David L. Brautigan

Fu Z, Gailey CD, Wang EJ, Brautigan DL, Ciliogenesis associated kinase 1 (CILK1): targets and functions in various organ systems., 2019; FEBS letters. () . PMID: 31506943

Oh YS, Wang EJ, Gailey CD, Brautigan DL, Allen BL, Fu Z, Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis., 2019; Cells. 8(7) . PMID: 31277411 | PMCID: PMC6678984

Shi L, Li K, Guo Y, Banerjee A, Wang Q, Lorenz UM, Parlak M, Sullivan LC, Onyema OO, Arefanian S, Stelow EB, Brautigan DL, Bullock TNJ, Brown MG, Krupnick AS, Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer., 2018; Proceedings of the National Academy of Sciences of the United States of America. 115(46) 11808-11813. PMID: 30381460 | PMCID: PMC6243255

Brautigan DL, Gielata M, Heo J, Kubicka E, Wilkins LR, Selective toxicity of caffeic acid in hepatocellular carcinoma cells., 2018; Biochemical and biophysical research communications. 505(2) 612-617. PMID: 30278886

McClinch K, A Avelar R, Callejas D, Izadmehr S, Wiredja D, Perl A, Sangodkar J, Kastrinsky DB, Schlatzer D, Cooper M, Kiselar J, Stachnik A, Yao S, Hoon D, McQuaid D, Zaware N, Gong Y, Brautigan DL, Plymate S, Sprenger CC, Oh WK, Levine AC, Kirschenbaum A, Sfakianos JP, Sears RC, DiFeo A, Ioannou YA, Ohlmeyer M, Narla G, Galsky MD, Small molecule activators of protein phosphatase 2A for the treatment of castration-resistant prostate cancer., 2018; Cancer research. () . PMID: 29358171

Tong Y, Park S, Wu D, Harris TE, Moskaluk CA, Brautigan DL, Fu Z, Modulation of GSK3β autoinhibition by Thr-7 and Thr-8., 2018; FEBS letters. () . PMID: 29377106

Brautigan DL, Li R, Kubicka E, Turner SD, Garcia JS, Weintraut ML, Wong EA, Lysolecithin as feed additive enhances collagen expression and villus length in the jejunum of broiler chickens., 2017; Poultry science. 96(8) 2889-2898. PMID: 28444343

Ziembik MA, Bender TP, Larner JM, Brautigan DL, Functions of protein phosphatase-6 in NF-κB signaling and in lymphocytes., 2017; Biochemical Society transactions. 45(3) 693-701. PMID: 28620030 | PMCID: PMC5473023

Sarkar S, Brautigan DL, Larner JM, Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP., 2017; Molecular cancer research : MCR. 15(8) 1063-1072. PMID: 28536143 | PMCID: PMC5697428

Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky DB, Zaware N, Izadmehr S, Mazhar S, Wiredja DD, O'Connor CM, Hoon D, Dhawan NS, Schlatzer D, Yao S, Leonard D, Borczuk AC, Gokulrangan G, Wang L, Svenson E, Farrington CC, Yuan E, Avelar RA, Stachnik A, Smith B, Gidwani V, Giannini HM, McQuaid D, McClinch K, Wang Z, Levine AC, Sears RC, Chen EY, Duan Q, Datt M, Haider S, Ma'ayan A, DiFeo A, Sharma N, Galsky MD, Brautigan DL, Ioannou YA, Xu W, Chance MR, Ohlmeyer M, Narla G, Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth., 2017; The Journal of clinical investigation. 127(6) 2081-2090. PMID: 28504649 | PMCID: PMC5451217

Biswas K, Sarkar S, Du K, Brautigan DL, Abbas T, Larner JM, The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance., 2017; Molecular cancer research : MCR. 15(6) 651-659. PMID: 28232384 | PMCID: PMC5687089

Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA, Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes., 2017; Molecular & cellular proteomics : MCP. 16(4) S244-S262. PMID: 28174228 | PMCID: PMC5393398

Li R, Turner SD, Brautigan DL, Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin., 2017; Biochemistry and biophysics reports. 4() 52-58. PMID: 29124187 | PMCID: PMC5668877

Wilkins LR, Brautigan DL, Wu H, Yarmohammadi H, Kubicka E, Serbulea V, Leitinger N, Liu W, Haaga JR, Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma., 2016; Cardiovascular and interventional radiology. () . PMID: 27872984

Farinha CM, Swiatecka-Urban A, Brautigan DL, Jordan P, Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity., 2016; Frontiers in chemistry. 4() 1. PMID: 26835446 | PMCID: PMC4718993

Luz S, Cihil KM, Brautigan DL, Amaral MD, Farinha CM, Swiatecka-Urban A, LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells., 2014; The Journal of biological chemistry. 289(21) 15080-93. PMID: 24727471 | PMCID: PMC4031558

Hall EH, Liu Y, Xiao A, Shock L, Brautigan DL, Mayo MW, Adusumilli PS, Jones DR, Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53., 2014; PloS one. 9(4) e95869. PMID: 24763730 | PMCID: PMC3999110

Griner EM, Dancik GM, Costello JC, Owens C, Guin S, Edwards MG, Brautigan DL, Theodorescu D, RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer., 2014; Molecular cancer research : MCR. 13(3) 483-92. PMID: 25516960 | PMCID: PMC4369172

Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe EW, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D, Discovery and characterization of small molecules that target the GTPase Ral., 2014; Nature. () . PMID: 25219851 | PMCID: PMC4351747

Ohama T, Wang L, Griner EM, Brautigan DL, Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions., 2013; BMC cell biology. 14() 42. PMID: 24063632 | PMCID: PMC3856536

