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Roger Abounader

Roger Abounader

Professor, Microbiology, Immunology, and Cancer Biology

Primary Location
OMS-4 Bldg., Rm 4819
Charlottesville, VA 22908
Primary Phone Number
434.982.6634
Email
[email protected]
Website
https://www.abounaderlab.org/

Bio & Overview

Research: My research focuses on understanding the molecular basis of brain tumor development and growth and on using the acquired knowledge to identify new targets and develop new approaches for experimental brain tumor therapy. Specifically, the following projects are ongoing in my lab at this time: Project 1: To study the role of non-coding RNAs in brain tumor and brain metastasis malignancy and uncover new therapeutic targets: Non-coding RNAs are regulatory RNAs that play important roles in regulating normal and cancer biology. We are studying the expressions, targets, mechanisms of action and functions of microRNAs, TUCRs and lncRNAs in gliomas and brain metastasis. The goal is to understand their role in brain tumor development and growth and identify new therapeutic targets in brain tumors. Project 2: To investigate Transcribed Ultra-Conserved Regions (TUCR) in gliomas: TUCR are regions of the genome that are greater than 200 base pairs in length and are highly conserved across two or more species. The expression of TUCRs is commonly deregulated in cancer, where they might exert crucial regulatory roles. However, the literature elucidating their functional roles and their mechanisms of action in cancer is very sparse, with the literature on their role in glioblastoma being inexistent. This project aims to identify TUCRs that are differentially expressed in glioblastoma, uncover potential correlations with clinical parameters, determine their functional role and mechanisms of action, and evaluate their potential as therapeutic targets. Project 3: To assess the roles and therapeutic targeting of T-Type calcium channels in brain tumors: We are performing a comprehensive investigation of the roles and potential therapeutic exploitation of T-type calcium channels in glioblastoma and medulloblastoma. We are specifically focusing on investigating their roles in mediating the recently discovered tumor promoting neuron/tumor cell interactions. Project 4: To study brain metastasis: Brain metastases affect > 200,000 patients in the US each year and has a dismal prognosis. However, this field is understudied and the processes and mechanisms of brain metastasis remain little known. We are investigating the roles of microRNAs in priming the brain microenvironment for metastasis from primary lung, breast and melanoma tumors using paired human tumors and metastasis animal models.

Academic Information

Department
Microbiology, Immunology, and Cancer Biology
Academic Title
Professor

Primary Education

  • BS, Biology, American University of Beirut, Lebanonnull
  • MD, Medicine, University of Heidelberg, Germanynull
  • PhD, Physiology, University of Heidelberg, Germanynull

Other Appointments

  • Professor, Neurology

Other Affiliations

  • MSTP
  • BIMS

Research Interests

Basic and translational brain tumor research

Research Disciplines

  • Biochemistry
  • Cancer Biology
  • Molecular Biology

Research Opportunities

  • Biochemistry
  • Bioinformatics & Genomics
  • Cancer Biology
  • Cell Biology
  • Molecular Biology

PhD Programs

  • Microbiology

Selected Publications

2026

Saha S, Zhang Y, Gibert MK, Jr., .. Abounader R. Therapeutic delivery of microRNAs discovered to target deregulated glioblastoma pathways inhibits tumor growth in mice. J Clin Invest. 2026; 136(16).

Hudson K, Zhang Y, Abounader R. Cholesterol metabolism emerges as a therapeutic target in chordoma. Neuro Oncol. 2026; 28(3):690-692.

Fu SH, Park C, Shah NA, et al. Use of Small-Molecule Inhibitors of CILK1 and AURKA as Cilia-Promoting Drugs to Decelerate Medulloblastoma Cell Replication. Biomedicines. 2026; 14(2).

Dube CJ, Zhang Y, Saha S, ... Abounader R. Microenvironment T-type calcium channels regulate neuronal and glial processes in tumor cells to promote glioblastoma growth. Neuro Oncol. 2026; 28(9):2123-2135.

2025

Zhang Y, Yuan F, Gibert MK, Jr…. Abounader R. Gain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1alpha in glioblastoma. bioRxiv. 2025.

Saha S, Zhang Y, Gilbert MK, Jr., ... Abounader R. Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma. bioRxiv. 2025.

Gibert MK, Zhang Y, Saha S, ... Abounader R. A comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas. bioRxiv. 2025.

