Clint L. Miller

Geurts, S., Tilly, M. J., Lu, Z., Stricker, B. H. C., Deckers, J. W., de Groot, N. M. S., . . . Kavousi, M. (2024). Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study. HYPERTENSION, 81(8), 1766-1775. doi:10.1161/HYPERTENSIONAHA.123.21858

Mori, M., Sakamoto, A., Kawakami, R., Guo, L., Slenders, L., Mosquera, J. V., . . . Finn, A. V. (2024). CD163⁺ Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma. CIRCULATION RESEARCH, 135(2), e4-e23. doi:10.1161/CIRCRESAHA.123.324082

Xu, J., Liu, Z., Yang, Q., Ma, Q., Zhou, Y., Cai, Y., . . . Huo, Y. (2024). Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation. CARDIOVASCULAR RESEARCH. doi:10.1093/cvr/cvae093

Mocci, G., Sukhavasi, K., Ord, T., Bankier, S., Singha, P., Arasu, U. T., . . . Bjorkegren, J. L. M. (2024). Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis. CIRCULATION RESEARCH, 134(11), 1405-1423. doi:10.1161/CIRCRESAHA.123.323184

Lu, H., Lary, C. W., Hodonsky, C. J., Peyser, P. A., Bos, D., van der Laan, S. W., . . . Medina-Gomez, C. (2024). Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. JOURNAL OF BONE AND MINERAL RESEARCH, 39(4), 443-452. doi:10.1093/jbmr/zjae022

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2024). Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci. CELL GENOMICS, 4(1). doi:10.1016/j.xgen.2023.100465

de Vries, P. S., Conomos, M. P., Singh, K., Nicholson, C. J., Jain, D., Hasbani, N. R., . . . Malhotra, R. (2023). Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. NATURE CARDIOVASCULAR RESEARCH, 2(12), 1159-+. doi:10.1038/s44161-023-00375-y

Mosquera, J. V., Auguste, G., Wong, D., Turner, A. W., Hodonsky, C. J., Alvarez-Yela, A. C., . . . Miller, C. L. (2023). Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. CELL REPORTS, 42(11). doi:10.1016/j.celrep.2023.113380

Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N. A., . . . Finn, A. V. (2024). Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 44(1), 300-313. doi:10.1161/ATVBAHA.123.319818

Mekke, J. M., Sakkers, T. R., Verwer, M. C., van den Dungen, N. A. M., Song, Y., Miller, C. L., . . . van der Laan, S. W. (2023). The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-43369-3

Kavousi, M., Bos, M. M., Barnes, H. J., Cardenas, C. L. L., Wong, D., Lu, H., . . . Miller, C. L. (2023). Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. NATURE GENETICS, 55(10), 1651-+. doi:10.1038/s41588-023-01518-4

Zheng, J., Wheeler, E., Pietzner, M., Andlauer, T. F. M., Yau, M. S., Hartley, A. E., . . . Tobias, J. H. (2023). Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization. ARTHRITIS & RHEUMATOLOGY, 75(10), 1781-1792. doi:10.1002/art.42538

Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N., . . . Finn, A. V. (2023). Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy.. bioRxiv. doi:10.1101/2023.07.05.547891

Zhang, W., Zhao, J., Deng, L., Ishimwe, N., Pauli, J., Wu, W., . . . Long, X. (2023). INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. CIRCULATION, 148(1), 47-67. doi:10.1161/CIRCULATIONAHA.123.063760

Wong, D., Auguste, G., Lino Cardenas, C. L., Turner, A. W., Chen, Y., Song, Y., . . . Miller, C. L. (2023). FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. CIRCULATION RESEARCH, 132(9), 1144-1161. doi:10.1161/CIRCRESAHA.122.321692

Song, Y., Cisternino, F., Mekke, J. M. M., de Borst, G. J. J., de Kleijn, D. P. V., Pasterkamp, G., . . . Miller, C. L. L. (2023). An automatic entropy method to efficiently mask histology whole-slide images. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-29638-1

