Ilya Levental

Castello-Serrano, I., Heberle, F. A., Diaz-Rohrer, B., Ippolito, R., Shurer, C. R., Lujan, P., . . . Levental, I. (2024). Partitioning to ordered membrane domains regulates the kinetics of secretory traffic. ELIFE, 12. doi:10.7554/eLife.89306

Zimmer, S. E., Giang, W., Levental, I., & Kowalczyk, A. P. (2024). The transmembrane domain of the desmosomal cadherin desmoglein-1 governs lipid raft association to promote desmosome adhesive strength.. bioRxiv. doi:10.1101/2024.04.24.590936

Castello-Serrano, I., Heberle, F. A., Diaz-Rohrer, B., Ippolito, R., Shurer, C. R., Lujan, P., . . . Levental, I. (2024). Partitioning to ordered membrane domains regulates the kinetics of secretory traffic.. bioRxiv. doi:10.1101/2023.04.18.537395

Doktorova, M., Levental, I., & Heberle, F. A. (2023). Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 15(12). doi:10.1101/cshperspect.a041393

Park, S., Levental, I., Pastor, R. W., & Im, W. (2023). Unsaturated Lipids Facilitate Partitioning of Transmembrane Peptides into the Liquid Ordered Phase. JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 19(15), 5303-5314. doi:10.1021/acs.jctc.3c00398

Sezgin, E., & Levental, I. (2023). Membranes in focus. BIOPHYSICAL JOURNAL, 122(11), E1-E4. doi:10.1016/j.bpj.2023.05.005

Wang, H. -Y., Chan, S. H., Dey, S., Castello-Serrano, I., Rosen, M. K., Ditlev, J. A., . . . Levental, I. (2023). Coupling of protein condensates to ordered lipid domains determines functional membrane organization. SCIENCE ADVANCES, 9(17). doi:10.1126/sciadv.adf6205

Shelby, S. A., Castello-Serrano, I., Wisser, K. C., Levental, I., & Veatch, S. L. (2023). Membrane phase separation drives responsive assembly of receptor signaling domains. NATURE CHEMICAL BIOLOGY, 19(6), 750-+. doi:10.1038/s41589-023-01268-8

Ward, A. E., Sokovikova, D., Waxham, M. N., Heberle, F. A., Levental, I., Levental, K. R., . . . Tamm, L. K. (2023). Serinc5 Restricts HIV Membrane Fusion by Altering Lipid Order and Heterogeneity in the Viral Membrane. ACS INFECTIOUS DISEASES, 9(4), 773-784. doi:10.1021/acsinfecdis.2c00478

Diaz-Rohrer, B., Castello-Serrano, I., Chan, S. H., Wang, H. -Y., Shurer, C. R., Levental, K. R., & Levental, I. (2023). Rab3 mediates a pathway for endocytic sorting and plasma membrane recycling of ordered microdomains. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(10). doi:10.1073/pnas.2207461120

Beltran, L. C., Cvirkaite-Krupovic, V., Miller, J., Wang, F., Kreutzberger, M. A. B., Patkowski, J. B., . . . Krupovic, M. (2023). Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-36349-8

Hernandez, L. M. R., & Levental, I. (2023). Lipid packing is disrupted in copolymeric nanodiscs compared with intact membranes. BIOPHYSICAL JOURNAL, 122(11), 2256-2266. doi:10.1016/j.bpj.2023.01.013

Levental, I., & Lyman, E. (2023). Regulation of membrane protein structure and function by their lipid nano-environment (Sept, 10.1038/s41580022-00524-4, 2022). NATURE REVIEWS MOLECULAR CELL BIOLOGY, 24(1), 79. doi:10.1038/s41580-022-00560-0

Levental, I., & Lyman, E. (2023). Regulation of membrane protein structure and function by their lipid nano-environment. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 24(2), 107-122. doi:10.1038/s41580-022-00524-4

Doktorova, M., & Levental, I. (2022). Cholesterol's balancing act: Defying the status quo. BIOPHYSICAL JOURNAL, 121(20), 3771-3773. doi:10.1016/j.bpj.2022.08.036

Matias, M. I., Yong, C. S., Foroushani, A., Goldsmith, C., Mongellaz, C., Sezgin, E., . . . Dardalhon, V. (2021). Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis. CELL REPORTS, 37(5). doi:10.1016/j.celrep.2021.109911

