Jae Hyun Shin

Shin, Jae Hyun

Primary Appointment

Assistant Professor, Medicine: Infectious Diseases and International Health


  • MD, Medicine, Seoul National University
  • Residency, Internal Medicine, Rochester General Hospital
  • Fellowship, Infectious Diseases, University of Virginia

Contact Information

PO Box 801340
MR-6, Room 2711
Charlottesville, VA 22908

Research Interests

Clostridium difficile infection, infection in aged host, microbiome-immune response interactions, innate immune response

Research Description

Dr. Shin's research focuses on Clostridium difficile infection in the aged host. His research using an aged mouse model of infection showed a significant deficiency in innate immune response in aged mice along with higher mortality. Changing of the intestinal microbiome by fecal transplant from young mice restores the immune response and improves survival, revealing an important immune-modulatory effect of the microbiome. The direction of the research is to identify the host response pathways mediating this microbiome effect on immune response.

Selected Publications