Douglas A. Bayliss

Gonye, E. C., Shi, Y., Li, K., Clements, R. T., Xu, W., & Bayliss, D. A. (2024). Intrinsic molecular proton sensitivity underlies GPR4 effects on retrotrapezoid nucleus (RTN) neuronal activation and CO2-stimulated breathing. . The Journal of neuroscience : the official journal of the Society for Neuroscience, e0799242024. doi:10.1523/jneurosci.0799-24.2024

Gonye, E. C., Dagli, A. V., Kumar, N. N., Clements, R. T., Xu, W., & Bayliss, D. A. (2024). Expression of Endogenous Epitope-Tagged GPR4 in the Mouse Brain. ENEURO, 11(3). doi:10.1523/ENEURO.0002-24.2024

Li, K., Abbott, S. B. G., Guyenet, P. G., & Bayliss, D. A. (2023). JP-RL-2023-285396: Reply to 'Letter to the Editor' (JP-LE-2023-285385). JOURNAL OF PHYSIOLOGY-LONDON, 601(18), 4173-4175. doi:10.1113/JP285396

Li, K., Gonye, E. C., Stornetta, R. L., Bayliss, C. B., Yi, G., Stornetta, D. S., . . . Bayliss, D. A. (2023). The astrocytic Na⁺-HCO₃^- exchanger NBCe1 is dispensable for respiratory chemosensitivity. JOURNAL OF PHYSIOLOGY-LONDON, 601(16), 3667-3686. doi:10.1113/JP284960

Souza, G. M. P. R., Stornetta, D. S., Shi, Y., Lim, E., Berry, F. E., Bayliss, D. A., & Abbott, S. B. G. (2023). Neuromedin B-Expressing Neurons in the Retrotrapezoid Nucleus Regulate Respiratory Homeostasis and Promote Stable Breathing in Adult Mice. JOURNAL OF NEUROSCIENCE, 43(30), 5501-5520. doi:10.1523/JNEUROSCI.0386-23.2023

Gonye, E. C., & Bayliss, D. A. (2023). Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups. FRONTIERS IN PHYSIOLOGY, 14. doi:10.3389/fphys.2023.1241662

Shi, Y., Sobrinho, C. R., Soto-Perez, J., Milla, B. M., Stornetta, D. S., Stornetta, R. L., . . . Bayliss, D. A. (2022). 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity. JOURNAL OF PHYSIOLOGY-LONDON, 600(11), 2789-2811. doi:10.1113/JP282279

Guyenet, P. G., & Bayliss, D. A. (2022). Central respiratory chemoreception.. Handbook of clinical neurology, 188, 37-72. doi:10.1016/b978-0-323-91534-2.00007-2

Chiu, Y. -H., Medina, C. B., Doyle, C. A., Zhou, M., Narahari, A. K., Sandilos, J. K., . . . Bayliss, D. A. (2021). Deacetylation as a receptor-regulated direct activation switch for pannexin channels. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-24825-y

Medina, C. B., Chiu, Y. -H., Stremska, M. E., Lucas, C. D., Poon, I., Tung, K. S., . . . Ravichandran, K. S. (2021). Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation. IMMUNITY, 54(8), 1715-+. doi:10.1016/j.immuni.2021.06.014

Li, K., Abbott, S. B. G., Shi, Y., Eggan, P., Gonye, E. C., & Bayliss, D. A. (2021). TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing. CELL REPORTS, 34(5). doi:10.1016/j.celrep.2021.108714

Narahari, A. K., Kreutzberger, A. J. B., Gaete, P. S., Chiu, Y. -H., Leonhardt, S. A., Medina, C. B., . . . Bayliss, D. A. (2021). ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels. ELIFE, 10. doi:10.7554/eLife.64787

Li, K., Shi, Y., Gonye, E. C., & Bayliss, D. A. (2021). TRPM4 Contributes to Subthreshold Membrane Potential Oscillations in Multiple Mouse Pacemaker Neurons. ENEURO, 8(6). doi:10.1523/ENEURO.0212-21.2021

