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Marc D. Breton

Marc D. Breton

Professor of Psychiatry and Neurobehavioral Sciences, Psychiatry and Neurobehavioral Sciences

Email
[email protected]

Bio & Overview

Dr. Breton’s research interests include modeling and simulation of blood glucose dynamics and the regulatory hormones network; modeling and simulation of the effect of exercise on glucose/insulin dynamics; modeling of the heart-glucose dynamics relationship; the artificial pancreas in diabetes: subcutaneous sensing/actuation closed loop systems; and optimization of continuous glucose sensor via signal processing and time series.

Academic Information

Department
Psychiatry and Neurobehavioral Sciences
Academic Title
Faculty

Primary Education

  • MS, Control Engineering, Ecole Centrale de Lille, 2001
  • PhD, System Engineering, University of Virginia, 2004

Other Appointments

  • Faculty, Systems and Information Engineering

Research Interests

Modeling and simulation of blood glucose dynamics and the regulatory hormones network; modeling and simulation of the effect of exercise on glucose/insulin dynamics; modeling of the heart-glucose dynamics relationship,

Selected Publications

2026

A nationwide 12‐month observatory of automated insulin delivery shows improved glucose control, sustained adoption, and reduced acute severe events
Riveline, Jean-Pierre, Julla, Jean-Baptiste, Bonnemaison, Elisabeth, Joubert, Michael, Lablanche, Sandrine, Gazagnes, Agnès Sola, Demarsy, Delphine, Gouet, Didier, Schaepelynck, Pauline, Amouyal, Chloé, Vale, Fabienne Dalla, Schletzer-Mari, Anne, Clavel, Sylvaine, Spiteri, Anne, Campinos, Catherine, Favre, Sandrine, Tauveron, Igor, Mathivon, Laurence, Borot, Sophie, Fagherazzi, Guy, Breton, Marc D., Gautier, Jean-François, Renard, EricDiabetes, Obesity and Metabolism2026; 28(2): 1179 - 1190.DOI: 10.1111/DOM.70302

 

 
A Performance-Based Adaptation Index for Automated Insulin Delivery Systems
Diaz C., Jenny L., Colmegna, Patricio, Pryor, Elliot, Breton, Marc D. Journal of Diabetes Science and Technology2026; 20(3): 942 - 953.DOI: 10.1177/19322968251315499

 

 
Accounting for Hypoglycemia Treatments in Continuous Glucose Metrics
Pryor, Elliott C., El Fathi, Anas, Breton, Marc D. Journal of Diabetes Science and Technology2026; 20(4): 1276 - 1284.DOI: 10.1177/19322968251329952

 

 
Glucose Predictions Improve Glycemic Control: A Digital Twin Evaluation
Herrero, Pau, Andorrà, Magí, Breton, Marc D., Peak, Ajandek, Koehler, Matthias, Klopfenstein, Yannick, Leppäaho, Eemeli, Zanon, Mattia, Ringemann, Christian, Lustenberger, Patrick, Glatzer, TimorDiabetes Technology and Therapeutics2026;DOI: 10.1177/15209156261432144

 

 
Human factors in the use and efficacy of decision support technologies for type 1 diabetes: evidence from a randomized controlled trial
Pavan, Jacopo, Nass, Ralf, Fabris, Chiara, Fathi, Anas El, Emory, Emma G., Santini, Giulio, Batista, Annanda M.F.B., Oliveri, Mary C., Koravi, Chaitanya K.L., Barnett, Charlie L., Barnard-Kelly, Katharine, Gonder-Frederick, Linda, Breton, Marc D. Diabetes Research and Clinical Practice2026; 231: 113049.DOI: 10.1016/J.DIABRES.2025.113049

 

 
Retrospective validation of digital twin therapy recommendations for type 1 diabetes using free-living data
Villa-Tamayo, María F., Vauchaussade, Gaspard, Pavan, Jacopo, El Fathi, Anas, Colmegna, Patricio, Breton, Marc D. IFAC Journal of Systems and Control2026; 100435.DOI: 10.1016/J.IFACSC.2026.100435

 

 
Safety and Feasibility of a Fully Automated Insulin Delivery System: FCL@Home, a Multicenter Randomized Clinical Trial in Individuals With Type 1 Diabetes
Moscoso-Vasquez, Marcela, Ekhlaspour, Laya, Brown, Sue A., DeBoer, Mark D., Berget, Cari, Cobry, Erin C., Wadwa, R. Paul, Capodanno, Gina, Cengiz, Eda, Wong, Jenise C., Pryor, Elliott C., Villa-Tamayo, Maria F., Holmes, Viola, Davis Prince, Sara, Escobar, Estella, Towers, Lindsey, Hosseininpour, Yasaman, Narayan, Avani, Koravi, Chaitanya L.K., Nguyen, Taylor, Fulkerson, David, Barnett, Charlotte L., Oliveri, Mary C., Breton, Marc D., Forlenza, Gregory P., Fathi, Anas E.L.Diabetes Care2026; 49(3): 401 - 409.DOI: 10.2337/DC25-1526

 

 
Safety and Feasibility of Algorithmic Continuous Glucose Monitoring-Based Titration in People with Type 2 Diabetes Using Insulin Degludec, With or Without Noninsulin Glucose-Lowering Drugs: A 16-Week Randomized Controlled Trial
El Fathi, Anas, Nass, Ralf, Levy, Carol J., Levister, Camilla, O’Malley, Grenye, Shah, Nirali A., Hassan, Shaziah, Quainoo, Cheryl, Koravi, Chaitanya L.K., Nguyen, Taylor N., Santini, Giulio Matteo, Emory, Emma, Alix, Carlene, Flanagan, Dillon K., Fulkerson, David, Clancy Oliveri, Mary, Laugesen, Christian, Lindeløv, Jonas K., Hansen, Peter W., Breton, Marc D. Diabetes Technology and Therapeutics2026;DOI: 10.1177/15209156261420193

 

 

2025

310-OR: Randomized Controlled Study of Algorithmic CGM-Based Degludec Titration in People with Type 2 Diabetes
EL FATHI, ANAS, NASS, RALF, LEVY, CAROL J., LEVISTER, CAMILLA, O'MALLEY, GRENYE, SHAH, NIRALI, EMORY, EMMA, FLANAGAN, DILLON, HANSEN, PETER W., BRETON, MARC D. Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-310-OR

 

 
653-P: Psychosocial Factors and Technology Perceptions Are Associated with Glycemic Outcomes in Fully Closed Loop Systems (FCL)
FERNANDES MOURA B BATISTA, ANNANDA, MOSCOSO-VASQUEZ, MARCELA, BROWN, SUE A., DEBOER, MARK D., GONDER-FREDERICK, LINDA, BRETON, MARC D. Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-653-P

 

 
918-P: Fully Closed Loop (FCL) System Improves Glycemic Control through Personalized Adaptation of Individual Insulin Needs in Adults, Young Adults, and Adolescents with Type 1 Diabetes (T1D)
MOSCOSO-VASQUEZ, MARCELA, FLANAGAN, DILLON, CLANCY-OLIVERI, MARY, ESCOBAR, ESTELLA, FULKERSON, DAVID, FORLENZA, GREGORY P., EKHLASPOUR, LAYA, BROWN, SUE A., BRETON, MARC D. Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-918-P

 

 
919-P: Sex Differences in Glycemic Outcomes Using Fully Automated Closed Loop (FCL) System in Type 1 Diabetes (T1D)—Insights and Implications
MOSCOSO-VASQUEZ, MARCELA, HOSSEINIPOUR, JASMINE Y., FLANAGAN, DILLON, FULKERSON, DAVID, BROWN, SUE A., EKHLASPOUR, LAYA, FORLENZA, GREGORY P., BRETON, MARC D., CENGIZ, EDADiabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-919-P

 

 
928-P: AI-Based Fully Closed Loop (FCL) Achieves Improved Glycemia vs. Hybrid Closed Loop (HCL) in People with Type 1 Diabetes (T1D)
FORLENZA, GREGORY P., MOSCOSO-VASQUEZ, MARCELA, BROWN, SUE A., CAPODANNO, GINA, CENGIZ, EDA, COBRY, ERIN C., DEBOER, MARK D., PAUL WADWA, R., WONG, JENISE C., EKHLASPOUR, LAYA, BRETON, MARC D. Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-928-P

 

 
939-P: People with Type 1 Diabetes (T1D) with High Baseline A1Cs Experience Drastic Glycemic Outcomes from Use of the Automated Insulin Delivery as Adaptive Network (AIDANET) Fully Closed Loop (FCL) System
TOWERS, LINDSEY, ESCOBAR, ESTELLA, NARAYAN, AVANI, HOSSEINIPOUR, JASMINE Y., MOSCOSO-VASQUEZ, MARCELA, EKHLASPOUR, LAYA, BRETON, MARC D., FORLENZA, GREGORY P.Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-939-P

 

 
949-P: Meal Composition and Postprandial Glucose (PPG) Excursions in a Fully Closed-Loop (FCL) Study
EKHLASPOUR, LAYA, HOSSEINIPOUR, JASMINE Y., NARAYAN, AVANI, PEREZ, ZACHARY D., HOLMES, VIOLA, BRETON, MARC D., BROWN, SUE A., FORLENZA, GREGORY P., CENGIZ, EDADiabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-949-P

 

 
963-P: Use of a Fully Closed Loop (FCL) System Improves Glycemic Outcomes in Youth and Adults with Type 1 Diabetes (T1D) Not Meeting Glycemic Goals
WONG, JENISE C., MOSCOSO-VASQUEZ, MARCELA, EKHLASPOUR, LAYA, BROWN, SUE A., BRETON, MARC D., FORLENZA, GREGORY P.Diabetes2025; 74(Supplement_1):.DOI: 10.2337/DB25-963-P

 

 
A Comparative Study of Transformer-Based Models for Multi-Horizon Blood Glucose Prediction
Karagoz, Meryem Altin, Breton, Marc D., El Fathi, AnasIFAC-PapersOnLine2025; 59(2): 155 - 160.DOI: 10.1016/J.IFACOL.2025.06.027

 

 
Algorithm-Driven Initiation and Adaptation of Hybrid Closed-Loop in Young Children with Type 1 Diabetes: A Pilot Study
Pavan, Jacopo, Cobry, Erin, Reed, Zachariah W., Villa-Tamayo, María F., Diaz C, Jenny L., DeBoer, Mark D., Schoelwer, Melissa, Jost, Emily, Kingman, Ryan, Holmes, Viola, Lum, John W., Koravi, Chaitanya L.K., Buckingham, Bruce, Beck, Roy, Wadwa, R. Paul, Breton, Marc D. Diabetes Technology and Therapeutics2025; 27(8): 587 - 596.DOI: 10.1089/DIA.2024.0650
 
Aligning Insulin Therapy with Individual Preferences: A Multi-objective Decision Support System
Pryor, Elliott C., Villa-Tamayo, María F., Pavan, Jacopo, Breton, Marc D. IFAC-PapersOnLine2025; 59(2): 167 - 172.DOI: 10.1016/J.IFACOL.2025.06.029

 

 
An Algorithm for Retrospectively Detecting Missing Meal Records in Type 1 Diabetes Datasets
Pavan, Jacopo, Villa-Tamayo, María F., Breton, Marc IFAC-PapersOnLine2025; 59(2): 85 - 90.DOI: 10.1016/J.IFACOL.2025.06.015

 

 
Artificial Intelligence in Diabetes Care: Applications, Challenges, and Opportunities Ahead
Parab, Rohit, Feeley, Jenna M., Valero, Maria, Chadalawada, Laya, Garcia, Gian-Gabriel P., Kar, Sudeshna Sil, Madabhushi, Anant, Breton, Marc D., Li, Jing, Shao, Hui, Pasquel, Francisco J.Endocrine Practice2025; 31(12): 1615 - 1625.DOI: 10.1016/J.EPRAC.2025.07.008

 

 
Capillary Ketone Monitoring–Guided Adaptation of Automated Insulin Delivery to Accommodate a Ketogenic Diet in an Individual With Type 1 Diabetes: Case Study and Literature Review
Lin, Ashley S., Horton, William B., Breton, Marc D., Stumpf, Meaghan M.Clinical Diabetes2025; 43(5): 858 - 860.DOI: 10.2337/CD25-0068

 

 
Data-Driven Anticipation of Meal Intakes for Automated Insulin Delivery Systems with Model Predictive Control Technology
Castillo, A., Breton, M. IFAC-PapersOnLine2025; 59(2): 55 - 60.DOI: 10.1016/J.IFACOL.2025.06.010

 

 
Distribution-based sub-population selection (DSPS): A method for in-silico reproduction of clinical trials outcomes
Ganji, Mohammadreza, El Fathi, Anas, Fabris, Chiara, Lv, Dayu, Kovatchev, Boris, Breton, Marc Computers in Biology and Medicine2025; 186: 109714.DOI: 10.1016/J.COMPBIOMED.2025.109714

 

 
Early Stages of Automated Insulin Delivery
Zisser, Howard, Hovorka, Roman, Basu, Ananda, Battelino, Tadej, Boughton, Charlotte K., Breton, Marc D., Buckingham, Bruce A., Brown, Sue A., Cherñavvsky, Daniel R., Dassau, Eyal, DeBoer, Mark D., Doyle, Francis J., Ekhlaspour, Laya, Fabris, Chiara, Forlenza, Gregory P., Haidar, Ahmad, Klonoff, David C., Kovatchev, Boris, Kowalski, Aaron J., Levy, Carol J., Kudva, Yogish C., Maahs, David M., Phillip, Moshe, Renard, Eric, Russell, Steven J., Shah, Viral N., Steil, Garry M., Wadwa, R. Paul, Weinzimer, Stuart A.Diabetes Technology and Therapeutics2025; 27(3_suppl):.DOI: 10.1089/DIA.2025.18802.HZ

 

