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Coleen A. McNamara

Coleen A. McNamara

Professor of Medicine/Cardiovascular Division, Beirne B. Carter Professor of Immunology and Co-Director of the Beirne B. Carter Center for Immunology Research, Medicine- Cardiovascular Medicine

Primary Location
PO Box 801386
Primary Phone Number
434.243.5854
Fax Number
434.924.1221
Email
[email protected]
Website
https://www.immunology.virginia.edu/McNamara/

Bio & Overview

Specific Research Ongoing in the McNamara lab Discovery of a single nucleotide polymorphism (SNP) in the human ID3 gene that is functionally relevant and associated with vascular disease in humans. The McNamara lab utilized three human cohorts with CAD imaging and found that in all 3 cohorts, a SNP in the Id3 gene at rs11574 was significantly associated with CAD. They further performed biochemical analysis of the Id3 proteins encoded by the common versus the disease-associated (risk) allele and demonstrated that the Id3 protein encoded by the risk allele had a significantly attenuated ability to bind and antagonize its partner protein resulting in altered gene expression (Circ Res) . Discovering the ways that this protein protects from CAD has the potential to lead to new and innovative precision approaches to CAD diagnosis, prevention and treatment. Id3 Regulates B-1b and Marginal Zone B (MZB) cells to protect from CVD The McNamara lab discovered that the B-1b B cell subset in mice and the MZB subtype in humans produces abundant atheroprotective natural IgM to oxidation specific epitopes (OSE) on LDL and protects from diet-induced atherosclerosis and inflammation in pre-clinical models. Id3 is a key molecular regulator of both of these subtypes. Single cell analysis of humans referred for coronary artery imaging and use of humanized murine systems have allowed us to unveil the key role for MZB in atheroprotective IgM production in humans. Projects are ongoing to identify the molecular and cellular mechanisms and key Id3 target genes (RNAseq, ChIPseq, etc.) responsible for mediating these effects and developing ways to modulate these genes. The McNamara lab is one of 6 international groups (UVA, Harvard, Mt. Sinai, Cambridge (UK), Karolinska (Sweden), Medical University of Vienna (Austria) funded by the Leducq Foundation to lead the field in dissecting the role of B lymphocytes in CVD. Other Id3 targets in CVD (Chemokine Receptors) One Id3 target with strong links to CVD are chemokine receptors. Utilizing flow and mass cytometry assessment of circulating immune cells from subjects with intravascular ultrasound with virtual histology (IVUS-VH) assessment of CAD. we have discovered that the amount of key chemokine receptors (CXCR4 and CCR6) on B-1 cells marks those with low amounts of artery plaque and characteristics that are associated with risk for heart attack. This project is part of an NIH funded Program Project Grant in collaboration with researchers in San Diego, La Jolla and the Medical College of Georgia . We are also currently combining genetics with nanomedicine to develop personalized approaches for immune strategies targeting B-1 cell chemokine receptor expression. Immune Checkpoint molecules in CVD The McNamara laboratory is part of another 5 year Leducq Transatlantic Network of Excellence (TNE) to study the role of checkpoint molecular in CVD. Checkpoint inhibitors have revolutionized the therapy of cancer and other immune-mediated diseases. Yet, despite preclinical studies identifying roles for checkpoint molecules in CVD, our understanding of how these molecules and therapies that target them impact human CVD is poorly understood. Together with investigators from the Mayo Clinic, Dartmouth, University of Oxford (UK), Lund University (Sweden), Leiden Academic Center for Drug Research (Netherlands), and Radboud University (Netherlands), the McNamara laboratory at UVA is working to unravel the impact of checkpoint molecules on CVD. IgE to alpha-gal and CVD In collaboration with Jeff Wilson and Thomas Platts-Mills at UVA, the McNamara lab recently reported (ATVB) that IgE to α-Gal, the primary cause of delayed anaphylaxis to red meat (α-Gal syndrome), was associated with increased atheroma burden and plaques with more unstable features as measured by IVUS-VH in 118 subjects presenting to UVA for coronary artery imaging. In the United States sensitization to α-Gal is recognized as a consequence of bites of the tick Amblyomma americanum. In collaboration with Dr. Loren Erickson in the Carter Immunology Center, the McNamara lab is now performing further studies to expand these findings and identify the mechanisms mediating these effects through a 5 year grant from the NIH. Precision Medicine The McNamara lab is using precision medicine approaches to also contribute to our knowledge of the broader impact of the immune system on CVD. They have developed the pipeline for high dimensional analysis of human PBMCs to identify unique immunophenotypes associated with disease burden and therapeutic responses. They are applying these innovative systems to clinical scenarios to aid in the development of personalized approaches to therapy. Current studies are focusing on studying human immune subtypes activated by IL-1β and IL-6 in subjects with systolic heart failure receiving IL-1β receptor antagonism or placebo and in subjects with advanced coronary artery imaging to quantitate plaque volume and progression. This work is supported by a Prominence to Preeminence (P2PE) Award from the University of Virginia.