Dube CJ, Lai M, Zhang Y, … Abounader R. T-type calcium channels regulate medulloblastoma and can be targeted for therapy. J Neurooncol. 2025; 173(1):121-130.

2024

Zhang, Y., Hudson, K., & Abounader, R. (2024). Diffuse midline (H3 K27M-mutant) glioma in adults-When resection fails to matter.. Neuro-oncology, 26(8), 1494-1495. doi:10.1093/neuonc/noae099

Zhang, Y., Hudson, K., & Abounader, R. (2024). Unraveling the hypoxic puzzle: LncRNA LUCAT1 drives glioblastoma in cooperation with HIF1α. NEURO-ONCOLOGY. doi:10.1093/neuonc/noae096

Gibert, M., Saha, S., Zhang, Y., Marcinkiewicz, P. P., Chagari, B., Roig-Laboy, C., . . . Abounader, R. (2023). A FIRST COMPREHENSIVE ANALYSIS OF TRANSCRIBED ULTRA CONSERVED REGIONS UNCOVERS IMPORTANT REGULATORY FUNCTIONS OF NOVEL NON-CODING TRANSCRIPTS IN GLIOMAS. In NEURO-ONCOLOGY Vol. 25. Retrieved from https://www.webofscience.com/

Hudson, K., Mondia, M. W., Zhang, Y., Saha, S., Gibert Jr, M. K., Dube, C., . . . Abounader, R. (2024). The role of microRNAs in brain metastasis. JOURNAL OF NEURO-ONCOLOGY, 166(2), 231-241. doi:10.1007/s11060-023-04541-x

2023

Hanif, F., Zhang, Y., Dube, C., Gibert, M. K., Saha, S., Hudson, K., . . . Abounader, R. (2023). miR-3174 Is a New Tumor Suppressor MicroRNA That Inhibits Several Tumor-Promoting Genes in Glioblastoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(11). doi:10.3390/ijms24119326

Dutta, A., Li, H., & Abounader, R. (2023). Cryptic lncRNA-encoded ORFs: A hidden source of regulatory proteins. JOURNAL OF CLINICAL INVESTIGATION, 133(5). doi:10.1172/JCI167271

Hudson, K., Gibert, M. K. J., Zhang, Y., Dube, C., Saha, S., Vernon, A., & Abounader, R. (2023). IDENTIFICATION AND CHARACTERIZATION OF NOVEL TRANSCRIBED ULTRACONSERVED REGIONS AS LONG NON-CODING RNAS IN MEDULLOBLASTOMA. In NEURO-ONCOLOGY Vol. 25. Retrieved from https://www.webofscience.com/

Li, Y., & Abounader, R. (2023). Editorial: GBM stem cells and the brain tumor microenvironment. FRONTIERS IN ONCOLOGY, 13. doi:10.3389/fonc.2023.1153803

2022

Gibert, M. K. J., Sarkar, A., Chagari, B., Roig-Laboy, C., Saha, S., Bednarek, S., . . . Abounader, R. (2022). Transcribed Ultraconserved Regions in Cancer. CELLS, 11(10). doi:10.3390/cells11101684

Mulcahy, E. Q. X., Zhang, Y., Colon, R. R., Cain, S. R., Gibert, M. K. J., Dube, C. J., . . . Abounader, R. (2022). MicroRNA 3928 Suppresses Glioblastoma through Downregulation of Several Oncogenes and Upregulation of p53. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(7). doi:10.3390/ijms23073930

Zhang, Y., Yuan, F., Grello, C., Reon, B., Gibert, M., Dube, C., . . . Abounader, R. (2022). GAIN-OF-FUNCTION MUTANT P53 REGULATES LONG-NONCODING RNAS IN GLIOBLASTOMA. In NEURO-ONCOLOGY Vol. 24 (pp. 39-40). Retrieved from https://www.webofscience.com/

Dube, C., Zhang, Y., Saha, S., Lai, M., Gibert, M., Escalante, M., . . . Abounader, R. (2022). T-TYPE CALCIUM CHANNELS DRIVE GLIOBLASTOMA GROWTH BY PROMOTING NEURONAL INTERACTIONS. In NEURO-ONCOLOGY Vol. 24 (pp. 24). Retrieved from https://www.webofscience.com/

2021

Saha, S., Zhang, Y., Wilson, B., Abounader, R., & Dutta, A. (2021). The tumor-suppressive long noncoding RNA DRAIC inhibits protein translation and induces autophagy by activating AMPK. JOURNAL OF CELL SCIENCE, 134(24). doi:10.1242/jcs.259306

