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Wei-Min Chen

Wei-Min Chen

Associate Professor, Public Health Sciences

Primary Location
PO Box 800717
Primary Phone Number

Bio & Overview

My research focuses on the design and statistical analysis of human gene mapping data. Recently, my research has focused on the development of methods for analyzing genome-wide SNP data in datasets that include thousands of individuals. Genome Wide Association Analysis I developed a general procedure to infer missing genotypes in family-based genomewide association studies (Chen and Abecasis 2007). This work allows efficient use of family collections in genome wide association (GWA) studies, especially when the GWA follows an initial linkage scan. With this approach, only a few selected individuals in each family need to be genotyped during the GWA, and genotypes of the remaining individuals can be mostly inferred based on the information from flanking markers and relatives. In this work, I also proposed efficient tests for GWA analysis of quantitative traits that allow for uncertainty in the estimation of missing genotypes. These methodologies have been successfully applied to the genomewide association analysis of the gene expression data as well as a large GWA study of ~100 aging related quantitative traits (mainly cardiovascular and personality traits) in >6,000 individuals from Sardinia. Robust Linkage and Association Tests I developed a general methodology framework for quantitative trait linkage analysis making use of the Generalized Estimating Equations (GEE) (Chen et al. 2004). Using this framework, I proposed novel robust linkage tests and investigated commonly used linkage methods (Chen et al. 2005). Power Analysis of Linkage and Association I developed an efficient method to perform analytical power calculation for the variance component linkage analysis in pedigrees of any size (Chen and Abecasis 2006). I also developed a general approach to calculate the power of the Transmission/Disequilibrium Test (TDT), a widely-used test and design for association studies (Chen and Deng 2001).

Academic Information

Department
Public Health Sciences
Academic Title
Assistant Professor

Primary Education

  • Postdoc, Statistical Genetics, University of Michigannull
  • M.S., Biomedical Sciences, Creighton University School of Medicinenull
  • M.S., Signal Processing, Peking Universitynull
  • B.S., Mathematical Statistics and Probability, Peking Universitynull
  • Ph.D., Biostatistics, Johns Hopkins School of Public Healthnull

Other Appointments

  • Assistant Professor, BMBG
  • Assistant Professor, SCBB

Other Affiliations

  • BIMS
  • Assistant Professor, BIMS
  • Genomic Sciences

Research Interests

Statistical genetics and genomics.

Research Disciplines

  • Bioinformatics and Genomics
  • Biophysics
  • Computational Biology
  • Genetics

Research Opportunities

  • Bioinformatics & Genomics
  • Computational Biology
  • Genetics

PhD Programs

  • Computational Biology

Selected Publications

2022

Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., . . . Morris, A. P. (2022). Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. NATURE GENETICS, 54(5), 560-+. doi:10.1038/s41588-022-01058-3

Torn, C., Liu, X., Onengut-Gumuscu, S., Counts, K. M., Moreno, J. L., Remedios, C. L., . . . Parikh, H. M. (2022). Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08058-7

2021

Braenne, I., Onengut-Gumuscu, S., Chen, R., Manichaikul, A. W., Rich, S. S., Chen, W. -M., & Farber, C. R. (2021). Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-01840-z

Robertson, C. C., Inshaw, J. R. J., Onengut-Gumuscu, S., Chen, W. -M., Santa Cruz, D. F., Yang, H., . . . Rich, S. S. (2021). Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. NATURE GENETICS, 53(7), 962-+. doi:10.1038/s41588-021-00880-5

Zimmerman, K. D., Schurr, T. G., Chen, W. -M., Nayak, U., Mychaleckyj, J. C., Quet, Q., . . . Ramos, P. S. (2021). Genetic landscape of Gullah African Americans. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 175(4), 905-919. doi:10.1002/ajpa.24333

Natarajan, P., Pampana, A., Graham, S. E., Ruotsalainen, S. E., Perry, J. A., de Vries, P. S., . . . Kuopio, T. (2021). Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22339-1

Graff, M., Justice, A. E., Young, K. L., Marouli, E., Zhang, X., Fine, R. S., . . . North, K. E. (2021). Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. AMERICAN JOURNAL OF HUMAN GENETICS, 108(4), 564-582. doi:10.1016/j.ajhg.2021.02.011