Academic Information

Department
Medicine- Cardiovascular Medicine
Academic Title
Professor

Primary Education

  • Fellowship, Cardiovascular Medicine, University of Virginianull
  • MD, Medical College of Ohionull
  • Residency, Internal Medicine, University of Virginianull

Other Appointments

  • Microbiology, Immunology, and Cancer Biology
  • Professor, Molecular Physiology and Biological Physics
  • Pathology
  • Pharmacology
  • Professor, MOMD

Other Affiliations

  • Cardiovascular Research Center
  • MSTP
  • Professor, BIMS

Research Interests

Immune System Regulation of Cardiometabolic Disease

Research Disciplines

  • Biotechnology
  • Cardiovascular Biology
  • Immunology
  • Molecular Biology
  • Physiology
  • Translational Science

Research Opportunities

  • Bioinformatics & Genomics
  • Biotechnology
  • Cardiovascular Disease
  • Cell Biology
  • Immunology
  • Molecular Biology

PhD Programs

  • Experimental Pathology
  • Microbiology
  • Physiology

Selected Publications

2022

Roy, P., Sidney, J., Lindestam Arlehamn, C. S., Phillips, E., Mallal, S., Armstrong Suthahar, S. S., . . . Ley, K. (2022). Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B. CIRCULATION RESEARCH, 131(3), 258-276. doi:10.1161/CIRCRESAHA.122.321116

Mazimba, S., Mwansa, H., Breathett, K., Strickling, J. E., Shah, K., McNamara, C., . . . Bilchick, K. C. (2022). Systemic arterial pulsatility index (SAPi) predicts adverse outcomes in advanced heart failure patients. HEART AND VESSELS, 37(10), 1719-1727. doi:10.1007/s00380-022-02070-7

Lempicki, M. D., Serbulea, V., Paul, S., Upchurch, C. M., Sahu, S., Gray, J. A., . . . Meher, A. K. (2022). BAFF 60-mer binding to BAFF receptor 3 utilizes the NF-κB1 signaling pathway to hyperactivate B cells.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 Suppl 1. doi:10.1096/fasebj.2022.36.s1.r2051

Pattarabanjird, T., Marshall, M., Upadhye, A., Srikakulapu, P., Garmey, J. C., Haider, A., . . . McNamara, C. A. (2022). B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. CIRCULATION RESEARCH, 130(7), 981-993. doi:10.1161/CIRCRESAHA.121.320436

Srikakulapu, P., Pattarabanjird, T., Upadhye, A., Bontha, S. V., Osinski, V., Marshall, M. A., . . . McNamara, C. A. (2022). B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.909475

2021

Osinski, V., Srikakulapu, P., Haider, Y. M., Marshall, M. A., Ganta, V. C., Annex, B. H., & McNamara, C. A. (2022). Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 42(1), 6-18. doi:10.1161/ATVBAHA.120.315501

Spinosa, M. D., Montgomery, W. G., Lempicki, M., Srikakulapu, P., Johnsrude, M. J., McNamara, C. A., . . . Meher, A. K. (2021). B Cell-Activating Factor Antagonism Attenuates the Growth of Experimental Abdominal Aortic Aneurysm. AMERICAN JOURNAL OF PATHOLOGY, 191(12), 2231-2244. doi:10.1016/j.ajpath.2021.08.012