Wang L, Brautigan DL, α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro., 2013; Nature communications. 4() 1559. PMID: 23463002 | PMCID: PMC3595137

Dziegielewska B, Brautigan DL, Larner JM, Dziegielewski J, T-type Ca2+ Channel Inhibition Induces p53 Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells., 2013; Molecular cancer research : MCR. () . PMID: 24362252

Martín-Montalvo A, González-Mariscal I, Pomares-Viciana T, Padilla-López S, Ballesteros M, Vazquez-Fonseca L, Gandolfo P, Brautigan DL, Navas P, Santos-Ocaña C, The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast., 2013; The Journal of biological chemistry. 288(39) 28126-37. PMID: 23940037 | PMCID: PMC3784724

Korrodi-Gregório L, Ferreira M, Vintém AP, Wu W, Muller T, Marcus K, Vijayaraghavan S, Brautigan DL, da Cruz E Silva OA, Fardilha M, da Cruz E Silva EF, Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa., 2013; BMC cell biology. 14() 15. PMID: 23506001 | PMCID: PMC3606321

Valerie NC, Dziegielewska B, Hosing AS, Augustin E, Gray LS, Brautigan DL, Larner JM, Dziegielewski J, Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells., 2013; Biochemical pharmacology. 85(7) 888-97. PMID: 23287412

Slingluff CL, Petroni GR, Molhoek KR, Brautigan DL, Chianese-Bullock KA, Shada AL, Smolkin ME, Olson WC, Gaucher A, Chase CM, Grosh WW, Weiss GR, Wagenseller AG, Olszanski AJ, Martin L, Shea SM, Erdag G, Ram P, Gershenwald JE, Weber MJ, Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47)., 2013; Clinical cancer research : an official journal of the American Association for Cancer Research. 19(13) 3611-20. PMID: 23620404 | PMCID: PMC3700572

Griner EM, Churchill ME, Brautigan DL, Theodorescu D, PKCα phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity., 2012; Oncogene. () . PMID: 22469974 | PMCID: PMC3578973

Eto M, Brautigan DL, Endogenous inhibitor proteins that connect Ser/Thr kinases and phosphatases in cell signaling., 2012; IUBMB life. 64(9) 732-9. PMID: 22815089 | PMCID: PMC3422418

Pitt J, Thorner M, Brautigan D, Larner J, Klein WL, Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols., 2012; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(1) 199-207. PMID: 23073831 | PMCID: PMC3528307

Holy M, Brautigan DL, Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases., 2012; Toxins. 4(10) 940-54. PMID: 23162706 | PMCID: PMC3496997

Sarkar S, Brautigan DL, Parsons SJ, Larner JM, Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells., 2012; Oncogene. 33(1) 26-33. PMID: 23246967 | PMCID: PMC3899837

Hosing AS, Valerie NC, Dziegielewski J, Brautigan DL, Larner JM, PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase., 2012; The Journal of biological chemistry. 287(12) 9230-9. PMID: 22298787 | PMCID: PMC3308816

Brautigan DL, Protein Ser/ Thr phosphatases - the ugly ducklings of cell signalling., 2012; The FEBS journal. () . PMID: 22519956

Sami F, Smet-Nocca C, Khan M, Landrieu I, Lippens G, Brautigan DL, Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2., 2011; Biochemistry. 50(30) 6567-78. PMID: 21714498 | PMCID: PMC3965691

Hall EH, Gurel V, Dahlberg AE, McMichael J, Brautigan DL, Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1., 2011; Cellular signalling. 23(12) 1972-7. PMID: 21787862 | PMCID: NIHMS312507

Martin-Montalvo A, Gonzalez-Mariscal I, Padilla S, Ballesteros M, Brautigan DL, Navas P, Santos-Ocaña C, Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p., 2011; The Biochemical journal. () . PMID: 21812761

Edelson JR, Brautigan DL, The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells., 2011; Toxins. 3(1) 105-19. PMID: 22069692 | PMCID: PMC3210456

Everett AD, Yang J, Rahman M, Dulloor P, Brautigan DL, Mitotic phosphorylation activates hepatoma-derived growth factor as a mitogen., 2011; BMC cell biology. 12() 15. PMID: 21489262 | PMCID: PMC3094319

Molhoek KR, Erdag G, Rasamny JK, Murphy C, Deacon D, Patterson JW, Slingluff CL, Brautigan DL, VEGFR-2 expression in human melanoma: revised assessment., 2011; International journal of cancer. Journal international du cancer. 129(12) 2807-15. PMID: 21544800 | PMCID: PMC3205910

Molhoek KR, Shada AL, Smolkin M, Chowbina S, Papin J, Brautigan DL, Slingluff CL, Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R., 2011; Melanoma research. 21(4) 274-84. PMID: 21654344 | PMCID: PMC3131461

Larner J, Brautigan DL, Thorner MO, D-chiro-inositol glycans in insulin signaling and insulin resistance., 2010; Molecular medicine (Cambridge, Mass.). 16(11) 543-52. PMID: 20811656 | PMCID: PMC2972396

Hans SK, Camara F, Altiti A, Martín-Montalvo A, Brautigan DL, Heimark D, Larner J, Grindrod S, Brown ML, Mootoo DR, Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha., 2010; Bioorganic & medicinal chemistry. 18(3) 1103-10. PMID: 20079654 | PMCID: PMC3408221

Ohama T, Brautigan DL, Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A., 2010; The Journal of biological chemistry. 285(12) 8711-8. PMID: 20100830 | PMCID: PMC2838294

Hall EH, Balsbaugh JL, Rose KL, Shabanowitz J, Hunt DF, Brautigan DL, Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK., 2010; Molecular & cellular proteomics : MCP. 9(12) 2853-63. PMID: 20798394 | PMCID: PMC3101865