Polfus, L. M., Darst, B. F., Highland, H., Sheng, X., Ng, M. C. Y., Below, J. E., . . . Haiman, C. A. (2021). Genetic discovery and risk characterization in type 2 diabetes across diverse populations. HUMAN GENETICS AND GENOMICS ADVANCES, 2(2). doi:10.1016/j.xhgg.2021.100029

Miller, R. G., Orchard, T. J., Onengut-Gumuscu, S., Chen, W. -M., Rich, S. S., & Costacou, T. (2021). Heterogeneous long-term trajectories of glycaemic control in type 1 diabetes. DIABETIC MEDICINE, 38(8). doi:10.1111/dme.14545

Miller, R. G., McGurnaghan, S. J., Onengut-Gumuscu, S., Chen, W. -M., Colhoun, H. M., Rich, S. S., . . . Costacou, T. (2021). Insulin resistance-associated genetic variants in type 1 diabetes. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(4). doi:10.1016/j.jdiacomp.2020.107842

Armstrong, N. M. D., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Cullell, N., Fernandez-Cadenas, I., . . . Keene, K. L. (2021). DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(7). doi:10.1371/journal.pone.0254562

Armstrong, N. M. D., Spragley, K. J., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Horn, P. J., . . . Keene, K. L. (2021). Multi-omic analysis of stroke recurrence in African Americans from the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(3). doi:10.1371/journal.pone.0247257

2020

Onengut-Gumuscu, S., Paila, U., Chen, W. -M., Ratan, A., Zhu, Z., Steck, A. K., . . . Rich, S. S. (2020). Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-75690-6

Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., . . . Natarajan, P. (2021). Inherited causes of clonal haematopoiesis in 97,691 whole genomes (vol 586, pg 763, 2020). NATURE, 591(7849), E27. doi:10.1038/s41586-021-03280-1

Li, X., Li, Z., Zhou, H., Gaynor, S. M., Liu, Y., Chen, H., . . . Lin, X. (2020). Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. NATURE GENETICS, 52(9), 969-+. doi:10.1038/s41588-020-0676-4

Keene, K. L., Hyacinth, H. I., Bis, J. C., Kittner, S. J., Mitchell, B. D., Cheng, Y. -C., . . . Fornage, M. (2020). Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. STROKE, 51(8), 2454-2463. doi:10.1161/STROKEAHA.120.029123

Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. A., . . . Davies, N. M. (2020). Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-17117-4

2019

Salem, R. M., Todd, J. N., Sandholm, N., Cole, J. B., Chen, W. -M., Andrews, D., . . . Florez, J. C. (2019). Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 30(10), 2000-2016. doi:10.1681/ASN.2019030218

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2019). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (vol 50, pg 524, 2018). NATURE GENETICS, 51(7), 1192-1193. doi:10.1038/s41588-019-0449-0

Valdes-Marquez, E., Parish, S., Clarke, R., Stari, T., Worrall, B. B., Hopewell, J. C., . . . Cheng, Y. -C. (2019). Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study. NEUROLOGY, 92(11), E1176-E1187. doi:10.1212/WNL.0000000000007091

Onengut-Gumuscu, S., Chen, W. -M., Robertson, C. C., Bonnie, J. K., Farber, E., Zhu, Z., . . . Rich, S. S. (2019). Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score. DIABETES CARE, 42(3), 406-415. doi:10.2337/dc18-1727

2018

Marquez, A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J., Chen, W. -M., Onengut-Gumuscu, S., . . . Martin, J. (2018). Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. GENOME MEDICINE, 10. doi:10.1186/s13073-018-0604-8

Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., . . . Alizadeh, B. Z. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. AMERICAN JOURNAL OF HUMAN GENETICS, 103(5), 691-706. doi:10.1016/j.ajhg.2018.09.009

Westra, H. -J., Martinez-Bonet, M., Onengut-Gumuscu, S., Lee, A., Luol, Y., Teslovich, N., . . . Raychaudhuri, S. (2018). Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. NATURE GENETICS, 50(10), 1366-+. doi:10.1038/s41588-018-0216-7

Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., . . . Neale, B. M. (2018). Analysis of shared heritability in common disorders of the brain. SCIENCE, 360(6395), 1313-+. doi:10.1126/science.aap8757

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. NATURE GENETICS, 50(4), 524-+. doi:10.1038/s41588-018-0058-3

