Anja Katrin Bielinsky

Rivard, R. S., Chang, Y. -C., Ragland, R. L., Thu, Y. -M., Kassab, M., Mandal, R. S., . . . Brown, E. J. (2024). Improved detection of DNA replication fork-associated proteins. CELL REPORTS, 43(5). doi:10.1016/j.celrep.2024.114178

Oram, M. K., Baxley, R. M., Simon, E. M., Lin, K., Chang, Y. -C., Wang, L., . . . Bielinsky, A. -K. (2024). RNF4 prevents genomic instability caused by chronic DNA under-replication. DNA REPAIR, 135. doi:10.1016/j.dnarep.2024.103646

Lin, K., Chang, Y. -C., Billmann, M., Ward, H. N., Le, K., Hassan, A. Z., . . . Myers, C. L. (2024). A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds. SCIENTIFIC REPORTS, 14(1). doi:10.1038/s41598-024-51735-y

Schmit, M. M., Baxley, R. M., Wang, L., Hinderlie, P., Kaufman, M., Simon, E., . . . Bielinsky, A. -K. (2024). A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells. OPEN BIOLOGY, 14(1). doi:10.1098/rsob.230407

Leung, W., Baxley, R. M., Traband, E., Chang, Y. -C., Rogers, C. B., Wang, L., . . . Bielinsky, A. -K. (2023). FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination. CELL REPORTS, 42(12). doi:10.1016/j.celrep.2023.113523

Medina-Rivera, M., Phelps, S., Sridharan, M., Becker, J., Lamb, N., Kumar, C., . . . Surtees, J. (2023). Elevated MSH2 MSH3 expression interferes with DNA metabolism in vivo. NUCLEIC ACIDS RESEARCH, 51(22), 12185-12206. doi:10.1093/nar/gkad934

Chang, Y. -C., Lin, K., Baxley, R. M., Durrett, W., Wang, L., Stojkova, O., . . . Bielinsky, A. -K. (2023). RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication. OPEN BIOLOGY, 13(8). doi:10.1098/rsob.230068

Rogers, C. B., Kram, R. E., Lin, K., Myers, C. L., Sobeck, A., Hendrickson, E. A., & Bielinsky, A. -K. (2023). Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining. CELL REPORTS, 42(5). doi:10.1016/j.celrep.2023.112428

Grange, L. J., Reynolds, J. J., Ullah, F., Isidor, B., Shearer, R. F., Latypova, X., . . . Stewart, G. S. (2022). Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34349-8

Lin, K., Chang, Y. -C., de Velasco, E. M. F., Wickman, K., Myers, C. L., & Bielinsky, A. -K. (2022). Scalable CRISPR-Cas9 chemical genetic screens in non-transformed human cells. STAR PROTOCOLS, 3(4). doi:10.1016/j.xpro.2022.101675

Kang, Z., Fu, P., Alcivar, A. L., Fu, H., Redon, C., Foo, T. K., . . . Xia, B. (2021). BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-26227-6

Chang, Y. -C., Oram, M. K., & Bielinsky, A. -K. (2021). SUMO-Targeted Ubiquitin Ligases and Their Functions in Maintaining Genome Stability. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(10). doi:10.3390/ijms22105391

Baxley, R. M., Leung, W., Schmit, M. M., Matson, J. P., Yin, L., Oram, M. K., . . . Bielinsky, A. -K. (2021). Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21878-x

Okamoto, Y., Abe, M., Mu, A., Tempaku, Y., Rogers, C. B., Mochizuki, A. L., . . . Takata, M. (2021). SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells. BLOOD, 137(3), 336-348. doi:10.1182/blood.2019003782

Schmit, M., & Bielinsky, A. -K. (2021). Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(2). doi:10.3390/ijms22020911

Mace, E. M., Paust, S., Conte, M. I., Baxley, R. M., Schmit, M. M., Patil, S. L., . . . Orange, J. S. (2020). Human NK cell deficiency as a result of biallelic mutations in MCM10. JOURNAL OF CLINICAL INVESTIGATION, 130(10), 5272-5286. doi:10.1172/JCI134966

Thakar, T., Leung, W., Nicolae, C. M., Clements, K. E., Shen, B., Bielinsky, A. -K., & Moldovan, G. -L. (2020). Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-16096-w

Stroik, S., Kurtz, K., Lin, K., Karachenets, S., Myers, C. L., Bielinsky, A. -K., & Hendrickson, E. A. (2020). EXO1 resection at G-quadruplex structures facilitates resolution and replication. NUCLEIC ACIDS RESEARCH, 48(9), 4960-4975. doi:10.1093/nar/gkaa199

Raghunandan, M., Yeo, J. E., Walter, R., Saito, K., Harvey, A. J., Ittershagen, S., . . . Sobeck, A. (2020). Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. HUMAN MOLECULAR GENETICS, 29(7), 1083-1095. doi:10.1093/hmg/ddz250

Paulson, C. N., John, K., Baxley, R. M., Kurniawan, F., Orellana, K., Francis, R., . . . Bielinsky, A. -K. (2019). The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10. OPEN BIOLOGY, 9(8). doi:10.1098/rsob.190117

Matson, J. P., Dumitru, R., Coryell, P., Baxley, R. M., Chen, W., Twaroski, K., . . . Cook, J. G. (2019). Correction: Rapid DNA replication origin licensing protects stem cell pluripotency.. eLife, 8, e49040. doi:10.7554/elife.49040