 
Early Stages of Automated Insulin Delivery
Zisser, Howard, Hovorka, Roman, Basu, Ananda, Battelino, Tadej, Boughton, Charlotte K., Breton, Marc D., Buckingham, Bruce A., Brown, Sue A., Cherñavvsky, Daniel R., Dassau, Eyal, DeBoer, Mark D., Doyle, Francis J., Ekhlaspour, Laya, Fabris, Chiara, Forlenza, Gregory P., Haidar, Ahmad, Klonoff, David C., Kovatchev, Boris, Kowalski, Aaron J., Levy, Carol J., Kudva, Yogish C., Maahs, David M., Phillip, Moshe, Renard, Eric, Russell, Steven J., Shah, Viral N., Steil, Garry M., Wadwa, R. Paul, Weinzimer, Stuart A.Journal of Diabetes Science and Technology2025; 19(4): 908 - 923.DOI: 10.1177/19322968251335685

 

 
Evaluation of an Automated Priming Bolus for Improving Prandial Glucose Control in Full Closed Loop Delivery
Moscoso-Vasquez, Marcela, Colmegna, Patricio, Barnett, Charlotte, Fuller, Morgan, Koravi, Chaitanya L.K., Brown, Sue A., DeBoer, Mark D., Breton, Marc D. Diabetes Technology and Therapeutics2025; 27(2): 93 - 100.DOI: 10.1089/DIA.2024.0315
 
Evolution of the Artificial Pancreas: Components and Integration—CGMs, Insulin, and AP Systems
Bergenstal, Richard M., Heller, Adam, Breton, Marc D., Vigersky, Robert, Brown, Susan A., Forlenza, Gregory P., Sherr, Jennifer L., Hovorka, Roman, Russell, Steven J., Damiano, Edward R., Putman, Melissa S., Beck, Roy W., Renard, Eric, Lal, Rayhan, Cobelli, Claudio, Dassau, Eyal, Akturk, Halis K., Weiss, Michael A., Skyler, Jay S.Journal of Diabetes Science and Technology2025; 19(4): 883 - 894.DOI: 10.1177/19322968251342239

 

 
Evolution of the Artificial Pancreas: Components and Integration—CGMs, Insulin, and AP Systems
Bergenstal, Richard M., Heller, Adam, Breton, Marc D., Vigersky, Robert, Brown, Susan A., Forlenza, Gregory P., Sherr, Jennifer L., Hovorka, Roman, Russell, Steven J., Damiano, Edward R., Putman, Melissa S., Beck, Roy W., Renard, Eric, Lal, Rayhan, Cobelli, Claudio, Dassau, Eyal, Akturk, Halis K., Weiss, Michael A., Skyler, Jay S.Diabetes Technology and Therapeutics2025; 27(3_suppl):.DOI: 10.1089/DIA.2025.18801.RMB

 

 
In-silico Assessment of Using Faster Insulin Analogs in Automated Insulin Delivery (AID) Systems Without Meal Announcement
Moscoso-Vasquez, Marcela, Breton, Marc D. IFAC-PapersOnLine2025; 59(2): 19 - 24.DOI: 10.1016/J.IFACOL.2025.06.004

 

 
In-Silico Validation of Parameter Optimization Strategies for Automated Insulin Delivery Systems using the UVA Replay Simulation Technology
Villa-Tamayo, María F., Pavan, Jacopo, Breton, Marc IFAC-PapersOnLine2025; 59(2): 127 - 132.DOI: 10.1016/J.IFACOL.2025.06.022

 

 
Metabolic Models, in Silico Trials, and Algorithms
Cinar, Ali, Basu, Ananda, Bequette, B. Wayne, Breton, Marc D., Buckingham, Bruce, Cengiz, Eda, Cobelli, Claudio, Dassau, Eyal, Doyle, Francis J., Fabris, Chiara, Facchinetti, Andrea, Hirsch, Irl, Hovorka, Roman, Jacobs, Peter G., Kovatchev, Boris P., Dalla Man, Chiara, Quinn, Laurie, Skyler, JayDiabetes Technology and Therapeutics2025; 27(3_suppl):.DOI: 10.1089/DIA.2025.18800.AC

 

 
Metabolic Models, in Silico Trials, and Algorithms
Cinar, Ali, Basu, Ananda, Bequette, B. Wayne, Breton, Marc D., Buckingham, Bruce, Cengiz, Eda, Cobelli, Claudio, Dassau, Eyal, Doyle, Francis J., Fabris, Chiara, Facchinetti, Andrea, Hirsch, Irl, Hovorka, Roman, Jacobs, Peter G., Kovatchev, Boris P., Dalla Man, Chiara, Quinn, Laurie, Skyler, JayJournal of Diabetes Science and Technology2025; 19(4): 895 - 907.DOI: 10.1177/19322968251338300

 

 
Miniaturized Neural Networks for Deploying Fully Closed Loop Insulin Delivery Systems: A Pilot Study Featuring Flexible Meal Announcement Options
Pryor, Elliott C., Moscoso-Vasquez, Marcela, Fulkerson, David, Holmes, Viola, Prince, Sara Davis, Koravi, Chaitanya L. K., El Fathi, Anas, Brown, Sue A., DeBoer, Mark D., Breton, Marc D. Journal of Diabetes Science and Technology2025; 19(6): 1464 - 1470.DOI: 10.1177/19322968251364283

 

 
 
Neural Networks for On-Chip Model Predictive Control: A Method to Build Optimized Training Datasets and its Application to Type-1 Diabetes
Castillo, Alberto, Pryor, Elliot, El Fathi, Anas, Kovatchev, Boris, Breton, Marc IEEE Transactions on Cybernetics2025; 55(7): 3062 - 3072.DOI: 10.1109/TCYB.2025.3562032

 

 
POGO: A Method for individualization of Automated Insulin Delivery Systems
Pryor, Elliott C., Moscoso-Vasquez, Marcela, Breton, Marc D. IFAC-PapersOnLine2025; 59(2): 43 - 48.DOI: 10.1016/J.IFACOL.2025.06.008

 

 
Postprandial Glucose Turnover Differs Between Adolescents and Adults With Type 1 Diabetes: Triple Tracer Mixed Meal Study
Romeres, Davide, Ruchi, F N U, Breton, Marc D, Basu, Ananda, DeBoer, Mark DJournal of Clinical Endocrinology and Metabolism2025; 110(3): 730 - 738.DOI: 10.1210/CLINEM/DGAE585

 

 
Registration and Real-Life Studies on Automated Insulin Delivery Systems
Akturk, Halis Kaan, Brown, Sue A., Beck, Roy W., Sherr, Jennifer L., Bergenstal, Richard M., Kovatchev, Boris P., Vigersky, Robert, Breton, Marc D., Hovorka, Roman, Klonoff, David C., Garg, Satish K.Journal of Diabetes Science and Technology2025; 19(4): 924 - 936.DOI: 10.1177/19322968251334993

 

 
Registration and Real-Life Studies on Automated Insulin Delivery Systems
Akturk, Halis Kaan, Brown, Sue A., Beck, Roy W., Sherr, Jennifer L., Bergenstal, Richard M., Kovatchev, Boris P., Vigersky, Robert, Breton, Marc D., Hovorka, Roman, Klonoff, David C., Garg, Satish K.Diabetes Technology and Therapeutics2025; 27(3_suppl):.DOI: 10.1089/DIA.2025.0130

 

 
Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems
Jacobs, Peter G., Levy, Carol J., Brown, Sue A., Riddell, Michael C., Cinar, Ali, Boughton, Charlotte K., Breton, Marc D., Dassau, Eyal, Forlenza, Greg, Henderson, Robert J., Hovorka, Roman, Maahs, David M., Munshi, Medha, Murphy, Helen, Polsky, Sarit, Pratley, Richard, Putman, Melissa S., Shah, Viral N., Wilson, Leah M., Zisser, Howard, Ekhlaspour, LayaDiabetes Technology and Therapeutics2025; 27(3_suppl):.DOI: 10.1089/DIA.2025.0129

 

 
Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems
Jacobs, Peter G., Levy, Carol J., Brown, Sue A., Riddell, Michael C., Cinar, Ali, Boughton, Charlotte K., Breton, Marc D., Dassau, Eyal, Forlenza, Greg, Henderson, Robert J., Hovorka, Roman, Maahs, David M., Munshi, Medha, Murphy, Helen, Polsky, Sarit, Pratley, Richard, Putman, Melissa S., Shah, Viral N., Wilson, Leah M., Zisser, Howard, Ekhlaspour, LayaJournal of Diabetes Science and Technology2025; 19(4): 937 - 949.DOI: 10.1177/19322968251338754

 

 
The Virtual DCCT: Adding Continuous Glucose Monitoring to a Landmark Clinical Trial for Prediction of Microvascular Complications
Kovatchev, Boris P., Lobo, Benjamin, Fabris, Chiara, Ganji, Mohammadreza, El Fathi, Anas, Breton, Marc D., Kanapka, Lauren, Kollman, Craig, Battelino, Tadej, Beck, Roy W.Diabetes Technology and Therapeutics2025; 27(3): 209 - 216.DOI: 10.1089/DIA.2024.0404

 

 
Toward Personalized Decision Support Systems for Type 1 Diabetes: Integrating Psychobehavioral Factors and Glycemic Control
Ganji, Mohammadreza, Koravi, Leela Krishna Chaitanya, Breton, Marc, Fabris, ChiaraJournal of Diabetes Science and Technology2025; 19(5): 1172 - 1182.DOI: 10.1177/19322968251359641

 

 

2024

75-OR: In-Silico Replay of Insulin Degludec and Liraglutide Clinical Trial Data in Subjects with Type 2 Diabetes
GANJIARJENAKI, MOHAMMADREZA, FABRIS, CHIARA, EL FATHI, ANAS, LV, DAYU, KOVATCHEV, BORIS, BRETON, MARC D. Diabetes2024; 73(Supplement_1):.DOI: 10.2337/DB24-75-OR

 

 
Adjusting Therapy Profiles When Switching to Ultra-Rapid Lispro in an Advanced Hybrid Closed-Loop System: An in Silico Study
Colmegna, Patricio, Diaz C., Jenny L., Garcia-Tirado, Jose, DeBoer, Mark D., Breton, Marc D. Journal of Diabetes Science and Technology2024; 18(3): 676 - 685.DOI: 10.1177/19322968221140401

 

 
Analysis on the Practical Identifiability of the Subcutaneous Oral Glucose Minimal Model
Villa-Tamayo, María F., Pavan, Jacopo, Breton, Marc IFAC-PapersOnLine2024; 58(24): 269 - 274.DOI: 10.1016/J.IFACOL.2024.11.048

 

 
Artificial Intelligence and Machine Learning for Improving Glycemic Control in Diabetes: Best Practices, Pitfalls, and Opportunities
Zarkogianni, Konstantia, Herrero, Pau, Castle, Jessica R., Nikita, Konstantina S., Vehi, Josep, Kovatchev, Boris, Bondia, Jorge, Doyle, Francis J., Cinar, Ali, Breton, Marc D., Mosquera-Lopez, Clara, Narayan, Rahul, Jacobs, Peter G., Facchinetti, Andrea, Battelino, TadejIEEE Reviews in Biomedical Engineering2024; 17: 19 - 41.DOI: 10.1109/RBME.2023.3331297

 

 
Attention Networks for Personalized Mealtime Insulin Dosing in People with Type 1 Diabetes
Fathi, Anas El, Pryor, Elliott, Breton, Marc D. IFAC-PapersOnLine2024; 58(24): 245 - 250.DOI: 10.1016/J.IFACOL.2024.11.044

 

 
Integration of a Safety Module to Prevent Rebound Hypoglycemia in Closed-Loop Artificial Pancreas Systems
Villa-Tamayo, María F., Colmegna, Patricio, Breton, Marc D. Journal of Diabetes Science and Technology2024; 18(2): 318 - 323.DOI: 10.1177/19322968231212205

 

 
Patient reported outcomes (PROs) and user experiences of young children with type 1 diabetes using t:slim X2 insulin pump with control-IQ technology
Hood, Korey K., Schneider-Utaka, Aika K., Reed, Zachariah W., Buckingham, Bruce A., Cobry, Erin, DeBoer, Mark D., Ekhlaspour, Laya, Schoelwer, Melissa, Paul Wadwa, R., Lum, John, Kollman, Craig, Beck, Roy W., Breton, Marc D. Diabetes Research and Clinical Practice2024; 208: 111114.DOI: 10.1016/J.DIABRES.2024.111114

 

 
Sustained 3-Year Improvement of Glucose Control With Hybrid Closed Loop in Children With Type 1 Diabetes While Going Through Puberty
Bismuth, Élise, Tubiana-Rufi, Nadia, Rynders, Corey A., Dalla-Vale, Fabienne, Bonnemaison, Elisabeth, Coutant, Régis, Farret, Anne, Poidvin, Amélie, Bouhours-Nouet, Natacha, Storey, Caroline, Donzeau, Aurélie, DeBoer, Mark D., Breton, Marc D., Villard, Orianne, Renard, ÉricDiabetes Care2024; 47(9): 1696 - 1703.DOI: 10.2337/DC24-0916

 

 
Use of diabetes technology in children
Schoelwer, Melissa J., DeBoer, Mark D., Breton, Marc D. Diabetologia2024; 67(10): 2075 - 2084.DOI: 10.1007/S00125-024-06218-0

 

 
Validation of the UVA Simulation Replay Methodology Using Clinical Data: Reproducing a Randomized Clinical Trial
Villa-Tamayo, María F., Colmegna, Patricio, Breton, Marc Diabetes Technology and Therapeutics2024; 26(10): 720 - 727.DOI: 10.1089/DIA.2023.0595

 

 

2023

277-OR: AID-Driven TIR Improvements in Young MDI Children with T1D Are Indistinguishable from Their Pump-Using Peers—A PEDAP Subanalysis
BRETON, MARC D., BUCKINGHAM, BRUCE A., DEBOER, MARK D., EKHLASPOUR, LAYA, FORLENZA, GREGORY P., SCHOELWER, MELISSA, PAUL WADWA, R., LUM, JOHN W., BECK, ROYDiabetes2023; 72(Supplement_1):.DOI: 10.2337/DB23-277-OR

 