Wang H, Owens C, Chandra N, Conaway MR, Brautigan DL, Theodorescu D, Phosphorylation of RalB is important for bladder cancer cell growth and metastasis., 2010; Cancer research. 70(21) 8760-9. PMID: 20940393 | PMCID: PMC3025490

Guergnon J, Derewenda U, Edelson JR, Brautigan DL, Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats., 2009; BMC biochemistry. 10() 24. PMID: 19835610 | PMCID: PMC2765987

Broglie P, Matsumoto K, Akira S, Brautigan DL, Ninomiya-Tsuji J, Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway., 2009; The Journal of biological chemistry. 285(4) 2333-9. PMID: 19955178 | PMCID: PMC2807291

Hall EH, Daugherty AE, Choi CK, Horwitz AF, Brautigan DL, Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion., 2009; The Journal of biological chemistry. 284(50) 34713-22. PMID: 19826001 | PMCID: PMC2787334

Mi J, Bolesta E, Brautigan DL, Larner JM, PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53., 2009; Molecular cancer therapeutics. 8(1) 135-40. PMID: 19139122

Mi J, Dziegielewski J, Bolesta E, Brautigan DL, Larner JM, Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6., 2009; PloS one. 4(2) e4395. PMID: 19198648 | PMCID: PMC2634843

Morales-Johansson H, Puria R, Brautigan DL, Cardenas ME, Human protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae., 2009; PloS one. 4(7) e6331. PMID: 19621075 | PMCID: PMC2708350

Ohama T, Okada M, Murata T, Brautigan DL, Hori M, Ozaki H, Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts., 2008; American journal of physiology. Gastrointestinal and liver physiology. 295(4) G766-75. PMID: 18703638

Molhoek KR, McSkimming CC, Olson WC, Brautigan DL, Slingluff CL, Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2., 2008; Cancer immunology, immunotherapy : CII. 58(6) 867-76. PMID: 18841360 | PMCID: PMC2688807

Wang W, Brautigan DL, Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells., 2008; BMC cell biology. 9() 62. PMID: 19036150 | PMCID: PMC2630314

Wang W, Stukenberg PT, Brautigan DL, Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells., 2008; Molecular biology of the cell. 19(11) 4852-62. PMID: 18716057 | PMCID: PMC2575180

Yoo SJ, Jimenez RH, Sanders JA, Boylan JM, Brautigan DL, Gruppuso PA, The alpha4-containing form of protein phosphatase 2A in liver and hepatic cells., 2008; Journal of cellular biochemistry. 105(1) 290-300. PMID: 18543252 | PMCID: PMC2597445

Wang W, Cronmiller C, Brautigan DL, Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis., 2008; Genetics. 179(4) 1823-33. PMID: 18689877 | PMCID: PMC2516061

Prickett TD, Ninomiya-Tsuji J, Broglie P, Muratore-Schroeder TL, Shabanowitz J, Hunt DF, Brautigan DL, TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB., 2008; The Journal of biological chemistry. 283(28) 19245-54. PMID: 18456659 | PMCID: PMC2443674

Fuller BG, Lampson MA, Foley EA, Rosasco-Nitcher S, Le KV, Tobelmann P, Brautigan DL, Stukenberg PT, Kapoor TM, Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient., 2008; Nature. 453(7198) 1132-6. PMID: 18463638 | PMCID: PMC2724008

Molhoek KR, Griesemann H, Shu J, Gershenwald JE, Brautigan DL, Slingluff CL, Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2., 2008; Cancer research. 68(11) 4392-7. PMID: 18519701 | PMCID: PMC2727753

Stefansson B, Ohama T, Daugherty AE, Brautigan DL, Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains., 2008; Biochemistry. 47(5) 1442-51. PMID: 18186651

Stefansson B, Brautigan DL, Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells., 2007; Cell cycle (Georgetown, Tex.). 6(11) 1386-92. PMID: 17568194

Eto M, Brautigan DL, Assay for three-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2., 2007; Methods in molecular biology (Clifton, N.J.). 365() 197-208. PMID: 17200563

Eto M, Kitazawa T, Matsuzawa F, Aikawa S, Kirkbride JA, Isozumi N, Nishimura Y, Brautigan DL, Ohki SY, Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor., 2007; Structure (London, England : 1993). 15(12) 1591-602. PMID: 18073109 | PMCID: PMC2217667

Li M, Stukenberg PT, Brautigan DL, Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins., 2007; Biochemistry. 47(1) 292-300. PMID: 18062707

Yang J, Roe SM, Prickett TD, Brautigan DL, Barford D, The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation., 2007; Biochemistry. 46(30) 8807-15. PMID: 17616149

Smith SC, Oxford G, Baras AS, Owens C, Havaleshko D, Brautigan DL, Safo MK, Theodorescu D, Expression of ral GTPases, their effectors, and activators in human bladder cancer., 2007; Clinical cancer research : an official journal of the American Association for Cancer Research. 13(13) 3803-13. PMID: 17606711

Li M, Satinover DL, Brautigan DL, Phosphorylation and functions of inhibitor-2 family of proteins., 2007; Biochemistry. 46(9) 2380-9. PMID: 17286390

Prickett TD, Brautigan DL, Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3., 2007; Molecular and cellular biology. 27(12) 4217-27. PMID: 17438131 | PMCID: PMC1900036

Eto M, Kirkbride J, Elliott E, Lo SH, Brautigan DL, Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions., 2007; The Journal of biological chemistry. 282(24) 17806-15. PMID: 17435217

