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David Parichy

David Parichy

Professor, Biology

Primary Location
Physical and Life Sciences Building 314
Email
[email protected]
Website
https://parichylab.org/

Bio & Overview

Much of our work focuses on cell signaling and mechanisms of lineage specification, differentiation and morphogenesis. Particular emphases have been on post-embryonic neural crest stem cells and their derivatives, including pigment cells and glia. Additional efforts focus on skin and scale development and regeneration, the evolution of pigmentation, melanoma progression, and other topics. /// We employ a very wide of approaches including single cell RNA-sequencing, super-resolution and time-lapse imaging in vivo, CRISPR/Cas9 mutagenesis and gene editing, cell transplantation, transgenesis and BAC recombineering, and forward genetic screening. The lab is unusually well equipped with our own Illumina NextSeq-550 sequencer, 10X Chromium controller, 3 laser confocal and spinning disk microscopes among others, an 1800 tank fish facility, and other instruments. This infrastructure allows extraordinary access to resources and training opportunities in cutting-edge methodologies. /// The lab's diverse research interests reflect my own unusually broad background, with training as a postdoc in genetics and genomics, as a grad student in population biology and experimental embryology, and as an undergrad in field biology and evolutionary ecology. /// I invest considerable effort in postdocs, grad students, and postbacs. I foster independence, critical thinking and a variety of career paths through frequent consultation and advising, group meetings and professional skills development (including writing, seminars, chalk talks), formulation of IDPs, structured mentoring opportunities, and help in building truly independent research programs. Grad students have gone on to outstanding postdocs whereas postdocs have gone on to excellent faculty positions, at UC-Irvine, UCSF, Boston College and Rhode Island College. Efforts also apply to undergraduates, with over 100 having participated in lab research and many contributing substantially to the projects of their grad student and postdoctoral mentors. Most undergrads begin as freshman or sophomores and stay until they graduate. /// At all levels, we particularly value the inclusion of individuals from underrepresented groups, socioeconomically disadvantaged backgrounds, and veterans, and we have made substantive contributions to advancing the goals of diversity, equity and inclusion through departmental committees and other activities. /// Our research has been funded continuously by NIGMS since the lab was founded in 2000 with support from NIH R01 grants until 2016 when two awards, NIH R01 GM096906 and NIH R01 GM111233, were folded into NIH R35 GM122471 MIRA , which gives us unusual flexibility in our research questions and approaches. We have also received support from NIH NICHD (one R01 and three R03s), NSF, and other sources.The lab has very diverse interests and we are always happy to entertain new ideas. We welcome postdoctoral scholars, graduate students and undergraduates.

Academic Information

Department
Biology
Academic Title
Pratt-Ivy Foundation Distinguished Professor of Morphogenesis

Primary Education

  • BA, Biology, Reed College, 1991
  • PhD, Population Biology, University of California, Davis, 1997
  • Postdoc, Genetics, Genomics, University of Virginia, 2000

Other Appointments

  • Pratt-Ivy Foundation Distinguished Professor of Morphogenesis, Cell Biology

Other Affiliations

  • MSTP
  • BIMS

Research Interests

Developmental Genetics, Evolution and Regeneration

Research Disciplines

  • Bioinformatics and Genomics
  • Cancer Biology
  • Cell and Developmental Biology
  • Development, Stem Cells & Regeneration
  • Genetics
  • Metabolism
  • Neuroimmunology
  • Neuroscience

Research Opportunities

  • Bioinformatics & Genomics
  • Cancer Biology
  • Cell Biology
  • Cellular and Molecular Metabolism
  • Development, Stem Cells & Regeneration
  • Genetics
  • Neuroimmunology
  • Neuroscience

PhD Programs

  • Cell Biology

Selected Publications

2019

Saunders, L. M., Mishra, A. K., Aman, A. J., Lewis, V. M., Toomey, M. B., Packer, J. S., . . . Parichy, D. M. (2019). Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. ELIFE, 8. doi:10.7554/eLife.45181

Lewis, V. M., Saunders, L. M., Larson, T. A., Bain, E. J., Sturiale, S. L., Gur, D., . . . Parichy, D. M. (2019). Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(24), 11806-11811. doi:10.1073/pnas.1901021116

2018

Spiewak, J. E., Bain, E. J., Liu, J., Kou, K., Sturiale, S. L., Patterson, L. B., . . . Parichy, D. M. (2018). Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLOS GENETICS, 14(9). doi:10.1371/journal.pgen.1007538

Aman, A. J., Fulbright, A. N., & Parichy, D. M. (2018). Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development. ELIFE, 7. doi:10.7554/eLife.37001

Patterson, L. B., & Parichy, D. M. (2018). Melanophores Tune Out the Noise to Make Stripes. DEVELOPMENTAL CELL, 45(5), 544-545. doi:10.1016/j.devcel.2018.05.014

2017

Hur, M., Gistelinck, C. A., Huber, P., Lee, J., Thompson, M. H., Monstad-Rios, A. T., . . . Kwon, R. Y. (2018). MicroCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ System. ZEBRAFISH, 15(1), 77-78. doi:10.1089/zeb.2017.1540

Hur, M., Gistelinck, C. A., Huber, P., Lee, J., Thompson, M. H., Monstad-Rios, A. T., . . . Kwon, R. Y. (2017). MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system. ELIFE, 6. doi:10.7554/eLife.26014

