Chongzhi Zang

How gene expression is regulated in chromatin is a fundamental question in molecular biology. The transcription program is a major determinant of cell identity; transcriptional regulation is involved in many biological processes and human diseases. High-throughput genomics technologies including sequencing, single-cell and spatial omics enable us to obtain massive data measuring the dynamic patterns of numerous factors and elements in the genome that affect chromatin states and gene regulation. The research in the Zang Lab focuses on two aspects: 1) developing quantitative models and computational methods for analyzing high-throughput data generated from emerging omics technologies; and 2) using innovative data science and combining computational and functional genomics approaches to study chromatin biology, epigenetics and transcriptional regulation in mammalian cell systems and human diseases such as cancer. More information can be found on the lab website: https://zanglab.github.io