Chance John Luckey
Associate Professor of Pathology, Pathology
415 Lane Rd MR5 Rm3051
Charlottesville, Virginia 22908
Bio & Overview
Academic Information
- Department
- Pathology
- Academic Title
- Associate Professor of Pathology
Primary Education
- BA, Science and Ethics, University of Georgia, 1991
- MD/PhD, Immunology, University of Virginia, 2001
Other Affiliations
- Cancer Center
- Immunology/Immunotherapy Program
- Graduate Student, Microbiology
- BIMS-Immunology
- BIMS-Immunology
- BIMS-Immunology
- Pathology (Experimental)
- BIMS-MSTP
- Beirne Carter Center for Immunology
- Graduate Student, MSTP
- MSTP
- MSTP
- BIMS
Research Interests
Research Disciplines
- Experimental Pathology
- Immunology
Research Opportunities
- Experimental Pathology
- Immunology
PhD Programs
- Experimental Pathology
Selected Publications
2024
Ozulumba, T., Zatorski, J. M., Arneja, A., Hammel, J. H., Braciale, T. J., Luckey, C. J., . . . Pompano, R. R. (2024). Mitigating reactive oxygen species production and increasing gel porosity improves lymphocyte motility and fibroblast spreading in photocrosslinked gelatin-thiol hydrogels.. bioRxiv. doi:10.1101/2024.01.14.574282
2023
Jajosky, R. P., Patel, K. R., Allen, J. W. L., Zerra, P. E., Chonat, S., Ayona, D., . . . Stowell, S. R. (2023). Antibody-mediated antigen loss switches augmented immunity to antibody-mediated immunosuppression. BLOOD, 142(12), 1082-1098. doi:10.1182/blood.2022018591
Prakash, A., Medved, J., Arneja, A., Niebuhr, C., Li, A. N., Tarrah, S., . . . Luckey, C. J. (2023). Class switching is differentially regulated in RBC alloimmunization and vaccination. TRANSFUSION, 63(4), 826-838. doi:10.1111/trf.17301
2022
Jash, A., Hay, A. M., Collins, J. B., Heo, J., Luckey, C. J., Hudson, K. E., & Zimring, J. C. (2023). The role of RBC antigen transgene integration sites on RBC biology in mice. TRANSFUSION, 63(1), 239-248. doi:10.1111/trf.17197
Moriconi, C., Dzieciatkowska, M., Roy, M., D'Alessandro, A., Roingeard, P., Lee, J. Y., . . . Hudson, K. E. (2022). Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. BRITISH JOURNAL OF HAEMATOLOGY, 198(3), 574-586. doi:10.1111/bjh.18287
Arthur, C. M., Patel, S. R., Sharma, A., Zerra, P. E., Chonat, S., Jajosky, R. P., . . . Stowell, S. R. (2022). Clodronate inhibits alloimmunization against distinct red blood cell alloantigens in mice. TRANSFUSION, 62(5), 948-953. doi:10.1111/trf.16872
Miller, R. M., Jordan, B. T., Mehlferber, M. M., Jeffery, E. D., Chatzipantsiou, C., Kaur, S., . . . Sheynkman, G. M. (2022). Enhanced protein isoform characterization through long-read proteogenomics. GENOME BIOLOGY, 23(1). doi:10.1186/s13059-022-02624-y
Soldatenko, A., Hoyt, L. R., Xu, L., Calabro, S., Lewis, S. M., Gallman, A. E., . . . Eisenbarth, S. C. (2022). Innate and Adaptive Immunity to Transfused Allogeneic RBCs in Mice Requires MyD88. JOURNAL OF IMMUNOLOGY, 208(4), 991-997. doi:10.4049/jimmunol.2100784
2021
Medved, J., Knott, B. M., Tarrah, S. N., Li, A. N., Shah, N., Moscovich, T. C., . . . Luckey, C. J. (2021). The lysophospholipid-binding molecule CD1D is not required for the alloimmunization response to fresh or stored RBCs in mice despite RBC storage driving alterations in lysophospholipids. TRANSFUSION, 61(7), 2169-2178. doi:10.1111/trf.16554
Goldfarb, A. N., Freeman, K. C., Sahu, R. K., Elagib, K. E., Holy, M., Arneja, A., . . . Delehanty, L. L. (2021). Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21938-2