 
59-OR: Glycemic Control with Extended Use of Automated Insulin Delivery (AID) in Children Age 2–6 Years with Type 1 Diabetes (T1D)
PAUL WADWA, R., REED, ZACHARIAH, BUCKINGHAM, BRUCE A., DEBOER, MARK D., EKHLASPOUR, LAYA, COBRY, ERIN C., SCHOELWER, MELISSA, BERGET, CARI, LUM, JOHN W., KOLLMAN, CRAIG, BECK, ROY, BRETON, MARC D., TRIAL STUDY GROUP, PEDAPDiabetes2023; 72(Supplement_1):.DOI: 10.2337/DB23-59-OR

 

 
899-P: Patient Reported Outcomes (PROs) for Young Children Using the Control IQ Hybrid Closed-Loop System (CIQ)
SCHNEIDER-UTAKA, AIKA, REED, ZACHARIAH, BUCKINGHAM, BRUCE A., COBRY, ERIN C., DEBOER, MARK D., EKHLASPOUR, LAYA, SCHOELWER, MELISSA, PAUL WADWA, R., LUM, JOHN W., KOLLMAN, CRAIG, BECK, ROY, BRETON, MARC D., HOOD, KOREY K., TRIAL STUDY GROUP, PEDAPDiabetes2023; 72(Supplement_1):.DOI: 10.2337/DB23-899-P

 

 
924-P: Glycemic Outcomes Improved and Maintained Regardless of Demographic Characteristics of Young Children with Type 1 Diabetes Using Closed-Loop System
DEBOER, MARK D., FORLENZA, GREGORY P., KINGMAN, RYAN S., SCHOELWER, MELISSA, WADWA, R. PAUL, LUM, JOHN W., KOLLMAN, CRAIG, BECK, ROY, BRETON, MARC D., EKHLASPOUR, LAYA, REED, ZACHARIAH, BUCKINGHAM, BRUCE A.Diabetes2023; 72(Supplement_1):.DOI: 10.2337/DB23-924-P

 

 
 
A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings
Shah, Viral N., Forlenza, Gregory P., Lind, Marcus, O’Neal, David N., Kerr, David, Nichols, James H., Cook, Curtiss B., Fleming, G. Alexander, Phillip, Moshe, Xu, Nicole Y., Nguyen, Kevin T., Klonoff, David C., Danne, Thomas, Mohan, Viswanathan, Mayorov, Alexander, Wang, Jing, Li, Chengdong, Galindo, Rodolfo J., Umpierrez, Guillermo E., Pasquel, Francisco J., Lansang, M. Cecilia, Close, Kelly L., Gutow, Hanna A., Mahoney, Katherine M., Espinoza, Juan C., Clements, Mark A., Benhamou, Pierre-Yves, Wright, Eugene E., Joubert, Michael, Weinberg, Melissa E., Rodbard, David, Agus, Michael S. D., Wolpert, Howard, Simonson, Gregg, Rayman, Gerry, Zilbermint, Mihail, Doyle, Francis J., Battelino, Tadej, Ahn, David, Freckmann, Guido, Chase, James Geoffrey, Dungan, Kathleen M., Koliwad, Suneil K., Masharani, Umesh, Kohn, Michael A., Choudhary, Pratik, Drincic, Angela, Spanakis, Elias K., Basu, Ananda, Breton, Marc D., Kovatchev, Boris, Hovorka, Roman, Liepmann, Dorian, Sode, Koji, Waki, Kayo, Peters, Anne L., Hoang, Thanh D., Pop-Busui, Rodica, Edelman, Steven V., Nørgaard, Kirsten, Seley, Jane Jeffrie, Litchman, Michelle L., Wake, Deborah J., Blevins, Thomas, Armaiz-Pena, Gustavo, Hirsch, Irl B., Sherr, Jennifer L., Bailey, Timothy S., Polonsky, William H., Bekele, Sewagegn Yeshiwas, Wallia, Amisha, Philis-Tsimikas, Athena, Ejskjaer, Niels, Lal, Rayhan A., Miller, Joshua D., Heinemann, Lutz, Leiter, Lawrence A., Ji, Linong, Jendle, Johan H., Castle, Jessica R., Gomez, Ana Maria, Bequette, B. Wayne, Leelarathna, Lalantha, Messler, Jordan, Mankovsky, Boris, Chen, Kong Y., Mader, Julia K., Pieber, Thomas, Joshi, Shashank R., Russell, Steven J., Lee, Wei-An (Andy), Mathioudakis, Nestoras N., Rhee, Eun-Jung, Al-Sofiani, Mohammed E.Journal of Diabetes Science and Technology2023; 17(5): 1226 - 1242.DOI: 10.1177/19322968221085273
 
A Meta-Analysis of Randomized Trial Outcomes for the t:slim X2 Insulin Pump with Control-IQ Technology in Youth and Adults from Age 2 to 72
Beck, Roy W., Kanapka, Lauren G., Breton, Marc D., Brown, Sue A., Wadwa, R. Paul, Buckingham, Bruce A., Kollman, Craig, Kovatchev, BorisDiabetes Technology and Therapeutics2023; 25(5): 329 - 342.DOI: 10.1089/DIA.2022.0558

 

 
Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes
Brown, Sue A., Colmegna, Patricio, Diaz, Jenny L., Koravi, Chaitanya L. K., Barnett, Charlotte L., Oliveri, Mary C., Fuller, Morgan, Breton, Marc D., DeBoer, Mark D., Villard, Orianne, Garcia-Tirado, Jose, Esquivel-Zuniga, RebecaDiabetes Care2023; 46(9): 1652 - 1658.DOI: 10.2337/DC23-0119

 

 
Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice
Murphy, Helen R, Russell, Steven J, Leelarathna, Lalantha, Ekhlaspour, Laya, Beck, Roy W, Laffel, Lori, Ambler-Osborn, Louise, Choudhary, Pratik, Klonoff, David C, Bosi, Emanuele, Lal, Rayhan A, Maahs, David M, Buckingham, Bruce A, de Beaufort, Carine, Cobelli, Claudio, DeSalvo, Daniel J, Hartnell, Sara, Lawton, Julia, Doyle, Francis J, Castle, Jessica R, Kowalski, Aaron, Ward, Candice, Carlson, Anders L, Bergenstal, Richard M, Simonson, Gregg D, Criego, Amy B, Gershenoff, Dana C, Heinemann, Lutz, Hood, Korey K, Barnard-Kelly, Katharine, Riddell, Michael C, Phillip, Moshe, Nimri, Revital, Davis, Elizabeth, Nørgaard, Kirsten, Close, Kelly L, Cai, Albert, Shvalb, Naama Fisch, Isaacs, Diana, Blanchette, Julia E, Brown, Sue A, Kovatchev, Boris P, Breton, Marc D, Gonder-Frederick, Linda A, Parkin, Christopher G, Rodbard, David, DeVries, J Hans, Danne, Thomas, Biester, Sarah, Biester, Torben, Kordonouri, Olga, Messer, Laurel H, Forlenza, Gregory P, Garg, Satish K, Shah, Viral N, Wadwa, R Paul, Amiel, Stephanie A, Gallen, Geraldine, Wilmot, Emma G, Bally, Lia, Renard, Eric, Haidar, Ahmad, Hirsch, Irl B, O’Neal, David, Oser, Sean, Oser, Tamara, Heller, Simon, de Bock, Martin I, Schatz, Desmond A, Battelino, Tadej, Dovc, Klemen, Sherr, Jennifer L, Weinzimer, Stuart A, Boughton, Charlotte K, Hovorka, RomanEndocrine Reviews2023; 44(2): 254 - 280.DOI: 10.1210/ENDREV/BNAC022
 
Deep Neural Network Architectures for an Embedded MPC Implementation: Application to an Automated Insulin Delivery System
Castillo, A., Villa-Tamayo, M.F., Pryor, E., Garcia-Tirado, J., Colmegna, P., Breton, M. IFAC-PapersOnLine2023; 56(2): 11521 - 11526.DOI: 10.1016/J.IFACOL.2023.10.443

 

 
Evaluation of a Web-Based Simulation Tool for Self-Management Support in Type 1 Diabetes: A Pilot Study
Colmegna, Patricio, Bisio, Alessandro, McFadden, Ryan, Wakeman, Christian, Oliveri, Mary Clancy, Nass, Ralf, Breton, Marc IEEE Transactions on Information Technology in Biomedicine2023; 27(1): 515 - 525.DOI: 10.1109/JBHI.2022.3209090

 

 
Hybrid Closed Loop Overcomes the Impact of Missed or Suboptimal Meal Boluses on Glucose Control in Children with Type 1 Diabetes Compared to Sensor-Augmented Pump Therapy
Breton, Marc D., Bismuth, Elise, Storey, Caroline, Poidvin, Amélie, Tubiana-Rufi, Nadia, Bonnemaison, Elisabeth, Faure, Nathalie, Farret, Anne, Renard, Eric, Hamel, Jean François, Coutant, Régis, Bouhours-Nouet, Natacha, Levaillant, Lucie, Donzeau, Aurélie, Amsellem-Jager, Jessica, Quemener, Emmanuel, Trely, Jeanne, Morinais, Paul, Perrard, Maelys, Place, Jérôme, Dalla-Vale, FabienneDiabetes Technology and Therapeutics2023; 25(6): 395 - 403.DOI: 10.1089/DIA.2022.0518

 

 
Maximizing Glycemic Benefits of Using Faster Insulin Formulations in Type 1 Diabetes: In Silico Analysis Under Open- and Closed-Loop Conditions
Diaz C., Jenny L., Colmegna, Patricio, Breton, Marc D. Diabetes Technology and Therapeutics2023; 25(4): 219 - 230.DOI: 10.1089/DIA.2022.0468

 

 
Performance Effect of Adjusting Insulin Sensitivity for Model-Based Automated Insulin Delivery Systems
Moscoso-Vasquez, Marcela, Fabris, Chiara, Breton, Marc D. Journal of Diabetes Science and Technology2023; 17(6): 1470 - 1481.DOI: 10.1177/19322968231206798

 

 
Predicting Immunological Risk for Stage 1 and Stage 2 Diabetes Using a 1-Week CGM Home Test, Nocturnal Glucose Increments, and Standardized Liquid Mixed Meal Breakfasts, with Classification Enhanced by Machine Learning
Brown, Sue A., Farhy, Leon S., Montaser, Eslam, Breton, Marc D., Kovatchev, Boris, DeBoer, Mark D.Diabetes Technology and Therapeutics2023; 25(9): 631 - 642.DOI: 10.1089/DIA.2023.0064

 

 
Reshaping Model Predictive Control Penalties for an Automated Insulin Delivery System in Type 1 Diabetes
Moscoso-Vásquez, Marcela, Garcia-Tirado, Jose, Colmegna, Patricio, Breton, Marc IFAC-PapersOnLine2023; 56(2): 9660 - 9665.DOI: 10.1016/J.IFACOL.2023.10.274

 

 
Safety and Efficacy of Sustained Automated Insulin Delivery Compared With Sensor and Pump Therapy in Adults With Type 1 Diabetes at High Risk for Hypoglycemia: A Randomized Controlled Trial
Renard, Eric, Joubert, Michael, Villard, Orianne, Dreves, Bleuenn, Reznik, Yves, Farret, Anne, Place, Jerome, Breton, Marc D., Kovatchev, Boris P.Diabetes Care2023; 46(12): 2180 - 2187.DOI: 10.2337/DC23-0685

 

 
Therapy Settings Associated with Optimal Outcomes for t:slim X2 with Control-IQ Technology in Real-World Clinical Care
Messer, Laurel H., Breton, Marc D. Diabetes Technology & Therapeutics2023; 25(12): 877 - 882.DOI: 10.1089/DIA.2023.0308

 

 
Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes
Wadwa, R. Paul, Reed, Zachariah W., Buckingham, Bruce A., DeBoer, Mark D., Ekhlaspour, Laya, Forlenza, Gregory P., Schoelwer, Melissa, Lum, John, Kollman, Craig, Beck, Roy W., Breton, Marc D. New England Journal of Medicine2023; 388(11): 991 - 1001.DOI: 10.1056/NEJMOA2210834

 

 
Using Reinforcement Learning to Simplify Mealtime Insulin Dosing for People with Type 1 Diabetes: In-Silico Experiments
Fathi, Anas El, Breton, Marc D. IFAC-PapersOnLine2023; 56(2): 11539 - 11544.DOI: 10.1016/J.IFACOL.2023.10.446

 

 

2022

Accuracy of a Factory-Calibrated Continuous Glucose Monitor in Individuals With Diabetes on Hemodialysis
Basu, Ananda, Stumpf, Meaghan M., Breton, Marc D., Voelmle, Mary K., Fuller, Morgan R., Myers, Helen E., McFadden, Ryan K., Luke, Zander S., Wakeman, Christian A., Clancy-Oliveri, Mary, Villard, Orianne, Rao, SwatiDiabetes Care2022; 45(7): 1666 - 1669.DOI: 10.2337/DC22-0073

 

 
Assessment for Predictors of Rise in Hemoglobin A1c During Extended Use of a Closed-Loop Control System
Schoelwer, Melissa J., Bisio, Alessandro, Breton, Marc D., DeBoer, Mark D.Diabetes Technology and Therapeutics2022; 24(4): 285 - 288.DOI: 10.1089/DIA.2021.0405

 

 
Impact of a Novel Diabetes Support System on a Cohort of Individuals With Type 1 Diabetes Treated With Multiple Daily Injections: A Multicenter Randomized Study
Bisio, Alessandro, Anderson, Stacey, Norlander, Lisa, O’Malley, Grenye, Robic, Jessica, Ogyaadu, Selassie, Hsu, Liana, Levister, Camilla, Ekhlaspour, Laya, Lam, David W., Levy, Carol, Buckingham, Bruce, Breton, Marc D. Diabetes Care2022; 45(1): 186 - 193.DOI: 10.2337/DC21-0838

 

 
Improvements in Parental Sleep, Fear of Hypoglycemia, and Diabetes Distress With Use of an Advanced Hybrid Closed-Loop System
Cobry, Erin C., Bisio, Alessandro, Wadwa, R. Paul, Breton, Marc D. Diabetes Care2022; 45(5): 1292 - 1295.DOI: 10.2337/DC21-1778