Zhang, M., Li, J., Wang, Q., Urabe, G., Tang, R., Huang, Y., . . . Guo, L. -W. (2023). Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation. MOLECULAR THERAPY-NUCLEIC ACIDS, 31. doi:10.1016/j.omtn.2023.02.024

Sakamoto, A., Kawakami, R., Mori, M., Guo, L., Paek, K. H., Mosquera, J. V., . . . Finn, A. V. (2023). CD163+macrophages restrain vascular calcification, promoting the development of high-risk plaque. JCI INSIGHT, 8(5). doi:10.1172/jci.insight.154922

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2023). Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.. medRxiv. doi:10.1101/2023.02.09.23285622

Aherrahrou, R., Lue, D., Perry, R. N., Aberra, Y. T., Khan, M. D., Soh, J. Y., . . . Civelek, M. (2023). Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes. CIRCULATION RESEARCH, 132(3), 323-338. doi:10.1161/CIRCRESAHA.122.321586

Safabakhsh, S., Ma, W. F., Miller, C. L. L., & Laksman, Z. (2023). Cardiovascular utility of single cell RNA-Seq. CURRENT OPINION IN CARDIOLOGY, 38(3), 193-200. doi:10.1097/HCO.0000000000001014

Mokry, M., Boltjes, A., Slenders, L., Bel-Bordes, G., Cui, K., Brouwer, E., . . . Pasterkamp, G. (2022). Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. NATURE CARDIOVASCULAR RESEARCH, 1(12), 1140-+. doi:10.1038/s44161-022-00171-0

Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk (vol 54, pg 804, 2022). NATURE GENETICS, 54(8), 1259. doi:10.1038/s41588-022-01142-8

Ma, L., Bryce, N. S., Turner, A. W., Di Narzo, A. F., Rahman, K., Xu, Y., . . . Kovacic, J. C. (2022). The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. PLOS GENETICS, 18(6). doi:10.1371/journal.pgen.1010261

Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. NATURE GENETICS, 54(6), 804-+. doi:10.1038/s41588-022-01069-0

Reddy, M. S., Serbulea, V., Shamsuzzaman, S., Salamon, A., Tripathi, R., Miller, C., . . . Owens, G. (2022). A Transcriptional Regulation Bioinformatics Pipeline to Predict Co-Regulated Genes in Vascular Smooth Muscle Cell Phenotypic Transitions During Atherosclerosis. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.L7569

Ma, W. F., Turner, A. W., Gancayco, C., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.969421

Hao, K., Ermel, R., Sukhavasi, K., Cheng, H., Ma, L., Li, L., . . . Kovacic, J. C. (2022). Integrative Prioritization of Causal Genes for Coronary Artery Disease. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 15(1). doi:10.1161/CIRCGEN.121.003365

Slenders, L., Landsmeer, L. P. L., Cui, K., Depuydt, M. A. C., Verwer, M., Mekke, J., . . . Mokry, M. (2022). Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.. European heart journal open, 2(1), oeab043. doi:10.1093/ehjopen/oeab043

Ma, W. F., Hodonsky, C. J., Turner, A. W., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. ATHEROSCLEROSIS, 340, 12-22. doi:10.1016/j.atherosclerosis.2021.11.025

Wang, Y., Gao, H., Wang, F., Ye, Z., Mokry, M., Turner, A. W., . . . Leeper, N. J. (2022). Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells. CARDIOVASCULAR RESEARCH, 118(13), 2792-2804. doi:10.1093/cvr/cvab347

Drake, J. C., Wilson, R. J., Laker, R. C., Guan, Y., Spaulding, H. R., Nichenko, A. S., . . . Yan, Z. (2021). Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(37). doi:10.1073/pnas.2025932118

Aguilar-Pineda, J. A., Vera-Lopez, K. J., Shrivastava, P., Chavez-Fumagalli, M. A., Nieto-Montesinos, R., Alvarez-Fernandez, K. L., . . . Lino Cardenas, C. L. (2021). Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. ISCIENCE, 24(9). doi:10.1016/j.isci.2021.102993

