Carol A. Gilchrist
Associate Professor, Medicine- Infectious Diseases and International Health
MR-6, Room 1707A
Charlottesville, VA 22908
Bio & Overview
Academic Information
- Department
- Medicine- Infectious Diseases and International Health
- Academic Title
- Assistant Professor
Primary Education
- PhD, University of Western Ontario, 1988
Research Interests
Selected Publications
2024
Ramakrishnan, G., Young, M. K., Nayak, U., Rigo, I., Marrs, A. S., Gilchrist, C. A., . . . Petri, W. A. (2024). Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection. ANAEROBE, 87. doi:10.1016/j.anaerobe.2024.102840
2023
Carey, M., Arju, T., Cotton, J. A., Alam, M., Kabir, M., Faruque, A. S. G., . . . Gilchrist, C. A. (2023). Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection. JOURNAL OF INFECTIOUS DISEASES, 228(9), 1292-1298. doi:10.1093/infdis/jiad257
Hendrick, J., Ma, J., Haughey, H., Coleman, R., Nayak, U., Kadl, A., . . . Petri, W. (2023). Pulmonary function and survival one year after dupilumab treatment of acute moderate to severe COVID-19: A follow up study from a Phase IIa trial. doi:10.1101/2023.09.01.23293947
Petri, W. A. O., Hossain, B., Kabir, M., So, H. H., Moreau, G. B., Nayak, U., . . . Gilchrist, C. A. (2023). Children develop Immunity to cryptosporidiosis in a high transmission intensity area.. medRxiv. doi:10.1101/2023.06.28.23292000
Gilchrist, C. A., Campo, J. J., Pablo, J. V., Ma, J. Z., Teng, A., Oberai, A., . . . Petri Jr, W. A. (2023). Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis. JOURNAL OF CLINICAL INVESTIGATION, 133(16). doi:10.1172/JCI166814
2022
Carpenter, R. M., Young, M. K., Petri, W. A. O., Lyons, G. R., Gilchrist, C., Carey, R. M., & Petri, W. A. J. (2022). Repressed Ang 1-7 in COVID-19 Is Inversely Associated with Inflammation and Coagulation. MSPHERE, 7(4). doi:10.1128/msphere.00220-22
Ngobeni, R., Gilchrist, C., & Samie, A. (2022). Prevalence and Distribution of Cryptosporidium spp. and Giardia lamblia in Rural and Urban Communities of South Africa. Turkiye parazitolojii dergisi, 46(1), 14-19. doi:10.4274/tpd.galenos.2021.37039
Saito-Nakano, Y., Makiuchi, T., Tochikura, M., Gilchrist, C. A., Petri, W. A. J., & Nozaki, T. (2022). ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica (vol 11, 794152, 2021). FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12. doi:10.3389/fcimb.2022.856477
2021
Kabir, M., Alam, M., Nayak, U., Arju, T., Hossain, B., Tarannum, R., . . . Gilchrist, C. A. (2021). Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition. PLOS PATHOGENS, 17(6). doi:10.1371/journal.ppat.1009445
Carey, M. A., Medlock, G. L., Alam, M., Kabir, M., Uddin, M. J., Nayak, U., . . . Gilchrist, C. A. (2021). Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis. CLINICAL INFECTIOUS DISEASES, 73(6), E1242-E1251. doi:10.1093/cid/ciab207
Saito-Nakano, Y., Makiuchi, T., Tochikura, M., Gilchrist, C. A., Petri, W. A. J., & Nozaki, T. (2021). ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 11. doi:10.3389/fcimb.2021.794152
Messa, A. J., Koster, P. C., Garrine, M., Gilchrist, C., Bartelt, L. A., Nhampossa, T., . . . Mandomando, I. (2021). Molecular diversity of Giardia duodenalis in children under 5 years from the Manhica district, Southern Mozambique enrolled in a matched case-control study on the aetiology of diarrhoea. PLOS NEGLECTED TROPICAL DISEASES, 15(1). doi:10.1371/journal.pntd.0008987
Steiner, K. L., Kabir, M., Hossain, B., Gilchrist, C. A., Ma, J. Z., Ahmed, T., . . . Petri, W. A. J. (2021). Delayed Time to Cryptosporidiosis in Bangladeshi Children is Associated with Greater Fecal IgA against Two Sporozoite-Expressed Antigens. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 104(1), 229-232. doi:10.4269/ajtmh.20-0657
