Wei-Min Chen
Associate Professor, Public Health Sciences
Bio & Overview
Academic Information
- Department
- Public Health Sciences
- Academic Title
- Assistant Professor
Primary Education
- Postdoc, Statistical Genetics, University of Michigannull
- M.S., Biomedical Sciences, Creighton University School of Medicinenull
- M.S., Signal Processing, Peking Universitynull
- B.S., Mathematical Statistics and Probability, Peking Universitynull
- Ph.D., Biostatistics, Johns Hopkins School of Public Healthnull
Other Appointments
- Assistant Professor, BMBG
- Assistant Professor, SCBB
Other Affiliations
- BIMS
- Assistant Professor, BIMS
- Genomic Sciences
Research Interests
Research Disciplines
- Bioinformatics and Genomics
- Biophysics
- Computational Biology
- Genetics
Research Opportunities
- Bioinformatics & Genomics
- Computational Biology
- Genetics
PhD Programs
- Computational Biology
Selected Publications
2022
Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., . . . Morris, A. P. (2022). Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. NATURE GENETICS, 54(5), 560-+. doi:10.1038/s41588-022-01058-3
Torn, C., Liu, X., Onengut-Gumuscu, S., Counts, K. M., Moreno, J. L., Remedios, C. L., . . . Parikh, H. M. (2022). Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-08058-7
2021
Braenne, I., Onengut-Gumuscu, S., Chen, R., Manichaikul, A. W., Rich, S. S., Chen, W. -M., & Farber, C. R. (2021). Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes. SCIENTIFIC REPORTS, 11(1). doi:10.1038/s41598-021-01840-z
Robertson, C. C., Inshaw, J. R. J., Onengut-Gumuscu, S., Chen, W. -M., Santa Cruz, D. F., Yang, H., . . . Rich, S. S. (2021). Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. NATURE GENETICS, 53(7), 962-+. doi:10.1038/s41588-021-00880-5
Zimmerman, K. D., Schurr, T. G., Chen, W. -M., Nayak, U., Mychaleckyj, J. C., Quet, Q., . . . Ramos, P. S. (2021). Genetic landscape of Gullah African Americans. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 175(4), 905-919. doi:10.1002/ajpa.24333
Natarajan, P., Pampana, A., Graham, S. E., Ruotsalainen, S. E., Perry, J. A., de Vries, P. S., . . . Kuopio, T. (2021). Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-22339-1
Graff, M., Justice, A. E., Young, K. L., Marouli, E., Zhang, X., Fine, R. S., . . . North, K. E. (2021). Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. AMERICAN JOURNAL OF HUMAN GENETICS, 108(4), 564-582. doi:10.1016/j.ajhg.2021.02.011
Polfus, L. M., Darst, B. F., Highland, H., Sheng, X., Ng, M. C. Y., Below, J. E., . . . Haiman, C. A. (2021). Genetic discovery and risk characterization in type 2 diabetes across diverse populations. HUMAN GENETICS AND GENOMICS ADVANCES, 2(2). doi:10.1016/j.xhgg.2021.100029
Miller, R. G., Orchard, T. J., Onengut-Gumuscu, S., Chen, W. -M., Rich, S. S., & Costacou, T. (2021). Heterogeneous long-term trajectories of glycaemic control in type 1 diabetes. DIABETIC MEDICINE, 38(8). doi:10.1111/dme.14545
Miller, R. G., McGurnaghan, S. J., Onengut-Gumuscu, S., Chen, W. -M., Colhoun, H. M., Rich, S. S., . . . Costacou, T. (2021). Insulin resistance-associated genetic variants in type 1 diabetes. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 35(4). doi:10.1016/j.jdiacomp.2020.107842
Armstrong, N. M. D., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Cullell, N., Fernandez-Cadenas, I., . . . Keene, K. L. (2021). DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(7). doi:10.1371/journal.pone.0254562
Armstrong, N. M. D., Spragley, K. J., Chen, W. -M., Hsu, F. -C., Brewer, M. S., Horn, P. J., . . . Keene, K. L. (2021). Multi-omic analysis of stroke recurrence in African Americans from the Vitamin Intervention for Stroke Prevention (VISP) clinical trial. PLOS ONE, 16(3). doi:10.1371/journal.pone.0247257
