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Marty W. Mayo

Marty W. Mayo

Professor, Biochemistry and Molecular Genetics

Primary Location
PO Box 800733
1340 JPA Pinn Hall Room 6223
Charlottesville, VA 22908
Primary Phone Number
434.924.2509
Fax Number
434.924.5069
Email
[email protected]

Bio & Overview

Within cells there exists a fine balance between survival and death. One of the earliest steps in the development of cancer is the ability of a cell to escape death. It is now well established that cells die through an orderly process known as programmed cell death or apoptosis. However, cells are able to overcome apoptotic pathways by upregulating gene products that inactivate the cell death machinery. Our group was among the first to describe that the transcription factor NF-kB is involved in the inhibition of cell death. Classical NF-kB, composed of a p50/p65 heterodimer protein complex, is ubiquitously expressed in cells. The activation of NF-kB by various stimuli, including tumor necrosis factor, stimulates the production of gene products that protect cells from apoptosis. Interestingly, the involvement of NF-kB in suppressing cell death implicates this transcription factor in cancer progression. Moreover, we have found that NF-kB is activated in response to chemotherapy and irradiation, and is required to overcome cell death by these agents. Therefore, the use of NF-kB inhibitors would have important implications for increasing the effectiveness of standard cancer therapy. Our laboratory is broadly interested in understanding transcrptional control of NF-kB by addressing four basic questions. First, we would like to determine the signaling pathways that are utilized by stress inducers to activate NF-kB-dependent gene expression. Second, we would like to elucidate how these stress pathways induce the transcriptional activation of NF-kB. In particular, determine whether DNA-binding, chromatin rearrangement and recruitment of co-activators are important in this process. Third, we would like to identify gene products regulated by NF-kB that are responsible for blocking apoptosis. Finally, we would like to identify and characterize pharmacological agents that inhibit NF-kB activation and determine whether these agents can be used in combination with standard cancer therapies. To address these questions our laboratory utilizes human cancer cell lines, as well as more complex human xenograft tumor models propagated in nude mice. It is a combination of these two experimental models that wil allow us to understand NF-kB regulated processes and to determine how these components are important in human cancer.

Academic Information

Department
Biochemistry and Molecular Genetics
Academic Title
Professor

Primary Education

  • BS, Microbiology, Clemson University, Clemson, SC, 1989
  • PhD, Microbiology and Immunology, East Carolina University, 1993
  • Postdoc, Cancer Research, University of North Carolina, Chapel Hill, NCnull

Other Appointments

  • Associate Professor, MII
  • Associate Professor, BMBG
  • Associate Professor, MOMD

Other Affiliations

  • Member, Molecular Genetics and Epigenetics Program
  • MSTP
  • Associate Professor, BIMS

Research Interests

Transcriptional Regulation by NFKB

Research Disciplines

  • Biochemistry
  • Cancer Biology
  • Epigenetics
  • Molecular Biology
  • Translational Science

Research Opportunities

  • Biochemistry
  • Cancer Biology
  • Epigenetics
  • Molecular Biology

PhD Programs

  • Biochemistry & Molecular Genetics

Selected Publications

2022

Liu, Y., Chudgar, N., Mastrogiacomo, B., He, D., Lankadasari, M. B., Bapat, S., . . . Jones, D. R. (2022). A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos. SCIENCE TRANSLATIONAL MEDICINE, 14(665). doi:10.1126/scitranslmed.abo1050

2021

Jones, G. D., Brandt, W. S., Shen, R., Sanchez-Vega, F., Tan, K. S., Martin, A., . . . Jones, D. R. (2021). A Genomic-Pathologic Annotated Risk Model to Predict Recurrence in Early-Stage Lung Adenocarcinoma. JAMA SURGERY, 156(2). doi:10.1001/jamasurg.2020.5601

2020

Przanowski, P., Lou, S., Tihagam, R. D., Mondal, T., Conlan, C., Shivange, G., . . . Bhatnagar, S. (2020). Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer. CANCER RESEARCH, 80(21), 4791-4804. doi:10.1158/0008-5472.CAN-20-1459

