Kathleen A. McManus
Associate Professor, Medicine- Infectious Diseases and International Health
MR-6
Charlottesville, VA 22908
Bio & Overview
Dr. McManus is an Associate Professor of Medicine at the University of Virginia (UVA) in the Division of Infectious Diseases and International Health. She joined the UVA faculty as a physician-scientist in summer 2017 with a research award from the Translational Health Research Institute of Virginia. In August 2018, she was awarded a K08 Mentored Career Development Award from the National Institute of Allergy and Infectious Diseases to study how insurance coverage expansion under the Affordable Care Act affected clinical outcomes for low-income people living with HIV. Her work is now supported by an R01 from the National Institute of Allergy and Infectious Diseases, which supports an interdisciplinary team studying how AIDS Drug Assistance Programs around the nation can best help people with HIV with low incomes achieve and maintain viral suppression.
As a clinician, Dr. McManus sees patients in the UVA Ryan White HIV Clinic, serving the Northwest Virginia region, and attends on the Infectious Diseases inpatient consult team. She is the Medical Director and Principal Investigator of the UVA Ryan White HIV/AIDS Program (RWHAP).
Dr. McManus is a member and previous co-chair of the HIV Medical Association's national Ryan White HIV Medical Providers Coalition Steering Committee. Through this position, she has the opportunity to advocate for robust support of the Ryan White HIV/AIDS Program and to provide expertise as a clinician and a researcher on national discussions about HIV care. She also chairs the Virginia Department of Health's ADAP Advisory Committee.
Dr. McManus is dedicated to mentoring and training the next generation of physicians, researchers, and physician-scientists, especially those interested in HIV, HIV prevention, Hepatitis C, opioid use disorder and other substance use disorders, access to care, epidemiology, and data science. She is the Director of the UVA Internal Medicine Residency's HIV Primary Care Track. She has mentored students at all levels—from undergraduate through infectious diseases fellowship—on research projects, international electives, and independent-study data analyses.
In terms of her training, Dr. McManus received her undergraduate degree in Chemistry from Dartmouth College and her medical doctorate from Columbia University College of Physicians and Surgeons. She completed Internal Medicine residency and Infectious Diseases fellowship at UVA, along with a Master of Science in Clinical Research during residency as part of the Internal Medicine residency's Clinical Investigator track. During her Infectious Diseases fellowship, she was awarded an Agency for Healthcare Research and Quality F32 award to support her research on the impact of the Affordable Care Act on HIV outcomes in Virginia.
Dr. McManus has also studied biomedical HIV prevention, Hepatitis C, COVID-19, and opioid use disorder among people with or at risk for HIV. Her goal is to build a vibrant, interdisciplinary team of researchers who identify and address barriers to viral suppression among people with HIV, improving individual health outcomes and advancing the nation's effort to end the HIV epidemic.