Sharma, A., Liu, X., Hadley, D., Hagopian, W., Chen, W. -M., Onengut-Gumuscu, S., . . . She, J. -X. (2018). Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. JOURNAL OF AUTOIMMUNITY, 89, 90-100. doi:10.1016/j.jaut.2017.12.008

Armstrong, N. M. D., Chen, W. -M., Brewer, M. S., Williams, S. R., Sale, M. M., Worrall, B. B., & Keene, K. L. (2018). Epigenome-Wide Analyses Identify Two Novel Associations With Recurrent Stroke in the Vitamin Intervention for Stroke Prevention Clinical Trial. FRONTIERS IN GENETICS, 9. doi:10.3389/fgene.2018.00358

2017

Norris, J. M., Lee, H. -S., Frederiksen, B., Erlund, I., Uusitalo, U., Yang, J., . . . Hagopian, W. (2018). Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. DIABETES, 67(1), 146-154. doi:10.2337/db17-0802

Wheeler, E., Leong, A., Liu, C. -T., Hivert, M. -F., Strawbridge, R. J., Podmore, C., . . . Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLOS MEDICINE, 14(9). doi:10.1371/journal.pmed.1002383

Steck, A. K., Xu, P., Geyer, S., Redondo, M. J., Antinozzi, P., Wentworth, J. M., . . . Pugliese, A. (2017). Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(8), 2873-2880. doi:10.1210/jc.2016-4003

Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Dzhivhuho, G., Rowles, J. L. I. I. I., . . . Sale, M. M. (2017). Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke. STROKE, 48(6), 1444-+. doi:10.1161/STROKEAHA.116.015677

Ng, M. C. Y., Graff, M., Lu, Y., Justice, A. E., Mudgal, P., Liu, C. -T., . . . North, K. E. (2017). Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLOS GENETICS, 13(4). doi:10.1371/journal.pgen.1006719

Sun, L., Dimitromanolakis, A., & Chen, W. -M. (2017). Identifying Cryptic Relationships. STATISTICAL HUMAN GENETICS: METHODS AND PROTOCOLS, 2ND EDITION, 1666, 45-60. doi:10.1007/978-1-4939-7274-6_4

2016

Torn, C., Liu, X., Hagopian, W., Lernmark, A., Simell, O., Rewers, M., . . . Krischer, J. (2016). Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27887

Liu, C. -T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., . . . Meigs, J. B. (2016). Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. AMERICAN JOURNAL OF HUMAN GENETICS, 99(1), 56-75. doi:10.1016/j.ajhg.2016.05.006

Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., . . . Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. NATURE GENETICS, 48(7), 803-+. doi:10.1038/ng.3572

Malik, R., Traylor, M., Pulit, S. L., Bevan, S., Hopewell, J. C., Holliday, E. G., . . . Dichgans, M. (2016). Low-frequency and common genetic variation in ischemic stroke The METASTROKE collaboration. NEUROLOGY, 86(13), 1217-1226. doi:10.1212/WNL.0000000000002528

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., . . . Fox, C. S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms10023

Uusitalo, U., Liu, X., Yang, J., Aronsson, C. A., Hummel, S., Butterworth, M., . . . Virtanen, S. M. (2016). Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA PEDIATRICS, 170(1), 20-28. doi:10.1001/jamapediatrics.2015.2757

Sharma, A., Liu, X., Hadley, D., Hagopian, W., Liu, E., Chen, W. -M., . . . She, J. -X. (2016). Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLOS ONE, 11(3). doi:10.1371/journal.pone.0152476

2015

Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Nelson, S., Southerland, A. M., . . . Worrall, B. B. (2016). Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. NEUROLOGY, 86(4), 351-359. doi:10.1212/WNL.0000000000002319

Gutierrez-Achury, J., Romanos, J., Bakker, S. F., Kumar, V., de Haas, E. C., Trynka, G., . . . Wijmenga, C. (2015). Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity. DIABETES CARE, 38, S37-S44. doi:10.2337/dcs15-2007

Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., . . . Raychaudhuri, S. (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. NATURE GENETICS, 47(9), 1085-+. doi:10.1038/ng.3379

Hu, X., Deutsch, A. J., Lenz, T. L., Onengut-Gumuscu, S., Han, B., Chen, W. -M., . . . Raychaudhuri, S. (2015). Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. NATURE GENETICS, 47(8), 898-+. doi:10.1038/ng.3353