Cornelissen, A., Fuller, D. T., Fernandez, R., Zhao, X., Kutys, R., Binns-Roemer, E., . . . Finn, A. V. (2021). APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(7), 2201-2214. doi:10.1161/ATVBAHA.120.315788

Miller, C. L., Kontorovich, A. R., Hao, K., Ma, L., Iyegbe, C., Bjorkegren, J. L. M., & Kovacic, J. C. (2021). Precision Medicine Approaches to Vascular Disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 77(20), 2531-2550. doi:10.1016/j.jacc.2021.04.001

Hartiala, J. A., Han, Y., Jia, Q., Hilser, J. R., Huang, P., Gukasyan, J., . . . Allayee, H. (2021). Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. EUROPEAN HEART JOURNAL, 42(9), 919-933. doi:10.1093/eurheartj/ehaa1040

Aherrahrou, R., Guo, L., Nagraj, V. P., Aguhob, A., Hinkle, J., Chen, L., . . . Civelek, M. (2020). Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. CIRCULATION RESEARCH, 127(12), 1552-1565. doi:10.1161/CIRCRESAHA.120.317415

Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., . . . Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(27), 15818-15826. doi:10.1073/pnas.2006348117

Wirka, R. C., Wagh, D., Paik, D. T., Pjanic, M., Trieu, N., Miller, C. L., . . . Quertermous, T. (2019). Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. NATURE MEDICINE, 25(8), 1280-+. doi:10.1038/s41591-019-0512-5

Xu, S., Xu, Y., Liu, P., Zhang, S., Liu, H., Slavin, S., . . . Jin, Z. G. (2019). The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. EUROPEAN HEART JOURNAL, 40(29), 2398-+. doi:10.1093/eurheartj/ehz303

Jaffre, F., Miller, C. L., Schaenzer, A., Evans, T., Roberts, A. E., Hahn, A., & Kontaridis, M. I. (2019). Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. CIRCULATION, 140(3), 207-224. doi:10.1161/CIRCULATIONAHA.118.037227

Wong, D., Turner, A. W., & Miller, C. L. (2019). Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(6), 1006-1017. doi:10.1161/ATVBAHA.119.312141

Zhao, Q., Wirka, R., Trieu, N., Nagao, M., Cheng, P., Miller, C. L., . . . Quertermous, T. (2019). TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression. GENOME MEDICINE, 11. doi:10.1186/s13073-019-0635-9

Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2019). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (vol 124, pg 1083, 2014). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2164. doi:10.1172/JCI129277

Turner, A. W., Wong, D., Khan, M. D., Dreisbach, C. N., Palmore, M., & Miller, C. L. (2019). Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis. FRONTIERS IN CARDIOVASCULAR MEDICINE, 6. doi:10.3389/fcvm.2019.00009

Nanda, V., Wang, T., Pjanic, M., Liu, B., Trieu, N., Matic, L. P., . . . Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLOS GENETICS, 14(11). doi:10.1371/journal.pgen.1007755

Iyer, D., Zhao, Q., Wirka, R., Naravane, A., Trieu, N., Liu, B., . . . Quertermous, T. (2018). Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. PLOS GENETICS, 14(10). doi:10.1371/journal.pgen.1007681

Liu, B., Pjanic, M., Wang, T., Nguyen, T., Gloudemans, M., Rao, A., . . . Quertermous, T. (2018). Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci. AMERICAN JOURNAL OF HUMAN GENETICS, 103(3), 377-388. doi:10.1016/j.ajhg.2018.08.001

Wang, Z., Civelek, M., Miller, C. L., Sheffield, N. C., Guertin, M. J., & Zang, C. (2018). BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. BIOINFORMATICS, 34(16), 2867-2869. doi:10.1093/bioinformatics/bty194

Turner, A. W., Wong, D., Dreisbach, C. N., & Miller, C. L. (2018). GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 5. doi:10.3389/fcvm.2018.00072

Kim, J. B., Pjanic, M., Trieu, N., Miller, C. L., Iyer, D., Liu, B., . . . Quertermous, T. (2017). TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells. PLOS GENETICS, 13(5). doi:10.1371/journal.pgen.1006750