Shi, Y., Stornetta, D. S., Reklow, R. J., Sahu, A., Wabara, Y., Nguyen, A., . . . Bayliss, D. A. (2021). A brainstem peptide system activated at birth protects postnatal breathing. NATURE, 589(7842), 426-+. doi:10.1038/s41586-020-2991-4

Barrett, P. Q., Guagliardo, N. A., & Bayliss, D. A. (2021). Ion Channel Function and Electrical Excitability in the Zona Glomerulosa: A Network Perspective on Aldosterone Regulation. ANNUAL REVIEW OF PHYSIOLOGY, VOL 83, 83, 451-475. doi:10.1146/annurev-physiol-030220-113038

DeLalio, L. J., Masati, E., Mendu, S., Ruddiman, C. A., Yang, Y., Johnstone, S. R., . . . Isakson, B. E. (2020). Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. KIDNEY INTERNATIONAL, 98(3), 630-644. doi:10.1016/j.kint.2020.04.041

Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., Shi, Y., & Bayliss, D. A. (2019). The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity. TRENDS IN NEUROSCIENCES, 42(11), 807-824. doi:10.1016/j.tins.2019.09.002

Bayliss, D. A., Czirják, G., Enyedi, P., Goldstein, S. A. N., Lesage, F., Minor, Jr., D. L., . . . Winn, B. T. (n.d.). Two P domain potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). doi:10.2218/gtopdb/f79/2019.4

Guagliardo, N. A., Yao, J., Stipes, E. J., Cechova, S., Le, T. H., Bayliss, D. A., . . . Barrett, P. Q. (2019). Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. HYPERTENSION, 73(2), 407-414. doi:10.1161/HYPERTENSIONAHA.118.11962

Good, M. E., Chiu, Y. -H., Poon, I. K. H., Jaffe, I. Z., Bayliss, D. A., Isakson, B. E., & Ravichandran, K. S. (2018). Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone". CIRCULATION RESEARCH, 122(11), E88-E89. doi:10.1161/CIRCRESAHA.118.313080

Sharma, A. K., Charles, E. J., Zhao, Y., Narahari, A. K., Baderdinni, P. K., Good, M. E., . . . Laubach, V. E. (2018). Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 315(2), L301-L312. doi:10.1152/ajplung.00004.2018

Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Kanbar, R., Shi, Y., Holloway, B. B., . . . Wenker, I. C. (2018). Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 596(15), 3029-3042. doi:10.1113/JP274357

Good, M. E., Chiu, Y. -H., Poon, I. K. H., Medina, C. B., Butcher, J. T., Mendu, S. K., . . . Ravichandran, K. S. (2018). Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. CIRCULATION RESEARCH, 122(4), 606-615. doi:10.1161/CIRCRESAHA.117.312380

Chiu, Y. -H., Schappe, M. S., Desai, B. N., & Bayliss, D. A. (2018). Revisiting multimodal activation and channel properties of Pannexin 1. JOURNAL OF GENERAL PHYSIOLOGY, 150(1), 19-39. doi:10.1085/jgp.201711888

Shi, Y., Stornetta, R. L., Stornetta, D. S., Onengut-Gumuscu, S., Farber, E. A., Turner, S. D., . . . Bayliss, D. A. (2017). Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus. JOURNAL OF NEUROSCIENCE, 37(48), 11744-11757. doi:10.1523/JNEUROSCI.2055-17.2017

Yao, J., McHedlishvili, D., McIntire, W. E., Guagliardo, N. A., Erisir, A., Coburn, C. A., . . . Barrett, P. Q. (2017). Functional TASK-3-Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells. HYPERTENSION, 70(2), 347-+. doi:10.1161/HYPERTENSIONAHA.116.08871

Yao, C., Li, Y., Shu, S., Yao, S., Lynch, C. I. I. I., Bayliss, D. A., & Chen, X. (2017). TASK channels contribute to neuroprotective action of inhalational anesthetics. SCIENTIFIC REPORTS, 7. doi:10.1038/srep44203

