stefanski, K. M., Balakrishnan, M., Waterson, A. G., . . . Kenworthy, A. K. (2022). High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts. ACS CENTRAL SCIENCE, 8(3), 370-378. doi:10.1021/acscentsci.1c01058

Kenworthy, A. K., Schmieder, S. S., Raghunathan, K., Tiwari, A., Wang, T., Kelly, C. V., & Lencer, W. I. (2021). Cholera Toxin as a Probe for Membrane Biology. TOXINS, 13(8). doi:10.3390/toxins13080543

Arumugam, S., Schmieder, S., Pezeshkian, W., Becken, U., Wunder, C., Chinnapen, D., . . . Johannes, L. (2021). Ceramide structure dictates glycosphingolipid nanodomain assembly and function. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-23961-9

Capone, R., Tiwari, A., Hadziselimovic, A., Peskova, Y., Hutchison, J. M., Sanders, C. R., & Kenworthy, A. K. (2021). The C99 domain of the amyloid precursor protein resides in the disordered membrane phase. JOURNAL OF BIOLOGICAL CHEMISTRY, 296. doi:10.1016/j.jbc.2021.100652

Han, B., Porta, J. C., Hanks, J. L., Peskova, Y., Binshtein, E., Dryden, K., . . . Kenworthy, A. K. (2020). Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy. SCIENCE ADVANCES, 6(49). doi:10.1126/sciadv.abc6185

Kreutzberger, A. J. B., Kiessling, V., Doyle, C. A., Schenk, N., Upchurch, C. M., Elmer-Dixon, M., . . . Tamm, L. K. (2020). Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2. ELIFE, 9. doi:10.7554/eLife.62506

Kenworthy, A. K. (2020). Choosing who can ride the raft. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 21(10), 566-567. doi:10.1038/s41580-020-00285-y

Kabbani, A. M., Raghunathan, K., Lencer, W. I., Kenworthy, A. K., & Kelly, C. V. (2020). Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(26), 14978-14986. doi:10.1073/pnas.2001119117

Marinko, J. T., Kenworthy, A. K., & Sanders, C. R. (2020). Peripheral myelin protein 22 preferentially partitions into ordered phase membrane domains. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(25), 14168-14177. doi:10.1073/pnas.2000508117

Rathinasabapathy, A., Copeland, C., Crabtree, A., Carrier, E. J., Moore, C., Shay, S., . . . West, J. D. (2020). Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension. FRONTIERS IN MEDICINE, 7. doi:10.3389/fmed.2020.00540

Kang, M., Day, C. A., & Kenworthy, A. K. (2019). A novel computational framework for D(t) from Fluorescence Recovery after Photobleaching data reveals various anomalous diffusion types in live cell membranes. TRAFFIC, 20(11), 867-880. doi:10.1111/tra.12690

Parton, R. G., del Pozo, M. A., Vassilopoulos, S., Nabi, I. R., Le Lay, S., Lundmark, R., . . . Lamaze, C. (2020). Caveolae: The FAQs. TRAFFIC, 21(1), 181-185. doi:10.1111/tra.12689

Foegeding, N. J., Raghunathan, K., Campbell, A. M., Kim, S. W., Lau, K. S., Kenworthy, A. K., . . . Ohi, M. D. (2019). Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability. INFECTION AND IMMUNITY, 87(4). doi:10.1128/IAI.00783-18

Insinna, C., Lu, Q., Teixeira, I., Harned, A., Semler, E. M., Stauffer, J., . . . Westlake, C. J. (2019). Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-08192-9

Raghunathan, K., & Kenworthy, A. K. (2018). Dynamic pattern generation in cell membranes: Current insights into membrane organization. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1860(10), 2018-2031. doi:10.1016/j.bbamem.2018.05.002

Raghunathan, K., Foegeding, N. J., Campbell, A. M., Cover, T. L., Ohi, M. D., & Kenworthy, A. K. (2018). Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA. INFECTION AND IMMUNITY, 86(5). doi:10.1128/IAI.00872-17

Kenworthy, A. K. (2018). Bigger Isn't Always Better: Bulking Up Impedes Receptor Internalization. BIOPHYSICAL JOURNAL, 114(6), 1255-1256. doi:10.1016/j.bpj.2018.01.037

Saito-Diaz, K., Benchabane, H., Tiwari, A., Tian, A., Li, B., Thompson, J. J., . . . Lee, E. (2018). APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. DEVELOPMENTAL CELL, 44(5), 566-+. doi:10.1016/j.devcel.2018.02.013

