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Ashok R Asthagiri

Ashok R Asthagiri

Professor of Neurosurgery, Neurological Surgery

Bio & Overview

Neurooncology (cancer genetics), neurocutaneous disorders (neurofibromatosis type 1 and 2, von Hippel-Lindau disease, tuberous sclerosis, Sturge-Weber syndrome), acoustic neuroma/vestibular schwannoma, hearing loss, meningioma, ependymoma, hemangioblastoma.

Academic Information

Department
Neurological Surgery

Other Appointments

  • Neurological Surgery

Other Affiliations

  • BIMS

Research Interests

Neurooncology (cancer genetics), neurocutaneous disorders (neurofibromatosis type 1 and 2, von Hippel-Lindau disease, tuberous sclerosis, Sturge-Weber syndrome), acoustic neuroma/vestibular schwannoma, hearing loss, meningioma, ependymoma, hemangioblastom

Research Disciplines

  • Neuroscience

Research Opportunities

  • Neuroscience

Selected Publications

2023

Saeed, Z., Tasleem, A., Asthagiri, A., Schiff, D., & Jo, J. (2023). Fatal Intracranial Hemorrhage With Belzutifan in von Hippel-Lindau Disease-Associated Hemangioblastoma: A Case Report. JCO PRECISION ONCOLOGY, 7. doi:10.1200/PO.23.00066

Asuzu, D. T., Shepard, M., Wang, T., Lopes, B., & Asthagiri, A. (2023). The Neurosarcoidosis. APPLIED RADIOLOGY, 52(2), 42-44. Retrieved from https://www.webofscience.com/

Moosa, S., Bond, A. E., Wang, T. R., Farzad, F., Asthagiri, A. R., & Elias, W. J. (2023). Stereotactic and Functional Neurosurgery Convection-Enhanced Delivery of Autologous Cerebrospinal Fluid Enhances Basal Ganglia Visualization during MRI-Guided Deep Brain Stimulation Surgery. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 101(2), 93-100. doi:10.1159/000528738

2022

Snyder, H., Wang, A. Y. -D., Ampie, L., Sarathy, D., Chatrath, A., Asthagiri, A. R., . . . Heilman, C. B. (2022). Primary Spinal Cord Astrocytomas: Two-Center Clinical Experience of Low- and High-Grade Lesions. WORLD NEUROSURGERY, 167, E1006-E1016. doi:10.1016/j.wneu.2022.08.130

Yogendran, L. V., Kalelioglu, T., Donahue, J. H., Ahmad, H., Phillips, K. A., Calautti, N. M., . . . Fadul, C. E. (2022). The landscape of brain tumor mimics in neuro-oncology practice. JOURNAL OF NEURO-ONCOLOGY, 159(3), 499-508. doi:10.1007/s11060-022-04087-4

Marino, A. C., Fadul, C. E., Lopes, M. B., Patel, S. H., & Asthagiri, A. R. (2022). Melanoma brain metastasis mimicking cortical laminar necrosis.. Surgical neurology international, 13, 584. doi:10.25259/sni_285_2022

2021

Huntoon, K., Shepard, M. J., Lukas, R. V., McCutcheon, I. E., Daniels, A. B., & Asthagiri, A. R. (2022). Hemangioblastoma diagnosis and surveillance in von Hippel-Lindau disease: a consensus statement. JOURNAL OF NEUROSURGERY, 136(6), 1511-1516. doi:10.3171/2021.3.JNS204203

Snyder, M. H., Ampie, L., DiDomenico, J. D., & Asthagiri, A. R. (2021). Bevacizumab as a surgery-sparing agent for spinal ependymoma in patients with neurofibromatosis type II: Systematic review and case. JOURNAL OF CLINICAL NEUROSCIENCE, 86, 79-84. doi:10.1016/j.jocn.2021.01.010

2020

Lazaro, T., Srinivasan, V. M., Rahman, M., Asthagiri, A., Barkhoudarian, G., Chambless, L. B., . . . Patel, A. J. (2020). Virtual education in neurosurgery during the COVID-19 pandemic. NEUROSURGICAL FOCUS, 49(6). doi:10.3171/2020.9.FOCUS20672

Silvestre, J., Gosse, T., Read, P., Gentzler, R., Purow, B., Asthagiri, A., . . . Fadul, C. E. (2021). Genesis of Quality Measurements to Improve the Care Delivered to Patients With Brain Metastases. JCO ONCOLOGY PRACTICE, 17(3), 146-+. doi:10.1200/OP.20.00233