Weaver, J. L., Arandjelovic, S., Brown, G., Mendu, S. K., Schappe, M. S., Buckley, M. W., . . . Bayliss, D. A. (2017). Hematopoietic pannexin 1 function is critical for neuropathic pain. SCIENTIFIC REPORTS, 7. doi:10.1038/srep42550

Chiu, Y. -H., Jin, X., Medina, C. B., Leonhardt, S. A., Kiessling, V., Bennett, B. C., . . . Bayliss, D. A. (2017). A quantized mechanism for activation of pannexin channels. Nature Communications, 8. doi:10.1038/ncomms14324

Shi, Y., Abe, C., Holloway, B. B., Shu, S., Kumar, N. N., Weaver, J. L., . . . Bayliss, D. A. (2016). Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. JOURNAL OF NEUROSCIENCE, 36(31), 8174-8187. doi:10.1523/JNEUROSCI.1096-16.2016

Manichaikul, A., Rich, S. S., Allison, M. A., Guagliardo, N. A., Bayliss, D. A., Carey, R. M., & Barrett, P. Q. (2016). KCNK3 Variants Are Associated With Hyperaldosteronism and Hypertension. HYPERTENSION, 68(2), 356-+. doi:10.1161/HYPERTENSIONAHA.116.07564

Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Ludwig, M. -G., Kumar, N. N., Shi, Y., . . . Wenker, I. C. (2016). Proton detection and breathing regulation by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 594(6), 1529-1551. doi:10.1113/JP271480

Vu, M. T., Du, G., Bayliss, D. A., & Horner, R. L. (2015). TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine. JOURNAL OF NEUROSCIENCE, 35(40), 13555-13567. doi:10.1523/JNEUROSCI.1445-15.2015

Guyenet, P. G., & Bayliss, D. A. (2015). Neural Control of Breathing and CO₂ Homeostasis. NEURON, 87(5), 946-961. doi:10.1016/j.neuron.2015.08.001

Zhou, C., Liang, P., Liu, J., Ke, B., Wang, X., Li, F., . . . Chen, X. (2015). HCN1 Channels Contribute to the Effects of Amnesia and Hypnosis but not Immobility of Volatile Anesthetics. ANESTHESIA AND ANALGESIA, 121(3), 661-666. doi:10.1213/ANE.0000000000000830

Adamson, S. E., Meher, A. K., Chiu, Y. -H., Sandilos, J. K., Oberholtzer, N. P., Walker, N. N., . . . Leitinger, N. (2015). Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. MOLECULAR METABOLISM, 4(9), 610-618. doi:10.1016/j.molmet.2015.06.009

Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Bayliss, D. A. (2015). Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. SCIENCE, 348(6240), 1255-1260. doi:10.1126/science.aaa0922

Billaud, M., Chiu, Y. -H., Lohman, A. W., Parpaite, T., Butcher, J. T., Mutchler, S. M., . . . Isakson, B. E. (2015). A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. SCIENCE SIGNALING, 8(364). doi:10.1126/scisignal.2005824

Zhang, H., Dong, H., Cilz, N. I., Kurada, L., Hu, B., Wada, E., . . . Lei, S. (2016). Neurotensinergic Excitation of Dentate Gyrus Granule Cells via Gα_q-Coupled Inhibition of TASK-3 Channels. CEREBRAL CORTEX, 26(3), 977-990. doi:10.1093/cercor/bhu267

Bayliss, D. A., Barhanin, J., Gestreau, C., & Guyenet, P. G. (2015). The role of pH-sensitive TASK channels in central respiratory chemoreception. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(5), 917-929. doi:10.1007/s00424-014-1633-9

Morenilla-Palao, C., Luis, E., Fernaadez-Pena, C., Quintero, E., Weaver, J. L., Bayliss, D. A., & Viana, F. (2014). Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation. CELL REPORTS, 8(5), 1571-1582. doi:10.1016/j.celrep.2014.08.003