Abounader, R., & Schiff, D. (2021). The blood-brain barrier limits the therapeutic efficacy of antibody-drug conjugates in glioblastoma. NEURO-ONCOLOGY, 23(12), 1993-1994. doi:10.1093/neuonc/noab223

Dube, C., Zhang, Y., Gibert, M. J., Mulcahy, E., Ottolini, M., Xu, E., . . . Abounader, R. (2021). T-TYPE CALCIUM CHANNELS DRIVE GLIOBLASTOMA INITIATION AND PROGRESSION. In NEURO-ONCOLOGY Vol. 23 (pp. 216). Retrieved from https://www.webofscience.com/

El Founini, Y., Chaoui, I., Dehbi, H., El Mzibri, M., Abounader, R., & Guessous, F. (2021). MicroRNAs: Key Regulators in Lung Cancer.. MicroRNA (Shariqah, United Arab Emirates), 10(2), 109-122. doi:10.2174/2211536610666210527102522

2020

Mulcahy, E. Q. X., Colon, R. R., & Abounader, R. (2020). HGF/MET Signaling in Malignant Brain Tumors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(20). doi:10.3390/ijms21207546

Xie, Z., Janczyk, P. L., Zhang, Y., Liu, A., Shi, X., Singh, S., . . . Li, H. (2020). A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-17279-1

Bannon, D. I., Bao, W., Turner, S. D., McCain, W. C., Dennis, W., Wolfinger, R., . . . Abounader, R. (2020). Gene expression in mouse muscle over time after nickel pellet implantation. METALLOMICS, 12(4), 528-538. doi:10.1039/c9mt00289h

Mulcahy, E., Colon, R., Zhang, Y., Gibert, M., Kim, J., Devairakkam, E., . . . Fadul, C. (2020). IDENTIFICATION OF PATHOGENESIS-RELEVANT MICRORNAS IN BRAIN METASTASIS. In NEURO-ONCOLOGY Vol. 22 (pp. 27). Retrieved from https://www.webofscience.com/

Ngulde, S. I., Sandabe, U. K., Abounader, R., Zhang, Y., & Hussaini, I. M. (2020). Activities of Some Medicinal Plants on the Proliferation and Invasion of Brain Tumor Cell Lines. ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES, 2020. doi:10.1155/2020/3626879

2019

Jung, J., Zhang, Y., Celiku, O., Zhang, W., Song, H., Williams, B. J., . . . Park, D. M. (2019). Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma. CANCER RESEARCH, 79(20), 5218-5232. doi:10.1158/0008-5472.CAN-19-0198

Yang, Y., Dodbele, S., Park, T., Glass, R., Bhat, K., Sulman, E. P., . . . Abounader, R. (2019). MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway. JOURNAL OF NEURO-ONCOLOGY, 145(1), 23-34. doi:10.1007/s11060-019-03275-z

Abounader, R., Bhat, K., Soffietti, R., Ghosh, S., & Viapiano, M. (2019). Highlights from the Literature. Neuro-Oncology, 21(7), 834-836. doi:10.1093/neuonc/noz101

Abounader, R., Bhat, K., Hegi, M., Soffietti, R., & Viapiano, M. (2019). Highlights from the Literature. Neuro-Oncology, 21(3), 293-295. doi:10.1093/neuonc/noz020

Abounader, R., Wick, W., Purow, B., Huse, J., & Gerstner, E. (2019). Highlights from the Literature. Neuro-Oncology, 21(2), 148-150. doi:10.1093/neuonc/noz008

Ngulde, S. I., Sandabe, U. K., Abounader, R., Dawson, T. K., Zhang, Y., Iliya, I., & Hussaini, I. M. (2019). Ethanol Extract of Securidaca longipedunculata Induces Apoptosis in Brain Tumor (U87) Cells. BIOMED RESEARCH INTERNATIONAL, 2019. doi:10.1155/2019/9826590

2018

Melhuish, T. A., Kowalczyk, I., Manukyan, A., Zhang, Y., Shah, A., Abounader, R., & Wotton, D. (2018). Myt1 and Myth1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1861(11), 983-995. doi:10.1016/j.bbagrm.2018.10.005