2020
Deichsel, E. L., Hillesland, H. K., Gilchrist, C. A., Naulikha, J. M., McGrath, C. J., Van Voorhis, W. C., . . . Pavlinac, P. B. (2020). Prevalence and Correlates of Cryptosporidium Infections in Kenyan Children With Diarrhea and Their Primary Caregivers. OPEN FORUM INFECTIOUS DISEASES, 7(12). doi:10.1093/ofid/ofaa533
Burgess, S. L., Leslie, J. L., Uddin, J., Oakland, D. N., Gilchrist, C., Moreau, G. B., . . . Petri, W. A. J. (2020). Gut microbiome communication with bone marrow regulates susceptibility to amebiasis. JOURNAL OF CLINICAL INVESTIGATION, 130(8), 4019-4024. doi:10.1172/JCI133605
2019
Donowitz, J. R., Parikh, H. I., Taniuchi, M., Gilchrist, C. A., Haque, R., Kirkpatrick, B. D., . . . Petri, W. A. J. (2019). Increased Fecal Lactobacillus Is Associated With a Positive Glucose Hydrogen Breath Test in Bangladeshi Children. OPEN FORUM INFECTIOUS DISEASES, 6(7). doi:10.1093/ofid/ofz266
Steiner, K. L., Kabir, M., Priest, J. W., Hossain, B., Gilchrist, C. A., Cook, H., . . . Petri, W. A. J. (2020). Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study. CLINICAL INFECTIOUS DISEASES, 70(2), 323-326. doi:10.1093/cid/ciz430
Gazi, M. A., Das, S., Mahfuz, M., Hasan, M. M., Hossain, M. S., Fahim, S. M., . . . Ahmed, T. (2019). Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh. BMJ OPEN GASTROENTEROLOGY, 6(1). doi:10.1136/bmjgast-2019-000294
2018
Korpe, P. S., Gilchrist, C., Burkey, C., Taniuchi, M., Ahmed, E., Madan, V., . . . Duggal, P. (2019). Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households. CLINICAL INFECTIOUS DISEASES, 68(7), 1073-1079. doi:10.1093/cid/ciy593
Kabir, M., Ahmed, E., Hossain, B., Alam, M., Ahmed, S., Taniuchi, M., . . . Haque, R. (2018). Giardia/Cryptosporidium QUIK CHEK Assay Is More Specific Than Quantitative Polymerase Chain Reaction for Rapid Point-of-care Diagnosis of Cryptosporidiosis in Infants in Bangladesh. CLINICAL INFECTIOUS DISEASES, 67(12), 1897-1903. doi:10.1093/cid/ciy372
Steiner, K. L., Ahmed, S., Gilchrist, C. A., Burkey, C., Cook, H., Ma, J. Z., . . . Faruque, A. S. G. (2018). Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study. CLINICAL INFECTIOUS DISEASES, 67(9), 1347-1355. doi:10.1093/cid/ciy310
Gilchrist, C. A., Cotton, J. A., Burkey, C., Arju, T., Gilmartin, A., Lin, Y., . . . Petri, W. A. (2018). Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing. JOURNAL OF INFECTIOUS DISEASES, 218(2), 259-264. doi:10.1093/infdis/jiy121
2017
Ngobeni, R., Samie, A., Moonah, S., Watanabe, K., Petri, W. A. J., & Gilchrist, C. (2017). Entamoeba Species in South Africa: Correlations With the Host Microbiome, Parasite Burdens, and First Description of Entamoeba bangladeshi Outside of Asia. JOURNAL OF INFECTIOUS DISEASES, 216(12), 1592-1600. doi:10.1093/infdis/jix535
Watanabe, K., Gilchrist, C. A., Uddin, M. J., Burgess, S. L., Abhyankar, M. M., Moonah, S. N., . . . Petri, W. A. J. (2017). Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis. PLOS PATHOGENS, 13(8). doi:10.1371/journal.ppat.1006513
Burgess, S. L., Gilchrist, C. A., Lynn, T. C., & Petri, W. A. J. (2017). Parasitic Protozoa and Interactions with the Host Intestinal Microbiota. INFECTION AND IMMUNITY, 85(8). doi:10.1128/IAI.00101-17
2016
Ramakrishnan, G., Wright, M., Alam, M., Naylor, C., Kabir, M., Zerin, A., . . . Gilchrist, C. A. (2017). Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 87(3), 272-274. doi:10.1016/j.diagmicrobio.2016.11.011