Academic Information
- Department
- Medicine- Infectious Diseases and International Health
Primary Education
- AB, Chemistry, Dartmouth College, 2006
- MD, undefinedColumbia University, 2010
- MSc, Clinical Research, University of Virginia, 2012
- Residency, Internal Medicine, University of Virginia, 2013
- Chief Resident, Internal Medicine, University of Virginia, 2014
- Fellowship, Infectious Diseases and International Health, University of Virginia, 2017
Other Affiliations
- BIMS
Research Interests
Research Disciplines
- Infectious Diseases/Biodefense
Research Opportunities
- Infectious Diseases
Selected Publications
2024
Chastain, D. B., Tu, P. J., Brizzi, M., Keedy, C. A., Baker, A. N., Jackson, B. T., . . . Cluck, D. B. (2024). Managing Modern Antiretroviral Therapy in the Intensive Care Unit: Overcoming Challenges for Critically Ill People With Human Immunodeficiency Virus. OPEN FORUM INFECTIOUS DISEASES, 11(5). doi:10.1093/ofid/ofae213
Bielick, C., Strumpf, A., Ghosal, S., Mcmurry, T., & Mcmanus, K. A. (2024). National Hospitalization Rates and In-Hospital Mortality Rates of Human Immunodeficiency Virus-Related Opportunistic Infections in the United States, 2011-2018. CLINICAL INFECTIOUS DISEASES. doi:10.1093/cid/ciae051
2023
McManus, K. A., Fuller, B., Killelea, A., Strumpf, A., Powers, S. D., & McQuade, E. T. R. (2023). Geographic Variation in Qualified Health Plan Coverage and Prior Authorization Requirements for HIV Preexposure Prophylaxis. JAMA NETWORK OPEN, 6(11). doi:10.1001/jamanetworkopen.2023.42781
Khazanchi, R., Powers, S., Killelea, A., Strumpf, A., Horn, T., Hamp, A., & McManus, K. A. A. (2023). Access to a novel first-line single-tablet HIV antiretroviral regimen in Affordable Care Act Marketplace plans, 2018-2020. JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE, 16(1). doi:10.1186/s40545-023-00559-8
McManus, K. A., Strumpf, A. M., Killelea, A., Horn, T., Steen, A., An, Z., . . . Keim-Malpass, J. (2023). Ryan White HIV/AIDS Part B and AIDS Drug Assistance Programs during COVID-19: safety net public health programs' challenges and innovations. FRONTIERS IN PUBLIC HEALTH, 11. doi:10.3389/fpubh.2023.1172009
2022
Khazanchi, R., Strumpf, A., Essien, U. R., Powers, S. D., & McManus, K. A. (2022). Geographic Accessibility of COVID-19 Test to Treat Sites by Race, Ethnicity, Age, and Rurality. JAMA NETWORK OPEN, 5(11). doi:10.1001/jamanetworkopen.2022.41144
McManus, K. A., Strumpf, A., Killelea, A., Horn, T., Hamp, A., & Keim-Malpass, J. (2022). Economic benefits of the United States' AIDS drug assistance Program: A systematic review of cost analyses to guide research and policy priorities. PREVENTIVE MEDICINE REPORTS, 29. doi:10.1016/j.pmedr.2022.101969
Geba, M. C., Powers, S., Williams, B., Dort, K. R., Rogawski McQuade, E. T., & McManus, K. A. (2022). A Missed Opportunity: Extragenital Screening for Gonorrhea and Chlamydia Sexually Transmitted Infections in People With HIV in a Southeastern Ryan White HIV/AIDS Program Clinic Setting. OPEN FORUM INFECTIOUS DISEASES, 9(7). doi:10.1093/ofid/ofac322
Srikanth, K., Killelea, A., Strumpf, A., Corbin-Gutierrez, E., Horn, T., & McManus, K. A. (2022). Associated Costs Are a Barrier to HIV Preexposure Prophylaxis Access in the United States. AMERICAN JOURNAL OF PUBLIC HEALTH, 112(6), 834-838. doi:10.2105/AJPH.2022.306793
