Barnett R. Nathan | University of Virginia School of Medicine

Bio & Overview

Laboratory research is directed toward the investigation of the pathophysiology of central nervous system infection. Experimental models include brain abscess and meningitis. New antimicrobials are tested for their efficacy in treating brain abscess and bacterial meningitis. The MRI changes in bacterial meningitis are also investigated. On a more cellular level investigations into the relative rolls of substance P, nitric oxide, and microgolia in models of CNS infection are investigated with tissue culture as well as molecular genetics techniques. Clinical investigation involves fever in the intensive care unit, particularly the role of neurogenic, non-infectious fever.

Academic Information

Department: Neurology

Research Interests

Experimental meningitis & brain abscess, the role of substance P & nitric oxide on microglia in CNS inflammation.

Selected Publications

2019

Rao, C. P. V., Suarez, J. I., Martin, R. H., Bauza, C., Georgiadis, A., Calvillo, E., . . . Tuan, V. B. (2020). Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2. NEUROCRITICAL CARE, 32(1), 88-103. doi:10.1007/s12028-019-00835-z

2018

Chen, W., McCollum, M. A., Bradley, E. B., Nathan, B. R., Chen, D. T., & Worden, M. K. (2019). Using Instrument-Guided Team Reflection and Debriefing to Cultivate Teamwork Knowledge, Skills, and Attitudes in Pre-Clerkship Learning Teams. MEDICAL SCIENCE EDUCATOR, 29(1), 45-50. doi:10.1007/s40670-018-00669-y

2016

Fried, H. I., Nathan, B. R., Rowe, A. S., Zabramski, J. M., Andaluz, N., Bhimraj, A., . . . Singh, J. M. (2016). The Insertion and Management of External Ventricular Drains: An Evidence-Based Consensus Statement. NEUROCRITICAL CARE, 24(1), 61-81. doi:10.1007/s12028-015-0224-8

2015

Gaieski, D. F., Nathan, B. R., & O'Brien, N. F. (2015). Emergency Neurologic Life Support: Meningitis and Encephalitis. NEUROCRITICAL CARE, 23, S110-S118. doi:10.1007/s12028-015-0165-2

2013

Myint, Z. W., Sen, J. M., Watts, N. L., Druzga, T. J., Nathan, B. R., Ward, M. D., . . . Fracasso, P. M. (2014). Reversible Posterior Leukoencephalopathy Syndrome During Regorafenib Treatment: A Case Report and Literature Review of Reversible Posterior Leukoencephalopathy Syndrome Associated With Multikinase Inhibitors. CLINICAL COLORECTAL CANCER, 13(2), 127-130. doi:10.1016/j.clcc.2013.12.003

Fletcher, J. J., Meurer, W., Dunne, M., Rajajee, V., Jacobs, T. L., Sheehan, K. M., . . . Kade, A. M. (2014). Inter-Observer Agreement on the Diagnosis of Neurocardiogenic Injury Following Aneurysmal Subarachnoid Hemorrhage. NEUROCRITICAL CARE, 20(2), 263-269. doi:10.1007/s12028-013-9941-z

Gaspard, N., Foreman, B., Judd, L. M., Brenton, J. N., Nathan, B. R., McCoy, B. M., . . . LaRoche, S. M. (2013). Intravenous ketamine for the treatment of refractory status epilepticus: A retrospective multicenter study. EPILEPSIA, 54(8), 1498-1503. doi:10.1111/epi.12247

2012

Gaieski, D. F., Nathan, B. R., Weingart, S. D., & Smith, W. S. (2012). Emergency Neurologic Life Support: Meningitis and Encephalitis. NEUROCRITICAL CARE, 17, 66-72. doi:10.1007/s12028-012-9751-8

Nathan, B. R., & Kincaid, O. (2012). Does experience doing lumbar punctures result in expertise? A medical maxim bites the dust. NEUROLOGY, 79(2), 115-116. doi:10.1212/WNL.0b013e31825dd3b0

2010

Kramer, A. H., Mikolaenko, I., Deis, N., Dumont, A. S., Kassell, N. F., Bleck, T. P., & Nathan, B. A. (2010). Intraventricular Hemorrhage Volume Predicts Poor Outcomes But Not Delayed Ischemic Neurological Deficits Among Patients With Ruptured Cerebral Aneurysms. NEUROSURGERY, 67(4), 1044-1052. doi:10.1227/NEU.0b013e3181ed1379

Kapnadak, S. G., Mikolaenko, I., Enfield, K., Gress, D. R., & Nathan, B. R. (2010). Ondine's Curse with Accompanying Trigeminal and Glossopharyngeal Neuralgia Secondary to Medullary Telangiectasia. NEUROCRITICAL CARE, 12(3), 395-399. doi:10.1007/s12028-009-9321-x