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Chance John Luckey

Chance John Luckey

Associate Professor of Pathology, Pathology

Primary Location
PO Box 800904
415 Lane Rd MR5 Rm3051
Charlottesville, Virginia 22908
Primary Phone Number
Fax Number
434.924.2151

Bio & Overview

UNLEASH: We work on cytokine control of memory lymphocytes, with a particular interest in the molecular regulators of vaccination and pathological antibodies in different disease states. Experimentally, we use i) mouse model systems of both vaccination and RBC alloimmunization as well as ii) study cytokine control of lymphocyte development in healthy humans and at-risk patients.

Academic Information

Department
Pathology
Academic Title
Associate Professor of Pathology

Primary Education

  • BA, Science and Ethics, University of Georgia, 1991
  • MD/PhD, Immunology, University of Virginia, 2001

Other Affiliations

  • Cancer Center
  • Immunology/Immunotherapy Program
  • Graduate Student, Microbiology
  • BIMS-Immunology
  • BIMS-Immunology
  • BIMS-Immunology
  • Pathology (Experimental)
  • BIMS-MSTP
  • Beirne Carter Center for Immunology
  • Graduate Student, MSTP
  • MSTP
  • MSTP
  • BIMS

Research Interests

Immune Memory

Research Disciplines

  • Experimental Pathology
  • Immunology

Research Opportunities

  • Experimental Pathology
  • Immunology

PhD Programs

  • Experimental Pathology

Selected Publications

2024

Ozulumba, T., Zatorski, J. M., Arneja, A., Hammel, J. H., Braciale, T. J., Luckey, C. J., . . . Pompano, R. R. (2024). Mitigating reactive oxygen species production and increasing gel porosity improves lymphocyte motility and fibroblast spreading in photocrosslinked gelatin-thiol hydrogels.. bioRxiv. doi:10.1101/2024.01.14.574282

2023

Jajosky, R. P., Patel, K. R., Allen, J. W. L., Zerra, P. E., Chonat, S., Ayona, D., . . . Stowell, S. R. (2023). Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. BLOOD, 142(12), 1082-1098. doi:10.1182/blood.2022018591

Prakash, A., Medved, J., Arneja, A., Niebuhr, C., Li, A. N., Tarrah, S., . . . Luckey, C. J. (2023). Class switching is differentially regulated in RBC alloimmunization and vaccination. TRANSFUSION, 63(4), 826-838. doi:10.1111/trf.17301

2022

Jash, A., Hay, A. M., Collins, J. B., Heo, J., Luckey, C. J., Hudson, K. E., & Zimring, J. C. (2023). The role of RBC antigen transgene integration sites on RBC biology in mice. TRANSFUSION, 63(1), 239-248. doi:10.1111/trf.17197

Moriconi, C., Dzieciatkowska, M., Roy, M., D'Alessandro, A., Roingeard, P., Lee, J. Y., . . . Hudson, K. E. (2022). Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. BRITISH JOURNAL OF HAEMATOLOGY, 198(3), 574-586. doi:10.1111/bjh.18287

Arthur, C. M., Patel, S. R., Sharma, A., Zerra, P. E., Chonat, S., Jajosky, R. P., . . . Stowell, S. R. (2022). Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice. TRANSFUSION, 62(5), 948-953. doi:10.1111/trf.16872

Miller, R. M., Jordan, B. T., Mehlferber, M. M., Jeffery, E. D., Chatzipantsiou, C., Kaur, S., . . . Sheynkman, G. M. (2022). Enhanced protein isoform characterization through long-read proteogenomics. GENOME BIOLOGY, 23(1). doi:10.1186/s13059-022-02624-y

Soldatenko, A., Hoyt, L. R., Xu, L., Calabro, S., Lewis, S. M., Gallman, A. E., . . . Eisenbarth, S. C. (2022). Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. JOURNAL OF IMMUNOLOGY, 208(4), 991-997. doi:10.4049/jimmunol.2100784

2021

Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., . . . Luckey, C. J. (2021). The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. TRANSFUSION, 61(7), 2169-2178. doi:10.1111/trf.16554

