Eugene J. Barrett

Lecturer, Medicine- Endocrinology and Metabolism

Primary Location

PO Box 801410
Fontaine Research Park 450 Ray C Hunt Dr.

Primary Phone Number

434.924.1175

Bio & Overview

Research in my laboratory focuses on studies of insulin action and how insulin's action is altered by insulin resistance, obesity, and diabetes mellitus. Specific studies currently underway involve measurement of the action of insulin to regulate its own delivery to skeletal and cardiac muscle by acting on endothelial cells and smooth muscle cells. Insulin relaxes smooth muscle cells associated with terminal arterioles and dilates microvascular vessels to enhance tissue perfusion thereby increasing the delivery of both insulin and glucose to the tissues. This vasodilator effect appears to be secondary to insulin’s action on the endothelial cell to increase the production of nitric oxide via the activation of the enzyme nitric oxide synthase. We have also demonstrated a second effect of insulin on the endothelial cell. This involves insulin promoting its own uptake at the luminal surface of the endothelial cell and which then transports the insulin across to the ablumenal surface of the cell where it is released and becomes available to act on target tissues like adipocytes and myocytes. We have experimental evidence that both the ability of insulin to cause smooth muscle relaxation and to promote its own transport are impaired in states of insulin resistance (e.g. obesity, type 2 diabetes). This step involving insulin transport across the endothelium appears to be the rate limiting step for overall insulin action on skeletal muscle (which is the major target tissue for insulin-mediated glucose disposal). We are also studying how these processes are affected by the action of other growth factors (growth hormone and IGF-I). A major hypothesis which we are exploring is that a significant fraction of the insulin resistance which is encountered in skeletal muscle in states like obesity, diabetes, and hypertension is attributable to impaired action of insulin on the microvasculature in addition to any effect on the muscle cell per se.

Academic Information

Department: Medicine- Endocrinology and Metabolism

Academic Title: Professor

Primary Education

Clinical Fellowship, Endocrinology & Metabolism, Yale School of Medicinenull
MD, University of Rochesternull
PhD, Biophysics, University of Rochesternull

Other Appointments

Endocrinology
Professor, MOMD

Other Affiliations

Cardiovascular Research Center
Professor, BIMS

Research Interests

Diabetes and Insulin Action

Selected Publications

2022

Love, K. M., Barrett, E. J., & Horton, W. B. (2022). Metformin's Impact on the Microvascular Response to Insulin. ENDOCRINOLOGY, 163(11). doi:10.1210/endocr/bqac162

Liu, J., Aylor, K. W., Chai, W., Barrett, E. J., & Liu, Z. (2022). Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 322(3), E293-E306. doi:10.1152/ajpendo.00240.2021

Love, K. M., Horton, W. B., Patrie, J. T., Jahn, L. A., Hartline, L. M., & Barrett, E. J. (2022). Predictors of arterial stiffness in adolescents and adults with type 1 diabetes: a cross-sectional study. BMJ OPEN DIABETES RESEARCH & CARE, 10(1). doi:10.1136/bmjdrc-2021-002491

2021

Jahn, L. A., Hartline, L., Liu, Z., & Barrett, E. J. (2022). Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 322(2), E173-E180. doi:10.1152/ajpendo.00287.2021

Jahn, L. A., Logan, B., Love, K. M., Horton, W. B., Eichner, N. Z., Hartline, L. M., . . . Barrett, E. J. (2022). Nitric oxide-dependent micro- and macrovascular dysfunction occurs early in adolescents with type 1 diabetes. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 322(2), E101-E108. doi:10.1152/ajpendo.00267.2021

Owusu, J., & Barrett, E. (2021). Early Microvascular Dysfunction: Is the Vasa Vasorum a "Missing Link" in Insulin Resistance and Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14). doi:10.3390/ijms22147574

Love, K. M., Jahn, L. A., Hartline, L. M., Patrie, J. T., Barrett, E. J., & Liu, Z. (2021). Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-90935-8

Love, K. M., Barrett, E. J., Malin, S. K., Reusch, J. E. B., Regensteiner, J. G., & Liu, Z. (2021). Diabetes pathogenesis and management: the endothelium comes of age. JOURNAL OF MOLECULAR CELL BIOLOGY, 13(7), 500-512. doi:10.1093/jmcb/mjab024