Penkert, H., Bertrand, A., Tiwari, V., Breimann, S., Mueller, S. A., Jordan, P. M., . . . Simons, M. (2021). Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. CELL REPORTS, 37(4). doi:10.1016/j.celrep.2021.109898

Zinocker, M. K., Svendsen, K., Levental, K. R., Levental, I., & Dankel, S. N. (2021). The homeoviscous adaptation to dietary lipids (HADL) hypothesis is probably incorrect Reply. AMERICAN JOURNAL OF CLINICAL NUTRITION, 113(6), 1712-1713. doi:10.1093/ajcn/nqab111

Sanders, D. W., Jumper, C. C., Ackerman, P. J., Bracha, D., Donlic, A., Kim, H., . . . Brangwynne, C. P. (2021). SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. ELIFE, 10. doi:10.7554/eLife.65962

Symons, J. L., Cho, K. -J., Chang, J. T., Du, G., Waxham, M. N., Hancock, J. F., . . . Levental, K. R. (2021). Lipidomic atlas of mammalian cell membranes reveals hierarchical variation induced by culture conditions, subcellular membranes, and cell lineages. SOFT MATTER, 17(2), 288-297. doi:10.1039/d0sm00404a

Doktorova, M., Symons, J. L., & Levental, I. (2020). Structural and functional consequences of reversible lipid asymmetry in living membranes. NATURE CHEMICAL BIOLOGY, 16(12), 1321-1330. doi:10.1038/s41589-020-00688-0

Marrink, S. J., & Levental, I. (2020). Computational and Experimental Advances in Biomembranes: Resolving Their Complexity Published as part of The Journal of Physical Chemistry virtual special issue "Computational and Experimental Advances in Biomembranes". JOURNAL OF PHYSICAL CHEMISTRY B, 124(45), 9975-9976. doi:10.1021/acs.jpcb.0c09401

Heberle, F. A., Doktorova, M., Scott, H. L., Skinkle, A. D., Waxham, M. N., & Levental, I. (2020). Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(33), 19943-19952. doi:10.1073/pnas.2002200117

Castello-Serrano, I., Lorent, J. H., Ippolito, R., Levental, K. R., & Levental, I. (2020). Myelin-Associated MAL and PLP Are Unusual among Multipass Transmembrane Proteins in Preferring Ordered Membrane Domains. JOURNAL OF PHYSICAL CHEMISTRY B, 124(28), 5930-5939. doi:10.1021/acs.jpcb.0c03028

Lorent, J. H., Levental, K. R., Ganesan, L., Rivera-Longsworth, G., Sezgin, E., Doktorova, M., . . . Levental, I. (2020). Author Correction: Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape. NATURE CHEMICAL BIOLOGY, 16(6), 710. doi:10.1038/s41589-020-0540-y

Lorent, J. H., Levental, K. R., Ganesan, L., Rivera-Longsworth, G., Sezgin, E., Doktorova, M. D., . . . Levental, I. (2020). Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape. NATURE CHEMICAL BIOLOGY, 16(6), 644-+. doi:10.1038/s41589-020-0529-6

Levental, K. R., Malmberg, E., Symons, J. L., Fan, Y. -Y., Chapkin, R. S., Ernst, R., & Levental, I. (2020). Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-15203-1

Levental, I., Levental, K. R., & Heberle, F. A. (2020). Lipid Rafts: Controversies Resolved, Mysteries Remain. TRENDS IN CELL BIOLOGY, 30(5), 341-353. doi:10.1016/j.tcb.2020.01.009

Ballweg, S., Sezgin, E., Doktorova, M., Covino, R., Reinhard, J., Wunnicke, D., . . . Ernst, R. (2020). Regulation of lipid saturation without sensing membrane fluidity. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-14528-1

Skinkle, A. D., Levental, K. R., & Levental, I. (2020). Cell-Derived Plasma Membrane Vesicles Are Permeable to Hydrophilic Macromolecules. BIOPHYSICAL JOURNAL, 118(6), 1292-1300. doi:10.1016/j.bpj.2019.12.040

Wang, H. -Y., Bharti, D., & Levental, I. (2020). Membrane Heterogeneity Beyond the Plasma Membrane. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 8. doi:10.3389/fcell.2020.580814

McGraw, C., Yang, L., Levental, I., Lyman, E., & Robinson, A. S. (2019). Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A_2A receptor. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1861(4), 760-767. doi:10.1016/j.bbamem.2019.01.001

Lorent, J. H., Diaz-Rohrer, B., Lin, X., Spring, K., Gorfe, A. A., Levental, K. R., & Levental, I. (2018). Structural determinants and functional consequences of protein affinity for membrane rafts (2017). NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04164-1