 

 
Insulin Delivery and Glucose Variability Throughout the Menstrual Cycle on Closed Loop Control for Women with Type 1 Diabetes
Levy, Carol J., O'Malley, Grenye, Raghinaru, Dan, Kudva, Yogish C., Laffel, Lori M., Pinsker, Jordan E., Lum, John W., Brown, Sue A., Kovatchev, Boris, Anderson, Stacey, Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Gondor-Fredrick, Linda, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Isganaitis, Elvira, Ambler-Osborn, Louise, Flint, Emily, Kim, Kenny, Roethke, Lindsay, Mei Church, Mei, Andre, Camille, Piper, Molly, Lam, David, Levister, Camilla, Ogyaadu, Selassie, Lovett, Jessica, Simha, Vinaya, Dadlani, Vikash, McCrady-Spitzer, Shelly, Reid, Corey, Kumari, Kanchan, Wadwa, R. Paul, Forlenza, Greg, Alonso, G. Todd, Slover, Robert, Jost, Emily, Messer, Laurel, Berget, Cari, Towers, Lindsey, Rossick-Solis, Alex, Buckingham, Bruce, Ekhlaspour, Laya, Jacobson, Tali, Town, Marissa, Tabatabai, Ideen, Keller, Jordan, Salas, Evalina, Doyle, Francis, Dassau, Eyal, Beck, Roy, Passman, Samantha, Campos, Tiffany, Kollman, Craig, Murphy, Carlos, Patibandla, Nandan, Borgman, Sarah, Arreaza-Rubin, Guillermo, Eggerman, Thomas, Green, Neal, Kovatchev, Boris, Anderson, Stacey, Breton, Marc, Wadwa, R. Paul, Buckingham, Bruce, Doyle, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreaza-Rubin, Guillermo, Beck, Roy, Janicek, Robert, Gabrielson, Deanna, Belle, Steven H., Castle, Jessica, Green, Jennifer, Legault, Laurent, Willi, Steven M., Wysham, Carol, Eggerman, ThomasDiabetes Technology and Therapeutics2022; 24(5): 357 - 361.DOI: 10.1089/DIA.2021.0431

 

 
Insulin Replacement Across the Menstrual Cycle in Women with Type 1 Diabetes: An In Silico Assessment of the Need for Ad Hoc Technology
Diaz C., Jenny L., Fabris, Chiara, Breton, Marc D., Cengiz, EdaDiabetes Technology and Therapeutics2022; 24(11): 832 - 841.DOI: 10.1089/DIA.2022.0154

 

 
Modeling the Effect of Subcutaneous Lixisenatide on Glucoregulatory Endocrine Secretions and Gastric Emptying in Type 2 Diabetes to Simulate the Effect of iGlarLixi Administration Timing on Blood Sugar Profiles
Gautier, Thibault, Silwal, Rupesh, Saremi, Aramesh, Boss, Anders, Breton, Marc D. Journal of Diabetes Science and Technology2022; 16(2): 428 - 433.DOI: 10.1177/19322968211015671

 

 
Outcomes of hybrid closed‐loop insulin delivery activated 24/7 versus evening and night in free‐living prepubertal children with type 1 diabetes: A multicentre, randomized clinical trial
Renard, Eric, Tubiana-Rufi, Nadia, Bonnemaison, Elisabeth, Coutant, Régis, Dalla-Vale, Fabienne, Bismuth, Elise, Faure, Nathalie, Bouhours-Nouet, Natacha, Farret, Anne, Storey, Caroline, Donzeau, Aurélie, Poidvin, Amélie, Amsellem-Jager, Jessica, Place, Jérôme, Breton, Marc D. Diabetes, Obesity and Metabolism2022; 24(3): 511 - 521.DOI: 10.1111/DOM.14605

 

 
Safety and Feasibility Evaluation of Step Count Informed Meal Boluses in Type 1 Diabetes: A Pilot Study
Ozaslan, Basak, Brown, Sue A., Pinnata, Jennifer, Barnett, Charlotte L., Carr, Kelly, Wakeman, Christian A., Clancy-Oliveri, Mary, Breton, Marc D. Journal of Diabetes Science and Technology2022; 16(3): 670 - 676.DOI: 10.1177/1932296821997917

 

 
Smartwatch gesture‐based meal reminders improve glycaemic control
Buckingham, Bruce, Vleugels, Katelijn, Corbett, John P., Kollar, Laura, Breton, Marc D., Brown, Sue A., Lal, Rayhan A., Hsu, LianaDiabetes, Obesity and Metabolism2022; 24(8): 1667 - 1670.DOI: 10.1111/DOM.14737

 

 
Titration of Long-Acting Insulin Using Continuous Glucose Monitoring and Smart Insulin Pens in Type 1 Diabetes: A Model-Based Carbohydrate-Free Approach
El Fathi, Anas, Fabris, Chiara, Breton, Marc D. Frontiers in Endocrinology2022; 12:.DOI: 10.3389/FENDO.2021.795895

 

 
Use of an Ultrarapid Acting Insulin Analog with Control-IQ: A Case Report
Schoelwer, Melissa J., DeBoer, Mark D., Breton, Marc D., Kovatchev, Boris P.Diabetes Technology and Therapeutics2022; 24(11): 856 - 857.DOI: 10.1089/DIA.2022.0192

 

 
User and Healthcare Professional Perspectives on Do-It-Yourself Artificial Pancreas Systems: A Need for Guidelines
Shepard, Jaclyn A., Klonoff, David, Street, Timothy, Breton, Marc, Barnard-Kelly, Katharine, Roberts, Joseph T. F., Nimri, RevitalJournal of Diabetes Science and Technology2022; 16(1): 224 - 227.DOI: 10.1177/1932296820957728

 

 
Using an Online Disturbance Rejection and Anticipation System to Reduce Hyperglycemia in a Fully Closed-Loop Artificial Pancreas System
Corbett, John P., Garcia-Tirado, Jose, Colmegna, Patricio, Diaz Castaneda, Jenny L., Breton, Marc D. Journal of Diabetes Science and Technology2022; 16(1): 52 - 60.DOI: 10.1177/19322968211059159

 

 

2021

A Multiple Hypothesis Approach to Estimating Meal Times in Individuals With Type 1 Diabetes
Corbett, John P., Breton, Marc D., Patek, Stephen D.Journal of Diabetes Science and Technology2021; 15(1): 141 - 146.DOI: 10.1177/1932296819883267

 

 
Advanced Closed-Loop Control System Improves Postprandial Glycemic Control Compared With a Hybrid Closed-Loop System Following Unannounced Meal
Garcia-Tirado, Jose, Diaz, Jenny L., Koravi, Chaitanya L.K., Corbett, John P., Dawson, Martha, Wakeman, Christian, Barnett, Charlotte L., Oliveri, Mary C., Myers, Helen, Breton, Marc D., DeBoer, Mark D., Esquivel-Zuniga, Rebeca, Krauthause, KatieDiabetes Care2021; 44(10): 2379 - 2387.DOI: 10.2337/DC21-0932

 

 
Advanced hybrid artificial pancreas system improves on unannounced meal response - In silico comparison to currently available system
Garcia-Tirado, Jose, Lv, Dayu, Corbett, John P., Colmegna, Patricio, Breton, Marc D. Computer Methods and Programs in Biomedicine2021; 211: 106401.DOI: 10.1016/J.CMPB.2021.106401

 

 
Anticipation of Historical Exercise Patterns by a Novel Artificial Pancreas System Reduces Hypoglycemia During and After Moderate-Intensity Physical Activity in People with Type 1 Diabetes
Brown, Sue A., Garcia-Tirado, Jose, Colmegna, Patricio, Koravi, Chaitanya L.K., Ozaslan, Basak, Corbett, John P., Barnett, Charlotte L., Pajewski, Michael, Oliveri, Mary C., Myers, Helen, Breton, Marc D., Laichuthai, NitchakarnDiabetes Technology and Therapeutics2021; 23(4): 277 - 285.DOI: 10.1089/DIA.2020.0516

 

 
Candidate Selection for Hybrid Closed Loop Systems
Forlenza, Gregory P., Breton, Marc D., Kovatchev, Boris P.Diabetes Technology and Therapeutics2021;DOI: 10.1089/DIA.2021.0217

 

 
Clinical Management and Pump Parameter Adjustment of the Control-IQ Closed-Loop Control System: Results from a 6-Month, Multicenter, Randomized Clinical Trial
O'Malley, Grenye, Messer, Laurel H., Levy, Carol J., Pinsker, Jordan E., Forlenza, Gregory P., Isganaitis, Elvira, Kudva, Yogish C., Ekhlaspour, Laya, Raghinaru, Dan, Lum, John, Brown, Sue A., S.A.B., Kovatchev, Boris, Anderson, Stacey, Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Gondor-Fredrick, Linda, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Laffel, Lori, E.I., Ambler-Osborn, Louise, Flint, Emily, Kim, Kenny, Roethke, Lindsay, J.E.P., Church, Mei Mei, Andre, Camille, Piper, Molly, C.J.L., Lam, David, G.O., Levister, Camilla, Ogyaadu, Selassie, Lovett, Jessica, Y.C.K., Simha, Vinaya, Dadlani, Vikash, McCrady-Spitzer, Shelly, Reid, Corey, Kumari, Kanchan, Wadwa, R. Paul, Forlenza, Gregory P., Alonso, G. Todd, Slover, Robert, Jost, Emily, L.H.M., Berget, Cari, Towers, Lindsey, Rossick-Solis, Alex, Buckingham, Bruce, L.E., Jacobson, Tali, Town, Marissa, Tabatabai, Ideen, Keller, Jordan, Salas, Evalina, Paulson, John A., Beck, J.L. Roy, Passman, Samantha, Campos, Tiffany, Kollman, D.R. Craig, Murphy, Carlos, Patibandla, Nandan, Borgman, Sarah, Arreza-Rubin, Guillermo, Eggerman, Thomas, Green, Neal, Kovatchev, Boris, S.A.B., Anderson, Stacey, Breton, Marc, Laffel, Lori, J.E.P., C.J.L., Y.C.K., Wadwa, R. Paul, Buckingham, Bruce, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreza-Rubin, Guillermo, Beck., J.L. RoyDiabetes Technology and Therapeutics2021; 23(4): 245 - 252.DOI: 10.1089/DIA.2020.0472

 

 
Closed-Loop Insulin Therapy Improves Glycemic Control in Adolescents and Young Adults: Outcomes from the International Diabetes Closed-Loop Trial
Isganaitis, Elvira, Raghinaru, Dan, Ambler-Osborn, Louise, Pinsker, Jordan E., Buckingham, Bruce A., Wadwa, R. Paul, Ekhlaspour, Laya, Kudva, Yogish C., Levy, Carol J., Forlenza, Gregory P., Beck, Roy W., Kollman, Craig, Lum, John W., Brown, Sue A., Laffel, Lori M., Kovatchev, Boris, Anderson, Stacey, Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Gondor-Fredrick, Linda, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Flint, Emily, Kim, Kenny, Roethke, Lindsay, Church, Mei Mei, Andre, Camille, Piper, Molly, Lam, David, O'Malley, Grenye, Levister, Camilla, Ogyaadu, Selassie, Lovett, Jessica, Simha, Vinaya, Dadlani, Vikash, McCrady-Spitzer, Shelly, Reid, Corey, Kumari, Kanchan, Forlenza, Greg, Alonso, G. Todd, Slover, Robert, Jost, Emily, Messer, Laurel, Berget, Cari, Towers, Lindsey, Rossick-Solis, Alex, Jacobson, Tali, Town, Marissa, Tabatabai, Ideen, Keller, Jordan, Salas, Evalina, Doyle, Francis, Dassau, Eyal, Passman, Samantha, Campos, Tiffany, Murphy, Carlos, Patibandla, Nandan, Borgman, Sarah, Arreaza-Rubín, Guillermo, Green, Neal, Kovatchev, Boris, Brown, Sue, Anderson, Stacey, Breton, Marc, Laffel, Lori, Pinsker, Jordan, Levy, Carol, Wadwa, R. Paul, Buckingham, Bruce, Doyle, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreaza-Rubín, Guillermo, Lum, John, Beck, Roy, Janicek, Robert, Gabrielson, Deanna, Belle, Steven H., Castle, Jessica, Green, Jennifer, Legault, Laurent, Willi, Steven M., Wysham, Carol, Eggerman, ThomasDiabetes Technology and Therapeutics2021; 23(5): 342 - 349.DOI: 10.1089/DIA.2020.0572

 

 
Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes
Kanapka, Lauren G., Wadwa, R. Paul, Breton, Marc D., Ruedy, Katrina J., Ekhlaspour, Laya, Forlenza, Gregory P., Cengiz, Eda, Schoelwer, Melissa J., Jost, Emily, Carria, Lori, Emory, Emma, Hsu, Liana J., Weinzimer, Stuart A., DeBoer, Mark D., Buckingham, Bruce A., Oliveri, Mary, Kollman, Craig, Dokken, Betsy B., Cherñavvsky, Daniel, Beck, Roy W.Diabetes Care2021; 44(2): 473 - 478.DOI: 10.2337/DC20-1729

 