Eom, D. S., & Parichy, D. M. (2017). CELL SIGNALING A macrophage relay for long-distance signaling during postembryonic tissue remodeling. SCIENCE, 355(6331), 1317-1319. doi:10.1126/science.aal2745

Woodcock, M. R., Vaughn-Wolfe, J., Elias, A., Kump, D. K., Kendall, K. D., Timoshevskaya, N., . . . Voss, S. R. (2017). Identification of Mutant Genes and Introgressed Tiger Salamander DNA in the Laboratory Axolotl, Ambystoma mexicanum. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-00059-1

2016

Parichy, D. M. (2016). The gar is a fish ... is a bird ... is a mammal?. NATURE GENETICS, 48(4), 344-345. doi:10.1038/ng.3532

McMenamin, S. K., Chandless, M. N., & Parichy, D. M. (2016). Working with zebrafish at postembryonic stages. ZEBRAFISH: CELLULAR AND DEVELOPMENTAL BIOLOGY, PT B: DEVELOPMENTAL BIOLOGY, 134, 587-607. doi:10.1016/bs.mcb.2015.12.001

2015

Eom, D. S., Bain, E. J., Patterson, L. B., Grout, M. E., & Parichy, D. M. (2015). Long-distance communication by specialized cellular projections during pigment pattern development and evolution. ELIFE, 4. doi:10.7554/eLife.12401

Parichy, D. M. (2015). Advancing biology through a deeper understanding of zebrafish ecology and evolution. ELIFE, 4. doi:10.7554/eLife.05635

2014

Parichy, D. M., & Spiewak, J. E. (2015). Origins of adult pigmentation: diversity in pigment stem cell lineages and implications for pattern evolution. PIGMENT CELL & MELANOMA RESEARCH, 28(1). doi:10.1111/pcmr.12332

Patterson, L. B., Bain, E. J., & Parichy, D. M. (2014). Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms6299

McMenamin, S. K., Bain, E. J., McCann, A. E., Patterson, L. B., Eom, D. S., Waller, Z. P., . . . Parichy, D. M. (2014). Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. SCIENCE, 345(6202), 1358-1361. doi:10.1126/science.1256251

Hamada, H., Watanabe, M., Lau, H. E., Nishida, T., Hasegawa, T., Parichy, D. M., & Kondo, S. (2014). Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning (vol 141, pg 318, 2014). DEVELOPMENT, 141(6), 1418. doi:10.1242/dev.108894

2013

Hamada, H., Watanabe, M., Lau, H. E., Nishida, T., Hasegawa, T., Parichy, D. M., & Kondo, S. (2014). Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. DEVELOPMENT, 141(2), 318-324. doi:10.1242/dev.099804

Inoue, S., Kondo, S., Parichy, D. M., & Watanabe, M. (2014). Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. PIGMENT CELL & MELANOMA RESEARCH, 27(2). doi:10.1111/pcmr.12192

Patterson, L. B., & Parichy, D. M. (2013). Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLOS GENETICS, 9(5). doi:10.1371/journal.pgen.1003561

McMenamin, S. K., Minchin, J. E. N., Gordon, T. N., Rawls, J. F., & Parichy, D. M. (2013). Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizzini. ENDOCRINOLOGY, 154(4), 1476-1487. doi:10.1210/en.2012-1734

McMenamin, S. K., & Parichy, D. M. (2013). Metamorphosis in Teleosts. ANIMAL METAMORPHOSIS, 103, 127-165. doi:10.1016/B978-0-12-385979-2.00005-8

2012

Eom, D. S., Inoue, S., Patterson, L. B., Gordon, T. N., Slingwine, R., Kondo, S., . . . Parichy, D. M. (2012). Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11. PLOS GENETICS, 8(8). doi:10.1371/journal.pgen.1002899

2011

Budi, E. H., Patterson, L. B., & Parichy, D. M. (2011). Post-Embryonic Nerve-Associated Precursors to Adult Pigment Cells: Genetic Requirements and Dynamics of Morphogenesis and Differentiation. PLOS GENETICS, 7(5). doi:10.1371/journal.pgen.1002044

Roeselers, G., Mittge, E. K., Stephens, W. Z., Parichy, D. M., Cavanaugh, C. M., Guillemin, K., & Rawls, J. F. (2011). Evidence for a core gut microbiota in the zebrafish. ISME JOURNAL, 5(10), 1595-1608. doi:10.1038/ismej.2011.38

2010

Elizondo, M. R., Budi, E. H., & Parichy, D. M. (2010). trpm7 Regulation of in Vivo Cation Homeostasis and Kidney Function Involves Stanniocalcin 1 and fgf23. ENDOCRINOLOGY, 151(12), 5700-5709. doi:10.1210/en.2010-0853

Larson, T. A., Gordon, T. N., Lau, H. E., & Parichy, D. M. (2010). Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. DEVELOPMENTAL BIOLOGY, 346(2), 296-309. doi:10.1016/j.ydbio.2010.07.035

Curran, K., Lister, J. A., Kunkel, G. R., Prendergast, A., Parichy, D. M., & Raible, D. W. (2010). Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. DEVELOPMENTAL BIOLOGY, 344(1), 107-118. doi:10.1016/j.ydbio.2010.04.023