Auer, P. L., Nalls, M., Meschia, J. F., Worrall, B. B., Longstreth, W. T. J., Seshadri, S., . . . Rich, S. S. (2015). Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke The NHLBI Exome Sequence Project. JAMA NEUROLOGY, 72(7), 781-788. doi:10.1001/jamaneurol.2015.0582

Carty, C. L., Keene, K. L., Cheng, Y. -C., Meschia, J. F., Chen, W. -M., Nalls, M., . . . Fornage, M. (2015). Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. STROKE, 46(8), 2063-2068. doi:10.1161/STROKEAHA.115.009044

Hadley, D., Hagopian, W., Liu, E., She, J. -X., Simell, O., Akolkar, B., . . . Agardh, D. (2015). HLA-DPB1☆04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study. AMERICAN JOURNAL OF GASTROENTEROLOGY, 110(6), 915-920. doi:10.1038/ajg.2015.150

Brorsson, C. A., Onengut, S., Chen, W. -M., Wenzlau, J., Yu, L., Baker, P., . . . Pociot, F. (2015). Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes. DIABETES, 64(8), 3017-3027. doi:10.2337/db14-1730

Onengut-Gumuscu, S., Chen, W. -M., Burren, O., Cooper, N. J., Quinlan, A. R., Mychaleckyj, J. C., . . . Rich, S. S. (2015). Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. NATURE GENETICS, 47(4), 381-U199. doi:10.1038/ng.3245

Anaya, J., Reon, B., Chen, W. -M., Bekiranov, S., & Duna, A. (2016). A pan-cancer analysis of prognostic genesl. PEERJ, 4. doi:10.7717/peerj.1499

2014

Torn, C., Hadley, D., Lee, H. -S., Hagopian, W., Lernmark, A., Simell, O., . . . Krischer, J. (2015). Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. DIABETES, 64(5), 1818-1829. doi:10.2337/db14-1497

Evangelou, M., Smyth, D. J., Fortune, M. D., Burren, O. S., Walker, N. M., Guo, H., . . . Wallace, C. (2014). A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations. GENETIC EPIDEMIOLOGY, 38(8), 661-670. doi:10.1002/gepi.21853

Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. -M., Guo, X., . . . Bowden, D. W. (2014). Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes. PLOS GENETICS, 10(8). doi:10.1371/journal.pgen.1004517

Tomlinson, M. J., Pitsillides, A., Pickin, R., Mika, M., Keene, K. L., Hou, X., . . . Onengut-Gumuscu, S. (2014). Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13. DIABETES, 63(12), 4360-4368. doi:10.2337/db13-1785

Fernandez, C. A., Smith, C., Yang, W., Date, M., Bashford, D., Larsen, E., . . . Relling, M. V. (2014). HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies. BLOOD, 124(8), 1266-1276. doi:10.1182/blood-2014-03-563742

Hu, X., Kim, H., Raj, T., Brennan, P. J., Trynka, G., Teslovich, N., . . . Raychaudhuri, S. (2014). Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells. PLOS GENETICS, 10(6). doi:10.1371/journal.pgen.1004404

Pontikos, N., Smyth, D. J., Schuilenburg, H., Howson, J. M. M., Walker, N. M., Burren, O. S., . . . Wallace, C. (2014). A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples. BMC GENOMICS, 15. doi:10.1186/1471-2164-15-274

Williams, S. R., Yang, Q., Chen, F., Liu, X., Keene, K. L., Jacques, P., . . . Sale, M. M. (2014). Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004214

Huang, J., Huffman, J. E., Yamkauchi, M., Trompet, S., Asselbergs, F. W., Sabater-Lleal, M., . . . O'Donnell, C. J. (2014). Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(5), 1093-1101. doi:10.1161/ATVBAHA.113.302088

Allen, E. K., Manichaikul, A., Chen, W. -M., Rich, S. S., Daly, K. A., & Sale, M. M. (2014). Evaluation of Replication of Variants Associated with Genetic Risk of Otitis Media. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104212

Keene, K. L., Chen, W. -M., Chen, F., Williams, S. R., Elkhatib, S. D., Hsu, F. -C., . . . Sale, M. M. (2014). Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial. FRONTIERS IN PUBLIC HEALTH, 2. doi:10.3389/fpubh.2014.00112