 
Health-Related Quality of Life and Treatment Satisfaction in Parents and Children with Type 1 Diabetes Using Closed-Loop Control
Cobry, Erin C., Kanapka, Lauren G., Cengiz, Eda, Carria, Lori, Ekhlaspour, Laya, Buckingham, Bruce A., Hood, Korey K., Hsu, Liana J., Messer, Laurel H., Schoelwer, Melissa J., Emory, Emma, Ruedy, Katrina J., Beck, Roy W., Wadwa, Raj Paul, Gonder-Frederick, Linda, Breton, Marc, DeBoer, Mark, Cherñavvsky, Daniel, Robic, Jessica, Voelmle, Mary, Conschafter, Katie, Morris, Kimberly, Barnett, Charlotte, Carr, Kelly, Hellmann, Jacob, Kime, Matthew, Oliveri, Mary, Forlenza, Greg, Alonso, G. Todd, Slover, Robert, Jost, Emily, Berget, Cari, Towers, Lindsey, Lange, Samantha, Maahs, David, Lal, Rayhan, Norlander, Lisa, Town, Marissa, Weir, Christine, Smith, Kerren, Shinksy, Deanna, Viana, Julia, Weinzimer, Stuart, Weyman, Kate, Zgorski, Melinda, Borgman, Sarah, Rusnak, Jessica, Kollman, Craig, Murphy, Carlos, Arreza-Rubin, Guillermo, Green, Neal, Kovatchev, Boris, Brown, Sue, Anderson, Stacey, Breton, Marc, Laffel, Lori, Pinsker, Jordan, Levy, Carol, Kudva, Yogish C., Doyle, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreza-Rubin, Guillermo, Lum, John, Janicek, Robert, Gabrielson, DeannaDiabetes Technology and Therapeutics2021; 23(6): 401 - 409.DOI: 10.1089/DIA.2020.0532

 

 
Impact of Accelerating Insulin on an Artificial Pancreas System Without Meal Announcement: An In Silico Examination
Colmegna, Patricio, Cengiz, Eda, Garcia-Tirado, Jose, Kraemer, Kristen, Breton, Marc D. Journal of Diabetes Science and Technology2021; 15(4): 833 - 841.DOI: 10.1177/1932296820928067

 

 
One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology
Breton, Marc D., Kovatchev, Boris P.Diabetes Technology and Therapeutics2021; 23(9): 601 - 608.DOI: 10.1089/DIA.2021.0097

 

 
Patient-Reported Outcomes in a Randomized Trial of Closed-Loop Control: The Pivotal International Diabetes Closed-Loop Trial
Kudva, Yogish C., Laffel, Lori M., Brown, Sue A., Raghinaru, Dan, Pinsker, Jordan E., Ekhlaspour, Laya, Levy, Carol J., Messer, Laurel H., Kovatchev, Boris P., Lum, John W., Beck, Roy W., Gonder-Frederick, Linda, Anderson, Stacey, Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Isganaitis, Elvira, Ambler-Osborn, Louise, Flint, Emily, Kim, Kenny, Roethke, Lindsay, Church, Mei, Andre, Camille, Piper, Molly, Lam, David, O'Malley, Grenye, Levister, Camilla, Ogyaadu, Selassie, Lovett, Jessica, Simha, Vinaya, Dadlani, Vikash, McCrady-Spitzer, Shelly, Reid, Corey, Kumari, Kanchan, Wadwa, R. Paul, Forlenza, Greg, Alonso, G. Todd, Slover, Robert, Jost, Emily, Berget, Cari, Towers, Lindsey, Rossick-Solis, Alex, Buckingham, Bruce, Jacobson, Tali, Town, Marissa, Tabatabai, Ideen, Keller, Jordan, Salas, Evalina, Doyle, Francis, Dassau, Eyal, Passman, Samantha, Campos, Tiffany, Kollman, Craig, Murphy, Carlos, Patibandla, Nandan, Borgman, Sarah, Arreaza-Rubín, Guillermo, Green, Neal, Anderson, Stacey, Breton, Marc, Kudva, Yogish C., Wadwa, R. Paul, Buckingham, Bruce, Doyle, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreaza-Rubín, Guillermo, Janicek, Robert, Gabrielson, Deanna, Belle, Steven H., Castle, Jessica, Green, Jennifer, Legault, Laurent, Willi, Steven M., Wysham, Carol, Eggerman, ThomasDiabetes Technology and Therapeutics2021; 23(10): 673 - 683.DOI: 10.1089/DIA.2021.0089

 

 
Predictors of Time-in-Range (70–180 mg/dL) Achieved Using a Closed-Loop Control System
Schoelwer, Melissa J., Kanapka, Lauren G., Wadwa, R. Paul, Breton, Marc D., Ruedy, Katrina J., Ekhlaspour, Laya, Forlenza, Gregory P., Cobry, Erin C., Messer, Laurel H., Cengiz, Eda, Jost, Emily, Carria, Lori, Emory, Emma, Hsu, Liana J., Weinzimer, Stuart A., Buckingham, Bruce A., Lal, Rayhan A., Oliveri, Mary Clancy, Kollman, Craig C., Dokken, Betsy B., Cherñavvsky, Daniel R., Beck, Roy W., DeBoer, Mark D., Gonder-Frederick, Linda, Robic, Jessica, Voelmle, Mary, Conschafter, Katie, Morris, Kimberly, Barnett, Charlotte, Carr, Kelly, Hellmann, Jacob, Kime, Matthew, Todd Alonso, G., Slover, Robert, Berget, Cari, Towers, Lindsey, Lange, Samantha, Buckingham, Bruce, Maahs, David, Lal, Rayhan, Ekhlaspour, Laya, Norlander, Lisa, Hood, Korey, Town, Marissa, Weir, Christine, Smith, Kerren, Hsu, Liana, Shinksy, Deanna, Viana, Julia, Cengiz, Eda, Weinzimer, Stuart, Weyman, Kate, Carria, Lori, Zgorski, Melinda, Ruedy, Katrina, Beck, Roy, Borgman, Sarah, Rusnak, Jessica, Kanapka, Lauren, Kollman, Craig, Murphy, Carlos, Arreza-Rubin, Guillermo, Green, Neal, Kovatchev, Boris, Brown, Sue, Anderson, Stacey, Breton, Marc, Laffel, Lori, Pinsker, Jordan, Levy, Carol, Kudva, Yogish C., Wadwa, R. Paul, Buckingham, Bruce, Doyle III, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreza-Rubin, Guillermo, Lum, John, Beck, Roy, Ruedy, Katrina, Janicek, Robert, Gabrielson, DeannaDiabetes Technology and Therapeutics2021; 23(7): 475 - 481.DOI: 10.1089/DIA.2020.0646

 

 
Replay Simulations with Personalized Metabolic Model for Treatment Design and Evaluation in Type 1 Diabetes
Hughes, Jonathan, Gautier, Thibault, Colmegna, Patricio, Fabris, Chiara, Breton, Marc D. Journal of Diabetes Science and Technology2021; 15(6): 1326 - 1336.DOI: 10.1177/1932296820973193

 

 
Response to Comment on “One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology” by Goran Petrovski et al.
Kovatchev, Boris, Breton, Marc Diabetes Technology and Therapeutics2021; 23(10): 729 - 729.DOI: 10.1089/DIA.2021.0209

 

 
Safety and Performance of the Tandem t:slim X2 with Control-IQ Automated Insulin Delivery System in Toddlers and Preschoolers
Ekhlaspour, Laya, Buckingham, Bruce A., Forlenza, Gregory P., Boranian, Emily, Berget, Cari, Wadwa, R. Paul, Norlander, Lisa, Hsu, Liana, Kingman, Ryan, Schoelwer, Melissa J., Deboer, Mark D., Emory, Emma, Breton, Marc D. Diabetes Technology and Therapeutics2021; 23(5): 384 - 391.DOI: 10.1089/DIA.2020.0507

 

 

2020

195-OR: Safety and Performance of the Tandem T:slim X2 with Control-IQ Automated Insulin Delivery System in Preschoolers, Age 2-6 Years Old
EKHLASPOUR, LAYA, FORLENZA, GREGORY P., SCHOELWER, MELISSA, DEBOER, MARK D., HSU, LIANA, KINGMAN, RYAN S., BORANIAN, EMILY, EMORY, EMMA, WADWA, R. PAUL, BUCKINGHAM, BRUCE A., BRETON, MARC D.Diabetes2020; 69(Supplement_1):.DOI: 10.2337/DB20-195-OR

 

 
A Randomized Trial of Closed-Loop Control in Children with Type 1 Diabetes
Breton, Marc D., Kanapka, Lauren G., Beck, Roy W., Ekhlaspour, Laya, Forlenza, Gregory P., Cengiz, Eda, Schoelwer, Melissa, Ruedy, Katrina J., Jost, Emily, Carria, Lori, Emory, Emma, Hsu, Liana J., Oliveri, Mary, Kollman, Craig C., Dokken, Betsy B., Weinzimer, Stuart A., DeBoer, Mark D., Buckingham, Bruce A., Cherñavvsky, Daniel, Wadwa, R. PaulNew England Journal of Medicine2020; 383(9): 836 - 845.DOI: 10.1056/NEJMOA2004736

 

 
Addition of New Therapeutic Agents to an Established Type 2 Diabetes Simulation Platform for Therapy Optimization: A Bayesian Model-Based Approach
Gautier, Thibault, Silwal, Rupesh, Breton, Marc IFAC-PapersOnLine2020; 53(2): 16317 - 16322.DOI: 10.1016/J.IFACOL.2020.12.649
 
An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes
Barnard-Kelly, Katharine D., Naranjo, Diana, Majidi, Shideh, Akturk, Halis K., Breton, Marc, Courtet, Philippe, Olié, Emilie, Lal, Rayhan A., Johnson, Nicole, Atkinson, Mark, Renard, EricCanadian Journal of Diabetes2020; 44(6): 541 - 544.DOI: 10.1016/J.JCJD.2020.01.008

 

 
Anticipating Meals with Behavioral Profiles in an Artificial Pancreas System - An Informed Multistage Model Predictive Control Approach
Corbett, John P., Colmegna, Patricio, Garcia-Tirado, Jose, Breton, Marc D. IFAC-PapersOnLine2020; 53(2): 16305 - 16310.DOI: 10.1016/J.IFACOL.2020.12.652

 

 
Automatically accounting for physical activity in insulin dosing for type 1 diabetes
Ozaslan, Basak, Patek, Stephen D., Fabris, Chiara, Breton, Marc D. Computer Methods and Programs in Biomedicine2020; 197: 105757.DOI: 10.1016/J.CMPB.2020.105757

 

 
Effect of Afrezza on Glucose Dynamics During HCL Treatment
Breton, Marc, Kraemer, Kristen, Weinzimer, Stuart, Galderisi, Alfonso, Cohen, Nathan, Calhoun, Peter, Cengiz, EdaDiabetes Care2020; 43(9): 2146 - 2152.DOI: 10.2337/DC20-0091

 

 
Evening and overnight closed-loop control versus 24/7 continuous closed-loop control for type 1 diabetes: a randomised crossover trial
Kovatchev, Boris P, Kollar, Laura, Anderson, Stacey M, Barnett, Charlotte, Breton, Marc D, Carr, Kelly, Gildersleeve, Rachel, Oliveri, Mary C, Wakeman, Christian A, Brown, Sue AThe Lancet Digital Health2020; 2(2): e64 - e73.DOI: 10.1016/S2589-7500(19)30218-3

 

 
Glycemic Outcomes of Use of CLC Versus PLGS in Type 1 Diabetes: A Randomized Controlled Trial
Brown, Sue A., Beck, Roy W., Raghinaru, Dan, Buckingham, Bruce A., Laffel, Lori M., Wadwa, R. Paul, Kudva, Yogish C., Levy, Carol J., Pinsker, Jordan E., Dassau, Eyal, Doyle, Francis J., Ambler-Osborn, Louise, Anderson, Stacey M., Church, Mei Mei, Ekhlaspour, Laya, Forlenza, Gregory P., Levister, Camilla, Simha, Vinaya, Breton, Marc D., Kollman, Craig, Lum, John W., Kovatchev, Boris P., Kovatchev, Boris, Anderson, Stacey, Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Gondor-Fredrick, Linda, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Laffel, Lori, Isganaitis, Elvira, Ambler-Osborn, Louise, Flint, Emily, Kim, Kenny, Roethke, Lindsay, Pinsker, Jordan, Church, Mei Mei, Andre, Camille, Piper, Molly, Levy, Carol, Lam, David, O’Malley, Grenye, Levister, Camilla, Ogyaadu, Selassie, Lovett, Jessica, Kudva, Yogish C., Simha, Vinaya, Dadlani, Vikash, McCrady-Spitzer, Shelly, Reid, Corey, Kumari, Kanchan, Wadwa, R. Paul, Forlenza, Greg, Alonso, G. Todd, Slover, Robert, Jost, Emily, Messer, Laurel, Berget, Cari, Towers, Lindsey, Rossick-Solis, Alex, Buckingham, Bruce, Ekhlaspour, Laya, Jacobson, Tali, Town, Marissa, Tabatabai, Ideen, Keller, Jordan, Salas, Evalina, Doyle, Francis, Dassau, Eyal, Lum, John, Beck, Roy, Passman, Samantha, Campos, Tiffany, Raghinaru, Dan, Kollman, Craig, Murphy, Carlos, Patibandla, Nandan, Borgman, Sarah, Arreza-Rubin, Guillermo, Eggerman, Thomas, Green, Neal, Kovatchev, Boris, Brown, Sue, Anderson, Stacey, Breton, Marc, Laffel, Lori, Pinsker, Jordan, Levy, Carol, Kudva, Yogish C., Wadwa, R. Paul, Buckingham, Bruce, Doyle III, Francis, Renard, Eric, Cobelli, Claudio, Reznik, Yves, Arreza-Rubin, Guillermo, Lum, John, Beck, Roy, Janicek, Robert, Gabrielson, Deanna, Belle, Steven H., Castle, Jessica, Green, Jennifer, Legault, Laurent, Willi, Steven M., Wysham, Carol, Eggerman, ThomasDiabetes Care2020; 43(8): 1822 - 1828.DOI: 10.2337/DC20-0124

 

 
Impact of Daily Physical Activity as Measured by Commonly Available Wearables on Mealtime Glucose Control in Type 1 Diabetes
Ozaslan, Basak, Patek, Stephen D., Breton, Marc D. Diabetes Technology and Therapeutics2020; 22(10): 742 - 748.DOI: 10.1089/DIA.2019.0517

 

 
Low Blood Glucose Index and Hypoglycaemia Risk: Insulin Glargine 300 U/mL Versus Insulin Glargine 100 U/mL in Type 2 Diabetes
Kovatchev, Boris, Meng, Zhaoling, Cali, Anna M. G., Perfetti, Riccardo, Breton, Marc D. Diabetes Therapy2020; 11(6): 1293 - 1302.DOI: 10.1007/S13300-020-00808-Y