Gaddis, D. E., Padgett, L. E., Wu, R., Nguyen, A., McSkimming, C., Dinh, H. Q., . . . Hedrick, C. C. (2021). Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(9), 2387-2398. doi:10.1161/ATVBAHA.120.314189

Ruiz, H. H., Nguyen, A., Wang, C., He, L., Li, H., Hallowell, P., . . . Schmidt, A. M. (2021). AGE/RAGE/DIAPH1 axis is associated with immunometabolic markers and risk of insulin resistance in subcutaneous but not omental adipose tissue in human obesity. INTERNATIONAL JOURNAL OF OBESITY, 45(9), 2083-2094. doi:10.1038/s41366-021-00878-3

Pattarabanjird, T., Li, C., & McNamara, C. (2021). B Cells in Atherosclerosis Mechanisms and Potential Clinical Applications. JACC-BASIC TO TRANSLATIONAL SCIENCE, 6(6), 546-563. doi:10.1016/j.jacbts.2021.01.006

Kassiteridi, C., Cole, J. E., Griseri, T., Falck-Hansen, M., Goddard, M. E., Seneviratne, A. N., . . . Monaco, C. (2021). CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. CIRCULATION RESEARCH, 129(2), 280-295. doi:10.1161/CIRCRESAHA.119.316062

Feinstein, M. J., Doyle, M. F., Stein, J. H., Sitlani, C. M., Fohner, A. E., Huber, S. A., . . . Delaney, J. A. C. (2021). Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women The Multi-Ethnic Study of Atherosclerosis-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(5), 1810-1817. doi:10.1161/ATVBAHA.120.315886

Kothari, H., Williams, C. M., McSkimming, C., Drago, F., Marshall, M. A., Garmey, J., . . . McNamara, C. A. (2021). Identification of human immune cell subtypes most responsive to IL-1β-induced inflammatory signaling using mass cytometry. SCIENCE SIGNALING, 14(673). doi:10.1126/scisignal.abc5763

Pattarabanjird, T., Wilson, J. M., Erickson, L. D., Workman, L. J., Qiao, H., Ghosheh, Y., . . . McNamara, C. A. (2022). Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 8. doi:10.3389/fcvm.2021.791028

Srikakulapu, P., Upadhye, A., Drago, F., Perry, H. M., Bontha, S. V., McSkimming, C., . . . McNamara, C. A. (2021). Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.636013

Keshavarz, B., Wiencek, J. R., Workman, L. J., Straesser, M. D., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2021). Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 182(5), 417-424. doi:10.1159/000514203

2020

Garmey, J. C., Hensien, J. M., Harmon, D. B., Osinski, V., McSkimming, C., Marshall, M. A., . . . Misiou, A. (2021). Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3) A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(2), 796-807. doi:10.1161/ATVBAHA.120.315588

Pattarabanjird, T., Cress, C., Nguyen, A., Taylor, A., Bekiranov, S., & McNamara, C. (2020). A Machine Learning Model Utilizing a Novel SNP Shows Enhanced Prediction of Coronary Artery Disease Severity. GENES, 11(12). doi:10.3390/genes11121446

Keshavarz, B., Wiencek, J., Bazydlo, L., Straesser, M., Workman, L., Platts-Mills, T., & Wilson, J. (2021). Quantitative Measurement of IgG to SARS-CoV-2 Proteins Using the Phadia ImmunoCAP 250. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), AB150. Retrieved from https://www.webofscience.com/

Padgett, L. E., Dinh, H. Q., Wu, R., Gaddis, D. E., Araujo, D. J., Winkels, H., . . . Hedrick, C. C. (2020). Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(12), 2845-2859. doi:10.1161/ATVBAHA.120.315106

Alencar, G. F., Owsiany, K. M., Karnewar, S., Sukhavasi, K., Mocci, G., Nguyen, A. T., . . . Owens, G. K. (2020). Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. CIRCULATION, 142(21), 2045-2059. doi:10.1161/CIRCULATIONAHA.120.046672

Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., . . . Ley, K. (2020). Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas. CIRCULATION RESEARCH, 127(3), 402-426. doi:10.1161/CIRCRESAHA.120.316903