Yoo SJ, Boylan JM, Brautigan DL, Gruppuso PA, Subunit composition and developmental regulation of hepatic protein phosphatase 2A (PP2A)., 2007; Archives of biochemistry and biophysics. 461(2) 186-93. PMID: 17391644 | PMCID: PMC1868455

Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal BM, Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions., 2007; Molecular and cellular biology. 27(9) 3390-404. PMID: 17325038 | PMCID: PMC1899975

Mi J, Guo C, Brautigan DL, Larner JM, Protein phosphatase-1alpha regulates centrosome splitting through Nek2., 2007; Cancer research. 67(3) 1082-9. PMID: 17283141

Satinover DL, Brautigan DL, Stukenberg PT, Aurora-A kinase and inhibitor-2 regulate the cyclin threshold for mitotic entry in Xenopus early embryonic cell cycles., 2006; Cell cycle (Georgetown, Tex.). 5(19) 2268-74. PMID: 16969136

Swain JE, Ding J, Brautigan DL, Villa-Moruzzi E, Smith GD, Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity., 2006; Biology of reproduction. 76(4) 628-38. PMID: 17182892

Kajino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J, Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway., 2006; The Journal of biological chemistry. 281(52) 39891-6. PMID: 17079228 | PMCID: PMC1797071

Guo C, Mi J, Brautigan DL, Larner JM, ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes., 2006; Cellular signalling. 19(3) 504-10. PMID: 17008050

Wu Y, Wang H, Brautigan DL, Liu Z, Activation of glycogen synthase in myocardium induced by intermittent hypoxia is much lower in fasted than in fed rats., 2006; American journal of physiology. Endocrinology and metabolism. 292(2) E469-75. PMID: 17003235

Gianchandani EP, Brautigan DL, Papin JA, Systems analyses characterize integrated functions of biochemical networks., 2006; Trends in biochemical sciences. 31(5) 284-91. PMID: 16616498

Prickett TD, Brautigan DL, The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A., 2006; The Journal of biological chemistry. 281(41) 30503-11. PMID: 16895907

Brautigan DL, Kruszewski A, Wang H, Chromium and vanadate combination increases insulin-induced glucose uptake by 3T3-L1 adipocytes., 2006; Biochemical and biophysical research communications. 347(3) 769-73. PMID: 16842748

Stefansson B, Brautigan DL, Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon., 2006; The Journal of biological chemistry. 281(32) 22624-34. PMID: 16769727

Wang H, Brautigan DL, Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase., 2006; Molecular & cellular proteomics : MCP. 5(11) 2124-30. PMID: 16887929

Yang CS, Vitto MJ, Busby SA, Garcia BA, Kesler CT, Gioeli D, Shabanowitz J, Hunt DF, Rundell K, Brautigan DL, Paschal BM, Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor., 2005; Molecular and cellular biology. 25(4) 1298-308. PMID: 15684382 | PMCID: PMC548022

Wang H, Kruszewski A, Brautigan DL, Cellular chromium enhances activation of insulin receptor kinase., 2005; Biochemistry. 44(22) 8167-75. PMID: 15924436

Brautigan DL, Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J, Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action., 2005; Biochemistry. 44(33) 11067-73. PMID: 16101290

Eto M, Kirkbride JA, Brautigan DL, Assembly of MYPT1 with protein phosphatase-1 in fibroblasts redirects localization and reorganizes the actin cytoskeleton., 2005; Cell motility and the cytoskeleton. 62(2) 100-9. PMID: 16106448

Molhoek KR, Brautigan DL, Slingluff CL, Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin., 2005; Journal of translational medicine. 3() 39. PMID: 16255777 | PMCID: PMC1289294

Li M, Stefansson B, Wang W, Schaefer EM, Brautigan DL, Phosphorylation of the Pro-X-Thr-Pro site in phosphatase inhibitor-2 by cyclin-dependent protein kinase during M-phase of the cell cycle., 2005; Cellular signalling. 18(8) 1318-26. PMID: 16377132

Prickett TD, Brautigan DL, Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits., 2004; The Journal of biological chemistry. 279(37) 38912-20. PMID: 15252037

Tountas NA, Brautigan DL, Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein., 2004; Journal of cell science. 117(0) 5905-12. PMID: 15522888

Tountas NA, Mandell JW, Everett AD, Brautigan DL, Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells., 2004; Histochemistry and cell biology. 121(4) 343-50. PMID: 15083373

Eto M, Kitazawa T, Brautigan DL, Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits., 2004; Proceedings of the National Academy of Sciences of the United States of America. 101(24) 8888-93. PMID: 15184667 | PMCID: PMC428442

Satinover DL, Leach CA, Stukenberg PT, Brautigan DL, Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein., 2004; Proceedings of the National Academy of Sciences of the United States of America. 101(23) 8625-30. PMID: 15173575 | PMCID: PMC423245

Ohki Sy, Eto M, Shimizu M, Takada R, Brautigan DL, Kainosho M, Distinctive solution conformation of phosphatase inhibitor CPI-17 substituted with aspartate at the phosphorylation-site threonine residue., 2003; Journal of molecular biology. 326(5) 1539-47. PMID: 12595264

Leach C, Shenolikar S, Brautigan DL, Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis., 2003; The Journal of biological chemistry. 278(28) 26015-20. PMID: 12697755

Murthy KS, Zhou H, Grider JR, Brautigan DL, Eto M, Makhlouf GM, Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase/myosin phosphatase targeting subunit 1 and protein kinase C/CPI-17 pathway., 2003; The Biochemical journal. 374(0) 145-55. PMID: 12733988 | PMCID: PMC1223565

Erdodi F, Kiss E, Walsh MP, Stefansson B, Deng JT, Eto M, Brautigan DL, Hartshorne DJ, Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases., 2003; Biochemical and biophysical research communications. 306(2) 382-7. PMID: 12804574