McManus, K. A., Davy-Mendez, T., Killelea, A., & Schranz, A. J. (2022). Access to Medications for Opioid Use Disorder for Persons With Human Immunodeficiency Virus in the United States: Gaps in Coverage by State AIDS Drug Assistance Programs. OPEN FORUM INFECTIOUS DISEASES, 9(4). doi:10.1093/ofid/ofac057
2021
McManus, K. A., Schurman, E., An, Z., Van Hook, R., Keim-Malpass, J., & Flickinger, T. E. (2022). Patient Perspective of People with HIV Who Gained Medicaid Through Medicaid Expansion: A Cross-Sectional Qualitative Study. AIDS RESEARCH AND HUMAN RETROVIRUSES, 38(7), 580-591. doi:10.1089/aid.2021.0129
Khazanchi, R., Powers, S. D., McQuade, E. T. R., & McManus, K. A. (2021). Inequities in the Geographic Accessibility of COVID-19 Biomedical Therapeutic Trials in the United States. JOURNAL OF GENERAL INTERNAL MEDICINE, 36(11), 3650-3653. doi:10.1007/s11606-021-07081-0
Powers, S. D., McQuade, E. T. R., Killelea, A., Horn, T., & McManus, K. A. (2021). Worsening Disparities in State-Level Uptake of Human Immunodeficiency Virus Preexposure Prophylaxis, 2014-2018. OPEN FORUM INFECTIOUS DISEASES, 8(7). doi:10.1093/ofid/ofab293
Flickinger, T. E., Sherbuk, J. E., de Guex, K. P., Villarreal, D. A., Hilgart, M., McManus, K. A., . . . Dillingham, R. (2021). Adapting an m-Health Intervention for Spanish-Speaking Latinx People Living with HIV in the Nonurban Southern United States. TELEMEDICINE REPORTS, 2(1), 46-55. doi:10.1089/tmr.2020.0018
2020
McManus, K. A., Srikanth, K., Powers, S. D., Dillingham, R., & McQuade, E. T. R. (2021). Medicaid Expansion's Impact on Human Immunodeficiency Virus Outcomes in a Nonurban Southeastern Ryan White HIV/AIDS Program Clinic. OPEN FORUM INFECTIOUS DISEASES, 8(2). doi:10.1093/ofid/ofaa595
Arant, E. C., Harding, C., Geba, M., Targonski, P. V., & McManus, K. A. (2021). Human Immunodeficiency Virus (HIV) and Aging: Multimorbidity in Older People With HIV in One Nonurban Southeastern Ryan White HIV/AIDS Program Clinic. OPEN FORUM INFECTIOUS DISEASES, 8(1). doi:10.1093/ofid/ofaa584
Sherbuk, J. E., Williams, B., McManus, K. A., & Dillingham, R. (2020). Financial, Food, and Housing Insecurity Due to Coronavirus Disease 2019 Among At-Risk People With Human Immunodeficiency Virus in a Nonurban Ryan White HIV/AIDS Program Clinic. OPEN FORUM INFECTIOUS DISEASES, 7(10). doi:10.1093/ofid/ofaa423
Sherbuk, J. E., Tabackman, A., McManus, K. A., Kemp Knick, T., Schexnayder, J., Flickinger, T. E., & Dillingham, R. (2020). A qualitative study of perceived barriers to hepatitis C care among people who did not attend appointments in the non-urban US South. HARM REDUCTION JOURNAL, 17(1). doi:10.1186/s12954-020-00409-9
Sherbuk, J. E., Knick, T. K., Canan, C., Ross, P., Helbert, B., Cantrell, E. S., . . . Dillingham, R. (2020). Development of an Interdisciplinary Telehealth Model of Provider Training and Comprehensive Care for Hepatitis C and Opioid Use Disorder in a High-Burden Region. JOURNAL OF INFECTIOUS DISEASES, 222, S354-S364. doi:10.1093/infdis/jiaa141
Sherbuk, J. E., Petros de Guex, K., Anazco Villarreal, D., Knight, S., McManus, K. A., Flickinger, T., & Dillingham, R. (2020). Beyond Interpretation: The Unmet Need for Linguistically and Culturally Competent Care for Latinx People Living with HIV in a Southern Region with a Low Density of Spanish Speakers. AIDS RESEARCH AND HUMAN RETROVIRUSES, 36(11), 933-941. doi:10.1089/aid.2020.0088