 

 
Mapping data to virtual patients in type 1 diabetes
Colmegna, Patricio, Wang, Ke, Garcia-Tirado, Jose, Breton, Marc D. Control Engineering Practice2020; 103: 104605.DOI: 10.1016/J.CONENGPRAC.2020.104605

 

 
Multi-Hour Blood Glucose Prediction in Type 1 Diabetes: A Patient-Specific Approach Using Shallow Neural Network Models
Kushner, Taisa, Sankaranarayanan, Sriram, Breton, Marc D. Diabetes Technology and Therapeutics2020; 22(12): 883 - 891.DOI: 10.1089/DIA.2020.0061

 

 
Randomized Controlled Trial of Mobile Closed-Loop Control
Kovatchev, Boris, Anderson, Stacey M., Raghinaru, Dan, Kudva, Yogish C., Laffel, Lori M., Levy, Carol, Pinsker, Jordan E., Wadwa, R. Paul, Buckingham, Bruce, Doyle, Francis J., Brown, Sue A., Church, Mei Mei, Dadlani, Vikash, Dassau, Eyal, Ekhlaspour, Laya, Forlenza, Gregory P., Isganaitis, Elvira, Lam, David W., Lum, John, Beck, Roy W., Kovatchev, Boris, Anderson, Stacey M., Brown, Sue A., Emory, Emma, Voelmle, Mary, Conshafter, Katie, Morris, Kim, Oliveri, Mary, Mitchell, Harry, Calvo, Kayla, Wakeman, Christian, Breton, Marc, Laffel, Lori M., Isganaitis, Elvira, Ambler-Osborn, Louise, Flint, Emily, Schultz, Alan, Kim, Kenny, Pinsker, Jordan E., Church, Mei Mei, Andre, Camille, Levy, Carol, Lam, David W., O’Malley, Grenye, Levister, Camilla, Ogyaadu, Selassie, Kudva, Yogish C., Dadlani, Vikash, Simha, Vinaya, McCrady-Spitzer, Shelly, Reid, Corey, Wadwa, R. Paul, Forlenza, Gregory P., Jost, Emily, Messer, Laurel, Berget, Cari, Towers, Lindsey, Buckingham, Bruce, Ekhlaspour, Laya, Hsu, Liana, Loebner, Sarah, Doyle, Francis J., Dassau, Eyal, Lum, John, Beck, Roy W., Campos, Tiffany, Passman, Samantha, Murphy, Carlos, Patibandla, Nandan, Raghinaru, Dan, Kollman, CraigDiabetes Care2020; 43(3): 607 - 615.DOI: 10.2337/DC19-1310

 

 
Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Based on Total Daily Insulin in Adolescents with Type 1 Diabetes
Gautier, Thibault, Fabris, Chiara, Carr, Kelly, Clancy-Oliveri, Mary, DeBoer, Mark D., Breton, Marc D., Robic, Jessica L., Schoelwer, Melissa J., Brown, Sue A., Anderson, Stacey M., Cherñavvsky, Daniel R.Diabetes Technology and Therapeutics2020; 22(8): 594 - 601.DOI: 10.1089/DIA.2019.0471

 

 
Suicide and Self-inflicted Injury in Diabetes: A Balancing Act
Akturk, Halis K., Majidi, Shideh, Barnard-Kelly, Katharine D., Breton, Marc, Renard, Eric, Naranjo, Diana, Lal, Rayhan A., Courtet, Philippe, Olié, Emilie, Johnson, NicoleJournal of Diabetes Science and Technology2020; 14(6): 1010 - 1016.DOI: 10.1177/1932296819891136

 

 
The Use of a Smart Bolus Calculator Informed by Real-time Insulin Sensitivity Assessments Reduces Postprandial Hypoglycemia Following an Aerobic Exercise Session in Individuals With Type 1 Diabetes
Chernavvsky, Daniel R., Fabris, Chiara, Pinnata, Jennifer, Carr, Kelly A., Koravi, Chaitanya L.K., Barnett, Charlotte L., Oliveri, Mary C., Anderson, Stacey M., Breton, Marc D., Nass, Ralf M.Diabetes Care2020; 43(4): 799 - 805.DOI: 10.2337/DC19-1675

 

 

2019

A Review of Predictive Low Glucose Suspend and its Effectiveness in Preventing Nocturnal Hypoglycemia
Breton, Marc, Spanakis, Elias K., Chen, Ethan, King, Fraya, Klonoff, David C., Kohn, Michael A.Diabetes Technology and Therapeutics2019; 21(10): 602 - 609.DOI: 10.1089/DIA.2019.0119

 

 
Closed loop control in adolescents and children during winter sports: Use of the Tandem Control‐IQ AP system
Kruse, Geoff, Pinnata, Jennifer, Kovatchev, Boris P., Breton, Marc D., Chernavvsky, Daniel, Deboer, Mark D., Forlenza, Gregory P., Wadwa, R. Paul, Messer, Laurel H., Maahs, David M., Buckingham, Bruce A., Town, Marissa, Ekhlaspour, LayaPediatric Diabetes2019;DOI: 10.1111/PEDI.12867

 

 
Closed-loop control with unannounced exercise for adults with type 1 diabetes using the Ensemble Model Predictive Control
Garcia-Tirado, Jose, Corbett, John P., Boiroux, Dimitri, Jørgensen, John Bagterp, Breton, Marc D. Journal of Process Control2019; 80: 202 - 210.DOI: 10.1016/J.JPROCONT.2019.05.017

 

 
Closed‐loop driven by control‐to‐range algorithm outperforms threshold‐low‐glucose‐suspend insulin delivery on glucose control albeit not on nocturnal hypoglycaemia in prepubertal patients with type 1 diabetes in a supervised hotel setting
Renard, Eric, Tubiana-Rufi, Nadia, Bonnemaison-Gilbert, Elisabeth, Coutant, Régis, Dalla-Vale, Fabienne, Farret, Anne, Poidvin, Amélie, Bouhours-Nouet, Natacha, Abettan, Charlotte, Storey-London, Caroline, Donzeau, Aurelie, Place, Jerome, Breton, Marc D. Diabetes, Obesity and Metabolism2019; 21(1): 183 - 187.DOI: 10.1111/DOM.13482

 

 
Continuous Glucose Monitors and Activity Trackers to Inform Insulin Dosing in Type 1 Diabetes: The University of Virginia Contribution
Fabris, Chiara, Ozaslan, Basak, Breton, Marc D. Sensors2019; 19(24): 5386.DOI: 10.3390/S19245386

 

 
Hybrid Closed-Loop Control Is Safe and Effective for People with Type 1 Diabetes Who Are at Moderate to High Risk for Hypoglycemia
Anderson, Stacey M., Buckingham, Bruce A., Breton, Marc D., Robic, Jessica L., Barnett, Charlotte L., Wakeman, Christian A., Oliveri, Mary C., Brown, Sue A., Ly, Trang T., Clinton, Paula K., Hsu, Liana J., Kingman, Ryan S., Norlander, Lisa M., Loebner, Sarah E., Reuschel-DiVirglio, Suzette, Kovatchev, Boris P.Diabetes Technology and Therapeutics2019; 21(6): 356 - 363.DOI: 10.1089/DIA.2019.0018

 

 
Improving Glucose Prediction Accuracy in Physically Active Adolescents With Type 1 Diabetes
Hajizadeh, Iman, Rashid, Mudassir, Hobbs, Nicole, Turksoy, Kamuran, Cinar, Ali, Breton, Marc Journal of Diabetes Science and Technology2019; 13(4): 718 - 727.DOI: 10.1177/1932296818820550

 

 
In Silico Analysis of an Exercise-Safe Artificial Pancreas With Multistage Model Predictive Control and Insulin Safety System
Corbett, John P., Ozaslan, Basak, Garcia-Tirado, Jose, Breton, Marc D., Colmegna, PatricioJournal of Diabetes Science and Technology2019; 13(6): 1054 - 1064.DOI: 10.1177/1932296819879084

 

 
Successful At-Home Use of the Tandem Control-IQ Artificial Pancreas System in Young Children During a Randomized Controlled Trial
Forlenza, Gregory P., Ekhlaspour, Laya, Breton, Marc, Maahs, David M., Wadwa, R. Paul, DeBoer, Mark, Messer, Laurel H., Town, Marissa, Pinnata, Jennifer, Kruse, Geoff, Buckingham, Bruce A., Cherñavvsky, DanielDiabetes Technology and Therapeutics2019; 21(4): 159 - 169.DOI: 10.1089/DIA.2019.0011

 

 

2018

Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses
Rosales, Nicolás, Campos-Náñez, Enrique, Breton, Marc, Colmegna, Patricio, Garelli, Fabricio, De Battista, Hernán, Fushimi, Emilia, Sánchez-Peña, Ricardo, García-Violini, Demián, Moscoso-Vásquez, Marcela, Beruto, Valeria, Scibona, Paula, Rodriguez, Cintia, Giunta, Javier, Simonovich, Ventura, Belloso, Waldo H., Cherñavvsky, Daniel, Grosembacher, LuisJournal of Diabetes Science and Technology2018; 12(5): 914 - 925.DOI: 10.1177/1932296818786488

 

 
Body Mass Index Effect on Differing Responses to Psychological Stress in Blood Glucose Dynamics in Patients With Type 1 Diabetes
Ozaslan, Basak, Patek, Stephen D., Grabman, Jesse H., Shepard, Jaclyn A., Dassau, Eyal, Breton, Marc D., Kudva, Yogish C., Brown, Sue A., Basu, Ananda, Pinsker, Jordan E., Doyle, Francis J., Gonder-Frederick, LindaJournal of Diabetes Science and Technology2018; 12(3): 657 - 664.DOI: 10.1177/1932296818758103

 

 
Combining Short-Term Interval Training with Caloric Restriction Improves ß-Cell Function in Obese Adults
Francois, Monique E., Gilbertson, Nicole M., Eichner, Natalie Z. M., Heiston, Emily M., Fabris, Chiara, Breton, Marc, Mehaffey, J. Hunter, Hassinger, Taryn, Hallowell, Peter T., Malin, Steven K.Nutrients2018; 10(6): 717.DOI: 10.3390/NU10060717

 

 
Continuous Glucose Monitoring and Insulin Informed Advisory System with Automated Titration and Dosing of Insulin Reduces Glucose Variability in Type 1 Diabetes Mellitus
Breton, Marc D., Patek, Stephen D., Lv, Dayu, Schertz, Elaine, Robic, Jessica, Pinnata, Jennifer, Kollar, Laura, Barnett, Charlotte, Wakeman, Christian, Oliveri, Mary, Fabris, Chiara, Chernavvsky, Daniel, Kovatchev, Boris P., Anderson, Stacey M.Diabetes Technology and Therapeutics2018; 20(8): 531 - 540.DOI: 10.1089/DIA.2018.0079

 

 
Diabetes Technological Revolution: Winners and Losers?
Barnard, Katharine D., Breton, Marc D. Journal of Diabetes Science and Technology2018; 12(6): 1227 - 1230.DOI: 10.1177/1932296818788872

 

 
Economic Value of Improved Accuracy for Self-Monitoring of Blood Glucose Devices for Type 1 and Type 2 Diabetes in England
McQueen, Robert Brett, Breton, Marc D., Craig, Joyce, Holmes, Hayden, Whittington, Melanie D., Ott, Markus A., Campbell, Jonathan D.Journal of Diabetes Science and Technology2018; 12(5): 992 - 1001.DOI: 10.1177/1932296818769098

 

 
Identifiability Analysis of Three Control-Oriented Models for Use in Artificial Pancreas Systems
Garcia-Tirado, Jose, Zuluaga-Bedoya, Christian, Breton, Marc D. Journal of Diabetes Science and Technology2018; 12(5): 937 - 952.DOI: 10.1177/1932296818788873

 

 
Impact of Short-Term Exercise Training Intensity on β-cell Function in Older Obese Adults with Prediabetes
Francois, Monique E., Eichner, Natalie Z. M., Gilbertson, Nicole M., Heiston, Emily M., Malin, Steven K., Fabris, Chiara, Breton, Marc Journal of Applied Physiology2018; 125(6): 1979 - 1986.DOI: 10.1152/JAPPLPHYSIOL.00680.2018

 

 
Late and Missed Meal Boluses with Multiple Daily Insulin Injections
NORLANDER, LISA M., ANDERSON, STACEY, LEVY, CAROL J., EKHLASPOUR, LAYA, LAM, DAVID W., HSU, LIANA, LOEBNER, SARAH E., OGYAADU, SELASSIE J., O'MALLEY, GRENYE, LEVISTER, CAMILLA M., BRETON, MARC D., BUCKINGHAM, BRUCEDiabetes2018; 67(Supplement_1):.DOI: 10.2337/DB18-992-P

 

 
Recent Exposure to Hypoglycemia Increases Glucose Variability Following a Hyper/Hypoglycemic Metabolic Challenge in T1D
Fabris, Chiara, Farhy, Leon S., Anderson, Stacey M., Nass, Ralf M., Kovatchev, Boris P., Breton, Marc D. Journal of Diabetes Science and Technology2018; 12(2): 311 - 317.DOI: 10.1177/1932296817729392

 

 
The Contribution of Physical Activity in Blood Glucose Concentration for People with Type 1 Diabetes
Boiroux, Dimitri, Jørgensen, John Bagterp, Patek, Stephen D., Breton, Marc D.IFAC-PapersOnLine2018; 51(27): 270 - 275.DOI: 10.1016/J.IFACOL.2018.11.630

 

 
The Financial Impact of Inaccurate Blood Glucose Monitoring Systems
Fortwaengler, Kurt, Campos-Náñez, Enrique, Parkin, Christopher G., Breton, Marc D. Journal of Diabetes Science and Technology2018; 12(2): 318 - 324.DOI: 10.1177/1932296817731423

 