Eto M, Leach C, Tountas NA, Brautigan DL, Phosphoprotein inhibitors of protein phosphatase-1., 2003; Methods in enzymology. 366() 243-60. PMID: 14674253

Oliver CJ, Terry-Lorenzo RT, Elliott E, Bloomer WA, Li S, Brautigan DL, Colbran RJ, Shenolikar S, Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology., 2002; Molecular and cellular biology. 22(13) 4690-701. PMID: 12052877 | PMCID: PMC133892

Everett AD, Kamibayashi C, Brautigan DL, Transgenic expression of protein phosphatase 2A regulatory subunit B56gamma disrupts distal lung differentiation., 2002; American journal of physiology. Lung cellular and molecular physiology. 282(6) L1266-71. PMID: 12003782

Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY, The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases., 2002; The Journal of biological chemistry. 277(35) 31818-25. PMID: 12082107

Deng JT, Sutherland C, Brautigan DL, Eto M, Walsh MP, Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase., 2002; The Biochemical journal. 367(0) 517-24. PMID: 12144526 | PMCID: PMC1222907

Guo CY, Brautigan DL, Larner JM, Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation., 2002; The Journal of biological chemistry. 277(44) 41756-61. PMID: 12202491

Everett AD, Brautigan DL, Developmental expression of alpha4 protein phosphatase regulatory subunit in tissues affected by Opitz syndrome., 2002; Developmental dynamics : an official publication of the American Association of Anatomists. 224(4) 461-4. PMID: 12203739

Eto M, Elliott E, Prickett TD, Brautigan DL, Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation., 2002; The Journal of biological chemistry. 277(46) 44013-20. PMID: 12221103

Leach C, Eto M, Brautigan DL, Domains of type 1 protein phosphatase inhibitor-2 required for nuclear and cytoplasmic localization in response to cell-cell contact., 2002; Journal of cell science. 115(0) 3739-45. PMID: 12235284

Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S, Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton., 2002; The Journal of biological chemistry. 277(48) 46535-43. PMID: 12270929

Wang H, Brautigan DL, A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2., 2002; The Journal of biological chemistry. 277(51) 49605-12. PMID: 12393858

Eto M, Bock R, Brautigan DL, Linden DJ, Cerebellar long-term synaptic depression requires PKC-mediated activation of CPI-17, a myosin/moesin phosphatase inhibitor., 2002; Neuron. 36(6) 1145-58. PMID: 12495628

Broustas CG, Grammatikakis N, Eto M, Dent P, Brautigan DL, Kasid U, Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity., 2001; The Journal of biological chemistry. 277(4) 3053-9. PMID: 11719507

MacDonald JA, Eto M, Borman MA, Brautigan DL, Haystead TA, Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase., 2001; FEBS letters. 493(2) 91-4. PMID: 11287002

Shenolikar S, Brautigan DL, Meeting report: targeting protein phosphatases-medicines for the new millenium., 2001; Science's STKE : signal transduction knowledge environment. 2000(57) pe1. PMID: 11752618

Ohki S, Eto M, Kariya E, Hayano T, Hayashi Y, Yazawa M, Brautigan D, Kainosho M, Solution NMR structure of the myosin phosphatase inhibitor protein CPI-17 shows phosphorylation-induced conformational changes responsible for activation., 2001; Journal of molecular biology. 314(4) 839-49. PMID: 11734001

Guo CY, Brautigan DL, Larner JM, ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation., 2001; The Journal of biological chemistry. 277(7) 4839-44. PMID: 11723136

Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL, Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C alpha and delta isoforms., 2001; The Journal of biological chemistry. 276(31) 29072-8. PMID: 11397799

Woodsome TP, Eto M, Everett A, Brautigan DL, Kitazawa T, Expression of CPI-17 and myosin phosphatase correlates with Ca(2+) sensitivity of protein kinase C-induced contraction in rabbit smooth muscle., 2001; The Journal of physiology. 535(0) 553-64. PMID: 11533144 | PMCID: PMC2278797

Hayashi Y, Senba S, Yazawa M, Brautigan DL, Eto M, Defining the structural determinants and a potential mechanism for inhibition of myosin phosphatase by the protein kinase C-potentiated inhibitor protein of 17 kDa., 2001; The Journal of biological chemistry. 276(43) 39858-63. PMID: 11517233

Etter EF, Eto M, Wardle RL, Brautigan DL, Murphy RA, Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation., 2001; The Journal of biological chemistry. 276(37) 34681-5. PMID: 11461918

Everett AD, Stoops TD, Nairn AC, Brautigan D, Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes., 2001; American journal of physiology. Heart and circulatory physiology. 281(1) H161-7. PMID: 11406481

Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL, Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4., 2001; Proceedings of the National Academy of Sciences of the United States of America. 98(12) 6650-5. PMID: 11371618 | PMCID: PMC34408

Liu J, Brautigan DL, Glycogen synthase association with the striated muscle glycogen-targeting subunit of protein phosphatase-1. Synthase activation involves scaffolding regulated by beta-adrenergic signaling., 2000; The Journal of biological chemistry. 275(34) 26074-81. PMID: 10856301

Eto M, Wong L, Yazawa M, Brautigan DL, Inhibition of myosin/moesin phosphatase by expression of the phosphoinhibitor protein CPI-17 alters microfilament organization and retards cell spreading., 2000; Cell motility and the cytoskeleton. 46(3) 222-34. PMID: 10913968

Liu J, Brautigan DL, Insulin-stimulated phosphorylation of the protein phosphatase-1 striated muscle glycogen-targeting subunit and activation of glycogen synthase., 2000; The Journal of biological chemistry. 275(21) 15940-7. PMID: 10748124