Pemov, A., Dewan, R., Hansen, N. F., Chandrasekharappa, S. C., Ray-Chaudhury, A., Jones, K., . . . Asthagiri, A. R. (2020). Comparative clinical and genomic analysis of neurofibromatosis type 2-associated cranial and spinal meningiomas. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-69074-z

2019

Miller, T. W., Traphagen, N. A., Li, J., Lewis, L. D., Lopes, B., Asthagiri, A., . . . Fadul, C. E. (2019). Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma. JOURNAL OF NEURO-ONCOLOGY, 144(3), 563-572. doi:10.1007/s11060-019-03258-0

2018

Sokolowski, J. D., Ruhl, D. S., Kesser, B. W., & Asthagiri, A. R. (2018). Case Report: Facial Nerve Bifurcation Noted During Resection of Vestibular Schwannoma. OPERATIVE NEUROSURGERY, 15(4), E36-E39. doi:10.1093/ons/opx287

deTorres, A. T., Brewer, C. C., Zalewski, C. K., King, K. A., Walker, R., Scott, G. C., . . . Kim, H. J. (2018). Audiologic Natural History of Small Volume Cochleovestibular Schwannomas in Neurofibromatosis Type 2. OTOLOGY & NEUROTOLOGY, 39(3), 357-364. doi:10.1097/MAO.0000000000001690

Taylor, D. G., Ilyas, A., Mehta, G. U., Chen, C. -J., Schiff, D., Oldfield, E. H., & Asthagiri, A. R. (2018). Variable response of CNS hemangioblastomas to Pazopanib in a single patient with von Hippel-Lindau disease: Case report. JOURNAL OF CLINICAL NEUROSCIENCE, 50, 154-156. doi:10.1016/j.jocn.2018.01.040

2017

Paisan, G. M., Buell, T. J., Raper, D., & Asthagiri, A. (2017). Lumbosacral Subdural Hematoma After Glioblastoma Multiforme Resection: Possible Radiographic Evidence for the Downward Migration of Intracranial Blood. WORLD NEUROSURGERY, 108. doi:10.1016/j.wneu.2017.08.189

Dewan, R., Pemov, A., Dutra, A. S., Pak, E. D., Edwards, N. A., Ray-Chaudhury, A., . . . Germanwala, A. V. (2017). First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehensive genomic study of two cranial meningiomas with vastly different clinical presentation. BMC CANCER, 17. doi:10.1186/s12885-017-3127-6

2016

Raper, D. M. S., Zukas, A. M., Schiff, D., & Asthagiri, A. R. (2017). Geographically Remote Cerebral Venous Sinus Thrombosis in Patients with Intracranial Tumors. WORLD NEUROSURGERY, 98, 555-562. doi:10.1016/j.wneu.2016.11.084

Ledur, P. F., Liu, C., He, H., Harris, A. R., Minussi, D. C., Zhou, H. -Y., . . . Zong, H. (2016). Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells. NEURO-ONCOLOGY, 18(10), 1413-1424. doi:10.1093/neuonc/now062

Hong, C. S., Starke, R. M., Hays, M. A., Mandell, J. W., Schiff, D., & Asthagiri, A. R. (2016). Redefining the Prevalence of Dural Involvement in Rosai-Dorfman Disease of the Central Nervous System. WORLD NEUROSURGERY, 90. doi:10.1016/j.wneu.2016.02.121

Montgomery, B. K., Alimchandani, M., Mehta, G. U., Dewan, R., Nesvick, C. L., Miettinen, M., . . . Germanwala, A. V. (2016). Tumors displaying hybrid schwannoma and neurofibroma features in patients with neurofibromatosis type 2. CLINICAL NEUROPATHOLOGY, 35(2), 78-83. doi:10.5414/NP300895

2014

Starke, R. M., Asthagiri, A. R., Jane, J. A., & Jane, J. A. (2014). Neurological Surgery Training Abroad as a Progression to the Final Year of Training and Transition to Independent Practice. Journal of Graduate Medical Education, 6(4), 715-720. doi:10.4300/jgme-d-14-00136.1