Escamilla-Rivera, V., Santhanakrishnan, M., Liu, J., Gibb, D. R., Forsmo, J. E., Foxman, E. F., . . . Hendrickson, J. E. (2021). Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.704072
Jash, A., Usaneerungrueng, C., Howie, H. L., Qiu, A., Luckey, C. J., Zimring, J. C., & Hudson, K. E. (2021). Antibodies to Low-Copy Number RBC Alloantigen Convert a Tolerogenic Stimulus to an Immunogenic Stimulus in Mice. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.629608
2020
Escamilla-Rivera, V., Liu, J., Gibb, D. R., Santhanakrishnan, M., Liu, D., Forsmo, J. E., . . . Hendrickson, J. E. (2020). Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice. BLOOD, 135(22), 1983-1993. doi:10.1182/blood.2020005018
2019
Balbuena-Merle, R., Curtis, S. A., Devine, L., Gibb, D. R., Karafin, M. S., Luckey, C. J., . . . Hendrickson, J. E. (2019). Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. TRANSFUSION, 59(10), 3219-3227. doi:10.1111/trf.15463
2016
Arneja, A., Salazar, J. E., Jiang, W., Hendrickson, J. E., Zimring, J. C., & Luckey, C. J. (2016). Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization. HAEMATOLOGICA, 101(11), E440-E444. doi:10.3324/haematol.2016.149278
Martin, P. S., Li, S., Nikiforow, S., Alyea, E. P. I. I. I., Antin, J. H., Armand, P., . . . Soiffer, R. J. (2016). Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation. HAEMATOLOGICA, 101(4), 499-505. doi:10.3324/haematol.2015.134841
2014
Farh, K. K. -H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., . . . Bernstein, B. E. (2015). Genetic and epigenetic fine mapping of causal autoimmune disease variants. NATURE, 518(7539), 337-343. doi:10.1038/nature13835
Lu, Y., Loh, Y. -H., Li, H., Cesana, M., Ficarro, S. B., Parikh, J. R., . . . Marto, J. A. (2014). Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells. CELL STEM CELL, 15(1), 92-101. doi:10.1016/j.stem.2014.04.002
Quillen, K., & Luckey, C. J. (2014). Blood and bombs: blood use after the Boston Marathon bombing of April 15, 2013. TRANSFUSION, 54(4), 1202-1203. doi:10.1111/trf.12642
2013
Luckey, C. J., & Silberstein, L. E. (2013). A mouse model of hemolytic disease of the newborn. BLOOD, 122(8), 1334-1335. doi:10.1182/blood-2013-07-512715
Zhou, F., Lu, Y., Ficarro, S. B., Adelmant, G., Jiang, W., Luckey, C. J., & Marto, J. A. (2013). Genome-scale proteome quantification by DEEP SEQ mass spectrometry. NATURE COMMUNICATIONS, 4. doi:10.1038/ncomms3171
Babic, A. M., Jang, S., Nicolov, E., Voicu, H., & Luckey, C. J. (2013). Culture of Mouse Amniotic Fluid-Derived Cells on Irradiated STO Feeders Results in the Generation of Primitive Endoderm Cell Lines Capable of Self-Renewal in vitro. CELLS TISSUES ORGANS, 198(2), 111-126. doi:10.1159/000353942
2012
Koleva, R. I., Ficarro, S. B., Radomska, H. S., Carrasco-Alfonso, M. J., Alberta, J. A., Webber, J. T., . . . Marto, J. A. (2012). C/EBPα and DEK coordinately regulate myeloid differentiation. BLOOD, 119(21), 4878-4888. doi:10.1182/blood-2011-10-383083
Luckey, C. J., & Weaver, C. T. (2012). Stem-Cell-like Qualities of Immune Memory; CD4+ T Cells Join the Party. CELL STEM CELL, 10(2), 107-108. doi:10.1016/j.stem.2012.01.011
2011
Luckey, C. J., Lu, Y., & Marto, J. A. (2011). Understanding the first steps in embryonic stem cell exit from the pluripotent state. TRANSFUSION, 51, 118S-124S. doi:10.1111/j.1537-2995.2011.03374.x