Hu, Sheng'en Shawn
Primary Appointment
Assistant Professor, Genome Sciences, Public Health Sciences
Education
- Ph.D, Tongji University
Contact Information
Telephone: 4349248430
Email: sh8tv@virginia.edu
Research Disciplines
Bioinformatics and Genomics, Biology, Cancer Biology, Computational Biology, Genetics, Immunology
Research Interests
Computational biology Bioinformatics Cancer immune therapy Chimeric antigen receptor (CAR) T-cell therapy Cancer epigenetics Method development Single-cell Genomics Transcriptional regulation Chromatin accessibility
Research Description
I worked as a postdoctoral fellow and research scientist from 2017-2024 at the University of Virginia, Department of Genome Sciences. Under the supervision of Dr. Chongzhi Zang, I developed a computational framework for the accurate estimation of enzyme intrinsic biases and improved analysis of high-throughput epigenetics data at the single-cell level (1). We further applied our framework and experiences in single-cell chromatin accessibility to explore the transcriptional regulation mechanism in different systems, including human coronary artery disease (2), human central memory T cells (3), and mouse primitive gut tube (4). My expertise in computational biology, research experience in chromatin biology and cancer epigenetics, and experience in single-cell genomics and epigenomics data analysis make me uniquely qualified for the proposed research.
As a research assistant professor at the University of Virginia, my current research focuses on 1) Integrative analysis with single-cell multiome data to explore the function of Chimeric antigen receptor (CAR) T-cell in cancer immune therapy. 2) developing quantitative models and computational methods for analyzing high-throughput sequencing data and imaging data at single-cell levels and 3) using bioinformatics approaches to study epigenetics and transcriptional regulation at various cancer types.