Cruickshanks, N., Zhang, Y., Hine, S., Gibert, M., Yuan, F., Oxford, M., . . . Abounader, R. (2019). Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma. CLINICAL CANCER RESEARCH, 25(2), 663-673. doi:10.1158/1078-0432.CCR-18-0926

Wick, W., Soffietti, R., Bhat, K., Abounader, R., & Pope, W. (2018). Highlights from the Literature. Neuro-Oncology, 20(10), 1289-1291. doi:10.1093/neuonc/noy141

Zhang, Y., Dube, C., Gibert, M. J., Cruickshanks, N., Wang, B., Coughlan, M., . . . Abounader, R. (2018). The p53 Pathway in Glioblastoma. CANCERS, 10(9). doi:10.3390/cancers10090297

Viapiano, M., Soffietti, R., Bhat, K., Wright, K., Abounader, R., & Aldape, K. (2018). Highlights from the Literature. Neuro-Oncology, 20(7), 870-872. doi:10.1093/neuonc/noy087

Zhang, Y., Kim, J., Mueller, A. C., Dey, B., Yang, Y., Lee, D. -H., . . . Abounader, R. (2019). Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma (vol 21, pg 720, 2014). CELL DEATH AND DIFFERENTIATION, 26(1), 197. doi:10.1038/s41418-018-0145-0

Olmez, I., Zhang, Y., Manigat, L., Benamar, M., Brenneman, B., Nakano, I., . . . Purow, B. (2018). Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. CANCER RESEARCH, 78(15), 4360-4369. doi:10.1158/0008-5472.CAN-17-3124

Viapiano, M., Soffietti, R., Bhat, K., Wright, K., Abounader, R., & Aldape, K. (2018). Highlights from the Literature. Neuro-Oncology, 20(6), 726-728. doi:10.1093/neuonc/noy062

Abounader, R. (2018). A new practical and versatile mouse model of proneural glioblastoma. NEURO-ONCOLOGY, 20(3), 299-301. doi:10.1093/neuonc/nox233

Gonzalez, P. P., Kim, J., Galvao, R. P., Cruickshanks, N., Abounader, R., & Zong, H. (2018). p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression. GLIA, 66(5), 999-1015. doi:10.1002/glia.23297

Huse, J., Wick, W., Lawler, S., Abounader, R., & Schiff, D. (2018). Highlights from the Literature. Neuro-Oncology, 20(1), 10-12. doi:10.1093/neuonc/nox224

2017

Viapiano, M., Bhat, K., Abounader, R., Wright, K., Wick, W., & Purow, B. (2017). Highlights from the Literature. Neuro-Oncology, 19(12), 1572-1575. doi:10.1093/neuonc/nox200

Abounader, R., Wright, K., Bhat, K., Chamberlain, M., Purow, B., & Soffietti, R. (2017). Highlights from the Literature. Neuro-Oncology, 19(10), 1294-1297. doi:10.1093/neuonc/nox157

Olmez, I., Brenneman, B., Xiao, A., Serbulea, V., Benamar, M., Zhang, Y., . . . Purow, B. (2017). Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. CLINICAL CANCER RESEARCH, 23(22), 6958-6968. doi:10.1158/1078-0432.CCR-17-0803

Aldape, K., Abounader, R., Bhat, K., Soffietti, R., Purow, B., & Huse, J. (2017). Highlights from the Literature. Neuro-Oncology, 19(8), 1021-1024. doi:10.1093/neuonc/nox114

Cruickshanks, N., Zhang, Y., Yuan, F., Pahuski, M., Gibert, M., & Abounader, R. (2017). Role and Therapeutic Targeting of the HGF/MET Pathway in Glioblastoma. CANCERS, 9(7). doi:10.3390/cancers9070087

Cruickshanks, N. A., Zhang, Y., Hatef, S., Wulfkuhle, J., Gallagher, I., Koeppel, A., . . . Abounader, R. (2017). Abstract 102: Overcoming MET inhibitor resistance in GBM therapy. In Cancer Research Vol. 77 (pp. 102). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2017-102

Guessous, F., Cruickshanks, N. A., Zhang, Y., Schiff, D., Sarkaria, J., & Abounader, R. (2017). Abstract 345: PTEN tumor suppressive effects in glioblastoma are partly mediated by MET downregulation via a p53-miR-34a axis. In Cancer Research Vol. 77 (pp. 345). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2017-345

Olmez, I., Love, S., Xiao, A., Manigat, L., Randolph, P., McKenna, B. D., . . . Purow, B. (2018). Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase alpha. NEURO-ONCOLOGY, 20(2), 192-202. doi:10.1093/neuonc/nox119