Srikakulapu, P., & McNamara, C. A. (2020). B Lymphocytes and Adipose Tissue Inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(5), 1110-1122. doi:10.1161/ATVBAHA.119.312467

Kroon, T., Harms, M., Maurer, S., Bonnet, L., Alexandersson, I., Lindblom, A., . . . Boucher, J. (2020). PPARγ and PPARα synergize to induce robust browning of white fat in vivo. MOLECULAR METABOLISM, 36. doi:10.1016/j.molmet.2020.02.007

Upadhye, A., Sturek, J. M., & McNamara, C. A. (2020). 2019 Russell Ross Memorial Lecture in Vascular Biology B Lymphocyte-Mediated Protective Immunity in Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(2), 309-322. doi:10.1161/ATVBAHA.119.313064

Gilbertson, N. M., Gaitan, J. M., Osinski, V., Rexrode, E. A., Garmey, J. C., Mehaffey, J. H., . . . Malin, S. K. (2020). Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial. PLOS ONE, 15(10). doi:10.1371/journal.pone.0239130

Osinski, V., Bauknight, D. K., Dasa, S. S. K., Harms, M. J., Kroon, T., Marshall, M. A., . . . McNamara, C. A. (2020). In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects. THERANOSTICS, 10(2), 585-601. doi:10.7150/thno.36572

2019

Cherepanova, O. A., Srikakulapu, P., Greene, E. S., Chaklader, M., Haskins, R. M., McCanna, M. E., . . . Owens, G. K. (2020). Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe-/- Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(1), 206-219. doi:10.1161/ATVBAHA.119.312771

Bilchick, K., Kothari, H., Narayan, A., Garmey, J., Omar, A., Capaldo, B., & McNamara, C. (2020). Cardiac resynchronization therapy reduces expression of inflammation-promoting genes related to interleukin-1β in heart failure. CARDIOVASCULAR RESEARCH, 116(7), 1311-1322. doi:10.1093/cvr/cvz232

Upadhye, A., Srikakulapu, P., Gonen, A., Hendrikx, S., Perry, H. M., Anh, N., . . . McNamara, C. A. (2019). Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. CIRCULATION RESEARCH, 125(10), E55-E70. doi:10.1161/CIRCRESAHA.119.315786

Upadhye, A., Srikakulapu, P., & McNamara, C. A. (2019). Cell- and Sex-Specific Role of FcγR (Fcγ Receptor) IIb in Experimental Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(7), 1269-1271. doi:10.1161/ATVBAHA.119.312916

Shikatani, E. A., Besla, R., Ensan, S., Upadhye, A., Khyzha, N., Li, A., . . . Robbins, C. S. (2019). c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. CELL REPORTS, 27(8), 2304-+. doi:10.1016/j.celrep.2019.04.090

Wilson, J. M., McNamara, C. A., & Platts-Mills, T. A. E. (2019). IgE, α-Gal and atherosclerosis. AGING-US, 11(7), 1900-1902. doi:10.18632/aging.101894

Bauknight, D. K., Osinski, V., Dasa, S. S. K., Nguyen, A. T., Marshall, M. A., Hartman, J., . . . Kelly, K. A. (2019). Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects. PLOS ONE, 14(11). doi:10.1371/journal.pone.0224917

Hamers, A. A. J., Dinh, H. Q., Thomas, G. D., Marcovecchio, P., Blatchley, A., Nakao, C. S., . . . Hedrick, C. C. (2019). Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(1), 25-36. doi:10.1161/ATVBAHA.118.311022

2018

Gonen, A., Choi, S. -H., Phuong, M., Agatisa-Boyle, C., Acks, D., Taylor, A. M., . . . Miller, Y. I. (2019). A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma1[S]. JOURNAL OF LIPID RESEARCH, 60(2), 436-445. doi:10.1194/jlr.D090852

Wilson, J. M., Nguyen, A. T., Schuyler, A. J., Commins, S. P., Taylor, A. M., Platts-Mills, T. A. E., & McNamara, C. A. (2018). IgE to the Mammalian Oligosaccharide Galactose--1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable CharacteristicsBrief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(7), 1665-1669. doi:10.1161/ATVBAHA.118.311222