Dewan, R., Pemov, A., Kim, H. J., Morgan, K. L., Vasquez, R. A., Chittiboina, P., . . . Asthagiri, A. R. (2015). Evidence of polyclonality in neurofibromatosis type 2-associated multilobulated vestibular schwannomas. NEURO-ONCOLOGY, 17(4), 566-573. doi:10.1093/neuonc/nou317

Starke, R. M., Jane, J. A. J., Asthagiri, A. R., & Jane, J. A. S. (2015). International rotations and resident education. JOURNAL OF NEUROSURGERY, 122(2), 237-239. doi:10.3171/2014.9.JNS142171

Asthagiri, A., Pouratian, N., & Youssef, A. S. (2014). Instructions for Obtaining SANS Neurosurgery Continuing Medical Education (CME) Credit. NEUROSURGERY, 75(3), N7. Retrieved from https://www.webofscience.com/

Holliday, M. A., Kim, H. J., Zalewski, C. K., Wafa, T., Dewan, R., King, K. A., . . . Asthagiri, A. R. (2014). Audiovestibular Characteristics of Small Cochleovestibular Schwannomas in Neurofibromatosis Type 2. OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 151(1), 117-124. doi:10.1177/0194599814529081

Lonser, R. R., Butman, J. A., Huntoon, K., Asthagiri, A. R., Wu, T., Bakhtian, K. D., . . . Oldfield, E. H. (2014). Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease Clinical article. JOURNAL OF NEUROSURGERY, 120(5), 1055-1062. doi:10.3171/2014.1.JNS131431

Sheehan, J., Starke, R. M., Pouratian, N., Litvack, Z., & Asthagiri, A. (2014). Identification of knowledge gaps in neurosurgery through analysis of responses to the Self-Assessment in Neurological Surgery (SANS).. World neurosurgery, 81(2), 229-233. doi:10.1016/j.wneu.2012.05.033

Asthagiri, A., Pouratian, N., & Youssef, A. S. (2014). Instructions for Obtaining SANS Neurosurgery Continuing Medical Education (CME) Credit. NEUROSURGERY, 74(6), N7. Retrieved from https://www.webofscience.com/

2013

Zusman, E. E., Heary, R. F., Stroink, A. R., Berger, M. S., Popp, A. J., Friedlander, R. M., . . . Asthagiri, A. R. (2013). Philanthropy Funding for Neurosurgery Research and Program Development. NEUROSURGERY, 73(1), 177-183. doi:10.1227/01.neu.0000429863.50018.f0

Ye, D. Y., Bakhtian, K. D., Asthagiri, A. R., & Lonser, R. R. (2013). Response.. Journal of neurosurgery, 118(6), 1380-1382. doi:10.3171/2012.11.jns122145

Crowley, R. W., Dumont, A. S., Asthagiri, A. R., Torner, J. C., Medel, R., Jane, J. A. J., . . . Kassell, N. F. (2014). Intraoperative Ultrasound Guidance for the Placement of Permanent Ventricular Cerebrospinal Fluid Shunt Catheters: A Single-Center Historical Cohort Study. WORLD NEUROSURGERY, 81(2), 397-403. doi:10.1016/j.wneu.2013.01.039

Ye, D. Y., Bakhtian, K. D., Asthagiri, A. R., & Lonser, R. R. (2013). Pregnancy and von Hippel-Lindau disease RESPONSE. JOURNAL OF NEUROSURGERY, 118(6), 1380-1382. Retrieved from https://www.webofscience.com/

2012

Ye, D. Y., Bakhtian, K. D., Asthagiri, A. R., & Lonser, R. R. (2012). Effect of pregnancy on hemangioblastoma development and progression in von Hippel-Lindau disease Clinical article. JOURNAL OF NEUROSURGERY, 117(5), 818-824. doi:10.3171/2012.7.JNS12367

Ksendzovsky, A., Walbridge, S., Saunders, R. C., Asthagiri, A. R., Heiss, J. D., & Lonser, R. R. (2012). Convection-enhanced delivery of M13 bacteriophage to the brain Laboratory investigation. JOURNAL OF NEUROSURGERY, 117(2), 197-203. doi:10.3171/2012.4.JNS111528

Crowley, R. W., Asthagiri, A. R., Starke, R. M., Zusman, E. E., Chiocca, E. A., & Lonser, R. R. (2012). In-training Factors Predictive of Choosing and Sustaining a Productive Academic Career Path in Neurological Surgery. NEUROSURGERY, 70(4), 1024-1032. doi:10.1227/NEU.0b013e3182367143

