Fallahi-Sichani, Mohammad
Primary Appointment
Assistant Professor, Biomedical Engineering
Education
- PhD, Chemical Engineering, University of Michigan
- Postdoc, Systems Biology, Harvard Medical School
Contact Information
415 Lane Rd
Building MR5, Room 2115
Charlottesville, Virginia 22903
Telephone: 434-924-9950
Email: fallahi@virginia.edu
Website: https://www.fallahi-sichani-lab.com/
Research Disciplines
Biotechnology, Cancer Biology, Computational Biology, Epigenetics, Experimental Pathology, Molecular Pharmacology, Molecular Physiology and Biological Physics
Research Interests
Cancer systems biology, Single-cell quantitative biology, Computational modeling
Research Description
Research in the Fallahi-Sichani Lab aims at designing, building and utilizing new experimental and computational tools, as means to discover fundamental mechanisms that regulate the behavior of human cells in response to perturbations, such as cytokines, environmental stress, and therapeutic drugs. By merging multiplexed, high-throughput, single-cell data acquisition with multi-scale computational modeling, we hope to understand the molecular mechanisms that underlie adaptive cell fate decisions in the presence of cell-autonomous, microenvironment, and therapy-induced selective pressures, and elucidate how they vary under unhealthy conditions, particularly in cancer cells. From a therapeutic point of view, a detailed understanding of these mechanisms will provide a rational basis for choosing the optimal therapeutic targets to: (i) maximize the desired effect in diseased cells (e.g. tumor cell killing), (ii) prevent the development of therapeutic resistance, and (iii) reduce therapy-induced adverse effects in healthy cells.