Caso, R., Sanchez-Vega, F., Tan, K. S., Mastrogiacomo, B., Zhou, J., Jones, G. D., . . . Jones, D. R. (2020). The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma. JOURNAL OF THORACIC ONCOLOGY, 15(12), 1844-1856. doi:10.1016/j.jtho.2020.08.005

Saha, S., Kiran, M., Kuscu, C., Chatrath, A., Wotton, D., Mayo, M. W., & Dutta, A. (2020). Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB Activation. CANCER RESEARCH, 80(5), 950-963. doi:10.1158/0008-5472.CAN-19-3460

Morris, B. B., Wages, N. A., Grant, P. A., Stukenberg, P. T., Gentzler, R. D., Hall, R. D., . . . Mayo, M. W. (2021). MYBL2-Driven Transcriptional Programs Link Replication Stress and Error-prone DNA Repair With Genomic Instability in Lung Adenocarcinoma. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.585551

2019

Szymura, S. J., Zaemes, J. P., Allison, D. F., Clift, S. H., D'Innocenzi, J. M., Gray, L. G., . . . Mayo, M. W. (2019). NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. CELL COMMUNICATION AND SIGNALING, 17. doi:10.1186/s12964-019-0335-5

2018

Uchiyama, R., Kupkova, K., Shetty, S. J., Linford, A. S., Pray-Grant, M. G., Wagar, L. E., . . . Auble, D. T. (2018). Histone H3 lysine 4 methylation signature associated with human undernutrition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(48), E11264-E11273. doi:10.1073/pnas.1722125115

Shivange, G., Urbanek, K., Przanowski, P., Perry, J. S. A., Jones, J., Haggart, R., . . . Tushir-Singh, J. (2018). A Single-Agent Dual-Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer. CANCER CELL, 34(2), 331-+. doi:10.1016/j.ccell.2018.07.005

2017

Amin, E. M., Liu, Y., Deng, S., Tan, K. S., Chudgar, N., Mayo, M. W., . . . Jones, D. R. (2017). The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK. SCIENCE SIGNALING, 10(497). doi:10.1126/scisignal.aah3941

Olmez, I., Love, S., Xiao, A., Manigat, L., Randolph, P., McKenna, B. D., . . . Purow, B. (2018). Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. NEURO-ONCOLOGY, 20(2), 192-202. doi:10.1093/neuonc/nox119

2016

Liu, Y., Amin, E. B., Mayo, M. W., Chudgar, N. P., Bucciarelli, P. R., Kadota, K., . . . Jones, D. R. (2016). CK2α′ Drives Lung Cancer Metastasis by Targeting BRMS1 Nuclear Export and Degradation. CANCER RESEARCH, 76(9), 2675-2686. doi:10.1158/0008-5472.CAN-15-2888

2014

Wamsley, J. J., Kumar, M., Allison, D. F., Clift, S. H., Holzknecht, C. M., Szymura, S. J., . . . Mayo, M. W. (2015). Activin Upregulation by NF-κB Is Required to Maintain Mesenchymal Features of Cancer Stem-like Cells in Non-Small Cell Lung Cancer. CANCER RESEARCH, 75(2), 426-435. doi:10.1158/0008-5472.CAN-13-2702

Liu, Y., Mayo, M. W., Xiao, A., Hall, E. H., Amin, E. B., Kadota, K., . . . Jones, D. R. (2015). Loss of BRMS1 Promotes a Mesenchymal Phenotype through NF-κB-Dependent Regulation of Twist1. MOLECULAR AND CELLULAR BIOLOGY, 35(1), 303-317. doi:10.1128/MCB.00869-14

Yeung, F., Ramsey, C. S., Popko-Scibor, A. E., Allison, D. F., Gray, L. G., Shin, M., . . . Mayo, M. W. (2015). Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD+-dependent deacetylases. ONCOGENE, 34(6), 798-804. doi:10.1038/onc.2014.39

Hall, E. H., Liu, Y., Xiao, A., Shock, L., Brautigan, D. L., Mayo, M. W., . . . Jones, D. R. (2014). Inhibition of Breast Cancer Metastasis Suppressor 1 Promotes a Mesenchymal Phenotype in Lung Epithelial Cells That Express Oncogenic K-RasV12 and Loss of p53. PLOS ONE, 9(4). doi:10.1371/journal.pone.0095869