Ye, D. Y., Bakhtian, K. D., Asthagiri, A. R., & Lonser, R. R. (2012). Von Hippel-Lindau disease and pregnancy Response. JOURNAL OF NEUROSURGERY, 117(5), 816-817. Retrieved from https://www.webofscience.com/

Dirks, M. S., Butman, J. A., Kim, H. J., Wu, T., Morgan, K., Tran, A. P., . . . Asthagiri, A. R. (2012). Natural history of neurofibromatosis Type 2 tumors Response. JOURNAL OF NEUROSURGERY, 117(1), 108. Retrieved from https://www.webofscience.com/

Ksendzovsky, A., Walbridge, S., Saunders, R. C., Asthagiri, A. R., Heiss, J. D., & Lonser, R. R. (2012). Convection-enhanced delivery Response. JOURNAL OF NEUROSURGERY, 117(2), 195-196. Retrieved from https://www.webofscience.com/

Asthagiri, A. R., Vasquez, R. A., Butman, J. A., Wu, T., Morgan, K., Brewer, C. C., . . . Lonser, R. R. (2012). Mechanisms of Hearing Loss in Neurofibromatosis Type 2. PLOS ONE, 7(9). doi:10.1371/journal.pone.0046132

2011

Xu, D. S., Dirks, M. S., Quezado, M. M., Lubensky, I. A., Zhuang, Z., Lonser, R. R., & Asthagiri, A. R. (2011). A von Hippel-Lindau Disease-Associated Microcystic Adenoma of the Ethmoid Sinus: Case Report. NEUROSURGERY, 69(4), E1017-E1021. doi:10.1227/NEU.0b013e318223b7a7

Asthagiri, A. R., Walbridge, S., Heiss, J. D., & Lonser, R. R. (2011). Convection-enhanced delivery Response. JOURNAL OF NEUROSURGERY, 115(3), 465-466. doi:10.3171/2010.11.JNS101801

Asthagiri, A. R., Walbridge, S., Heiss, J. D., & Lonser, R. R. (2011). Effect of concentration on the accuracy of convective imaging distribution of a gadolinium-based surrogate tracer Laboratory investigation. JOURNAL OF NEUROSURGERY, 115(3), 467-473. doi:10.3171/2011.3.JNS101381

Yang, C., Asthagiri, A. R., Iyer, R. R., Lu, J., Xu, D. S., Ksendzovsky, A., . . . Lonser, R. R. (2011). Missense mutations in the NF2 gene result in the quantitative loss of merlin protein and minimally affect protein intrinsic function. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(12), 4980-4985. doi:10.1073/pnas.1102198108

Asthagiri, A. R., Mehta, G. U., Butman, J. A., Baggenstos, M., Oldfield, E. H., & Lonser, R. R. (2011). Long-term stability after multilevel cervical laminectomy for spinal cord tumor resection in von Hippel-Lindau disease Clinical article. JOURNAL OF NEUROSURGERY-SPINE, 14(4), 444-452. doi:10.3171/2010.11.SPINE10429

2010

Wind, J. J., Bakhtian, K. D., Sweet, J. A., Mehta, G. U., Thawani, J. P., Asthagiri, A. R., . . . Lonser, R. R. (2011). Long-term outcome after resection of brainstem hemangioblastomas in von Hippel-Lindau disease. JOURNAL OF NEUROSURGERY, 114(5), 1312-1318. doi:10.3171/2010.9.JNS10839

Mehta, G. U., Heiss, J. D., Park, J. K., Asthagiri, A. R., Zaghloul, K. A., & Lonser, R. R. (2010). Neurological Surgery at the National Institutes of Health. WORLD NEUROSURGERY, 74(1), 49-59. doi:10.1016/j.wneu.2010.05.027

Heiss, J. D., Walbridge, S., Asthagiri, A. R., & Lonser, R. R. (2010). Image-guided convection-enhanced delivery of muscimol to the primate brain Laboratory investigation. JOURNAL OF NEUROSURGERY, 112(4), 790-795. doi:10.3171/2009.7.JNS09652

Mehta, G. U., Asthagiri, A. R., Bakhtian, K. D., Auh, S., Oldfield, E. H., & Lonser, R. R. (2010). Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease Clinical article. JOURNAL OF NEUROSURGERY-SPINE, 12(3), 233-242. doi:10.3171/2009.10.SPINE09592