Levental, K. R., Surma, M. A., Skinkle, A. D., Lorent, J. H., Zhou, Y., Klose, C., . . . Levental, I. (2017). ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis. SCIENCE ADVANCES, 3(11). doi:10.1126/sciadv.aao1193

Lorent, J. H., Diaz-Rohrer, B., Lin, X., Spring, K., Gorfe, A. A., Levental, K. R., & Levental, I. (2017). Structural determinants and functional consequences of protein affinity for membrane rafts. NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-01328-3

Burns, M., Wisser, K., Wu, J., Levental, I., & Veatch, S. L. (2017). Miscibility Transition Temperature Scales with Growth Temperature in a Zebrafish Cell Line. BIOPHYSICAL JOURNAL, 113(6), 1212-1222. doi:10.1016/j.bpj.2017.04.052

Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017). The mystery of membrane organization: composition, regulation and roles of lipid rafts. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 18(6), 361-374. doi:10.1038/nrm.2017.16

He, J., Zhang, F., Tay, L. W. R., Boroda, S., Nian, W., Levental, K. R., . . . Du, G. (2017). Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival. FASEB JOURNAL, 31(7), 2893-2904. doi:10.1096/fj.201601353R

Ganesan, L., Shieh, P., Bertozzi, C. R., & Levental, I. (2017). Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation. SCIENTIFIC REPORTS, 7. doi:10.1038/srep41147

Rissanen, S., Grzybek, M., Orlowski, A., Rog, T., Cramariuc, O., Levental, I., . . . Vattulainen, I. (2017). Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin. FRONTIERS IN PHYSIOLOGY, 8. doi:10.3389/fphys.2017.00252

Lin, X., Lorent, J. H., Skinlde, A. D., Levental, K. R., Waxham, M. N., Gorfe, A. A., & Levental, I. (2016). Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation. JOURNAL OF PHYSICAL CHEMISTRY B, 120(46), 11930-11941. doi:10.1021/acs.jpcb.6b06815

Lin, X., Zhang, S., Ding, H., Levental, I., & Gorfe, A. A. (2016). The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration. FEBS LETTERS, 590(19), 3368-3374. doi:10.1002/1873-3468.12383

Levental, I., & Veatch, S. L. (2016). The Continuing Mystery of Lipid Rafts. JOURNAL OF MOLECULAR BIOLOGY, 428(24), 4749-4764. doi:10.1016/j.jmb.2016.08.022

Tulodziecka, K., Diaz-Rohrer, B. B., Farley, M. M., Chan, R. B., Di Paolo, G., Levental, K. R., . . . Levental, I. (2016). Remodeling of the postsynaptic plasma membrane during neural development. MOLECULAR BIOLOGY OF THE CELL, 27(22), 3480-3489. doi:10.1091/mbc.E16-06-0420

Tisza, M. J., Zhao, W., Fuentes, J. S. R., Prijic, S., Chen, X., Levental, I., & Chang, J. T. (2016). Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts. ONCOTARGET, 7(32), 51553-51568. doi:10.18632/oncotarget.9928

Levental, K. R., Lorent, J. H., Lin, X., Skinkle, A. D., Surma, M. A., Stockenbojer, E. A., . . . Levental, I. (2016). Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order. BIOPHYSICAL JOURNAL, 110(8), 1800-1810. doi:10.1016/j.bpj.2016.03.012

Wolfe, A. R., Debeb, B. G., Lacerda, L., Larson, R., Bambhroliya, A., Huang, X., . . . Woodward, W. A. (2015). Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a. BREAST CANCER RESEARCH AND TREATMENT, 154(3), 495-508. doi:10.1007/s10549-015-3645-3

Piktel, E., Niemirowicz, K., Wnorowska, U., Watek, M., Wollny, T., Gluszek, K., . . . Bucki, R. (2016). The Role of Cathelicidin LL-37 in Cancer Development. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 64(1), 33-46. doi:10.1007/s00005-015-0359-5

Ganesan, L., & Levental, I. (2015). Pharmacological Inhibition of Protein Lipidation. JOURNAL OF MEMBRANE BIOLOGY, 248(6), 929-941. doi:10.1007/s00232-015-9835-4

Lorent, J. H., & Levental, I. (2015). Structural determinants of protein partitioning into ordered membrane domains and lipid rafts. CHEMISTRY AND PHYSICS OF LIPIDS, 192, 23-32. doi:10.1016/j.chemphyslip.2015.07.022