2013

Cieslik, M., Hoang, S. A., Baranova, N., Chodaparambil, S., Kumar, M., Allison, D. F., . . . Bekiranov, S. (2013). Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition. EPIGENETICS & CHROMATIN, 6. doi:10.1186/1756-8935-6-28

Kumar, M., Allison, D. F., Baranova, N. N., Wamsley, J. J., Katz, A. J., Bekiranov, S., . . . Mayo, M. W. (2013). NF-κB Regulates Mesenchymal Transition for the Induction of Non-Small Cell Lung Cancer Initiating Cells. PLOS ONE, 8(7). doi:10.1371/journal.pone.0068597

2012

Liu, Y., Mayo, M. W., Nagji, A. S., Hall, E. H., Shock, L. S., Xiao, A., . . . Jones, D. R. (2013). BRMS1 Suppresses Lung Cancer Metastases through an E3 Ligase Function on Histone Acetyltransferase p300. CANCER RESEARCH, 73(4), 1308-1317. doi:10.1158/0008-5472.CAN-12-2489

Margalef, P., Fernandez-Majada, V., Villanueva, A., Garcia-Carbonell, R., Iglesias, M., Lopez, L., . . . Espinosa, L. (2012). A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer. CELL REPORTS, 2(4), 840-854. doi:10.1016/j.celrep.2012.08.028

Hoang, S., Cieślik, M., Chodaparambil, S., Baranova, N., Kumar, M., Allison, D., . . . Bekiranov, S. (2012). Epigenetic reprogramming in the epithelial-to-mesenchymal transition. BMC Proceedings, 6(S6). doi:10.1186/1753-6561-6-s6-o28

Allison, D. F., Wamsley, J., Kumar, M., Li, D., Gray, L. G., Hart, G. W., . . . Mayo, M. W. (2012). Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(42), 16888-16893. doi:10.1073/pnas.1208468109

Locke, L. W., Mayo, M. W., Yoo, A. D., Williams, M. B., & Berr, S. S. (2012). PET imaging of tumor associated macrophages using mannose coated 64Cu liposomes. BIOMATERIALS, 33(31), 7785-7793. doi:10.1016/j.biomaterials.2012.07.022

Dutta, P., Tanti, G. K., Sharma, S., Goswami, S. K., Komath, S. S., Mayo, M. W., . . . Muthuswami, R. (2012). Global Epigenetic Changes Induced by SWI2/SNF2 Inhibitors Characterize Neomycin-Resistant Mammalian Cells. PLOS ONE, 7(11). doi:10.1371/journal.pone.0049822

2011

Glidden, E. J., Gray, L. G., Vemuru, S., Li, D., Harris, T. E., & Mayo, M. W. (2012). Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(1), 581-588. doi:10.1074/jbc.M111.304337

Liu, Y., Mayo, M. W., Nagji, A. S., Smith, P. W., Ramsey, C. S., Li, D., & Jones, D. R. (2012). Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. ONCOGENE, 31(9), 1143-1154. doi:10.1038/onc.2011.308

2010

Mikesh, L. M., Kumar, M., Erdag, G., Hogan, K. T., Molhoek, K. R., Mayo, M. W., & Slingluff, C. L. J. (2010). Evaluation of molecular markers of mesenchymal phenotype in melanoma. MELANOMA RESEARCH, 20(6), 485-495. doi:10.1097/CMR.0b013e32833fafb4

Xu, X., Hoang, S., Mayo, M. W., & Bekiranov, S. (2010). Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression. BMC BIOINFORMATICS, 11. doi:10.1186/1471-2105-11-396

Sturgill, T. W., Stoddard, P. B., Cohn, S. M., & Mayo, M. W. (2010). The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. MOLECULAR CANCER, 9. doi:10.1186/1476-4598-9-104

Allison, D. F., & Mayo, M. W. (2010). StIKKing Together: Do Multiple IKK Pathways Cooperate in the DNA-Damage Response?. MOLECULAR CELL, 37(4), 453-454. doi:10.1016/j.molcel.2010.02.004