Nassiri, F., Abounader, R., Wright, K., Aldape, K., Hegi, M., & Huse, J. (2017). Highlights from the Literature. Neuro-Oncology, 19(6), 746-749. doi:10.1093/neuonc/nox074

Zhang, Y., Cruickshanks, N., Yuan, F., Wang, B., Pahuski, M., Wulfkuhle, J., . . . Abounader, R. (2017). Targetable T-type Calcium Channels Drive Glioblastoma. CANCER RESEARCH, 77(13), 3479-3490. doi:10.1158/0008-5472.CAN-16-2347

Wright, K., Abounader, R., Bhat, K., Viapiano, M. S., Pope, W., & Aldape, K. (2017). Highlights from the Literature. Neuro-Oncology, 19(3), 309-311. doi:10.1093/neuonc/nox010

Pope, W., Huse, J., Abounader, R., Purow, B., Wick, W., & Aldape, K. (2017). Highlights from the Literature. Neuro-Oncology, 19(1), 9-11. doi:10.1093/neuonc/now280

Zhang, Y., Cruickshanks, N., Pahuski, M., Yuan, F., Dutta, A., Schiff, D., . . . Abounader, R. (2017). Noncoding RNAs in Glioblastoma. In GLIOBLASTOMA (pp. 95-130). doi:10.15586/codon.glioblastoma.2017.ch6

2016

Reon, B. J., Anaya, J., Zhang, Y., Mandell, J., Purow, B., Abounader, R., & Dutta, A. (2016). Expression of lncRNAs in Low-Grade Gliomas and Glioblastoma Multiforme: An In Silico Analysis. PLOS MEDICINE, 13(12). doi:10.1371/journal.pmed.1002192

Huse, J., Abounader, R., Purow, B., Hegi, M., Soffietti, R., & Aldape, K. (2016). Highlights from the Literature. Neuro-Oncology, 18(11), 1472-1474. doi:10.1093/neuonc/now215

Zaaroor, M., Sinai, A., Goldsher, D., Eran, A., Nassar, M., Schlesinger, I., . . . Parker, D. (2016). 5th International Symposium on Focused Ultrasound. In Journal of Therapeutic Ultrasound Vol. 4. Springer Science and Business Media LLC. doi:10.1186/s40349-016-0076-5

Vega, R. A., Zhang, Y., Curley, C., Price, R. L., & Abounader, R. (2016). 370 Magnetic Resonance-Guided Focused Ultrasound Delivery of Polymeric Brain-Penetrating Nanoparticle MicroRNA Conjugates in Glioblastoma. In Neurosurgery Vol. 63 (pp. 210). Ovid Technologies (Wolters Kluwer Health). doi:10.1227/01.neu.0000489858.08559.c8

2015

Highlights from the Literature (2015). Neuro-Oncology, 17(12), 1547-1549. doi:10.1093/neuonc/nov279

Zhang, Y., Cruickshanks, N., Wulfkuhle, J., Gallagher, I., Schiff, D., Petricoin, E., . . . Abounader, R. (2015). ATPS-01INHIBITION OF T-TYPE CALCIUM CHANNELS SENSITIZES GLIOBLASTOMA STEM CELLS TO CHEMOTHERAPY. In Neuro-Oncology Vol. 17 (pp. v18.1-v18). Oxford University Press (OUP). doi:10.1093/neuonc/nov204.01

Highlights from the Literature (2015). Neuro-Oncology, 17(10), 1309-1311. doi:10.1093/neuonc/nov195

Lee, D. -H., Zhang, Y., Kassam, A. B., Park, M. -J., Gardner, P., Prevedello, D., . . . Park, D. M. (2015). Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma. PLOS ONE, 10(8). doi:10.1371/journal.pone.0134426

2014

Awad, A. J., Burns, T. C., Zhang, Y., & Abounader, R. (2014). Targeting MET for glioma therapy. NEUROSURGICAL FOCUS, 37(6). doi:10.3171/2014.9.FOCUS14520

Feng, C., Zhang, Y., Yin, J., Li, J., Abounader, R., & Zuo, Z. (2014). Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma. NEURO-ONCOLOGY, 16(8), 1078-1085. doi:10.1093/neuonc/nou010