Copeland, C. A., Han, B., Tiwari, A., Austin, E. D., Loyd, J. E., West, J. D., & Kenworthy, A. K. (2017). A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal. MOLECULAR BIOLOGY OF THE CELL, 28(22), 3095-3111. doi:10.1091/mbc.E17-06-0421

Simunovic, M., Manneville, J. -B., Renard, H. -F., Evergren, E., Raghunathan, K., Bhatia, D., . . . Callan-Jones, A. (2017). Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins. CELL, 170(1). doi:10.1016/j.cell.2017.05.047

Tiwari, A., Copeland, C. A., Han, B., Hanson, C. A., Raghunathan, K., & Kenworthy, A. K. (2016). Caveolin-1 is an aggresome-inducing protein. SCIENTIFIC REPORTS, 6. doi:10.1038/srep38681

Chandrasekaran, R., Kenworthy, A. K., & Lacy, D. B. (2016). Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. PLOS PATHOGENS, 12(12). doi:10.1371/journal.ppat.1006070

Raghunathan, K., Wong, T. H., Chinnapen, D. J., Lencer, W. I., Jobling, M. G., & Kenworthy, A. K. (2016). Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains. BIOPHYSICAL JOURNAL, 111(12), 2547-2550. doi:10.1016/j.bpj.2016.11.008

Han, B., Copeland, C. A., Kawano, Y., Rosenzweig, E. B., Austin, E. D., Shahmirzadi, L., . . . Kenworthy, A. K. (2016). Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy. TRAFFIC, 17(12), 1297-1312. doi:10.1111/tra.12452

Klaus, C. J. S., Raghunathan, K., DiBenedetto, E., & Kenworthy, A. K. (2016). Analysis of diffusion in curved surfaces and its application to tubular membranes. MOLECULAR BIOLOGY OF THE CELL, 27(24), 3937-3946. doi:10.1091/mbc.E16-06-0445

Kraft, L. J., Dowler, J., Manral, P., & Kenworthy, A. K. (2016). Size, organization, and dynamics of soluble SQSTM1 and LC3-SQSTM1 complexes in living cells. AUTOPHAGY, 12(9), 1660-1674. doi:10.1080/15548627.2016.1199299

Cui, Y., Kenworthy, A. K., Edidin, M., Divan, R., Rosenmann, D., & Wang, P. (2016). Analyzing Single Giant Unilamellar Vesicles With a Slotline-Based RF Nanometer Sensor. IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, 64(4), 1339-1347. doi:10.1109/TMTT.2016.2536021

Kraft, L. J., Manral, P., Dowler, J., & Kenworthy, A. K. (2016). Nuclear LC3 Associates with Slowly Diffusing Complexes that Survey the Nucleolus. TRAFFIC, 17(4), 369-399. doi:10.1111/tra.12372

Schlebach, J. P., Barrett, P. J., Day, C. A., Kim, J. H., Kenworthy, A. K., & Sanders, C. R. (2016). Topologically Diverse Human Membrane Proteins Partition to Liquid-Disordered Domains in Phase-Separated Lipid Vesicles. BIOCHEMISTRY, 55(7), 985-988. doi:10.1021/acs.biochem.5b01154

Han, B., Copeland, C. A., Tiwari, A., & Kenworthy, A. K. (2016). Assembly and Turnover of Caveolae: What Do We Really Know?. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 4. doi:10.3389/fcell.2016.00068

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Arozena, A. A., . . . Zughaier, S. M. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). AUTOPHAGY, 12(1), 1-222. doi:10.1080/15548627.2015.1100356

Day, C. A., Baetz, N. W., Copeland, C. A., Kraft, L. J., Han, B., Tiwari, A., . . . Kenworthy, A. K. (2015). Microtubule Motors Power Plasma Membrane Tubulation in Clathrin-Independent Endocytosis. TRAFFIC, 16(6), 572-590. doi:10.1111/tra.12269

Han, B., Tiwari, A., & Kenworthy, A. K. (2015). Tagging Strategies Strongly Affect the Fate of Overexpressed Caveolin-1. TRAFFIC, 16(4), 417-438. doi:10.1111/tra.12254

Kenworthy, A. K. (2015). Lipid Domains. Preface.. Current topics in membranes, 75, xiii-xvii. doi:10.1016/s1063-5823(15)00033-2

Kang, M., Andreani, M., & Kenworthy, A. K. (2015). Validation of Normalizations, Scaling, and Photofading Corrections for FRAP Data Analysis. PLOS ONE, 10(5). doi:10.1371/journal.pone.0127966

Renard, H. -F., Simunovic, M., Lemiere, J., Boucrot, E., Garcia-Castillo, M. D., Arumugam, S., . . . Johannes, L. (2015). Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. NATURE, 517(7535), 493-+. doi:10.1038/nature14064