Gilchrist, C. A. (2016). The E. histolytica Genome Structure and Virulence.. Current tropical medicine reports, 3(4), 158-163. doi:10.1007/s40475-016-0088-9
Korpe, P. S., Haque, R., Gilchrist, C., Valencia, C., Niu, F., Lu, M., . . . Petri, W. A. J. (2016). Natural History of Cryptosporidiosis in a Longitudinal Study of Slum-Dwelling Bangladeshi Children: Association with Severe Malnutrition. PLOS NEGLECTED TROPICAL DISEASES, 10(5). doi:10.1371/journal.pntd.0004564
Spadafora, L. J., Kearney, M. R., Siddique, A., Ali, I. K., Gilchrist, C. A., Arju, T., . . . Cangelosi, G. A. (2016). Species-Specific Immunodetection of an Entamoeba histolytica Cyst Wall Protein. PLOS NEGLECTED TROPICAL DISEASES, 10(5). doi:10.1371/journal.pntd.0004697
2015
Gilchrist, C. A., Petri, S. E., Schneider, B. N., Reichman, D. J., Jiang, N., Begum, S., . . . Petri, W. A. J. (2016). Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan Parasite Entamoeba histolytica. JOURNAL OF INFECTIOUS DISEASES, 213(10), 1579-1585. doi:10.1093/infdis/jiv772
Gilchrist, C. A., Turner, S. D., Riley, M. F., Petri, W. A. J., & Hewlett, E. L. (2015). Whole-Genome Sequencing in Outbreak Analysis. CLINICAL MICROBIOLOGY REVIEWS, 28(3), 541-563. doi:10.1128/CMR.00075-13
Ramakrishnan, G., Pedersen, K., Guenette, D., Sink, J., Hague, R., Petri, W. A. J., . . . Gilchrist, C. A. (2015). Utility of recombinant fragment C for assessment of anti-tetanus antibodies in plasma. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 82(1), 11-13. doi:10.1016/j.diagmicrobio.2015.01.016
2014
Gilchrist, C. A. (2014). Entamoeba bangladeshi: An insight.. Tropical parasitology, 4(2), 96-98. doi:10.4103/2229-5070.138536
2013
Kato, K., Takegawa, Y., Ralston, K. S., Gilchrist, C. A., Hamano, S., Petri, W. A. J., & Shinohara, Y. (2013). Sialic acid-dependent attachment of mucins from three mouse strains to Entamoeba histolytica. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 436(2), 252-258. doi:10.1016/j.bbrc.2013.05.085
2012
Abhyankar, M. M., Shrimal, S., Gilchrist, C. A., Bhattacharya, A., & Petri, W. A. J. (2012). The Entamoeba histolytica serum-inducible transmembrane kinase EhTMKB1-9 is involved in intestinal amebiasis. INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE, 2, 243-248. doi:10.1016/j.ijpddr.2012.01.002
Royer, T. L., Gilchrist, C., Kabir, M., Arju, T., Ralston, K. S., Haque, R., . . . Petri, W. A. J. (2012). Entamoeba bangladeshi nov sp., Bangladesh. EMERGING INFECTIOUS DISEASES, 18(9), 1543-1545. doi:10.3201/eid1809.120122
Gilchrist, C. A., Ali, I. K. M., Kabir, M., Alam, F., Scherbakova, S., Ferlanti, E., . . . Caler, E. (2012). A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence. BMC MICROBIOLOGY, 12. doi:10.1186/1471-2180-12-151
2011
Duggal, P., Guo, X., Haque, R., Peterson, K. M., Ricklefs, S., Mondal, D., . . . Petri, W. A. J. (2011). A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. JOURNAL OF CLINICAL INVESTIGATION, 121(3), 1191-1198. doi:10.1172/JCI45294
2010
Abhyankar, M. M., Haviland, S. M., Gilchrist, C. A., & Petri, W. A. (2010). Development of a negative selectable marker for Entamoeba histolytica.. Journal of visualized experiments : JoVE, (46), 2410. doi:10.3791/2410
Gilchrist, C. A., Moore, E. S., Zhang, Y., Bousquet, C. B., Lannigan, J. A., Mann, B. J., & Petri, W. A. J. (2010). Regulation of Virulence of Entamoeba histolytica by the URE3-BP Transcription Factor. MBIO, 1(1). doi:10.1128/mBio.00057-10
Buss, S. N., Hamano, S., Vidrich, A., Evans, C., Zhang, Y., Crasta, O. R., . . . Petri, W. A. J. (2010). Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 40(7), 833-843. doi:10.1016/j.ijpara.2009.12.007