Gaddis, D. E., Padgett, L. E., Wu, R., McSkimming, C., Romines, V., Taylor, A. M., . . . Hedrick, C. C. (2018). Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-03493-5

Kothari, H., Nguyen, A. T., Yang, X., Hisada, Y., Tsimikas, S., Mackman, N., . . . McNamara, C. A. (2018). Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 11(3), 221-229. doi:10.1007/s12265-018-9790-4

Srikakulapu, P., Upadhye, A., Davy, J., & McNamara, C. A. (2018). Perivascular Adipose Tissue near Aortic Arch is a Major Site for Atheroprotective IgM Producing B-1 Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38. doi:10.1161/atvb.38.suppl_1.665

Osinski, V., Ganta, V. C., Nguyen, A. T., Annex, B. H., & McNamara, C. A. (2018). Helix-loop-helix Transcription Factor 1d3 Promotes lschemia-induced Angiogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38. doi:10.1161/atvb.38.suppl_1.342

2017

Marcovecchio, P. M., Thomas, G. D., Mikulski, Z., Ehinger, E., Mueller, K. A. L., Blatchley, A., . . . Hedrick, C. C. (2017). Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(11), 2043-+. doi:10.1161/ATVBAHA.117.309123

Thomas, G. D., Hamers, A. A. J., Nakao, C., Marcovecchio, P., Taylor, A. M., McSkimming, C., . . . Hedrick, C. C. (2017). Human Blood Monocyte Subsets A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(8), 1548-+. doi:10.1161/ATVBAHA.117.309145

Malin, S. K., Kaplan, J. L., Meng, L., Garmey, J. C., Kirby, J. L., Taylor, A. M., . . . McNamara, C. A. (2017). Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity. OBESITY SCIENCE & PRACTICE, 3(2), 193-200. doi:10.1002/osp4.105

Srikakulapu, P., & McNamara, C. A. (2017). B cells and atherosclerosis. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 312(5), H1060-H1067. doi:10.1152/ajpheart.00859.2016

Kohlgrueber, S., Upadhye, A., Dyballa-Rukes, N., McNamara, C. A., & Altschmied, J. (2017). Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology. ANTIOXIDANTS & REDOX SIGNALING, 26(13), 679-699. doi:10.1089/ars.2016.6946

Srikakulapu, P., Upadhye, A., Rosenfeld, S. M., Marshall, M. A., McSkimming, C., Hickman, A. W., . . . McNamara, C. A. (2017). Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells. FRONTIERS IN PHYSIOLOGY, 8. doi:10.3389/fphys.2017.00719

Srikakulapu, P., Upadhye, A., Rosenfeld, S. M., Kouhestani, K., Marshall, M., Prohaska, T. A., . . . McNamara, C. A. (2017). B-1b Cells Produce IgM to Malondialdehyde-Modified Low Density Lipoprotein in Perivascular Adipose Tissue in Response to Immunization And Attenuate Diet Induced Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

Kohlgrueber, S., Dyballa-Rukes, N., Metzger, S., Anh, N., Garmey, J., McNamara, C., . . . Altschmied, J. (2017). Expression, Phosphorylation and Interaction Partners of the Transcription Factor Grainyhead-like 3 in the Endothelium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

Osinski, V., Harms, M., Boucher, J., & McNamara, C. (2017). PPARα/γ Agonist Tesaglitazar Reduces Inflammatory Macrophage Numbers And Induces Adipose Ucp-1 Expression In Diabetic Ob/ob Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

2016

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., . . . Mackman, N. (2016). Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays (vol 139, pg 90, 2016). THROMBOSIS RESEARCH, 147, 63. doi:10.1016/j.thromres.2016.09.009

Schaheen, B., Downs, E. A., Serbulea, V., Almenara, C. C. P., Spinosa, M., Su, G., . . . Ailawadi, G. (2016). B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(11), 2191-+. doi:10.1161/ATVBAHA.116.307559

Cheng, H. -Y., Gaddis, D. E., Wu, R., McSkimming, C., Haynes, L. D., Taylor, A. M., . . . Hedrick, C. C. (2016). Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 126(9), 3236-3246. doi:10.1172/JCI83136