McManus, K. A., Killelea, A., Honeycutt, E., An, Z., & Keim-Malpass, J. (2020). Assisters Succeed in Insurance Navigation for People Living with HIV and People at Increased Risk of HIV in a Complex Coverage Landscape. AIDS RESEARCH AND HUMAN RETROVIRUSES, 36(10), 842-851. doi:10.1089/aid.2020.0013
Diepstra, K., Lu, H., McManus, K. A., Rogawski McQuade, E. T., Rhodes, A. G., & Westreich, D. (2020). What we talk about when we talk about durable viral suppression. AIDS, 34(11), 1683-1686. doi:10.1097/QAD.0000000000002612
McManus, K. A., Ferey, J., Farrell, E., & Dillingham, R. (2020). National Survey of US HIV Clinicians: Knowledge and Attitudes About the Affordable Care Act and Opinions of its Impact on Quality of Care and Barriers to Care. OPEN FORUM INFECTIOUS DISEASES, 7(7). doi:10.1093/ofid/ofaa225
McManus, K. A., Powers, S., Killelea, A., Tello-Trillo, S., & Rogawski McQuade, E. (2020). Regional Disparities in Qualified Health Plans' Prior Authorization Requirements for HIV Pre-exposure Prophylaxis in the United States. JAMA NETWORK OPEN, 3(6). doi:10.1001/jamanetworkopen.2020.7445
Kaperak, C., Elwood, S., Saint-Surin, T., Winstead-Derlega, C., Brennan, R. O., Dillingham, R., & McManus, K. A. (2020). A Cross-Sectional Study on the Affordable Care Act from the Perspective of People Living with HIV: The Interplay between Knowledge, Stigma, Trust, and Attitudes. AIDS RESEARCH AND TREATMENT, 2020. doi:10.1155/2020/6081721
2019
McManus, K. A., Christensen, B., Nagraj, V. P., Furl, R., Yerkes, L., Swindells, S., . . . Dillingham, R. (2020). Evidence From a Multistate Cohort: Enrollment in Affordable Care Act Qualified Health Plans' Association With Viral Suppression. CLINICAL INFECTIOUS DISEASES, 71(10), 2572-2580. doi:10.1093/cid/ciz1123
McManus, K. A., Debolt, C., Elwood, S., Saint-Surin, T., Winstead-Derlega, C., Brennan, R. O., . . . Flickinger, T. E. (2019). Facilitators and Barriers: Clients' Perspective on the Virginia AIDS Drug Assistance Program's Affordable Care Act Implementation. AIDS RESEARCH AND HUMAN RETROVIRUSES, 35(8), 734-745. doi:10.1089/aid.2018.0254
Aggarwal, R., Pham, M., Dillingham, R., & McManus, K. A. (2019). Expanded HIV Clinic-Based Mental Health Care Services: Association With Viral Suppression. OPEN FORUM INFECTIOUS DISEASES, 6(4). doi:10.1093/ofid/ofz146
Sherbuk, J. E., McManus, K. A., Knick, T. K., Canan, C. E., Flickinger, T., & Dillingham, R. (2019). Disparities in Hepatitis C Linkage to Care in the Direct Acting Antiviral Era: Findings From a Referral Clinic With an Embedded Nurse Navigator Model. FRONTIERS IN PUBLIC HEALTH, 7. doi:10.3389/fpubh.2019.00362
2018
McManus, K. A., Rhodes, A., Yerkes, L., Engelhard, C. L., Ingersoll, K. S., & Dillingham, R. (2018). Year 2 of Affordable Care Act Qualified Health Plans (QHPs) in a Medicaid Nonexpansion State: QHPs Associated With Viral Suppression for Virginia AIDS Drug Assistance Program Clients. OPEN FORUM INFECTIOUS DISEASES, 5(12). doi:10.1093/ofid/ofy283
Sherbuk, J. E., McManus, K. A., McQuade, E. T. R., Knick, T., Henry, Z., & Dillingham, R. (2018). Hepatitis C Within a Single Health System: Progression Along the Cascade to Cure Is Higher for Those With Substance Misuse When Linked to a Clinic With Embedded Support Services. OPEN FORUM INFECTIOUS DISEASES, 5(9). doi:10.1093/ofid/ofy202
McManus, K. A., McManus, K., & Dillingham, R. (2018). National Survey of United States Human Immunodeficiency Virus Medical Providers' Knowledge and Attitudes About the Affordable Care Act. CLINICAL INFECTIOUS DISEASES, 67(9), 1403-1410. doi:10.1093/cid/ciy296