 
The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day
Visentin, Roberto, Campos-Náñez, Enrique, Schiavon, Michele, Lv, Dayu, Vettoretti, Martina, Breton, Marc, Kovatchev, Boris P., Dalla Man, Chiara, Cobelli, ClaudioJournal of Diabetes Science and Technology2018; 12(2): 273 - 281.DOI: 10.1177/1932296818757747

 

 
Trends in Insulin Pen Priming
GRENYE, O'MALLEY, OGYAADU, SELASSIE J., LAM, DAVID W., NORLANDER, LISA M., ROBIC, JESSICA, LEVISTER, CAMILLA M., ANDERSON, STACEY, HSU, LIANA, LOEBNER, SARAH E., EKHLASPOUR, LAYA, BRETON, MARC D., BUCKINGHAM, BRUCE A., LEVY, CAROL J.Diabetes2018; 67(Supplement_1):.DOI: 10.2337/DB18-83-LB

 

 

2017

Analysis of the Accuracy and Performance of a Continuous Glucose Monitoring Sensor Prototype: An In-Silico Study Using the UVA/PADOVA Type 1 Diabetes Simulator
Breton, Marc D., Hinzmann, Rolf, Campos-Nañez, Enrique, Riddle, Susan, Schoemaker, Michael, Schmelzeisen-Redeker, GuentherJournal of Diabetes Science and Technology2017; 11(3): 545 - 552.DOI: 10.1177/1932296816680633

 

 
Artificial Pancreas: First Clinical Trials in Argentina
Sánchez-Peña, R., Colmegna, P., Grosembacher, L., Breton, M., De Battista, H., Garelli, F., Belloso, W.H., Campos-Nánez, E., Simonovich, V., Beruto, V., Scibona, P., Chernavvsky, D.IFAC-PapersOnLine2017; 50(1): 7731 - 7736.DOI: 10.1016/J.IFACOL.2017.08.1151

 

 
Clinical Impact of Blood Glucose Monitoring Accuracy: An In-Silico Study
Campos-Náñez, Enrique, Fortwaengler, Kurt, Breton, Marc D. Journal of Diabetes Science and Technology2017; 11(6): 1187 - 1195.DOI: 10.1177/1932296817710474

 

 
Closed-Loop Control During Intense Prolonged Outdoor Exercise in Adolescents With Type 1 Diabetes: The Artificial Pancreas Ski Study
Forlenza, Gregory P., Wadwa, R. Paul, Messer, Laurel H., Maahs, David M., Breton, Marc D., Cherñavvsky, Daniel R., DeBoer, Mark D., Robic, Jessica, Kovatchev, Boris P.Diabetes Care2017; 40(12): 1644 - 1650.DOI: 10.2337/DC17-0883

 

 
Commissioning procedure for predictive control based on ARX models of Type 1 Diabetes Mellitus patients
Griva, Lucas, Breton, Marc, Chernavvsky, Daniel, Basualdo, MartaIFAC-PapersOnLine2017; 50(1): 11023 - 11028.DOI: 10.1016/J.IFACOL.2017.08.2482

 

 
Effect of BGM Accuracy on the Clinical Performance of CGM: An In-Silico Study
Campos-Náñez, Enrique, Breton, Marc D. Journal of Diabetes Science and Technology2017; 11(6): 1196 - 1206.DOI: 10.1177/1932296817710476

 

 
Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery
Dassau, Eyal, Doyle, Francis J., Pinsker, Jordan E., Bevier, Wendy C., Bradley, Paige K., Kovatchev, Boris, Anderson, Stacey M., Brown, Sue A., Breton, Marc D., Chernavvsky, Daniel, Kollman, Craig, Lum, John W., Beck, Roy W., Cheng, Peiyao, Ly, Trang T., Shanmugham, Satya, Buckingham, Bruce A., Hood, Korey K., Bruttomesso, Daniela, Del Favero, Simone, Calore, Roberta, Cobelli, Claudio, Avogaro, Angelo, Boscari, FedericoDiabetes Technology and Therapeutics2017; 19(1): 18 - 24.DOI: 10.1089/DIA.2016.0333

 

 
Handling Exercise During Closed Loop Control
Breton, Marc D. Diabetes Technology and Therapeutics2017; 19(6): 328 - 330.DOI: 10.1089/DIA.2017.0191

 

 
Heart rate informed artificial pancreas system enhances glycemic control during exercise in adolescents with T1D: DEBOER et al .
Topchyan, Katarina, Francis, Gary L., Kovatchev, Boris P., Cherñavvsky, Daniel R., Breton, Marc D., DeBoer, Mark D.Pediatric Diabetes2017; 18(7): 540 - 546.DOI: 10.1111/PEDI.12454

 

 
Improving the Safety and Functionality of an Artificial Pancreas System for Use in Younger Children: Input from Parents and Physicians
Gildersleeve, Rachel, Riggs, Sara L., Cherñavvsky, Daniel R., Breton, Marc D., DeBoer, Mark D.Diabetes Technology and Therapeutics2017; 19(11): 660 - 674.DOI: 10.1089/DIA.2017.0150

 

 
Overnight Closed-Loop Control Improves Glycemic Control in a Multicenter Study of Adults With Type 1 Diabetes
Brown, Sue A, Breton, Marc D, Anderson, Stacey M, Kollar, Laura, Keith-Hynes, Patrick, Levy, Carol J, Lam, David W, Levister, Camilla, Baysal, Nihat, Kudva, Yogish C, Basu, Ananda, Dadlani, Vikash, Hinshaw, Ling, McCrady-Spitzer, Shelly, Bruttomesso, Daniela, Visentin, Roberto, Galasso, Silvia, del Favero, Simone, Leal, Yenny, Boscari, Federico, Avogaro, Angelo, Cobelli, Claudio, Kovatchev, Boris PJournal of Clinical Endocrinology and Metabolism2017; 102(10): 3674 - 3682.DOI: 10.1210/JC.2017-00556

 

 
 
Performance of an Artificial Pancreas System for Young Children with Type 1 Diabetes
Breton, Marc D., Wakeman, Christian, Schertz, Elaine M., Emory, Emma G., Robic, Jessica L., Kollar, Laura L., Kovatchev, Boris P., Cherñavvsky, Daniel R., DeBoer, Mark D.Diabetes Technology and Therapeutics2017; 19(5): 293 - 298.DOI: 10.1089/DIA.2016.0424

 

 
Utilisation d’un système d’aide a la decision pour la gestion glycémique lors d’une activité physique modérée chez le diabétique de type 1
Breton, Marc, Ben Brahim, Najib, Schertz, Elaine, Barnett, Charlotte, Robic, Jessica, Pinnata, Jennifer, Anderson, Stacey, Renard, EricDiabetes and Metabolism2017; 43(2 (Supp.)): A21.DOI: 10.1016/S1262-3636(17)30165-9

 

 

2016

Are Risk Indices Derived From CGM Interchangeable With SMBG-Based Indices?
Patek, Stephen D., Breton, Marc D., Fabris, ChiaraJournal of Diabetes Science and Technology2016; 10(1): 50 - 59.DOI: 10.1177/1932296815599177

 

 
Comparing Simple Insulin Sensitivity Indices to the Oral Minimal Model Postexercise
Rynders, Corey A., Weltman, Judy Y., Malin, Steven K., Jiang, Boyi, Breton, Marc, BARRETT, EUGENE J., Weltman, ArthurMedicine and Science in Sports and Exercise2016; 48(1): 66 - 72.DOI: 10.1249/MSS.0000000000000728

 

 
Day-and-Night Closed-Loop Control Using the Unified Safety System in Adolescents With Type 1 Diabetes at Camp
Buckingham, Bruce A., DeSalvo, Daniel J., Shanmugham, Satya, Satin-Smith, Marta, Oliveri, Mary C., Schertz, Elaine, Breton, Marc D., Cherñavvsky, Daniel R., DeBoer, Mark D., Ly, Trang T.Diabetes Care2016; 39(8): e106 - e107.DOI: 10.2337/DC16-0817

 

 
Economic Value of Improved Accuracy for Self-Monitoring of Blood Glucose Devices for Type 1 Diabetes in Canada
McQueen, R. Brett, Breton, Marc D., Ott, Markus, Koa, Helena, Beamer, Bruce, Campbell, Jonathan D.Journal of Diabetes Science and Technology2016; 10(2): 366 - 377.DOI: 10.1177/1932296815599551

 

 
Hemoglobin A1c and Self-Monitored Average Glucose: Validation of the Dynamical Tracking eA1c Algorithm in Type 1 Diabetes
Kovatchev, Boris P., Breton, Marc D. Journal of Diabetes Science and Technology2016; 10(2): 330 - 335.DOI: 10.1177/1932296815608870

 

 
Multinational Home Use of Closed-Loop Control Is Safe and Effective
Renard, Eric, Farret, Anne, Place, Jerome, Dasanayake, Isuru S., Doyle, Francis J., Dassau, Eyal, Boscari, Federico, Bruttomesso, Daniela, Del Favero, Simone, Calore, Roberta, Cobelli, Claudio, Avogaro, Angelo, Pinsker, Jordan E., Bevier, Wendy C., Bradley, Paige K., Breton, Marc D., Chernavvsky, Daniel, Kovatchev, Boris, Anderson, Stacey M., Brown, Sue A., Keith-Hynes, Patrick, Raghinaru, Dan, Kollman, Craig, Lum, John W., Beck, Roy W., Buckingham, Bruce A., Ly, Trang T., Shanmugham, Satya, Nimri, Revital, Phillip, MosheDiabetes Care2016; 39(7): 1143 - 1150.DOI: 10.2337/DC15-2468

 

 
 
Retrospective Optimization of Daily Insulin Therapy Parameters: Control Subject to a Regenerative Disturbance Process**This material is based upon work supported in part by the National Institutes of Health under Grant No. NIH/NIDDK R01DK051562. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the sponsors. S. D. Patek and M. D. Breton disclose equity interest in TypeZero Technologies, Inc.
Patek, Stephen D., Lv, Dayu, Campos-Nanez, Enrique, Breton, Marc IFAC-PapersOnLine2016; 49(7): 773 - 778.DOI: 10.1016/J.IFACOL.2016.07.281

 

 
Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor
Finan, Daniel A., McCann, Thomas W., Levy, Brian L., Venugopalan, Ramakrishna, Breton, Marc D., Patek, Stephen D., Kovatchev, Boris P., Dassau, Eyal, Doyle, Francis J.Journal of Diabetes Science and Technology2016; 10(1): 104 - 110.DOI: 10.1177/1932296815593292

 

 
Use of an artificial pancreas among adolescents for a missed snack bolus and an underestimated meal bolus: AP in adolescents for insulin omission
Kovatchev, Boris P, Breton, Marc D, Cherñavvsky, Daniel R, Keith-Hynes, Patrick, Mize, Benton, McElwee, Molly, Dunsmore, Spencer F, Wakeman, Christian, Demartini, Susan, DeBoer, Mark DPediatric Diabetes2016; 17(1): 28 - 35.DOI: 10.1111/PEDI.12230

 

 
Value of Improved Accuracy for Self-Monitoring of Blood Glucose Devices in Germany
McQueen, RB, Breton, M, Ott, M, Campbell, JDValue in Health2016; 19(7): A696.DOI: 10.1016/J.JVAL.2016.09.2007

 

 

2015

1. Closed-Loop Control with DIAS vs. Sensor-Augmented Pump Therapy in Adolescents and Young Adults with Type 1 Diabetes at Camp (99-L)
Ly, Trang T., Cherñavvsky, Daniel, Satin-Smith, Marta, Desalvo, Daniel J., Shanmugham, Satya, Keith-Hynes, Patrick, Breton, Marc D., Buckingham, Bruce A.Nederlands Tijdschrift voor Diabetologie2015; 13(3): 55 - 56.DOI: 10.1007/S12467-015-0022-0

 

 
Assessing Sensor Accuracy for Non-Adjunct Use of Continuous Glucose Monitoring
Kovatchev, Boris P., Patek, Stephen D., Ortiz, Edward Andrew, Breton, Marc D. Diabetes Technology and Therapeutics2015; 17(3): 177 - 186.DOI: 10.1089/DIA.2014.0272

 

 
Economic Value Of Improved Accuracy For Self-Monitoring Of Blood Glucose Devices For Type 1 Diabetes
McQueen, RB, Breton, M., Ott, M., Koa, H., Beamer, B., Campbell, J.D.Value in Health2015; 18(3): A4 - A5.DOI: 10.1016/J.JVAL.2015.03.025

 

 
Fluctuations of Hyperglycemia and Insulin Sensitivity Are Linked to Menstrual Cycle Phases in Women With T1D
Brown, Sue A., Jiang, Boyi, Wakeman, Christian, Breton, Marc D., McElwee-Malloy, MollyJournal of Diabetes Science and Technology2015; 9(6): 1192 - 1199.DOI: 10.1177/1932296815608400

 

 
Identification of Main Factors Explaining Glucose Dynamics During and Immediately After Moderate Exercise in Patients With Type 1 Diabetes
Ben Brahim, Najib, Breton, Marc D., Place, Jerome, Renard, EricJournal of Diabetes Science and Technology2015; 9(6): 1185 - 1191.DOI: 10.1177/1932296815607864

 

 
Multinight “Bedside” Closed-Loop Control for Patients with Type 1 Diabetes
Brown, Sue A., Kovatchev, Boris P., Breton, Marc D., Anderson, Stacey M., Keith-Hynes, Patrick, Patek, Stephen D., Jiang, Boyi, Ben Brahim, Najib, Vereshchetin, Paul, Bruttomesso, Daniela, Avogaro, Angelo, Del Favero, Simone, Boscari, Federico, Galasso, Silvia, Visentin, Roberto, Monaro, Marco, Cobelli, ClaudioDiabetes Technology and Therapeutics2015; 17(3): 203 - 209.DOI: 10.1089/DIA.2014.0259

 

 
Pharmacokinetic Model of the Transport of Fast-Acting Insulin From the Subcutaneous and Intradermal Spaces to Blood
Lv, Dayu, Kulkarni, Sandip D., Chan, Alice, Keith, Stephen, Pettis, Ron, Kovatchev, Boris P., Farhi, Leon S., Breton, Marc D. Journal of Diabetes Science and Technology2015; 9(4): 831 - 840.DOI: 10.1177/1932296815573864