Miller, C. L., & Leeper, N. J. (2016). Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis.. JACC. Basic to translational science, 1(7), 680-683. doi:10.1016/j.jacbts.2016.09.006

Knight, W. E., Chen, S., Zhang, Y., Oikawa, M., Wu, M., Zhou, Q., . . . Yan, C. (2016). PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(45), E7116-E7125. doi:10.1073/pnas.1607728113

Pjanic, M., Miller, C. L., Wirka, R., Kim, J. B., DiRenzo, D. M., & Quertermous, T. (2016). Genetics and Genomics of Coronary Artery Disease. CURRENT CARDIOLOGY REPORTS, 18(10). doi:10.1007/s11886-016-0777-y

Matic, L. P., Rykaczewska, U., Razuvaev, A., Sabater-Lleal, M., Lengquist, M., Miller, C. L., . . . Hedin, U. (2016). Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(9), 1947-1961. doi:10.1161/ATVBAHA.116.307893

Kojima, Y., Volkmer, J. -P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., . . . Leeper, N. J. (2016). CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. NATURE, 536(7614), 86-+. doi:10.1038/nature18935

Miller, C. L., Pjanic, M., Wang, T., Nguyen, T., Cohain, A., Lee, J. D., . . . Quertermous, T. (2016). Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12092

Perez, M. V., Pavlovic, A., Shang, C., Wheeler, M. T., Miller, C. L., Liu, J., . . . Ashley, E. A. (2015). Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(22), 2522-2533. doi:10.1016/j.jacc.2015.09.061

Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., . . . Ashley, E. A. (2015). Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLOS GENETICS, 11(10). doi:10.1371/journal.pgen.1005496

Miller, C. L., Pjanic, M., & Quertermous, T. (2015). From Locus Association to Mechanism of Gene Causality The Devil Is in the Details. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(10), 2079-2080. doi:10.1161/ATVBAHA.115.306366

Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap. GENOMICS DATA, 5, 36-37. doi:10.1016/j.gdata.2015.05.007

Sazonova, O., Zhao, Y., Nuernberg, S., Miller, C., Pjanic, M., Castano, V. G., . . . Quertermous, T. (2015). Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005202

Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005155

Miller, C. L., Assimes, T. L., Montgomery, S. B., & Quertermous, T. (2014). Dissecting the Causal Genetic Mechanisms of Coronary Heart Disease. CURRENT ATHEROSCLEROSIS REPORTS, 16(5). doi:10.1007/s11883-014-0406-4

Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., . . . Sczakiel, G. (2014). Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004263

Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2014). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 124(3), 1083-1097. doi:10.1172/JCI70391

Oikawa, M., Wu, M., Lim, S., Knight, W. E., Miller, C. L., Cai, Y., . . . Yan, C. (2013). Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 64, 11-19. doi:10.1016/j.yjmcc.2013.08.003

Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., Diaz, R., . . . Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7). doi:10.1371/journal.pgen.1003652

Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., Maegdefessel, L., . . . Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-+. doi:10.1161/ATVBAHA.112.300399

Miller, C. L., Cai, Y., Oikawa, M., Thomas, T., Dostmann, W. R., Zaccolo, M., . . . Yan, C. (2011). Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. BASIC RESEARCH IN CARDIOLOGY, 106(6), 1023-1039. doi:10.1007/s00395-011-0228-2

Cai, Y., Miller, C. L., Nagel, D. J., Jeon, K. -I., Lim, S., Gao, P., . . . Yan, C. (2011). Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(3), 616-623. doi:10.1161/ATVBAHA.110.212621

Jeon, K. -I., Jono, H., Miller, C. L., Cai, Y., Lim, S., Liu, X., . . . Yan, C. (2010). Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS JOURNAL, 277(24), 5026-5039. doi:10.1111/j.1742-4658.2010.07908.x

Miller, C. L., & Yan, C. (2010). Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 3(5), 507-515. doi:10.1007/s12265-010-9203-9