Prewitt, A. R., Ghose, S., Frump, A. L., Datta, A., Austin, E. D., Kenworthy, A. K., & de Caestecker, M. P. (2015). Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension. JOURNAL OF BIOLOGICAL CHEMISTRY, 290(2), 960-971. doi:10.1074/jbc.M114.591057

Kraft, L. J., Nguyen, T. A., Vogel, S. S., & Kenworthy, A. K. (2014). Size, stoichiometry, and organization of soluble LC3-associated complexes. AUTOPHAGY, 10(5), 861-877. doi:10.4161/auto.28175

Mazerik, J. N., Kraft, L. J., Kenworthy, A. K., & Tyska, M. J. (2014). Motor and Tail Homology 1 (TH1) Domains Antagonistically Control Myosin-1 Dynamics. BIOPHYSICAL JOURNAL, 106(3), 649-658. doi:10.1016/j.bpj.2013.12.038

Song, Y., Kenworthy, A. K., & Sanders, C. R. (2014). Cholesterol as a co-solvent and a ligand for membrane proteins. PROTEIN SCIENCE, 23(1), 1-22. doi:10.1002/pro.2385

Hanson, C. A., Drake, K. R., Baird, M. A., Han, B., Kraft, L. J., Davidson, M. W., & Kenworthy, A. K. (2013). Overexpression of Caveolin-1 Is Sufficient to Phenocopy the Behavior of a Disease-Associated Mutant. TRAFFIC, 14(6), 663-677. doi:10.1111/tra.12066

Kang, M., Day, C. A., Kenworthy, A. K., & DiBenedetto, E. (2012). Simplified Equation to Extract Diffusion Coefficients from Confocal FRAP Data. TRAFFIC, 13(12), 1589-1600. doi:10.1111/tra.12008

Day, C. A., Kraft, L. J., Kang, M., & Kenworthy, A. K. (2012). Analysis of protein and lipid dynamics using confocal fluorescence recovery after photobleaching (FRAP).. Current protocols in cytometry, Chapter 2, Unit2.19. doi:10.1002/0471142956.cy0219s62

Chinnapen, D. J. -F., Hsieh, W. -T., te Welscher, Y. M., Saslowsky, D. E., Kaoutzani, L., Brandsma, E., . . . Lencer, W. I. (2012). Lipid Sorting by Ceramide Structure from Plasma Membrane to ER for the Cholera Toxin Receptor Ganglioside GM1. DEVELOPMENTAL CELL, 23(3), 573-586. doi:10.1016/j.devcel.2012.08.002

Kraft, L. J., & Kenworthy, A. K. (2012). Imaging protein complex formation in the autophagy pathway: analysis of the interaction of LC3 and Atg4B^C74A in live cells using Forster resonance energy transfer and fluorescence recovery after photobleaching. JOURNAL OF BIOMEDICAL OPTICS, 17(1). doi:10.1117/1.JBO.17.1.011008

Day, C. A., & Kenworthy, A. K. (2012). Mechanisms Underlying the Confined Diffusion of Cholera Toxin B-Subunit in Intact Cell Membranes. PLOS ONE, 7(4). doi:10.1371/journal.pone.0034923

Lapierre, L. A., Ducharme, N. A., Drake, K. R., Goldenring, J. R., & Kenworthy, A. K. (2012). Coordinated regulation of caveolin-1 and Rab11a in apical recycling compartments of polarized epithelial cells. EXPERIMENTAL CELL RESEARCH, 318(2), 103-113. doi:10.1016/j.yexcr.2011.10.010

Kang, M., DiBenedetto, E., & Kenworthy, A. K. (2011). Proposed Correction to Feder's Anomalous Diffusion FRAP Equations. BIOPHYSICAL JOURNAL, 100(3), 791-792. doi:10.1016/j.bpj.2010.11.091

Kang, M., Day, C. A., DiBenedetto, E., & Kenworthy, A. K. (2010). A Quantitative Approach to Analyze Binding Diffusion Kinetics by Confocal FRAP. BIOPHYSICAL JOURNAL, 99(9), 2737-2747. doi:10.1016/j.bpj.2010.09.013

Cha, B., Zhu, X. C., Chen, W., Jones, M., Ryoo, S., Zachos, N. C., . . . Donowitz, M. (2010). NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid. JOURNAL OF CELL SCIENCE, 123(14), 2434-2443. doi:10.1242/jcs.056713

Drake, K. R., Kang, M., & Kenworthy, A. K. (2010). Nucleocytoplasmic Distribution and Dynamics of the Autophagosome Marker EGFP-LC3. PLOS ONE, 5(3). doi:10.1371/journal.pone.0009806