Srikakulapu, P., Hu, D., Yin, C., Mohanta, S. K., Bontha, S. V., Peng, L., . . . Habenicht, A. J. R. (2016). Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(6), 1174-+. doi:10.1161/ATVBAHA.115.306983

Harmon, D. B., Srikakulapu, P., Kaplan, J. L., Oldham, S. N., McSkimming, C., Garmey, J. C., . . . McNamara, C. A. (2016). Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(4), 682-691. doi:10.1161/ATVBAHA.116.307166

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., . . . Mackman, N. (2016). Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays. THROMBOSIS RESEARCH, 139, 90-97. doi:10.1016/j.thromres.2016.01.011

2015

Kaplan, J. L., Marshall, M. A., McSkimming, C. C., Harmon, D. B., Garmey, J. C., Oldham, S. N., . . . McNamara, C. A. (2015). Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue. MOLECULAR METABOLISM, 4(11), 779-794. doi:10.1016/j.molmet.2015.07.010

Adamson, S. E., Meher, A. K., Chiu, Y. -H., Sandilos, J. K., Oberholtzer, N. P., Walker, N. N., . . . Leitinger, N. (2015). Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. MOLECULAR METABOLISM, 4(9), 610-618. doi:10.1016/j.molmet.2015.06.009

Rosenfeld, S. M., Perry, H. M., Gonen, A., Prohaska, T. A., Srikakulapu, P., Grewal, S., . . . McNamara, C. A. (2015). B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. CIRCULATION RESEARCH, 117(3), E28-E39. doi:10.1161/CIRCRESAHA.117.306044

2014

Meher, A. K., Johnston, W. F., Lu, G., Pope, N. H., Bhamidipati, C. M., Harmon, D. B., . . . Ailawadi, G. (2014). B2 Cells Suppress Experimental Abdominal Aortic Aneurysms. AMERICAN JOURNAL OF PATHOLOGY, 184(11), 3130-3141. doi:10.1016/j.ajpath.2014.07.006

Nackiewicz, D., Dey, P., Szczerba, B., Mohammad, S., Kaplan, J. L., McNamara, C. A., . . . Bagavant, H. (2014). Inhibitor of Differentiation 3, a Transcription Factor, Regulates Hyperlipidemia-Associated Kidney Disease. NEPHRON EXPERIMENTAL NEPHROLOGY, 126(3), 141-147. doi:10.1159/000362452

Manichaikul, A., Rich, S. S., Perry, H., Yeboah, J., Law, M., Davis, M., . . . Taylor, A. M. (2014). A Functionally Significant Polymorphism in ID3 Is Associated with Human Coronary Pathology. PLOS ONE, 9(3). doi:10.1371/journal.pone.0090222

2013

Morris-Rosenfeld, S., Lipinski, M. J., & McNamara, C. A. (2014). Understanding the role of B cells in atherosclerosis: potential clinical implications. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 10(1), 77-89. doi:10.1586/1744666X.2014.857602

Perry, H. M., Oldham, S. N., Fahl, S. P., Que, X., Gonen, A., Harmon, D. B., . . . McNamara, C. A. (2013). Helix-Loop-Helix Factor Inhibitor of Differentiation 3 Regulates Interleukin-5 Expression and B-1a B Cell Proliferation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(12), 2771-2779. doi:10.1161/ATVBAHA.113.302571

Nackiewicz, D., Manichaikul, A., Szczerba, B., Dey, P., Rich, S., McNamara, C., . . . Bagavant, H. (2013). Inhibitor Of Differentiation 3, A Transcription Factor Regulates Susceptibility To Kidney Disease. ARTHRITIS AND RHEUMATISM, 65, S240. Retrieved from https://www.webofscience.com/

Choi, S. -H., Yin, H., Ravandi, A., Armando, A., Dumlao, D., Kim, J., . . . Miller, Y. I. (2013). Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages. PLOS ONE, 8(12). doi:10.1371/journal.pone.0083145