Horton, W. B., Jahn, L. A., Hartline, L. M., Aylor, K. W., Patrie, J. T., & Barrett, E. J. (2022). Acute hyperglycaemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans. JOURNAL OF PHYSIOLOGY-LONDON, 600(4), 949-962. doi:10.1113/JP281286

Meijer, R. I., & Barrett, E. J. (2021). The Insulin Receptor Mediates Insulin's Early Plasma Clearance by Liver, Muscle, and Kidney. BIOMEDICINES, 9(1). doi:10.3390/biomedicines9010037

Horton, W. B., Jahn, L. A., Hartline, L. M., Aylor, K. W., Patrie, J. T., & Barrett, E. J. (2021). Insulin increases central aortic stiffness in response to hyperglycemia in healthy humans: A randomized four-arm study. DIABETES & VASCULAR DISEASE RESEARCH, 18(2). doi:10.1177/14791641211011009

2020

Horton, W. B., & Barrett, E. J. (2021). Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease. ENDOCRINE REVIEWS, 42(1), 29-55. doi:10.1210/endrev/bnaa025

Horton, W. B., Jahn, L. A., Hartline, L. M., Aylor, K. W., Patrie, J. T., & Barrett, E. J. (2020). Hyperglycemia does not inhibit insulin's effects on microvascular perfusion in healthy humans: a randomized crossover study. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 319(4), E753-E762. doi:10.1152/ajpendo.00300.2020

Fu, Z., Gong, L., Liu, J., Wu, J., Barrett, E. J., Aylor, K. W., & Liu, Z. (2020). Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00555

2019

Wang, N., Tan, A. W. K., Jahn, L. A., Hartline, L., Patrie, J. T., Lin, S., . . . Liu, Z. (2020). Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance. DIABETES CARE, 43(3), 634-642. doi:10.2337/dc19-1465

Chai, W., Aylor, K., Liu, Z., Gan, L. -M., Michaelsson, E., & Barrett, E. (2019). Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 317(6), E1063-E1069. doi:10.1152/ajpendo.00203.2019

Spence, J. D., Viscoli, C. M., Inzucchi, S. E., Dearborn-Tomazos, J., Ford, G. A., Gorman, M., . . . Radziszewska, B. (2019). Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial. JAMA NEUROLOGY, 76(5), 526-535. doi:10.1001/jamaneurol.2019.0079

Neumiller, J. J., Kalyani, R. R., Herman, W. H., Grant, R. W., Wysham, C. H., Inzucchi, S. E., . . . Barrett, E. J. (2019). Evidence supports prediabetes treatment. SCIENCE, 364(6438), 341-342. doi:10.1126/science.aax3548

2018

Gray, S. M., & Barrett, E. J. (2018). Insulin transport into the brain. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 315(2), C125-C136. doi:10.1152/ajpcell.00240.2017

2017

Good, M. E., Chiu, Y. -H., Poon, I. K. H., Medina, C. B., Butcher, J. T., Mendu, S. K., . . . Ravichandran, K. S. (2018). Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. CIRCULATION RESEARCH, 122(4), 606-615. doi:10.1161/CIRCRESAHA.117.312380

Barrett, E. J., Liu, Z., Khamaisi, M., King, G. L., Klein, R., Klein, B. E. K., . . . Casellini, C. M. (2017). Diabetic Microvascular Disease: An Endocrine Society Scientific Statement. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(12), 4343-4410. doi:10.1210/jc.2017-01922

Santen, R. J., Barrett, E. J., Siragy, H. M., Farhi, L. S., Fishbein, L., & Carey, R. M. (2017). The Jewel in theCrown: Specific Aims Section of Investigator-Initiated Grant Proposals. JOURNAL OF THE ENDOCRINE SOCIETY, 1(9), 1194-1202. doi:10.1210/js.2017-00318

Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., 't Roodt, J. O., . . . Stehouwer, C. D. A. (2017). Independent tissue contributors to obesity-associated insulin resistance. JCI INSIGHT, 2(13). doi:10.1172/jci.insight.89695

