Zang, Chongzhi


Chongzhi Zang

Primary Appointment

Assistant Professor, Public Health Sciences


  • BS, Physics, Peking University
  • PhD, Physics, George Washington University
  • Postdoc, Biostatistics and Computational Biology, Harvard University

Contact Information

Telephone: 4342435397

Research Interests

Bioinformatics methodology development; Epigenetics and chromatin biology; Transcriptional regulation; Cancer genomics and epigenomics; Statistical methods for biomedical data integration; Theoretical and computational biophysics

Research Description

The research in my lab focuses on developing computational methodologies and integrative genomics approaches to study epigenetics and transcriptional regulation of gene expression in a variety of mammalian cell systems and human diseases such as cancer.

How gene expression is regulated in chromatin is a fundamental question in molecular biology. High-throughput technologies such as next-generation sequencing (NGS) have become powerful tools for studying gene regulation at the genomic scale. We conduct computational research that leverages these genomics technologies. Some research directions include:

1. Next-generation sequencing bioinformatics

We are interested in developing statistical methods and novel algorithms for analyzing massive data from next-generation sequencing (NGS) coupled with various assays for studying genomic chromatin profiles, such as ChIP-seq for transcription factor and histone mark profiling, ATAC-seq and DNase-seq for chromatin accessibility profiling, etc. As a pioneer in ChIP-seq bioinformatics, we developed SICER (Bioinformatics 2009)

Selected Publications