2012

Lipinski, M. J., Campbell, K. A., Duong, S. Q., Welch, T. J., Garmey, J. C., Doran, A. C., . . . McNamara, C. A. (2012). Loss of Id3 Increases VCAM-1 Expression, Macrophage Accumulation, and Atherogenesis in Ldlr-/- Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(12), 2855-+. doi:10.1161/ATVBAHA.112.300352

Perry, H. M., & McNamara, C. A. (2012). Refining the Role of B Cells in Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(7), 1548-1549. doi:10.1161/ATVBAHA.112.249235

Bourque, J. M., Schietinger, B. J., Kennedy, J. L., Pearce, E. A., Christopher, J. M., Taylor, A. M., . . . Kramer, C. M. (2012). Usefulness of Cardiovascular Magnetic Resonance Imaging of the Superficial Femoral Artery for Screening Patients With Diabetes Mellitus for Atherosclerosis. AMERICAN JOURNAL OF CARDIOLOGY, 110(1), 50-56. doi:10.1016/j.amjcard.2012.02.048

Campbell, K. A., Lipinski, M. J., Doran, A. C., Skaflen, M. D., Fuster, V., & McNamara, C. A. (2012). Lymphocytes and the Adventitial Immune Response in Atherosclerosis. CIRCULATION RESEARCH, 110(6), 889-900. doi:10.1161/CIRCRESAHA.111.263186

Perry, H. M., Bender, T. P., & McNamara, C. A. (2012). B cell subsets in atherosclerosis. FRONTIERS IN IMMUNOLOGY, 3. doi:10.3389/fimmu.2012.00373

2011

Cutchins, A., Harmon, D. B., Kirby, J. L., Doran, A. C., Oldham, S. N., Skaflen, M., . . . McNamara, C. A. (2012). Inhibitor of Differentiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(2), 317-U352. doi:10.1161/ATVBAHA.111.234856

Doran, A. C., Lipinski, M. J., Oldham, S. N., Garmey, J. C., Campbell, K. A., Skaflen, M. D., . . . McNamara, C. A. (2012). .B-Cell Aortic Homing and Atheroprotection Depend on Id3. CIRCULATION RESEARCH, 110(1), E1-U6. doi:10.1161/CIRCRESAHA.111.256438

Bagavant, H., Scindia, Y., Nackiewicz, D., Nandula, S. R., Doran, A., Cutchins, A., . . . McNamara, C. (2011). Deficiency of a Transcriptional Regulator, Inhibitor of Differentiation 3, Induces Glomerulonephritis in Apolipoprotein E-Deficient Mice A Model Linking Hyperlipidemia and Renal Disease. AMERICAN JOURNAL OF PATHOLOGY, 179(2), 651-660. doi:10.1016/j.ajpath.2011.04.029

Lipinski, M. J., Perry, H. M., Doran, A. C., Oldham, S. N., & McNamara, C. A. (2011). Comment on "Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis". JOURNAL OF IMMUNOLOGY, 186(1), 4. doi:10.4049/jimmunol.1090119

2010

Deliri, H., Meller, N., Kadakkal, A., Malhotra, R., Brewster, J., Doran, A. C., . . . McNamara, C. A. (2011). Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(1), 110-+. doi:10.1161/ATVBAHA.110.212068

Doran, A. C., Lehtinen, A. B., Meller, N., Lipinski, M. J., Slayton, R. P., Oldham, S. N., . . . McNamara, C. A. (2010). Id3 Is a Novel Atheroprotective Factor Containing a Functionally Significant Single-Nucleotide Polymorphism Associated With Intima-Media Thickness in Humans. CIRCULATION RESEARCH, 106(7), 1303-U299. doi:10.1161/CIRCRESAHA.109.210294

Harmon, D. B., Cutchins, A., Oldham, S. N., Perry, H., & McNamara, C. A. (2010). Loss of Id3 Alters the Inflammatory Profile of Visceral Adipose Tissue in Mice Fed a High-Fat Diet. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11), E217. Retrieved from https://www.webofscience.com/

Deliri, H., Lipinski, M. J., Garmey, J. C., Oldham, S. N., Skaflen, M. D., & McNamara, C. A. (2010). Id3 and ABF1 Are Transcriptional Regulators of Matrix Metalloproteinase-9 in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11), E319. Retrieved from https://www.webofscience.com/