 

 

2014

Accuracy and Robustness of Dynamical Tracking of Average Glycemia (A1c) to Provide Real-Time Estimation of Hemoglobin A1c Using Routine Self-Monitored Blood Glucose Data
Kovatchev, Boris P., Flacke, Frank, Sieber, Jochen, Breton, Marc D. Diabetes Technology and Therapeutics2014; 16(5): 303 - 309.DOI: 10.1089/DIA.2013.0224

 

 
Adding Heart Rate Signal to a Control-to-Range Artificial Pancreas System Improves the Protection Against Hypoglycemia During Exercise in Type 1 Diabetes
Breton, Marc D., Brown, Sue A., Karvetski, Colleen Hughes, Kollar, Laura, Topchyan, Katarina A., Anderson, Stacey M., Kovatchev, Boris P.Diabetes Technology and Therapeutics2014; 16(8): 506 - 511.DOI: 10.1089/DIA.2013.0333

 

 
Computing the Surveillance Error Grid Analysis: Procedure and Examples
Kovatchev, Boris P., Wakeman, Christian A., Breton, Marc D., Kost, Gerald J., Louie, Richard F., Tran, Nam K., Klonoff, David C.Journal of Diabetes Science and Technology2014; 8(4): 673 - 684.DOI: 10.1177/1932296814539590

 

 
Effect of Algorithm Aggressiveness on the Performance of the Hypoglycemia-Hyperglycemia Minimizer (HHM) System
Finan, Daniel A., McCann, Thomas W., Rhein, Kathleen, Dassau, Eyal, Breton, Marc D., Patek, Stephen D., Anhalt, Henry, Kovatchev, Boris P., Doyle, Francis J., Anderson, Stacey M., Zisser, Howard, Venugopalan, RamakrishnaJournal of Diabetes Science and Technology2014; 8(4): 685 - 690.DOI: 10.1177/1932296814534589

 

 
Effects of Exercise Intensity on Postprandial Improvement in Glucose Disposal and Insulin Sensitivity in Prediabetic Adults
Barrett, Eugene J., Weltman, Arthur, Rynders, Corey A., Jiang, Boyi, Breton, Marc, Weltman, Judy Y., Patrie, JamesJournal of Clinical Endocrinology and Metabolism2014; 99(1): 220 - 228.DOI: 10.1210/JC.2013-2687

 

 
Multicenter Closed-Loop Insulin Delivery Study Points to Challenges for Keeping Blood Glucose in a Safe Range by a Control Algorithm in Adults and Adolescents with Type 1 Diabetes from Various Sites
Zisser, Howard, Renard, Eric, Kovatchev, Boris, Cobelli, Claudio, Avogaro, Angelo, Nimri, Revital, Magni, Lalo, Buckingham, Bruce A., Chase, H. Peter, Doyle, Francis J., Lum, John, Calhoun, Peter, Kollman, Craig, Dassau, Eyal, Farret, Anne, Place, Jerome, Breton, Marc, Anderson, Stacey M., Dalla Man, Chiara, Del Favero, Simone, Bruttomesso, Daniela, Filippi, Alessio, Scotton, Rachele, Phillip, Moshe, Atlas, Eran, Muller, Ido, Miller, Shahar, Toffanin, Chiara, Raimondo, Davide Martino, De Nicolao, Giuseppe, Beck, Roy W.Diabetes Technology and Therapeutics2014; 16(10): 613 - 622.DOI: 10.1089/DIA.2014.0066

 

 
Overnight Glucose Control With an Automated, Unified Safety System in Children and Adolescents With Type 1 Diabetes at Diabetes Camp
Ly, Trang T., Buckingham, Bruce A., Wilson, Darrell M., De Salvo, Daniel, Clinton, Paula, Benassi, Kari, Breton, Marc D., Keith-Hynes, Patrick, Mize, Benton, Chernavvsky, Daniel, Kovatchev, Boris P., Place, JérómeDiabetes Care2014; 37(8): 2310 - 2316.DOI: 10.2337/DC14-0147

 

 
P278 Robustesse de l’estimation dynamique en temps réel de l’HbA1c, à partir des données d’autosurveillance glycémique (ASG)
Breton, M., Flacke, F., Sieber, J., Kovatchev, B.Diabetes and Metabolism2014; 40((Supp.)): A93.DOI: 10.1016/S1262-3636(14)72569-8

 

 
P281 Précision de l’estimation dynamique en temps réel de l’HbA1c, à partir de données d’autosurveillance glycémique (ASG)
Breton, M., Flacke, F., Sieber, J., Kovatchev, B.Diabetes and Metabolism2014; 40((Supp.)): A94.DOI: 10.1016/S1262-3636(14)72572-8

 

 
Safety of Outpatient Closed-Loop Control: First Randomized Crossover Trials of a Wearable Artificial Pancreas
Kovatchev, Boris P., Renard, Eric, Cobelli, Claudio, Zisser, Howard C., Keith-Hynes, Patrick, Anderson, Stacey M., Brown, Sue A., Chernavvsky, Daniel R., Breton, Marc D., Mize, Lloyd B., Farret, Anne, Place, Jérôme, Bruttomesso, Daniela, Del Favero, Simone, Boscari, Federico, Galasso, Silvia, Avogaro, Angelo, Magni, Lalo, Di Palma, Federico, Toffanin, Chiara, Messori, Mirko, Dassau, Eyal, Doyle, Francis J.Diabetes Care2014; 37(7): 1789 - 1796.DOI: 10.2337/DC13-2076

 

 
The artificial pancreas: current status and future prospects in the management of diabetes
Peyser, Thomas, Dassau, Eyal, Breton, Marc, Skyler, Jay S.Annals of the New York Academy of Sciences2014; 1311(1): 102 - 123.DOI: 10.1111/NYAS.12431

 

 
The UVA/PADOVA Type 1 Diabetes Simulator: New Features
Man, Chiara Dalla, Micheletto, Francesco, Lv, Dayu, Breton, Marc, Kovatchev, Boris, Cobelli, ClaudioJournal of Diabetes Science and Technology2014; 8(1): 26 - 34.DOI: 10.1177/1932296813514502

 

 

2013

DiAs Web Monitoring: A Real-Time Remote Monitoring System Designed for Artificial Pancreas Outpatient Trials
Place, Jérôme, Renard, Eric, Robert, Antoine, Ben Brahim, Najib, Keith-Hynes, Patrick, Breton, Marc, Kovatchev, Boris, Farret, Anne, Pelletier, Marie-Josée, Buckingham, BruceJournal of Diabetes Science and Technology2013; 7(6): 1427 - 1435.DOI: 10.1177/193229681300700603

 

 
Feasibility of Outpatient Fully Integrated Closed-Loop Control
Kovatchev, Boris P., Renard, Eric, Cobelli, Claudio, Zisser, Howard C., Keith-Hynes, Patrick, Anderson, Stacey M., Brown, Sue A., Chernavvsky, Daniel R., Breton, Marc D., Farret, Anne, Pelletier, Marie-Josée, Place, Jérôme, Bruttomesso, Daniela, Del Favero, Simone, Visentin, Roberto, Filippi, Alessio, Scotton, Rachele, Avogaro, Angelo, Doyle, Francis J.Diabetes Care2013; 36(7): 1851 - 1858.DOI: 10.2337/DC12-1965

 

 
Historical data enhances safety supervision system performance in T1DM insulin therapy risk management
Hughes-Karvetski, Colleen, Patek, Stephen D., Breton, Marc D., Kovatchev, Boris P.Computer Methods and Programs in Biomedicine2013; 109(2): 220 - 225.DOI: 10.1016/j.cmpb.2011.12.016

 

 
Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients
Lv, Dayu, Breton, Marc D., Farhy, Leon S.Diabetes Technology and Therapeutics2013; 15(11): 935 - 941.DOI: 10.1089/DIA.2013.0150

 

 

2012

Association of Basal Hyperglucagonemia with Impaired Glucagon Counterregulation in Type 1 Diabetes
Farhy, Leon S., Chan, Alice, Breton, Marc D., Anderson, Stacey M., Kovatchev, Boris P., McCall, Anthony L.Frontiers in Physiology2012; 3:.DOI: 10.3389/fphys.2012.00040

 

 
Fully Integrated Artificial Pancreas in Type 1 Diabetes
Magni, Lalo, Toffanin, Chiara, De Nicolao, Giuseppe, Dalla Man, Chiara, Del Favero, Simone, Cobelli, Claudio, Bruttomesso, Daniela, Avogaro, Angelo, Breton, Marc, Anderson, Stacey, Patek, Stephen, Demartini, Susan, Hughes-Karvetski, Colleen, Kovatchev, Boris, Doyle, Francis J., Dassau, Eyal, Zisser, Howard, Farret, Anne, Place, Jerome, Renard, EricDiabetes2012; 61(9): 2230 - 2237.DOI: 10.2337/db11-1445

 

 
In silico Models of Alcohol Dependence and Treatment
Kovatchev, Boris, Breton, Marc, Johnson, BankoleFrontiers in Psychiatry2012; 3:.DOI: 10.3389/fpsyt.2012.00004

 

 
Modular Closed-Loop Control of Diabetes
Patek, S. D., Magni, L., Dassau, E., Hughes-Karvetski, C., Toffanin, C., De Nicolao, G., Del Favero, S., Breton, M., Man, C. D., Renard, E., Zisser, H., Doyle, F. J., Cobelli, C., Kovatchev, B. P.IEEE Transactions on Biomedical Engineering2012; 59(11): 2986 - 2999.DOI: 10.1109/TBME.2012.2192930

 

 
Muscle microvascular recruitment predicts insulin sensitivity in middle-aged patients with type 1 diabetes mellitus
Chan, A., Barrett, E. J., Anderson, S. M., Kovatchev, B. P., Breton, M. D.Diabetologia2012; 55(3): 729 - 736.DOI: 10.1007/S00125-011-2402-3

 

 
Pilot Studies of Wearable Outpatient Artificial Pancreas in Type 1 Diabetes
Kovatchev, Boris P., Keith-Hynes, Patrick, Ben Brahim, Najib, Breton, Marc, Patek, Stephen D., Zisser, Howard, Dassau, Eyal, Bruttomesso, Daniela, Avogaro, Angelo, Cobelli, Claudio, Del Favero, Simone, Renard, Eric, Place, Jérôme, Farret, Anne, Doyle, Francis J.Diabetes Care2012; 35(9): e65 - e67.DOI: 10.2337/dc12-0660

 

 

2011

Anticipating the next meal using meal behavioral profiles: A hybrid model-based stochastic predictive control algorithm for T1DM
Hughes, C.S., Patek, S.D., Breton, M., Kovatchev, B.P.Computer Methods and Programs in Biomedicine2011; 102(2): 138 - 148.DOI: 10.1016/j.cmpb.2010.04.011

 

 
Correction Insulin Advisory System Based on Meal Behavioral Profiles*
Patek, Stephen D., Hughes, Colleen S., Vereshchetin, Pavel, Breton, Marc, Kovatchev, Boris P.IFAC Proceedings Volumes2011; 44(1): 8354 - 8359.DOI: 10.3182/20110828-6-IT-1002.02223

 

 
Novel Methodology to Determine the Accuracy of the OmniPod Insulin Pump: A Key Component of the Artificial Pancreas System
Zisser, Howard, Breton, Marc, Dassau, Eyal, Markova, Kateryna, Bevier, Wendy, Seborg, Dale, Kovatchev, BorisJournal of Diabetes Science and Technology2011; 5(6): 1509 - 1518.DOI: 10.1177/193229681100500627

 

 
Systematic method to assess microvascular recruitment using contrast-enhanced ultrasound. Application to insulin-induced capillary recruitment in subjects with T1DM
Chan, Alice, Kovatchev, Boris P., Anderson, Stacey M., Breton, Marc D.Computer Methods and Programs in Biomedicine2011; 102(2): 219 - 226.DOI: 10.1016/j.cmpb.2010.03.008

 

 

2010

Hypoglycemia Prevention via Pump Attenuation and Red-Yellow-Green “Traffic” Lights Using Continuous Glucose Monitoring and Insulin Pump Data
Hughes, Colleen S., Patek, Stephen D., Breton, Marc D., Kovatchev, Boris P.Journal of Diabetes Science and Technology2010; 4(5): 1146 - 1155.DOI: 10.1177/193229681000400513

 

 
Impact of Blood Glucose Self-Monitoring Errors on Glucose Variability, Risk for Hypoglycemia, and Average Glucose Control in Type 1 Diabetes: An In Silico Study
Breton, Marc D., Kovatchev, Boris P.Journal of Diabetes Science and Technology2010; 4(3): 562 - 570.DOI: 10.1177/193229681000400309

 

 
Multinational Study of Subcutaneous Model-Predictive Closed-Loop Control in Type 1 Diabetes Mellitus: Summary of the Results
Kovatchev, Boris, Cobelli, Claudio, Man, Chiara Dalla, Facchinetti, Andrea, Anderson, Stacey, Clarke, William, Breton, Marc, Magni, Lalo, De Nicolao, Giuseppe, Patek, Stephen, Bruttomesso, Daniela, Maran, Alberto, Costa, Silvana, Avogaro, Angelo, Renard, Eric, Place, Jerome, Farret, AnneJournal of Diabetes Science and Technology2010; 4(6): 1374 - 1381.DOI: 10.1177/193229681000400611

 

 
Nonlinear Metabolic Effect of Insulin Across the Blood Glucose Range in Patients with Type 1 Diabetes Mellitus
Chan, Alice, Heinemann, Lutz, Anderson, Stacey M., Breton, Marc D., Kovatchev, Boris P.Journal of Diabetes Science and Technology2010; 4(4): 873 - 881.DOI: 10.1177/193229681000400416

 

 
The Accuracy of a New Real-Time Continuous Glucose Monitoring Algorithm: An Analysis
Kovatchev, Boris, Breton, Marc Journal of Diabetes Science and Technology2010; 4(1): 119 - 122.DOI: 10.1177/193229681000400115