Gray, S. M., Aylor, K. W., & Barrett, E. J. (2017). Unravelling the regulation of insulin transport across the brain endothelial cell. DIABETOLOGIA, 60(8), 1512-1521. doi:10.1007/s00125-017-4285-4

Irace, C., Messiniti, V., Tassone, B., Cortese, C., Barrett, E. J., & Gnasso, A. (2017). Evidence for congruent impairment in micro and macrovascular function in type 1 diabetes. PLOS ONE, 12(11). doi:10.1371/journal.pone.0187525

2016

Keller, T. C. S., Butcher, J. T., Broseghini-Filho, G. B., Marziano, C., DeLalio, L. J., Rogers, S., . . . Isakson, B. E. (2016). Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbX). HYPERTENSION, 68(6), 1494-1503. doi:10.1161/HYPERTENSIONAHA.116.08171

Meijer, R. I., Gray, S. M., Aylor, K. W., & Barrett, E. J. (2016). Pathways for insulin access to the brain: the role of the microvascular endothelial cell. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 311(5), H1132-H1138. doi:10.1152/ajpheart.00081.2016

Chai, W., Fu, Z., Aylor, K. W., Barrett, E. J., & Liu, Z. (2016). Liraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed rats. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 311(3), E640-E648. doi:10.1152/ajpendo.00205.2016

Malin, S. K., Rynders, C. A., Weltman, J. Y., Roberts, L. J. I. I., Barrett, E. J., & Weltman, A. (2016). Endothelial Function Following Glucose Ingestion in Adults with Prediabetes: Role of Exercise Intensity. OBESITY, 24(7), 1515-1521. doi:10.1002/oby.21522

Malin, S. K., Liu, Z., Barrett, E. J., & Weltman, A. (2016). Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 17(1), 81-90. doi:10.1007/s11154-016-9352-5

Jahn, L. A., Hartline, L., Rao, N., Logan, B., Kim, J. J., Aylor, K., . . . Barrett, E. J. (2016). Insulin Enhances Endothelial Function Throughout the Arterial Tree in Healthy But Not Metabolic Syndrome Subjects. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101(3), 1198-1206. doi:10.1210/jc.2015-3293

Malin, S. K., Rynders, C. A., Weltman, J. Y., Barrett, E. J., & Weltman, A. (2016). Exercise Intensity Modulates Glucose-Stimulated Insulin Secretion when Adjusted for Adipose, Liver and Skeletal Muscle Insulin Resistance. PLOS ONE, 11(4). doi:10.1371/journal.pone.0154063

Rynders, C. A., Weltman, J. Y., Malin, S. K., Jiang, B., Breton, M., Barrett, E. J., & Weltman, A. (2016). Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 48(1), 66-72. doi:10.1249/MSS.0000000000000728

2015

Kusters, Y. H. A. M., & Barrett, E. J. (2016). Muscle microvasculature's structural and functional specializations facilitate muscle metabolism. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 310(6), E379-E387. doi:10.1152/ajpendo.00443.2015

Zhao, L., Fu, Z., Wu, J., Aylor, K. W., Barrett, E. J., Cao, W., & Liu, Z. (2015). Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity. CLINICAL SCIENCE, 129(12), 1025-1036. doi:10.1042/CS20150143

Zhao, L., Fu, Z., Wu, J., Aylor, K. W., Barrett, E. J., Cao, W., & Liu, Z. (2015). Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses. JOURNAL OF PHYSIOLOGY-LONDON, 593(17), 4067-4079. doi:10.1113/JP270371

Wang, H., Wang, A. X., Aylor, K., & Barrett, E. J. (2015). Caveolin-1 phosphorylation regulates vascular endothelial insulin uptake and is impaired by insulin resistance in rats. DIABETOLOGIA, 58(6), 1344-1353. doi:10.1007/s00125-015-3546-3

Kusters, Y. H. A., Schalkwijk, C. G., Houben, A. J. H., Roodt, J. O. T., Joris, P. J., Mensink, R. P., . . . Stehouwer, C. D. A. (2015). Weight loss improves impaired muscle capillary recruitment in overweight/obese men: effects on metabolic insulin resistance. DIABETOLOGIA, 58, S16. Retrieved from https://www.webofscience.com/