Leung, W., Baxley, R. M., Moldovan, G. -L., & Bielinsky, A. -K. (2019). Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA. GENES, 10(1). doi:10.3390/genes10010010

Kurniawan, F., Shi, K., Kurahashi, K., Bielinsky, A. -K., & Aihara, H. (2018). Crystal Structure of Entamoeba histolytica Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication. ISCIENCE, 3, 102-+. doi:10.1016/j.isci.2018.04.011

Becker, J. R., Gallo, D., Leung, W., Croissant, T., Thu, Y. M., Hai, D. N., . . . Bielinsky, A. -K. (2018). Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner. NUCLEIC ACIDS RESEARCH, 46(11), 5634-5650. doi:10.1093/nar/gky313

Matson, J. P., Dumitru, R., Coryell, P., Baxley, R. M., Chen, W., Twaroski, K., . . . Cook, J. G. (2017). Rapid DNA replication origin licensing protects stem cell pluripotency. ELIFE, 6. doi:10.7554/eLife.30473

Baxley, R. M., & Bielinsky, A. -K. (2017). Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks. GENES, 8(2). doi:10.3390/genes8020073

Zhang, T., Fultz, B. L., Das-Bradoo, S., & Bielinsky, A. -K. (2016). Mapping ubiquitination sites of S. cerevisiae Mcm10.. Biochemistry and biophysics reports, 8, 212-218. doi:10.1016/j.bbrep.2016.09.003

Bielinsky, A. -K., & Leung, W. (2016). Not just for coding: a new role for histone tails in replication enzyme activation. FEBS Journal, 283(23), 4244-4246. doi:10.1111/febs.13958

Bielinsky, A. -K. (2016). Mcm10: The glue at replication forks. CELL CYCLE, 15(22), 3024-3025. doi:10.1080/15384101.2016.1216925

Thu, Y. M., Van Riper, S. K., Higgins, L., Zhang, T., Becker, J. R., Markowski, T. W., . . . Bielinsky, A. K. (2016). Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression. CELL REPORTS, 15(6), 1254-1265. doi:10.1016/j.celrep.2016.04.017

Bielinsky, A. -K. (2015). Penetrating enemy territory: Soluble PCNA-peptides stress out MYCN-overexpressing neuroblastomas. EBIOMEDICINE, 2(12), 1844-1845. doi:10.1016/j.ebiom.2015.12.012

Becker, J. R., Pons, C., Hai, D. N., Costanzo, M., Boone, C., Myers, C. L., & Bielinsky, A. -K. (2015). Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing. PLOS GENETICS, 11(11). doi:10.1371/journal.pgen.1005659

Avdulov, S., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J. R., Beadnell, T. C., . . . Polunovsky, V. A. (2015). eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells. CANCER RESEARCH, 75(4), 687-697. doi:10.1158/0008-5472.CAN-14-2571

Alver, R. C., Zhang, T., Josephrajan, A., Fultz, B. L., Hendrix, C. J., Das-Bradoo, S., & Bielinsky, A. -K. (2014). The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage. NUCLEIC ACIDS RESEARCH, 42(13), 8389-8404. doi:10.1093/nar/gku479

Thu, Y. M., & Bielinsky, A. -K. (2014). MCM10: One tool for all-Integrity, maintenance and damage control. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 30, 121-130. doi:10.1016/j.semcdb.2014.03.017

Becker, J. R., Hai, D. N., Wang, X., & Bielinsky, A. -K. (2014). Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair. CELL CYCLE, 13(11). doi:10.4161/cc.28652

Ragland, R. L., Patel, S., Rivard, R. S., Smith, K., Peters, A. A., Bielinsky, A. -K., & Brown, E. J. (2013). RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. GENES & DEVELOPMENT, 27(20), 2259-2273. doi:10.1101/gad.223180.113

Thu, Y. M., & Bielinsky, A. -K. (2013). Enigmatic roles of Mcm10 in DNA replication. TRENDS IN BIOCHEMICAL SCIENCES, 38(4), 184-194. doi:10.1016/j.tibs.2012.12.003

Du, W., Josephrajan, A., Adhikary, S., Bowles, T., Bielinsky, A. -K., & Eichman, B. F. (2013). Mcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil Domain. PLOS ONE, 8(7). doi:10.1371/journal.pone.0070518

Nguyen, H. D., Becker, J., Thu, Y. M., Costanzo, M., Koch, E. N., Smith, S., . . . Bielinsky, A. -K. (2013). Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. PLOS ONE, 8(6). doi:10.1371/journal.pone.0066379

Das-Bradoo, S., Nguyen, H. D., & Bielinsky, A. -K. (2010). Damage-specific modification of PCNA. CELL CYCLE, 9(18), 3674-3679. doi:10.4161/cc.9.18.13121

Alver, R. C., & Bielinsky, A. -K. (2010). Termination at sTop2. MOLECULAR CELL, 39(4), 487-489. doi:10.1016/j.molcel.2010.08.006

Nguyen, H. D., & Bielinsky, A. -K. (2010). HDM2 ERKs PCNA. JOURNAL OF CELL BIOLOGY, 190(4), 487-489. doi:10.1083/jcb.201007096

Haworth, J., Alver, R. C., Anderson, M., & Bielinsky, A. -K. (2010). Ubc4 and Not4 Regulate Steady- State Levels of DNA Polymerase-α to Promote Efficient and Accurate DNA Replication. MOLECULAR BIOLOGY OF THE CELL, 21(18), 3205-3219. doi:10.1091/mbc.e09-06-0452