2017
Schafer, K. R., Albrecht, H., Dillingham, R., Hogg, R. S., Jaworsky, D., Kasper, K., . . . Ohl, M. E. (2017). The Continuum of HIV Care in Rural Communities in the United States and Canada: What Is Known and Future Research Directions. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 75(1), 35-44. doi:10.1097/QAI.0000000000001329
Liu, P., Dillingham, R., & McManus, K. A. (2017). Hospital days attributable to immune reconstitution inflammatory syndrome in persons living with HIV before and after the 2012 DHHS HIV guidelines (vol 14, 25, 2017). AIDS RESEARCH AND THERAPY, 14. doi:10.1186/s12981-017-0155-x
Liu, P., Dillingham, R., & McManus, K. (2017). Hospital days attributable to immune reconstitution inflammatory syndrome in persons living with HIV before and after the 2012 DHHS HIV guidelines. AIDS RESEARCH AND THERAPY, 14. doi:10.1186/s12981-017-0152-0
2016
McManus, K. A., Rodney, R. C., Rhodes, A., Bailey, S., & Dillingham, R. (2016). Affordable Care Act Qualified Health Plan Enrollment for AIDS Drug Assistance Program Clients: Virginia's Experience and Best Practices. AIDS RESEARCH AND HUMAN RETROVIRUSES, 32(9), 885-891. doi:10.1089/aid.2016.0033
McManus, K. A., McGonigle, K. M., Engelhard, C. L., & Dillingham, R. (2016). PPACA and Low-Income People Living with HIV: 2014 Qualified Health Plan Enrollment in a Medicaid Nonexpansion State. SOUTHERN MEDICAL JOURNAL, 109(6), 371-377. doi:10.14423/SMJ.0000000000000469
McManus, K. A., Rhodes, A., Bailey, S., Yerkes, L., Engelhard, C. L., Ingersoll, K. S., . . . Dillingham, R. (2016). Affordable Care Act Qualified Health Plan Coverage: Association With Improved HIV Viral Suppression for AIDS Drug Assistance Program Clients in a Medicaid Nonexpansion State. CLINICAL INFECTIOUS DISEASES, 63(3), 396-403. doi:10.1093/cid/ciw277
Millard, M. A., McManus, K. A., & Wispelwey, B. (2016). Severe Sepsis due to Clostridium perfringens Bacteremia of Urinary Origin: A Case Report and Systematic Review. CASE REPORTS IN INFECTIOUS DISEASES, 2016. doi:10.1155/2016/2981729
2014
Cresce, N. D., McManus, K. A., Sifri, C. D., & Wilson, B. B. (2014). Encephalopathy despite thiamine repletion during alcohol withdrawal. CLEVELAND CLINIC JOURNAL OF MEDICINE, 81(6), 350-352. doi:10.3949/ccjm.81a.13103
McManus, K. A., Pinkerton, R., & Dillingham, R. (2014). Effects of recent Virginia AIDS Drug Assistance Program policy changes on diabetes and hyperlipidemia control in people living with HIV. SAGE OPEN MEDICINE, 2. doi:10.1177/2050312114532809
2013
Huang, J. C., Gold, S., McManus, K. A., & Wispelwey, B. (2013). Case report: Rhabdomyolysis in the setting of acute human immunodeficiency virus infection. Case Reports in Clinical Medicine, 02(03), 198-202. doi:10.4236/crcm.2013.23054
McManus, K. A., Engelhard, C. L., & Dillingham, R. (2013). Current Challenges to the United States' AIDS Drug Assistance Program and Possible Implications of the Affordable Care Act. AIDS RESEARCH AND TREATMENT, 2013. doi:10.1155/2013/350169
2010
Lum, C., McAndrews, M. P., Holodny, A. I., McManus, K. A., Crawley, A., Chakraborty, S., & Mikulis, D. J. (2011). Investigating Agenesis of the Corpus Callosum Using Functional MRI: A Study Examining Interhemispheric Coordination of Motor Control. JOURNAL OF NEUROIMAGING, 21(1), 65-68. doi:10.1111/j.1552-6569.2009.00430.x