2014

Barrett, E. J., Keske, M. A., Rattigan, S., & Eringa, E. C. (2014). CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary. JOURNAL OF PHYSIOLOGY-LONDON, 592(23), 5129-5131. doi:10.1113/jphysiol.2014.282137

Barrett, E. J., Keske, M. A., Rattigan, S., & Eringa, E. C. (2014). Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa. JOURNAL OF PHYSIOLOGY-LONDON, 592(23), 5137-5138. doi:10.1113/jphysiol.2014.284604

Gray, S. M., Meijer, R. I., & Barrett, E. J. (2014). Insulin Regulates Brain Function, but How Does It Get There?. DIABETES, 63(12), 3992-3997. doi:10.2337/db14-0340

Fu, Z., Zhao, L., Aylor, K. W., Carey, R. M., Barrett, E. J., & Liu, Z. (2014). Angiotensin-(1-7) Recruits Muscle Microvasculature and Enhances Insulin's Metabolic Action via Mas Receptor. HYPERTENSION, 63(6), 1219-1227. doi:10.1161/HYPERTENSIONAHA.113.03025

Chai, W., Zhang, X., Barrett, E. J., & Liu, Z. (2014). Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin's Metabolic Action in the Presence of Insulin Resistance. DIABETES, 63(8), 2788-2799. doi:10.2337/db13-1597

Rynders, C. A., Weltman, J., Patrie, J., Roberts, L. J., Barrett, E., & Weltman, A. (2014). Relationship Between Isoprostanes/Isofurans And Markers Of Cardiometabolic Risk In Prediabetic Adults. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 46(5), 549. doi:10.1249/01.mss.0000495110.98519.a1

Hallmark, R., Patrie, J. T., Liu, Z., Gaesser, G. A., Barrett, E. J., & Weltman, A. (2014). The Effect of Exercise Intensity on Endothelial Function in Physically Inactive Lean and Obese Adults. PLOS ONE, 9(1). doi:10.1371/journal.pone.0085450

2013

Rynders, C. A., Weltman, J. Y., Jiang, B., Breton, M., Patrie, J., Barrett, E. J., & Weltman, A. (2014). Effects of Exercise Intensity on Postprandial Improvement in Glucose Disposal and Insulin Sensitivity in Prediabetic Adults. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 99(1), 220-228. doi:10.1210/jc.2013-2687

Swift, D. L., Weltman, J. Y., Patrie, J. T., Saliba, S. A., Gaesser, G. A., Barrett, E. J., & Weltman, A. (2014). Predictors of Improvement in Endothelial Function After Exercise Training in a Diverse Sample of Postmenopausal Women. JOURNAL OF WOMENS HEALTH, 23(3), 260-266. doi:10.1089/jwh.2013.4420

Wang, H., Wang, A. X., Aylor, K., & Barrett, E. J. (2013). Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport. DIABETES, 62(12), 4030-4042. doi:10.2337/db13-0627

Genders, A. J., Frison, V., Abramson, S. R., & Barrett, E. J. (2013). Endothelial Cells Actively Concentrate Insulin During its Transendothelial Transport. MICROCIRCULATION, 20(5), 434-439. doi:10.1111/micc.12044

Anderson, A., & Barrett, E. J. (2013). Severe Hypernatremia From a Urea-Induced Diuresis due to Body Protein Wasting in an Insulin-Resistant Type 2 Diabetic Patient. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 98(5), 1800-1802. doi:10.1210/jc.2012-3225

Zhao, L., Chai, W., Fu, Z., Dong, Z., Aylor, K. W., Barrett, E. J., . . . Liu, Z. (2013). Globular Adiponectin Enhances Muscle Insulin Action via Microvascular Recruitment and Increased Insulin Delivery. CIRCULATION RESEARCH, 112(9), 1263-1271. doi:10.1161/CIRCRESAHA.111.300388

Barrett, E. J., & Liu, Z. (2013). The endothelial cell: An "early responder" in the development of insulin resistance. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 14(1), 21-27. doi:10.1007/s11154-012-9232-6