Zhang, Y., Kim, J., Mueller, A. C., Dey, B., Yang, Y., Lee, D. -H., . . . Abounader, R. (2014). Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma. CELL DEATH AND DIFFERENTIATION, 21(5), 720-734. doi:10.1038/cdd.2013.196

Kim, J., Zhang, Y., Skalski, M., Hayes, J., Kefas, B., Schiff, D., . . . Abounader, R. (2014). microRNA-148a Is a Prognostic oncomiR That Targets MIG6 to Regulate EGFR and Apoptosis in Glioblastoma. CANCER RESEARCH, 74(5), 1541-1553. doi:10.1158/0008-5472.CAN-13-1449

Kim, J., Zhang, Y., Skalski, M., Hayes, J., Kefas, B., Schiff, D., . . . Abounader, R. (2014). microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-5222

Zhang, Y., Kim, J., Mueller, A. C., Dey, B., Yang, Y., Lee, D., . . . Abounader, R. (2014). Identification and characterization of microRNA-134 as a novel receptor tyrosine kinase-regulated tumor suppressive hub in glioblastoma. In CANCER RESEARCH Vol. 74. doi:10.1158/1538-7445.AM2014-1909

Negishi, M., Wongpalee, S. P., Sarkar, S., Park, J., Lee, K. Y., Shibata, Y., . . . Dutta, A. (2014). A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins. PLOS ONE, 9(4). doi:10.1371/journal.pone.0095216

Zhang, Y., Schiff, D., Park, D., & Abounader, R. (2014). MicroRNA-608 and MicroRNA-34a Regulate Chordoma Malignancy by Targeting EGFR, Bcl-xL and MET. PLOS ONE, 9(3). doi:10.1371/journal.pone.0091546

Floyd, D. H., Zhang, Y., Dey, B. K., Kefas, B., Breit, H., Marks, K., . . . Purow, B. W. (2014). Novel Anti-Apoptotic MicroRNAs 582-5p and 363 Promote Human Glioblastoma Stem Cell Survival via Direct Inhibition of Caspase 3, Caspase 9, and Bim. PLOS ONE, 9(5). doi:10.1371/journal.pone.0096239

2013

Kefas, B., Floyd, D. H., Comeau, L., Frisbee, A., Dominguez, C., diPierro, C. G., . . . Purow, B. (2013). A miR-297/hypoxia/DGK- axis regulating glioblastoma survival. NEURO-ONCOLOGY, 15(12), 1652-1663. doi:10.1093/neuonc/not118

Kofman, A. V., Kim, J., Park, S. Y., Dupart, E., Letson, C., Bao, Y., . . . Abounader, R. (2013). microRNA-34a promotes DNA damage and mitotic catastrophe. CELL CYCLE, 12(22), 3500-3511. doi:10.4161/cc.26459

Huang, X., Zhang, Y., Tang, Y., Butler, N., Kim, J., Guessous, F., . . . Abounader, R. (2013). A Novel PTEN/Mutant p53/c-Myc/Bcl-XL Axis Mediates Context-Dependent Oncogenic Effects of PTEN with Implications for Cancer Prognosis and Therapy. NEOPLASIA, 15(8), 952-+. doi:10.1593/neo.13376

Kofman, A. V., Letson, C., Dupart, E., Bao, Y., Newcomb, W. W., Schiff, D., . . . Abounader, R. (2013). The p53-microRNA-34a axis regulates cellular entry receptors for tumor-associated human herpes viruses. MEDICAL HYPOTHESES, 81(1), 62-67. doi:10.1016/j.mehy.2013.04.012

Dominguez, C. L., Floyd, D. H., Xiao, A., Mullins, G. R., Kefas, B. A., Xin, W., . . . Purow, B. W. (2013). Diacylglycerol Kinase a Is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers. CANCER DISCOVERY, 3(7), 782-797. doi:10.1158/2159-8290.CD-12-0215

Zhang, Y., Farenholtz, K. E., Yang, Y., Guessous, F., diPierro, C. G., Calvert, V. S., . . . Abounader, R. (2013). Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition. CLINICAL CANCER RESEARCH, 19(6), 1433-1444. doi:10.1158/1078-0432.CCR-12-2832

Guessous, F., Alvarado-Velez, M., Marcinkiewicz, L., Zhang, Y., Kim, J., Heister, S., . . . Abounader, R. (2013). Oncogenic effects of miR-10b in glioblastoma stem cells. JOURNAL OF NEURO-ONCOLOGY, 112(2), 153-163. doi:10.1007/s11060-013-1047-0