2013

Allen, E. K., Chen, W. -M., Weeks, D. E., Chen, F., Hou, X., Mattos, J. L., . . . Sale, M. M. (2013). A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 14(6), 791-800. doi:10.1007/s10162-013-0411-2

Franceschini, N., Fox, E., Zhang, Z., Edwards, T. L., Nalls, M. A., Sung, Y. J., . . . Zhu, X. (2013). Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations. AMERICAN JOURNAL OF HUMAN GENETICS, 93(3), 545-554. doi:10.1016/j.ajhg.2013.07.010

Yadav, S., Cotlarciuc, I., Munroe, P. B., Khan, M. S., Nalls, M. A., Bevan, S., . . . Sharma, P. (2013). Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke. STROKE, 44(10), 2703-2709. doi:10.1161/STROKEAHA.113.002186

van Dongen, J., Willemsen, G., Chen, W. -M., de Geus, E. J. C., & Boomsma, D. I. (2013). Heritability of metabolic syndrome traits in a large population-based sample. JOURNAL OF LIPID RESEARCH, 54(10), 2914-2923. doi:10.1194/jlr.P041673

Hinks, A., Cobb, J., Marion, M. C., Prahalad, S., Sudman, M., Bowes, J., . . . Thompson, S. D. (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. NATURE GENETICS, 45(6), 664-+. doi:10.1038/ng.2614

Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., . . . Haiman, C. A. (2013). A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. NATURE GENETICS, 45(6), 690-+. doi:10.1038/ng.2608

Ferreira, R. C., Freitag, D. F., Cutler, A. J., Howson, J. M. M., Rainbow, D. B., Smyth, D. J., . . . Todd, J. A. (2013). Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases. PLOS GENETICS, 9(4). doi:10.1371/journal.pgen.1003444

Liu, C. -T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., . . . Fox, C. S. (2013). Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci. PLOS GENETICS, 9(8). doi:10.1371/journal.pgen.1003681

Langefeld, C. D., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., Chen, W. -M., . . . Ramos, P. S. (2013). Identification Of Autoimmune Disease Risk Alleles That Are Under Recent Selection In The Sea Island Gullah African Americans. ARTHRITIS AND RHEUMATISM, 65, S60-S61. Retrieved from https://www.webofscience.com/

Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., . . . Mignot, E. (2013). ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy. PLOS GENETICS, 9(2). doi:10.1371/journal.pgen.1003270

Jia, X., Han, B., Onengut-Gumuscu, S., Chen, W. -M., Concannon, P. J., Rich, S. S., . . . de Bakker, P. I. W. (2013). Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens. PLOS ONE, 8(6). doi:10.1371/journal.pone.0064683

Ramos, P. S., Titus, N., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., . . . Langefeld, C. D. (2013). Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina. ARTHRITIS AND RHEUMATISM, 65, S61. Retrieved from https://www.webofscience.com/

2012

Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y. -C., . . . Markus, H. S. (2012). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. LANCET NEUROLOGY, 11(11), 951-962. doi:10.1016/S1474-4422(12)70234-X

Cheng, Y. -C., Anderson, C. D., Bione, S., Keene, K., Maguire, J. M., Nalls, M., . . . Mitchell, B. D. (2012). Are Myocardial Infarction-Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?. STROKE, 43(4), 980-U143. doi:10.1161/STROKEAHA.111.632075

Chen, M. -H., Huang, J., Chen, W. -M., Larson, M. G., Fox, C. S., Vasan, R. S., . . . Yang, Q. (2012). Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study. PLOS ONE, 7(12). doi:10.1371/journal.pone.0051589

Manichaikul, A., Palmas, W., Rodriguez, C. J., Peralta, C. A., Divers, J., Guo, X., . . . Mychaleckyj, J. C. (2012). Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis. PLOS GENETICS, 8(4), 285-298. doi:10.1371/journal.pgen.1002640

Elbers, C. C., Guo, Y., Tragante, V., van Iperen, E. P. A., Lanktree, M. B., Castillo, B. A., . . . Keating, B. J. (2012). Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050198

2011

Stanton, C. M., Yates, J. R. W., den Hollander, A. I., Seddon, J. M., Swaroop, A., Stambolian, D., . . . Wright, A. F. (2011). Complement factor D in age-related macular degeneration.. Investigative ophthalmology & visual science, 52(12), 8828-8834. doi:10.1167/iovs.11-7933