Swift, D. L., Weltman, J. Y., Patrie, J. T., Barrett, E. J., Gaesser, G. A., & Weltman, A. (2013). EVALUATION OF RACIAL DIFFERENCES IN RESTING AND POSTPRANDIAL ENDOTHELIAL FUNCTION IN POSTMENOPAUSAL WOMEN MATCHED FOR AGE, FITNESS AND BODY COMPOSITION. ETHNICITY & DISEASE, 23(1), 43-48. Retrieved from https://www.webofscience.com/

2012

Barrett, E. J., & Eringa, E. C. (2012). The Vascular Contribution to Insulin Resistance: Promise, Proof, and Pitfalls. DIABETES, 61(12), 3063-3065. doi:10.2337/db12-0948

Barrett, E. J., & Rattigan, S. (2012). Muscle Perfusion Its Measurement and Role in Metabolic Regulation. DIABETES, 61(11), 2661-2668. doi:10.2337/db12-0271

Eggleston, E. M., Jahn, L. A., & Barrett, E. J. (2013). Early Microvascular Recruitment Modulates Subsequent Insulin-Mediated Skeletal Muscle Glucose Metabolism During Lipid Infusion. DIABETES CARE, 36(1), 104-110. doi:10.2337/dc11-2399

Meijer, R. I., de Boer, M. P., Groen, M. R., Eringa, E. C., Rattigan, S., Barrett, E. J., . . . Serne, E. H. (2012). Insulin-Induced Microvascular Recruitment in Skin and Muscle are Related and Both are Associated with Whole-Body Glucose Uptake. MICROCIRCULATION, 19(6), 494-500. doi:10.1111/j.1549-8719.2012.00174.x

Wang, H., Wang, A. X., & Barrett, E. J. (2012). Insulin-Induced Endothelial Cell Cortical Actin Filament Remodeling: A Requirement for Trans-Endothelial Insulin Transport. MOLECULAR ENDOCRINOLOGY, 26(8), 1327-1338. doi:10.1210/me.2012-1003

Upchurch, C. T., & Barrett, E. J. (2012). Screening for Coronary Artery Disease in Type 2 Diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 97(5), 1434-1442. doi:10.1210/jc.2011-2122

Rynders, C. A., Weltman, J., Barrett, E. J., & Weltman, A. (2012). High Intensity Exercise Improves Glucose Tolerance in Pre-diabetic Adults. JOURNAL OF GENERAL INTERNAL MEDICINE, 27, 593. Retrieved from https://www.webofscience.com/

Meijer, R. I., Serne, E. C., Yudkin, J. S., Alta, C. A. F., Barrett, E. J., Van Hinsbergh, V. W., . . . Eringa, E. C. (2012). Insulin induced vasoreactivity is impaired after short-term high fat feeding and is dependent on perivascular adipose tissue as well as resistance artery properties. EUROPEAN HEART JOURNAL, 33, 745-746. Retrieved from https://www.webofscience.com/

Rynders, C. A., Chan, A., Weltman, J. Y., Barrett, E. J., & Weltman, A. (2012). Effects of acute moderate- and high-intensity exercise on glucose disposal and beta-cell function. FASEB JOURNAL, 26. Retrieved from https://www.webofscience.com/

Angadi, S., Weltman, N., Patrie, J., Barrett, E., Weltman, A., Brock, D., . . . Gaesser, G. (2012). Effects of a Low-carbohydrate vs. High-carbohydrate, High-fiber Diet on Soluble Cell Adhesion Molecules and Endothelial Function in Adults With Metabolic Syndrome. FASEB JOURNAL, 26. Retrieved from https://www.webofscience.com/

Meijer, R. I., Serne, E. H., Yudkin, J. S., Alta, C. -L. F., Barrett, E. J., van Hinsbergh, V. W., . . . Eringa, E. C. (2012). Vasocrine signaling from perivascular adipose tissue impairs insulin-mediated vasodilatation in muscle in early obesity. VASCULAR PHARMACOLOGY, 56(5-6), 354-355. doi:10.1016/j.vph.2011.08.135

2011

Chan, A., Barrett, E. J., Anderson, S. M., Kovatchev, B. P., & Breton, M. D. (2012). Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus. DIABETOLOGIA, 55(3), 729-736. doi:10.1007/s00125-011-2402-3