Poon, I. K. H., Chiu, Y. -H., Armstrong, A. J., Kinchen, J. M., Juncadella, I. J., Bayliss, D. A., & Ravichandran, K. S. (2014). Unexpected link between an antibiotic, pannexin channels and apoptosis. NATURE, 507(7492), 329-+. doi:10.1038/nature13147

Lazarenko, R., Geisler, J., Bayliss, D., Larner, J., & Li, C. (2014). D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 387(1-2), 1-7. doi:10.1016/j.mce.2014.02.004

Chiu, Y. -H., Ravichandran, K. S., & Bayliss, D. A. (2014). Intrinsic properties and regulation of Pannexin 1 channel. CHANNELS, 8(2), 1-7. doi:10.4161/chan.27545

Kenwood, B. M., Weaver, J. L., Bajwa, A., Poon, I. K., Byrne, F. L., Murrow, B. A., . . . Hoehn, K. L. (2014). Identification of a novel mitochondria! uncoupler that does not depolarize the plasma membrane. MOLECULAR METABOLISM, 3(2), 114-123. doi:10.1016/j.molmet.2013.11.005

Wang, S., Benamer, N., Zanella, S., Kumar, N. N., Shi, Y., Bevengut, M., . . . Bayliss, D. A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons. JOURNAL OF NEUROSCIENCE, 33(41), 16033-16044. doi:10.1523/JNEUROSCI.2451-13.2013

Kazmierczak, M., Zhang, X., Chen, B., Mulkey, D. K., Shi, Y., Wagner, P. G., . . . Jegla, T. (2013). External pH modulates EAG superfamily K⁺ channels through EAG-specific acidic residues in the voltage sensor. JOURNAL OF GENERAL PHYSIOLOGY, 141(6), 721-735. doi:10.1085/jgp.201210938

Wang, S., Shi, Y., Shu, S., Guyenet, P. G., & Bayliss, D. A. (2013). Phox2b-Expressing Retrotrapezoid Neurons Are Intrinsically Responsive to H⁺ and CO₂. JOURNAL OF NEUROSCIENCE, 33(18), 7756-7761. doi:10.1523/JNEUROSCI.5550-12.2013

Zhou, C., Douglas, J. E., Kumar, N. N., Shu, S., Bayliss, D. A., & Chen, X. (2013). Forebrain HCN1 channels contribute to hypnotic actions of ketamine.. Anesthesiology, 118(4), 785-795. doi:10.1097/aln.0b013e318287b7c8

Bonin, R. P., Zurek, A. A., Yu, J., Bayliss, D. A., & Orser, B. A. (2013). Hyperpolarization-Activated Current (I_h) Is Reduced in Hippocampal Neurons from Gabra5-/- Mice. PLOS ONE, 8(3). doi:10.1371/journal.pone.0058679

Sandilos, J. K., & Bayliss, D. A. (2012). Physiological mechanisms for the modulation of pannexin 1 channel activity. JOURNAL OF PHYSIOLOGY-LONDON, 590(24), 6257-6266. doi:10.1113/jphysiol.2012.240911

Lohman, A. W., Weaver, J. L., Billaud, M., Sandilos, J. K., Griffiths, R., Straub, A. C., . . . Isakson, B. E. (2012). S-Nitrosylation Inhibits Pannexin 1 Channel Function. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(47). doi:10.1074/jbc.M112.397976

Guagliardo, N. A., Yao, J., Hu, C., Schertz, E. M., Tyson, D. A., Carey, R. M., . . . Barrett, P. Q. (2012). TASK-3 Channel Deletion in Mice Recapitulates Low-Renin Essential Hypertension. HYPERTENSION, 59(5), 999-+. doi:10.1161/HYPERTENSIONAHA.111.189662

Sandilos, J. K., Chiu, Y. -H., Chekeni, F. B., Armstrong, A. J., Walk, S. F., Ravichandran, K. S., & Bayliss, D. A. (2012). Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(14), 11303-11311. doi:10.1074/jbc.M111.323378