Liu J, Wu J, Oliver C, Shenolikar S, Brautigan DL, Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit., 2000; The Biochemical journal. 346() 77-82. PMID: 10657242 | PMCID: PMC1220825

Kitazawa T, Eto M, Woodsome TP, Brautigan DL, Agonists trigger G protein-mediated activation of the CPI-17 inhibitor phosphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility., 2000; The Journal of biological chemistry. 275(14) 9897-900. PMID: 10744661

Guo CY, Wang Y, Brautigan DL, Larner JM, Histone H1 dephosphorylation is mediated through a radiation-induced signal transduction pathway dependent on ATM., 1999; The Journal of biological chemistry. 274(26) 18715-20. PMID: 10373485

Chung H, Brautigan DL, Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression., 1999; Cellular signalling. 11(8) 575-80. PMID: 10433518

Chung H, Nairn AC, Murata K, Brautigan DL, Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2., 1999; Biochemistry. 38(32) 10371-6. PMID: 10441131

Eto M, Karginov A, Brautigan DL, A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes., 1999; Biochemistry. 38(51) 16952-7. PMID: 10606530

Edwards SC, Van Dyke TB, Van Dyke TH, Brautigan DL, Chromatographic isolation of PP2A from Limulus lateral eyes. Conventional and small scale methods., 1998; Methods in molecular biology (Clifton, N.J.). 93() 219-34. PMID: 9664540

Liao H, Li Y, Brautigan DL, Gundersen GG, Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau., 1998; The Journal of biological chemistry. 273(34) 21901-8. PMID: 9705329

Wu J, Liu J, Thompson I, Oliver CJ, Shenolikar S, Brautigan DL, A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits., 1998; FEBS letters. 439(1) 185-91. PMID: 9849903

Beutler KT, Pankewycz O, Brautigan DL, Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine., 1998; Biological trace element research. 61(1) 19-31. PMID: 9498328

Kakinoki Y, Somers J, Brautigan DL, Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle., 1998; The Journal of biological chemistry. 272(51) 32308-14. PMID: 9405437

Murata K, Hirano K, Villa-Moruzzi E, Hartshorne DJ, Brautigan DL, Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts., 1997; Molecular biology of the cell. 8(4) 663-73. PMID: 9247646 | PMCID: PMC276117

Murata K, Wu J, Brautigan DL, B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A., 1997; Proceedings of the National Academy of Sciences of the United States of America. 94(20) 10624-9. PMID: 9380685 | PMCID: PMC23426

Brautigan DL, Phosphatases as partners in signaling networks., 1997; Advances in second messenger and phosphoprotein research. 31() 113-24. PMID: 9344246

Dent P, Reardon DB, Wood SL, Lindorfer MA, Graber SG, Garrison JC, Brautigan DL, Sturgill TW, Inactivation of raf-1 by a protein-tyrosine phosphatase stimulated by GTP and reconstituted by Galphai/o subunits., 1996; The Journal of biological chemistry. 271(6) 3119-23. PMID: 8621710

Wu J, Kleiner U, Brautigan DL, Protein phosphatase type-1 and glycogen bind to a domain in the skeletal muscle regulatory subunit containing conserved hydrophobic sequence motif., 1996; Biochemistry. 35(43) 13858-64. PMID: 8901529

Reardon DB, Wood SL, Brautigan DL, Bell GI, Dent P, Sturgill TW, Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin., 1996; The Biochemical journal. 314() 401-4. PMID: 8670047 | PMCID: PMC1217062

Brautigan DL, Focus on women., 1996; Science (New York, N.Y.). 273(5280) 1325a. PMID: 17792214

Williams JP, Jo H, Hunnicutt RE, Brautigan DL, McDonald JM, Tyrosine phosphorylation of phosphatase inhibitor 2., 1995; Journal of cellular biochemistry. 57(3) 415-22. PMID: 7768977

Brautigan DL, Flicking the switches: phosphorylation of serine/threonine protein phosphatases., 1995; Seminars in cancer biology. 6(4) 211-7. PMID: 8541516

Wang LY, Orser BA, Brautigan DL, MacDonald JF, Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A., 1994; Nature. 369(6477) 230-2. PMID: 8183343

Martin BL, Shriner CL, Brautigan DL, Concurrent purification of type-1 and type-2A protein phosphatase catalytic subunits., 1994; Protein expression and purification. 5(3) 211-7. PMID: 7950363

Brautigan DL, Protein phosphatases., 1994; Recent progress in hormone research. 49() 197-214. PMID: 8146424

Toivola DM, Eriksson JE, Brautigan DL, Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates., 1994; FEBS letters. 344(2) 175-80. PMID: 8187879

Chen J, Parsons S, Brautigan DL, Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts., 1994; The Journal of biological chemistry. 269(11) 7957-62. PMID: 7510677

Belandia B, Brautigan D, Martín-Pérez J, Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus., 1994; Molecular and cellular biology. 14(1) 200-6. PMID: 8264587 | PMCID: PMC358370

Brautigan DL, Passing or failing? Is biomedical science meeting national needs?, 1993; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 7(9) 730-2. PMID: 8330678

Brautigan DL, Pinault FM, Serine phosphorylation of protein tyrosine phosphatase (PTP1B) in HeLa cells in response to analogues of cAMP or diacylglycerol plus okadaic acid., 1993; Molecular and cellular biochemistry. 127() 121-9. PMID: 7935344

Boylan JM, Brautigan DL, Madden J, Raven T, Ellis L, Gruppuso PA, Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats., 1992; The Journal of clinical investigation. 90(1) 174-9. PMID: 1321840 | PMCID: PMC443078