Chen, W. -M., Manichaikul, A., & Rich, S. S. (2011). Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees.. BMC proceedings, 5 Suppl 9, S68. doi:10.1186/1753-6561-5-s9-s68

Hsu, F. -C., Sides, E. G., Mychaleckyj, J. C., Worrall, B. B., Elias, G. A., Liu, Y., . . . Sale, M. M. (2011). Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. NEUROLOGY, 77(16), 1543-1550. doi:10.1212/WNL.0b013e318233b1f9

Chen, W. -M., Allen, E. K., Mychaleckyj, J. C., Chen, F., Hou, X., Rich, S. S., . . . Sale, M. M. (2011). Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM). BMC MEDICAL GENETICS, 12. doi:10.1186/1471-2350-12-124

Manichaikul, A., Chen, W. -M., Williams, K., Wong, Q., Sale, M. M., Pankow, J. S., . . . Mychaleckyj, J. C. (2012). Analysis of family- and population-based samples in cohort genome-wide association studies. HUMAN GENETICS, 131(2), 275-287. doi:10.1007/s00439-011-1071-0

Morahan, G., Mehta, M., James, I., Chen, W. -M., Akolkar, B., Erlich, H. A., . . . Rich, S. S. (2011). Tests for Genetic Interactions in Type 1 Diabetes Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs. DIABETES, 60(3), 1030-1040. doi:10.2337/db10-1195

Sale, M. M., Chen, W. -M., Weeks, D. E., Mychaleckyj, J. C., Hou, X., Marion, M., . . . Daly, K. A. (2011). Evaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM). PLOS ONE, 6(8). doi:10.1371/journal.pone.0022297

Solorzano, G., Chen, F., Mychaleckyj, J. C., Chen, W. -M., Hsu, F. -C., Sale, M., & Worrall, B. B. (2011). Antihypertensive Class And Stroke Recurrence: An Analysis Of The VISP Trial. STROKE, 42(3), E348. Retrieved from https://www.webofscience.com/

2010

Ding, J., Gudjonsson, J. E., Liang, L., Stuart, P. E., Li, Y., Chen, W., . . . Abecasis, G. R. (2010). Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals.. American journal of human genetics, 87(6), 779-789. doi:10.1016/j.ajhg.2010.10.024

Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W. -M. (2010). Robust relationship inference in genome-wide association studies. BIOINFORMATICS, 26(22), 2867-2873. doi:10.1093/bioinformatics/btq559

Baratz, K. H., Tosakulwong, N., Ryu, E., Brown, W. L., Branham, K., Chen, W., . . . Edwards, A. O. (2010). E2-2 protein and Fuchs's corneal dystrophy.. The New England journal of medicine, 363(11), 1016-1024. doi:10.1056/nejmoa1007064

Kanda, A., Stambolian, D., Chen, W., Curcio, C. A., Abecasis, G. R., & Swaroop, A. (2010). Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.. Molecular vision, 16, 1317-1323.

Strunnikova, N. V., Maminishkis, A., Barb, J. J., Wang, F., Zhi, C., Sergeev, Y., . . . Miller, S. S. (2010). Transcriptome analysis and molecular signature of human retinal pigment epithelium.. Human molecular genetics, 19(12), 2468-2486. doi:10.1093/hmg/ddq129

Scuteri, A., Sanna, S., Chen, W. -M., Uda, M., Albai, G., Strait, J., . . . Abecasis, G. R. (2010). Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLOS GENETICS, 6(4). doi:10.1371/journal.pgen.0030115

Patel, R. K., Elias, G. A., Hsu, F. -C., Mychaleckyj, J. C., Chen, W. -M., Worrall, B. B., & Sale, M. M. (2010). Investigation of Recurrent Stroke Risk in the Vitamin Intervention for Stroke Prevention (VISP) Trial Suggests Different Genetic Influences on Prevalent and Incident Stroke. STROKE, 41(4), E335. Retrieved from https://www.webofscience.com/

Elias, G. A., Patel, R. K., Chen, W. -M., Mychaleckyj, J. C., Hsu, F. -C., Worrall, B. B., & Sale, M. M. (2010). Association of a Transcobalamin 2 (TCN2) Variant Located in the 3UTR With Post-stroke Homocysteine Level in Subjects From the Vitamin Intervention for Stroke Prevention Trial. STROKE, 41(4), E335. Retrieved from https://www.webofscience.com/