Giorgio Carta

Professor, Chemical Engineering

Primary Location

PO Box 400741
Chemical Engineering Bldg, 118

Primary Phone Number

434.924.6281

[email protected]

Website

http://www.che.virginia.edu/people/faculty/carta.php

Bio & Overview

The emphasis of our work is on the downstream processing of biotechnology products. Our efforts are devoted to: The development of physical and mathematical models to describe and optimize chromatographic processes for the recovery, separation, and purification of biological compounds and of adsorption processes for the efficient removal and recovery of aqueous contaminants. The development of novel advanced materials for bioseparations including large-pore particles, gel-composite media, and polymer-grafted ion exchangers for high performance and high throughput protein separations. We are especially interested in polymer hydrogels as separation media since such gels can be synthesized with a range of properties desirable for protein chromatography. Studies on protein transport in ion exchangers using a variety of macroscopic and microscopic techniques with the goal of gaining a fundamental understanding of equilibrium and transport processes. We are studying the fundamental relationships between polymer properties and partitioning and diffusion phenomena of proteins in order to develop criteria for optimum design of the separation medium. Preparative chromatofocusing for efficient pH-gradient based protein separations using stationary phases containing weak acid or weak base groups and non-adsorbed buffers. Our work is focused on developing optimum buffer compositions and modeling pH transitions that permit efficient separations of protein variants.

Academic Information

Department: Chemical Engineering

Academic Title: Professor

Primary Education

PhD, Chemical Engineering, University of Delaware, 1984

Other Affiliations

Biotechnology Research Discipline, BIMS

Research Interests

Separations Technology and Biocatalysis

Research Disciplines

Biotechnology

Research Opportunities

Biotechnology

Selected Publications

Creasy A, Barker G, Yao Y, Carta G, Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model., 2015; Biotechnology journal. () . PMID: 26015091

Wu Y, Abraham D, Carta G, Particle size effects on protein and virus-like particle adsorption on perfusion chromatography media., 2014; Journal of chromatography. A. 1375() 92-100. PMID: 25512122

Wu Y, Simons J, Hooson S, Abraham D, Carta G, Protein and virus-like particle adsorption on perfusion chromatography media., 2013; Journal of chromatography. A. 1297() 96-105. PMID: 23726244

Carta G, Predicting protein dynamic binding capacity from batch adsorption tests., 2012; Biotechnology journal. 7(10) 1216-20. PMID: 22623375

Tao Y, Carta G, Ferreira G, Robbins D, Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: II. Adsorption kinetics., 2011; Journal of chromatography. A. 1218(11) 1530-7. PMID: 21300361

Tao Y, Carta G, Ferreira G, Robbins D, Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: I. Adsorption equilibrium., 2011; Journal of chromatography. A. 1218(11) 1519-29. PMID: 21306721

Costanzo JA, Ober CA, Black R, Carta G, Fernandez EJ, Evaluation of polymer matrices for an adsorptive approach to plasma detoxification., 2010; Biomaterials. 31(10) 2857-65. PMID: 20045183

Bankston TE, Carta G, Apolipoprotein A-I(Milano) anion exchange chromatography: Self association and adsorption equilibrium., 2010; Biotechnology journal. 5(10) 1028-39. PMID: 20931599

Dattolo L, Keller EL, Carta G, pH transients in hydroxyapatite chromatography columns-Effects of operating conditions and media properties., 2010; Journal of chromatography. A. 1217(48) 7573-8. PMID: 21030032

Bankston TE, Dattolo L, Carta G, pH Transients in hydroxyapatite chromatography columns-experimental evidence and phenomenological modeling., 2010; Journal of chromatography. A. 1217(14) 2123-31. PMID: 20193952

Bankston TE, Carta G, Apolipoprotein A-I(Milano) anion exchange chromatography: mass transfer and adsorption kinetics., 2010; Biotechnology journal. 5(10) 1040-9. PMID: 20931600

Perez-Almodovar EX, Carta G, IgG adsorption on a new protein A adsorbent based on macroporous hydrophilic polymers. I. Adsorption equilibrium and kinetics., 2009; Journal of chromatography. A. 1216(47) 8339-47. PMID: 19783254

Perez-Almodovar EX, Carta G, IgG adsorption on a new protein A adsorbent based on macroporous hydrophilic polymers II. Pressure-flow curves and optimization for capture., 2009; Journal of chromatography. A. 1216(47) 8348-54. PMID: 19786279