Goldfarb, A. N., Freeman, K. C., Sahu, R. K., Elagib, K. E., Holy, M., Arneja, A., . . . Delehanty, L. L. (2021). Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21938-2

Escamilla-Rivera, V., Santhanakrishnan, M., Liu, J., Gibb, D. R., Forsmo, J. E., Foxman, E. F., . . . Hendrickson, J. E. (2021). Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.704072

Jash, A., Usaneerungrueng, C., Howie, H. L., Qiu, A., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2021). Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.629608

2020

Escamilla-Rivera, V., Liu, J., Gibb, D. R., Santhanakrishnan, M., Liu, D., Forsmo, J. E., . . . Hendrickson, J. E. (2020). Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. BLOOD, 135(22), 1983-1993. doi:10.1182/blood.2020005018

2019

Balbuena-Merle, R., Curtis, S. A., Devine, L., Gibb, D. R., Karafin, M. S., Luckey, C. J., . . . Hendrickson, J. E. (2019). Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. TRANSFUSION, 59(10), 3219-3227. doi:10.1111/trf.15463

2016

Arneja, A., Salazar, J. E., Jiang, W., Hendrickson, J. E., Zimring, J. C., & Luckey, C. J. (2016). Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization. HAEMATOLOGICA, 101(11), E440-E444. doi:10.3324/haematol.2016.149278

Martin, P. S., Li, S., Nikiforow, S., Alyea, E. P. I. I. I., Antin, J. H., Armand, P., . . . Soiffer, R. J. (2016). Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation. HAEMATOLOGICA, 101(4), 499-505. doi:10.3324/haematol.2015.134841

2014

Farh, K. K. -H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., . . . Bernstein, B. E. (2015). Genetic and epigenetic fine mapping of causal autoimmune disease variants. NATURE, 518(7539), 337-343. doi:10.1038/nature13835

Lu, Y., Loh, Y. -H., Li, H., Cesana, M., Ficarro, S. B., Parikh, J. R., . . . Marto, J. A. (2014). Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells. CELL STEM CELL, 15(1), 92-101. doi:10.1016/j.stem.2014.04.002

Quillen, K., & Luckey, C. J. (2014). Blood and bombs: blood use after the Boston Marathon bombing of April 15, 2013. TRANSFUSION, 54(4), 1202-1203. doi:10.1111/trf.12642

2013

Luckey, C. J., & Silberstein, L. E. (2013). A mouse model of hemolytic disease of the newborn. BLOOD, 122(8), 1334-1335. doi:10.1182/blood-2013-07-512715

Zhou, F., Lu, Y., Ficarro, S. B., Adelmant, G., Jiang, W., Luckey, C. J., & Marto, J. A. (2013). Genome-scale proteome quantification by DEEP SEQ mass spectrometry. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms3171

Babic, A. M., Jang, S., Nicolov, E., Voicu, H., & Luckey, C. J. (2013). Culture of Mouse Amniotic Fluid-Derived Cells on Irradiated STO Feeders Results in the Generation of Primitive Endoderm Cell Lines Capable of Self-Renewal in vitro. CELLS TISSUES ORGANS, 198(2), 111-126. doi:10.1159/000353942

2012

Koleva, R. I., Ficarro, S. B., Radomska, H. S., Carrasco-Alfonso, M. J., Alberta, J. A., Webber, J. T., . . . Marto, J. A. (2012). C/EBPα and DEK coordinately regulate myeloid differentiation. BLOOD, 119(21), 4878-4888. doi:10.1182/blood-2011-10-383083

Luckey, C. J., & Weaver, C. T. (2012). Stem-Cell-like Qualities of Immune Memory; CD4+ T Cells Join the Party. CELL STEM CELL, 10(2), 107-108. doi:10.1016/j.stem.2012.01.011

2011

Luckey, C. J., Lu, Y., & Marto, J. A. (2011). Understanding the first steps in embryonic stem cell exit from the pluripotent state. TRANSFUSION, 51, 118S-124S. doi:10.1111/j.1537-2995.2011.03374.x