2012

Kim, J., Zhang, Y., Guessous, F., & Abounader, R. (2012). microRNA-148a: A novel oncogenic microRNA in glioblastoma. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-3165

Kofman, A., Guessous, F., diPierro, C. G., Dupart, E., Bao, Y., Dhamala, S., . . . Abounader, R. (2012). Exploration of microRNA-34a effects in human glioma cell lines. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-3163

Zhang, Y., Farenholtz, K., Yang, Y., Guessous, F., Schiff, D., Purow, B., . . . Abounader, R. (2012). Hepatocyte growth factor sensitizes brain tumor cells and xenografts to c -Met kinase inhibition. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-1821

Guessous, F., Yang, Y., Johnson, E., Marcinkiewicz, L., Smith, M., Zhang, Y., . . . Abounader, R. (2012). Cooperation between c-Met and focal adhesion kinase pathways in medulloblastoma and implications for therapy. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-1252

Zhang, Y., Dutta, A., & Abounader, R. (2012). The role of microRNAs in glioma initiation and progression. FRONTIERS IN BIOSCIENCE-LANDMARK, 17, 700-712. doi:10.2741/3952

2011

Guessous, F., Yang, Y., Johnson, E., Marcinkiewicz, L., Smith, M., Zhang, Y., . . . Abounader, R. (2012). Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy. MOLECULAR CANCER THERAPEUTICS, 11(2), 288-297. doi:10.1158/1535-7163.MCT-11-0490

Catania, A., Maira, F., Skarmoutsou, E., D'Amico, F., Abounader, R., & Mazzarino, M. C. (2012). Insight into the role of microRNAs in brain tumors (Review). INTERNATIONAL JOURNAL OF ONCOLOGY, 40(3), 605-624. doi:10.3892/ijo.2011.1305

Kofman, A. V., & Abounader, R. (2011). When tumor cells make blood vessels: implications for glioblastoma therapy. FUTURE ONCOLOGY, 7(7), 841-843. doi:10.2217/FON.11.58

Kofman, A., Marcinkiewicz, L., Dupart, E., Lyshchev, A., Martynov, B., Ryndin, A., . . . Abounader, R. (2011). The roles of viruses in brain tumor initiation and oncomodulation. JOURNAL OF NEURO-ONCOLOGY, 105(3), 451-466. doi:10.1007/s11060-011-0658-6

Guessous, F., Alvarado, M., Zhang, Y., Heister, S., Kefas, B., Schiff, D., & Abounader, R. (2011). Characterization of microRNA-10b in human glioblastoma. In CANCER RESEARCH Vol. 71. doi:10.1158/1538-7445.AM2011-126

Alvarado-Velez, M., Guessous, F., & Abounader, R. (2011). Characterization of microRNA-10b in human Glioblastoma. FASEB JOURNAL, 25. Retrieved from https://www.webofscience.com/

2010

Guessous, F., Zhang, Y., Catania, A., Li, Y., Kofman, A., Kefas, B., . . . Abounader, R. (2010). Abstract 2067: Effects of microRNA-34a on brain tumor cells and glioblastoma stem cells. In Cancer Research Vol. 70 (pp. 2067). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am10-2067

Zhang, Y., Farenholtz, K., Yang, Y., Guessous, F., Kofman, A. V., Christensen, J., & Abounader, R. (2010). Abstract 3625: Exogenous short-term activation of c-Met and EGFR sensitizes them to kinase inhibitors. In Cancer Research Vol. 70 (pp. 3625). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am10-3625

Guessous, F., Zhang, Y., Kofman, A., Catania, A., Li, Y., Schiff, D., . . . Abounader, R. (2010). microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. CELL CYCLE, 9(6), 1031-1036. doi:10.4161/cc.9.6.10987

Zhang, Y., Guessous, F., Kofman, A., Schiff, D., & Abounader, R. (2010). XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. IDRUGS, 13(2), 112-121. Retrieved from https://www.webofscience.com/

Guessous, F., Zhang, Y., diPierro, C., Marcinkiewicz, L., Sarkaria, J., Schiff, D., . . . Abounader, R. (2010). An Orally Bioavailable c-Met Kinase Inhibitor Potently Inhibits Brain Tumor Malignancy and Growth. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 10(1), 28-35. doi:10.2174/1871520611009010028