Ihida-Stansbury, K., Ames, J., Chokshi, M., Aiad, N., Sanyal, S., Kawabata, K. C., . . . Jones, P. L. (2015). Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs. PULMONARY CIRCULATION, 5(2), 382-397. doi:10.1086/681272

Sezgin, E., Gutmann, T., Buhl, T., Dirkx, R., Grzybek, M., Coskun, U., . . . Schwille, P. (2015). Adaptive Lipid Packing and Bioactivity in Membrane Domains. PLOS ONE, 10(4). doi:10.1371/journal.pone.0123930

Beck-Garcia, K., Beck-Garcia, E., Bohler, S., Zorzin, C., Sezgin, E., Levental, I., . . . Schamel, W. W. A. (2015). Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1853(4), 802-809. doi:10.1016/j.bbamcr.2014.12.017

Diaz-Rohrer, B., Levental, K. R., & Levental, I. (2014). Rafting through traffic: Membrane domains in cellular logistics. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1838(12), 3003-3013. doi:10.1016/j.bbamem.2014.07.029

Schwarzer, R., Levental, I., Gramatica, A., Scolari, S., Buschmann, V., Veit, M., & Herrmann, A. (2014). The cholesterol-binding motif of the HIV-1 glycoprotein gp41 regulates lateral sorting and oligomerization. CELLULAR MICROBIOLOGY, 16(10), 1565-1581. doi:10.1111/cmi.12314

Diaz-Rohrer, B. B., Levental, K. R., Simons, K., & Levental, I. (2014). Membrane raft association is a determinant of plasma membrane localization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(23), 8500-8505. doi:10.1073/pnas.1404582111

Zhou, Y., Maxwell, K. N., Sezgin, E., Lu, M., Liang, H., Hancock, J. F., . . . Levental, I. (2013). Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(50), 35660-35670. doi:10.1074/jbc.M113.519116

Sezgin, E., Chwastek, G., Aydogan, G., Levental, I., Simons, K., & Schwille, P. (2013). Photoconversion of Bodipy-Labeled Lipid Analogues. CHEMBIOCHEM, 14(6), 695-698. doi:10.1002/cbic.201300038

Sezgin, E., Levental, I., Grzybek, M., Schwarzmann, G., Mueller, V., Honigmann, A., . . . Schwille, P. (2012). Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1818(7), 1777-1784. doi:10.1016/j.bbamem.2012.03.007

Sezgin, E., Kaiser, H. -J., Baumgart, T., Schwille, P., Simons, K., & Levental, I. (2012). Elucidating membrane structure and protein behavior using giant plasma membrane vesicles. NATURE PROTOCOLS, 7(6), 1042-1051. doi:10.1038/nprot.2012.059

Kaiser, H. -J., Surma, M. A., Mayer, F., Levental, I., Grzybek, M., Klemm, R. W., . . . Lingwood, D. (2011). Molecular Convergence of Bacterial and Eukaryotic Surface Order. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(47), 40631-40637. doi:10.1074/jbc.M111.276444

Thaa, B., Levental, I., Herrmann, A., & Veit, M. (2011). Intrinsic membrane association of the cytoplasmic tail of influenza virus M2 protein and lateral membrane sorting regulated by cholesterol binding and palmitoylation. BIOCHEMICAL JOURNAL, 437, 389-397. doi:10.1042/BJ20110706

Levental, I., Grzybek, M., & Simons, K. (2011). Raft domains of variable properties and compositions in plasma membrane vesicles. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(28), 11411-11416. doi:10.1073/pnas.1105996108

Levental, I., Lingwood, D., Grzybek, M., Coskun, U., & Simons, K. (2010). Palmitoylation regulates raft affinity for the majority of integral raft proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(51), 22050-22054. doi:10.1073/pnas.1016184107

Levental, I., Grzybek, M., & Simons, K. (2010). Greasing Their Way: Lipid Modifications Determine Protein Association with Membrane Rafts. BIOCHEMISTRY, 49(30), 6305-6316. doi:10.1021/bi100882y

Levental, I., Levental, K. R., Klein, E. A., Assoian, R., Miller, R. T., Wells, R. G., & Janmey, P. A. (2010). A simple indentation device for measuring micrometer-scale tissue stiffness. JOURNAL OF PHYSICS-CONDENSED MATTER, 22(19). doi:10.1088/0953-8984/22/19/194120