Du, G., Chen, X., Todorovic, M. S., Shu, S., Kapur, J., & Bayliss, D. A. (2011). TASK Channel Deletion Reduces Sensitivity to Local Anesthetic-induced Seizures. ANESTHESIOLOGY, 115(5), 1003-1011. doi:10.1097/ALN.0b013e3182343660

Lewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., . . . Chetkovich, D. M. (2011). Deletion of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Auxiliary Subunit TRIP8b Impairs Hippocampal I_h Localization and Function and Promotes Antidepressant Behavior in Mice. JOURNAL OF NEUROSCIENCE, 31(20), 7424-7440. doi:10.1523/JNEUROSCI.0936-11.2011

Meng, Q. -T., Xia, Z. -Y., Liu, J., Bayliss, D. A., & Chen, X. (2011). Local Anesthetic Inhibits Hyperpolarization-Activated Cationic Currents. MOLECULAR PHARMACOLOGY, 79(5), 866-873. doi:10.1124/mol.110.070227

Sandilos, J. K., Chekeni, F. B., Elliott, M. R., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Bayliss, D. A. (2011). Caspases Mediate Pannexin 1 Channel Activation in Apoptotic Cells. Biophysical Journal, 100(3), 101a. doi:10.1016/j.bpj.2010.12.759

Isakson, B. E., Billaud, M., Lohman, A. W., Straub, A. C., Sandilos, J. K., & Bayliss, D. A. (2011). S-nitrosylation of pannexin 1 reduces channel permeability, potentially regulating vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 8. Retrieved from https://www.webofscience.com/

Billaud, M., Lohman, A. W., Sandilos, J. K., Bayliss, D. A., & Isakson, B. E. (2011). Exclusive interaction between α1D-adrenergic receptor and pannexin 1 can mediate vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 118. Retrieved from https://www.webofscience.com/

Lazarenko, R. M., Stornetta, R. L., Bayliss, D. A., & Guyenet, P. G. (2011). Orexin A activates retrotrapezoid neurons in mice. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 175(2), 283-287. doi:10.1016/j.resp.2010.12.003

Guagliardo, N. A., Yao, J., Bayliss, D. A., & Barrett, P. Q. (2011). TASK channels are not required to mount an aldosterone secretory response to metabolic acidosis in mice. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 336(1-2), 47-52. doi:10.1016/j.mce.2010.11.017

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Ravichandran, K. S. (2010). Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. NATURE, 467(7317), 863-U136. doi:10.1038/nature09413

Guyenet, P. G., Stornetta, R. L., & Bayliss, D. A. (2010). Central Respiratory Chemoreception. JOURNAL OF COMPARATIVE NEUROLOGY, 518(19), 3883-3906. doi:10.1002/cne.22435

Lazarenko, R. M., Fortuna, M. G., Shi, Y., Mulkey, D. K., Takakura, A. C., Moreira, T. S., . . . Bayliss, D. A. (2010). Anesthetic Activation of Central Respiratory Chemoreceptor Neurons Involves Inhibition of a THIK-1-Like Background K⁺ Current. JOURNAL OF NEUROSCIENCE, 30(27), 9324-9334. doi:10.1523/JNEUROSCI.1956-10.2010

Lazarenko, R. M., Willcox, S. C., Shu, S., Berg, A. P., Jevtovic-Todorovic, V., Talley, E. M., . . . Bayliss, D. A. (2010). Motoneuronal TASK Channels Contribute to Immobilizing Effects of Inhalational General Anesthetics. JOURNAL OF NEUROSCIENCE, 30(22), 7691-7704. doi:10.1523/JNEUROSCI.1655-10.2010

Chen, X., Shu, S., Schwartz, L. C., Sun, C., Kapur, J., & Bayliss, D. A. (2010). Homeostatic Regulation of Synaptic Excitability: Tonic GABA_A Receptor Currents Replace I_h in Cortical Pyramidal Neurons of HCN1 Knock-Out Mice. JOURNAL OF NEUROSCIENCE, 30(7), 2611-2622. doi:10.1523/JNEUROSCI.3771-09.2010