Bloom, George S.
- BA, Biology, History, University of Pennsylvania
- PhD, Biology, University of Pennsylvania
- Postdoc, Cell Biology, University of North Carolina
- Postdoc, Cell Biology, Worcester Foundation for Exp. Biol
Department of Biology
PO Box 400328
Charlottesville, VA 22904-4328
Pathogenic mechanisms in Alzheimer's Disease and other neurodegenerative disorders
Research in our laboratory is now focused primarily on Alzheimers disease (AD), the most common form of a group of neurodegenerative disorders known collectively as tauopathies. The histopathological hallmark of AD is the presence in brain of extracellular plaques of ?-amyloid peptide fibrils, and intraneuronal neurofibrillary tangles, which are filaments composed of the protein, tau, and are found in all tauopathies. Despite the conspicuous appearance of plaques and tangles, a growing body of evidence points to their building blocks, ?-amyloid and tau oligomers, as being the toxic molecular species that cause AD. For example, we have found that tau expression is required for several adverse effects of ?-amyloid oligomers on neurons, including microtubules loss, ectopic re-rentry into the cell cycle and cytotoxicity. The goals of our work are to decipher the metabolic links that connect ?-amyloid and tau to damage neurons, to define the structures and pathological properties of various types of ?-amyloid and tau oligomers, and to develop effective therapeutic and diagnostic tools for AD.