2020
Onengut-Gumuscu, S., Paila, U., Chen, W. -M., Ratan, A., Zhu, Z., Steck, A. K., . . . Rich, S. S. (2020). Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-75690-6
Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., . . . Natarajan, P. (2021). Inherited causes of clonal haematopoiesis in 97,691 whole genomes (vol 586, pg 763, 2020). NATURE, 591(7849), E27. doi:10.1038/s41586-021-03280-1
Li, X., Li, Z., Zhou, H., Gaynor, S. M., Liu, Y., Chen, H., . . . Lin, X. (2020). Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. NATURE GENETICS, 52(9), 969-+. doi:10.1038/s41588-020-0676-4
Keene, K. L., Hyacinth, H. I., Bis, J. C., Kittner, S. J., Mitchell, B. D., Cheng, Y. -C., . . . Fornage, M. (2020). Genome-Wide Association Study Meta-Analysis of Stroke in 22 000 Individuals of African Descent Identifies Novel Associations With Stroke. STROKE, 51(8), 2454-2463. doi:10.1161/STROKEAHA.120.029123
Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. A., . . . Davies, N. M. (2020). Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-17117-4
2019
Salem, R. M., Todd, J. N., Sandholm, N., Cole, J. B., Chen, W. -M., Andrews, D., . . . Florez, J. C. (2019). Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 30(10), 2000-2016. doi:10.1681/ASN.2019030218
Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2019). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (vol 50, pg 524, 2018). NATURE GENETICS, 51(7), 1192-1193. doi:10.1038/s41588-019-0449-0
Valdes-Marquez, E., Parish, S., Clarke, R., Stari, T., Worrall, B. B., Hopewell, J. C., . . . Cheng, Y. -C. (2019). Relative effects of LDL-C on ischemic stroke and coronary disease A Mendelian randomization study. NEUROLOGY, 92(11), E1176-E1187. doi:10.1212/WNL.0000000000007091
Onengut-Gumuscu, S., Chen, W. -M., Robertson, C. C., Bonnie, J. K., Farber, E., Zhu, Z., . . . Rich, S. S. (2019). Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score. DIABETES CARE, 42(3), 406-415. doi:10.2337/dc18-1727
2018
Marquez, A., Kerick, M., Zhernakova, A., Gutierrez-Achury, J., Chen, W. -M., Onengut-Gumuscu, S., . . . Martin, J. (2018). Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. GENOME MEDICINE, 10. doi:10.1186/s13073-018-0604-8
Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., . . . Alizadeh, B. Z. (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. AMERICAN JOURNAL OF HUMAN GENETICS, 103(5), 691-706. doi:10.1016/j.ajhg.2018.09.009
Westra, H. -J., Martinez-Bonet, M., Onengut-Gumuscu, S., Lee, A., Luol, Y., Teslovich, N., . . . Raychaudhuri, S. (2018). Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. NATURE GENETICS, 50(10), 1366-+. doi:10.1038/s41588-018-0216-7
Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., . . . Neale, B. M. (2018). Analysis of shared heritability in common disorders of the brain. SCIENCE, 360(6395), 1313-+. doi:10.1126/science.aap8757
Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Dichgans, M. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. NATURE GENETICS, 50(4), 524-+. doi:10.1038/s41588-018-0058-3
Sharma, A., Liu, X., Hadley, D., Hagopian, W., Chen, W. -M., Onengut-Gumuscu, S., . . . She, J. -X. (2018). Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort. JOURNAL OF AUTOIMMUNITY, 89, 90-100. doi:10.1016/j.jaut.2017.12.008
Armstrong, N. M. D., Chen, W. -M., Brewer, M. S., Williams, S. R., Sale, M. M., Worrall, B. B., & Keene, K. L. (2018). Epigenome-Wide Analyses Identify Two Novel Associations With Recurrent Stroke in the Vitamin Intervention for Stroke Prevention Clinical Trial. FRONTIERS IN GENETICS, 9. doi:10.3389/fgene.2018.00358
2017