Majumdar, S., Genders, A. J., Inyard, A. C., Frison, V., & Barrett, E. J. (2012). Insulin entry into muscle involves a saturable process in the vascular endothelium. DIABETOLOGIA, 55(2), 450-456. doi:10.1007/s00125-011-2343-x

Upchurch, C. T., & Barrett, E. J. (2011). Which combination therapy is superior at reducing cardiovascular events in diabetic patients with hypertension?. Current diabetes reports, 11(3), 151-153. doi:10.1007/s11892-011-0177-z

Chai, W., Liu, J., Jahn, L. A., Fowler, D. E., Barrett, E. J., & Liu, Z. (2011). Salsalate Attenuates Free Fatty Acid-Induced Microvascular and Metabolic Insulin Resistance in Humans. DIABETES CARE, 34(7), 1634-1638. doi:10.2337/dc10-2345

Barrett, E. J., Wang, H., Upchurch, C. T., & Liu, Z. (2011). Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 301(2), E252-E263. doi:10.1152/ajpendo.00186.2011

Rynders, C. A., Weltman, J., Barrett, E. J., & Weltman, A. (2011). High Intensity Exercise Improves Glucose Tolerance in Pre-diabetic Adults. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5), 593. doi:10.1249/01.MSS.0000401636.03411.78

Meijer, R., Serne, E., Yudkin, J., Alta, C. -L., Barrett, E., van Hinsbergh, V., . . . Eringa, E. (2011). Two weeks of high fat diet alters the interaction between perivascular adipose tissue and muscle resistance arteries regarding insulin-induced vasoreactivity. JOURNAL OF VASCULAR RESEARCH, 48, 22. Retrieved from https://www.webofscience.com/

Weltman, A. L., Swift, D. L., Weltman, J. Y., Patrie, J. T., Gaesser, G. A., Saliba, S. A., & Barrett, E. J. (2011). The Effect of Exercise Training on Endothelial Function in African American and Caucasian Postmenopausal Women. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5), 741. doi:10.1249/01.MSS.0000402061.44319.b0

Gaesser, G., Angadi, S., Weltman, N., Rodriguez, J., Patrie, J., Barrett, E., . . . Weltman, A. (2011). Impairment of endothelial function despite improvements in traditional lipid markers in low-carbohydrate vs. high-carbohydrate, high-fiber diet in adults with metabolic syndrome. FASEB JOURNAL, 25. Retrieved from https://www.webofscience.com/

2010

Benedict, K. F., Coffin, G. S., Barrett, E. J., & Skalak, T. C. (2011). Hemodynamic Systems Analysis of Capillary Network Remodeling During the Progression of Type 2 Diabetes. MICROCIRCULATION, 18(1), 63-73. doi:10.1111/j.1549-8719.2010.00069.x

Liu, J., Jahn, L. A., Fowler, D. E., Barrett, E. J., Cao, W., & Liu, Z. (2011). Free Fatty Acids Induce Insulin Resistance in Both Cardiac and Skeletal Muscle Microvasculature in Humans. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96(2), 438-446. doi:10.1210/jc.2010-1174

Wang, N., Ko, S. -H., Chai, W., Li, G., Barrett, E. J., Tao, L., . . . Liu, Z. (2011). Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by TNFα. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(1), E195-E201. doi:10.1152/ajpendo.00414.2010

Wang, H., Wang, A. X., & Barrett, E. J. (2011). Caveolin-1 is required for vascular endothelial insulin uptake. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 300(1), E134-E144. doi:10.1152/ajpendo.00498.2010

Weltman, N. Y., Rynders, C. A., Gaesser, G. A., Weltman, J. Y., Barrett, E. J., & Weltman, A. (2010). Exercise intensity does not affect glucose disposal in euglycemic abdominally obese adults. OBESITY AND METABOLISM-MILAN, 6(4), 86-93. Retrieved from https://www.webofscience.com/

Swift, D. L., Weltman, J. Y., Patrie, J. T., Barrett, E. J., Gaesser, G. A., & Weltman, A. L. (2010). Fitness And Body Composition Do Not Affect Racial Differences In Endothelial Function In Postmenopausal Women. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 42(5), 304. doi:10.1249/01.MSS.0000384446.03936.9d

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