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Ajit Tiwari

Ajit Tiwari

Assistant Professor of Research, Molecular Physiology and Biological Physics

Email
[email protected]

Bio & Overview

My research is aimed towards understanding the role of microtubules, motors and components of membrane domains in Clathrin Independent Endocytosis (CIE) of growth factor receptors and other cargoes including bacterial toxins. In addition, I am also involved in studies aimed towards understanding the partitioning of proteins associated with Alzheimer’s disease and receptors for bacterial toxins, between raft and non-rafts domains of plasma membrane.

Academic Information

Department
Molecular Physiology and Biological Physics

Other Appointments

  • Cell Biology

Other Affiliations

  • BIMS
  • Molecular Physiology and Biological Physics

Research Interests

Membrane trafficking, bacterial toxin endocytosis, angiogenesis and Alzheimer's disease.

Research Disciplines

  • Molecular Physiology and Biological Physics

Selected Publications

2022

Fricke, N., Raghunathan, K., Tiwari, A., Stefanski, K. M., Balakrishnan, M., Waterson, A. G., . . . Kenworthy, A. K. (2022). High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts. ACS CENTRAL SCIENCE, 8(3), 370-378. doi:10.1021/acscentsci.1c01058

2021

Kenworthy, A. K., Schmieder, S. S., Raghunathan, K., Tiwari, A., Wang, T., Kelly, C. V., & Lencer, W. I. (2021). Cholera Toxin as a Probe for Membrane Biology. TOXINS, 13(8). doi:10.3390/toxins13080543

Capone, R., Tiwari, A., Hadziselimovic, A., Peskova, Y., Hutchison, J. M., Sanders, C. R., & Kenworthy, A. K. (2021). The C99 domain of the amyloid precursor protein resides in the disordered membrane phase. JOURNAL OF BIOLOGICAL CHEMISTRY, 296. doi:10.1016/j.jbc.2021.100652

2019

Insinna, C., Lu, Q., Teixeira, I., Harned, A., Semler, E. M., Stauffer, J., . . . Westlake, C. J. (2019). Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-018-08192-9

2018

Saito-Diaz, K., Benchabane, H., Tiwari, A., Tian, A., Li, B., Thompson, J. J., . . . Lee, E. (2018). APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. DEVELOPMENTAL CELL, 44(5), 566-+. doi:10.1016/j.devcel.2018.02.013

2017

Copeland, C. A., Han, B., Tiwari, A., Austin, E. D., Loyd, J. E., West, J. D., & Kenworthy, A. K. (2017). A disease-associated frameshift mutation in caveolin-1 disrupts caveolae formation and function through introduction of a de novo ER retention signal. MOLECULAR BIOLOGY OF THE CELL, 28(22), 3095-3111. doi:10.1091/mbc.E17-06-0421

2016

Tiwari, A., Copeland, C. A., Han, B., Hanson, C. A., Raghunathan, K., & Kenworthy, A. K. (2016). Caveolin-1 is an aggresome-inducing protein. SCIENTIFIC REPORTS, 6. doi:10.1038/srep38681

Han, B., Copeland, C. A., Tiwari, A., & Kenworthy, A. K. (2016). Assembly and Turnover of Caveolae: What Do We Really Know?. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 4. doi:10.3389/fcell.2016.00068

2015

Day, C. A., Baetz, N. W., Copeland, C. A., Kraft, L. J., Han, B., Tiwari, A., . . . Kenworthy, A. K. (2015). Microtubule Motors Power Plasma Membrane Tubulation in Clathrin-Independent Endocytosis. TRAFFIC, 16(6), 572-590. doi:10.1111/tra.12269

Han, B., Tiwari, A., & Kenworthy, A. K. (2015). Tagging Strategies Strongly Affect the Fate of Overexpressed Caveolin-1. TRAFFIC, 16(4), 417-438. doi:10.1111/tra.12254