Guo, Lian-Wang
Primary Appointment
Tenured Professor, Surgery
Education
- PhD, Plant Physiology, Chinese Academy of Sciences
Contact Information
409 Lane Rd, MR4(building), Room 2146
Charlottesville, VA 22903
Telephone: 4349241276
Email: lg8zr@virginia.edu
Website: https://pubmed.ncbi.nlm.nih.gov/?term=lian-wang+guo+OR+lianwang+guo&sort=pubdate
Research Disciplines
Biophysics, Epigenetics, Experimental Pathology, Molecular Biology, Molecular Physiology and Biological Physics, Retinal Neuroscience, Vascular Epigentics
Research Interests
Vascular wall remodeling, intimal hyperplasia, stenosis, aneurysm, retinal degeneration.
Research Description
The Guo lab studies vascular wall remodeling and retinal degeneration, with a focus on the role of histone-code readers and writers in driving cell phenotypic transitions. We aim to uncover new therapeutic targets for intervention to avert pathogenic cell states. Our research follows a trajectory from mechanistic investigation to therapeutic translation. For example, we delve into basic research on epigenetic dysregulations underlying post-surgery vascular wall thickening and stenosis. Concurrently, we are pioneering precision delivery strategies for chromatin-modulating "epi-drugs" in collaboration with surgeons and engineers. One innovative approach involves developing bio-adhesive nanoparticles suitable for painting on vein grafts to maintain graft patency. Another strategy is tailored for suppressing post-angioplasty restenosis by crafting injectable biomembrane-camouflaged delivery systems that home onto lesion sites. These initiatives have led to approved and pending patents. Our overarching goal is to tackle challenging medical issues by targeting dysregulated epigenetic mechanisms through seamless transitions from bench discoveries to translational innovations.