Finn AL, Gaido ML, Dillard M, Brautigan DL, Regulation of an epithelial chloride channel by direct phosphorylation and dephosphorylation., 1992; The American journal of physiology. 263(1) C172-5. PMID: 1322039

DeRemer MF, Saeli RJ, Brautigan DL, Edelman AM, Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation., 1992; The Journal of biological chemistry. 267(19) 13466-71. PMID: 1320022

Buzzi M, Lu L, Lombardi AJ, Posner MR, Brautigan DL, Fast LD, Frackelton AR, Differentiation-induced changes in protein-tyrosine phosphatase activity and commensurate expression of CD45 in human leukemia cell lines., 1992; Cancer research. 52(14) 4027-35. PMID: 1535552

Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, Avruch J, Raf-1 activates MAP kinase-kinase., 1992; Nature. 358(6385) 417-21. PMID: 1322500

Suganuma M, Fujiki H, Okabe S, Nishiwaki S, Brautigan D, Ingebritsen TS, Rosner MR, Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity., 1992; Toxicon : official journal of the International Society on Toxinology. 30(8) 873-8. PMID: 1326138

Chen J, Martin BL, Brautigan DL, Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation., 1992; Science (New York, N.Y.). 257(5074) 1261-4. PMID: 1325671

Gordon SE, Brautigan DL, Zimmerman AL, Protein phosphatases modulate the apparent agonist affinity of the light-regulated ion channel in retinal rods., 1992; Neuron. 9(4) 739-48. PMID: 1382474

Eriksson JE, Brautigan DL, Vallee R, Olmsted J, Fujiki H, Goldman RD, Cytoskeletal integrity in interphase cells requires protein phosphatase activity., 1992; Proceedings of the National Academy of Sciences of the United States of America. 89(22) 11093-7. PMID: 1332069 | PMCID: PMC50490

Brautigan DL, Great expectations: protein tyrosine phosphatases in cell regulation., 1992; Biochimica et biophysica acta. 1114(1) 63-77. PMID: 1390871

Fernandez A, Brautigan DL, Lamb NJ, Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit., 1992; The Journal of cell biology. 116(6) 1421-30. PMID: 1311712 | PMCID: PMC2289383

Nyomba BL, Brautigan DL, Schlender KK, Wang W, Bogardus C, Mott DM, Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects., 1991; The Journal of clinical investigation. 88(5) 1540-5. PMID: 1658044 | PMCID: PMC295665

Brautigan DL, Pinault FM, Activation of membrane protein-tyrosine phosphatase involving cAMP- and Ca2+/phospholipid-dependent protein kinases., 1991; Proceedings of the National Academy of Sciences of the United States of America. 88(15) 6696-700. PMID: 1650478 | PMCID: PMC52155

DeFranco DB, Qi M, Borror KC, Garabedian MJ, Brautigan DL, Protein phosphatase types 1 and/or 2A regulate nucleocytoplasmic shuttling of glucocorticoid receptors., 1991; Molecular endocrinology (Baltimore, Md.). 5(9) 1215-28. PMID: 1663212

Martin BL, Shriner CL, Brautigan DL, Modulation of type-1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus., 1991; FEBS letters. 285(1) 6-10. PMID: 1648514

Chung SK, Reinhart PH, Martin BL, Brautigan D, Levitan IB, Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel., 1991; Science (New York, N.Y.). 253(5019) 560-2. PMID: 1857986

Washburn T, Hocutt A, Brautigan DL, Korach KS, Uterine estrogen receptor in vivo: phosphorylation of nuclear specific forms on serine residues., 1991; Molecular endocrinology (Baltimore, Md.). 5(2) 235-42. PMID: 2038345

Kyriakis JM, Brautigan DL, Ingebritsen TS, Avruch J, pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity., 1991; The Journal of biological chemistry. 266(16) 10043-6. PMID: 1645334

Reinhart PH, Chung S, Martin BL, Brautigan DL, Levitan IB, Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phosphatase 2A., 1991; The Journal of neuroscience : the official journal of the Society for Neuroscience. 11(6) 1627-35. PMID: 1646298

Valentine MA, Widmer MB, Ledbetter JA, Pinault F, Voice R, Clark EA, Gallis B, Brautigan DL, Interleukin 2 stimulates serine phosphorylation of CD45 in CTLL-2.4 cells., 1991; European journal of immunology. 21(4) 913-9. PMID: 1850360

Gruppuso PA, Boylan JM, Smiley BL, Fallon RJ, Brautigan DL, Hepatic protein tyrosine phosphatases in the rat., 1991; The Biochemical journal. 274() 361-7. PMID: 1848753 | PMCID: PMC1150145

Gruppuso PA, Mikumo R, Brautigan DL, Braun L, Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes., 1991; The Journal of biological chemistry. 266(6) 3444-8. PMID: 1847373

Kovacina KS, Yonezawa K, Brautigan DL, Tonks NK, Rapp UR, Roth RA, Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation., 1990; The Journal of biological chemistry. 265(21) 12115-8. PMID: 2197270

Fernandez A, Brautigan DL, Mumby M, Lamb NJ, Protein phosphatase type-1, not type-2A, modulates actin microfilament integrity and myosin light chain phosphorylation in living nonmuscle cells., 1990; The Journal of cell biology. 111(1) 103-12. PMID: 2164027 | PMCID: PMC2116151

Brautigan DL, Sunwoo J, Labbé JC, Fernandez A, Lamb NJ, Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction., 1990; Nature. 344(6261) 74-8. PMID: 2406614

Gruppuso PA, Boylan JM, Posner BI, Faure R, Brautigan DL, Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats., 1990; The Journal of clinical investigation. 85(6) 1754-60. PMID: 2161429 | PMCID: PMC296637

Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM, Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A., 1990; Cell. 60(1) 167-76. PMID: 2153055

Gruppuso PA, Brautigan DL, Induction of hepatic glycogenesis in the fetal rat., 1989; The American journal of physiology. 256(1) E49-54. PMID: 2492154

Ishihara H, Martin BL, Brautigan DL, Karaki H, Ozaki H, Kato Y, Fusetani N, Watabe S, Hashimoto K, Uemura D, Calyculin A and okadaic acid: inhibitors of protein phosphatase activity., 1989; Biochemical and biophysical research communications. 159(3) 871-7. PMID: 2539153

Brautigan DL, Shriner CL, Protein phosphatase type 1 catalytic subunit forms nondissociable dimers., 1989; Archives of biochemistry and biophysics. 275(1) 44-52. PMID: 2554811

Picard A, Capony JP, Brautigan DL, Dorée M, Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish., 1989; The Journal of cell biology. 109(6) 3347-54. PMID: 2574724 | PMCID: PMC2115967

Roome J, O'Hare T, Pilch PF, Brautigan DL, Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors., 1988; The Biochemical journal. 256(2) 493-500. PMID: 2851993 | PMCID: PMC1135437

Gruppuso PA, Brautigan DL, Compartmentalized protein phosphorylation/dephosphorylation in glycogen particles from rabbit skeletal muscle., 1988; Biochemistry international. 16(6) 1027-32. PMID: 2845990

Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL, Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes., 1988; Proceedings of the National Academy of Sciences of the United States of America. 85(12) 4252-6. PMID: 2837763 | PMCID: PMC280405

Brautigan DL, Shriner CL, Methods to distinguish various types of protein phosphatase activity., 1988; Methods in enzymology. 159() 339-46. PMID: 2842599

Brautigan DL, Kuplic JD, Proposal for a pathway to mediate the metabolic effects of insulin., 1988; The International journal of biochemistry. 20(4) 349-56. PMID: 2835273

Brautigan DL, Molecular defects in ion channel regulation in cystic fibrosis predicted from analysis of protein phosphorylation/dephosphorylation., 1988; The International journal of biochemistry. 20(8) 745-52. PMID: 2458979

Rotenberg SA, Brautigan DL, Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments., 1987; The Biochemical journal. 243(3) 747-54. PMID: 2821989 | PMCID: PMC1147921

Shriner CL, Brautigan DL, Metal chelate affinity chromatography of Zn2+-inhibited protein Tyr(P) phosphatases., 1987; Journal of biochemical and biophysical methods. 14(5) 273-8. PMID: 2826566

Johnson GL, Brautigan DL, Shriner C, Jaspers S, Arino J, Mole JE, Miller TB, Mumby MC, Sequence homologies between type 1 and type 2A protein phosphatases., 1987; Molecular endocrinology (Baltimore, Md.). 1(10) 745-8. PMID: 2856400

Gruppuso PA, Shriner CL, Brautigan DL, Latent forms of type-1 protein phosphatase in rabbit skeletal muscle., 1987; Biochemical and biophysical research communications. 148(3) 1174-81. PMID: 2825677

Sparks JW, Brautigan DL, Molecular basis for substrate specificity of protein kinases and phosphatases., 1986; The International journal of biochemistry. 18(6) 497-504. PMID: 3011539

Gewirtz H, Olsson RA, Brautigan DL, Brown PR, Most AS, Adenosine's role in regulating basal coronary arteriolar tone., 1986; The American journal of physiology. 250(6) H1030-6. PMID: 3717357

Brautigan DL, Gruppuso PA, Mumby M, Protein phosphatase type-1 and type-2 catalytic subunits both bind inhibitor-2 and monoclonal immunoglobulins., 1986; The Journal of biological chemistry. 261(32) 14924-8. PMID: 3021755

Brautigan DL, Shriner CL, Gruppuso PA, Phosphorylase phosphatase catalytic subunit. Evidence that the Mr = 33,000 enzyme fragment is derived from a native protein of Mr = 70,000., 1985; The Journal of biological chemistry. 260(7) 4295-302. PMID: 2984200

Brautigan DL, Randazzo P, Shriner C, Fain JN, Phosphorylation of chloroform soluble compounds in plasma membranes of human epidermoid carcinoma A431 cells., 1985; Lipids. 20(7) 492-5. PMID: 2993780

Gruppuso PA, Johnson GL, Constantinides M, Brautigan DL, Phosphorylase phosphatase regulatory subunit. "Western" blotting with immunoglobulins against inhibitor-2 reveals a protein of Mr = 60,000., 1985; The Journal of biological chemistry. 260(7) 4288-94. PMID: 2984199

Sparks JW, Brautigan DL, Specificity of protein phosphotyrosine phosphatases. Comparison with mammalian alkaline phosphatase using polypeptide substrates., 1985; The Journal of biological chemistry. 260(4) 2042-5. PMID: 2982803

Shriner CL, Brautigan DL, Cytosolic protein phosphotyrosine phosphatases from rabbit kidney. Purification of two distinct enzymes that bind to Zn2+-iminodiacetate agarose., 1984; The Journal of biological chemistry. 259(18) 11383-90. PMID: 6088542

Gewirtz H, Brautigan DL, Olsson RA, Brown P, Most AS, Role of adenosine in the maintenance of coronary vasodilation distal to a severe coronary artery stenosis. Observations in conscious domestic swine., 1983; Circulation research. 53(1) 42-51. PMID: 6861296

Ballou LM, Brautigan DL, Fischer EH, Subunit structure and activation of inactive phosphorylase phosphatase., 1983; Biochemistry. 22(14) 3393-9. PMID: 6311247