Norris, J. M., Lee, H. -S., Frederiksen, B., Erlund, I., Uusitalo, U., Yang, J., . . . Hagopian, W. (2018). Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. DIABETES, 67(1), 146-154. doi:10.2337/db17-0802
Wheeler, E., Leong, A., Liu, C. -T., Hivert, M. -F., Strawbridge, R. J., Podmore, C., . . . Meigs, J. B. (2017). Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLOS MEDICINE, 14(9). doi:10.1371/journal.pmed.1002383
Steck, A. K., Xu, P., Geyer, S., Redondo, M. J., Antinozzi, P., Wentworth, J. M., . . . Pugliese, A. (2017). Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(8), 2873-2880. doi:10.1210/jc.2016-4003
Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Dzhivhuho, G., Rowles, J. L. I. I. I., . . . Sale, M. M. (2017). Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke. STROKE, 48(6), 1444-+. doi:10.1161/STROKEAHA.116.015677
Ng, M. C. Y., Graff, M., Lu, Y., Justice, A. E., Mudgal, P., Liu, C. -T., . . . North, K. E. (2017). Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLOS GENETICS, 13(4). doi:10.1371/journal.pgen.1006719
Sun, L., Dimitromanolakis, A., & Chen, W. -M. (2017). Identifying Cryptic Relationships. STATISTICAL HUMAN GENETICS: METHODS AND PROTOCOLS, 2ND EDITION, 1666, 45-60. doi:10.1007/978-1-4939-7274-6_4
2016
Torn, C., Liu, X., Hagopian, W., Lernmark, A., Simell, O., Rewers, M., . . . Krischer, J. (2016). Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27887
Liu, C. -T., Raghavan, S., Maruthur, N., Kabagambe, E. K., Hong, J., Ng, M. C. Y., . . . Meigs, J. B. (2016). Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. AMERICAN JOURNAL OF HUMAN GENETICS, 99(1), 56-75. doi:10.1016/j.ajhg.2016.05.006
Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., . . . Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. NATURE GENETICS, 48(7), 803-+. doi:10.1038/ng.3572
Malik, R., Traylor, M., Pulit, S. L., Bevan, S., Hopewell, J. C., Holliday, E. G., . . . Dichgans, M. (2016). Low-frequency and common genetic variation in ischemic stroke The METASTROKE collaboration. NEUROLOGY, 86(13), 1217-1226. doi:10.1212/WNL.0000000000002528
Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., . . . Fox, C. S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms10023
Uusitalo, U., Liu, X., Yang, J., Aronsson, C. A., Hummel, S., Butterworth, M., . . . Virtanen, S. M. (2016). Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study. JAMA PEDIATRICS, 170(1), 20-28. doi:10.1001/jamapediatrics.2015.2757
Sharma, A., Liu, X., Hadley, D., Hagopian, W., Liu, E., Chen, W. -M., . . . She, J. -X. (2016). Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort. PLOS ONE, 11(3). doi:10.1371/journal.pone.0152476
2015
Williams, S. R., Hsu, F. -C., Keene, K. L., Chen, W. -M., Nelson, S., Southerland, A. M., . . . Worrall, B. B. (2016). Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. NEUROLOGY, 86(4), 351-359. doi:10.1212/WNL.0000000000002319
Gutierrez-Achury, J., Romanos, J., Bakker, S. F., Kumar, V., de Haas, E. C., Trynka, G., . . . Wijmenga, C. (2015). Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity. DIABETES CARE, 38, S37-S44. doi:10.2337/dcs15-2007
Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., . . . Raychaudhuri, S. (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. NATURE GENETICS, 47(9), 1085-+. doi:10.1038/ng.3379
Hu, X., Deutsch, A. J., Lenz, T. L., Onengut-Gumuscu, S., Han, B., Chen, W. -M., . . . Raychaudhuri, S. (2015). Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. NATURE GENETICS, 47(8), 898-+. doi:10.1038/ng.3353
Auer, P. L., Nalls, M., Meschia, J. F., Worrall, B. B., Longstreth, W. T. J., Seshadri, S., . . . Rich, S. S. (2015). Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke The NHLBI Exome Sequence Project. JAMA NEUROLOGY, 72(7), 781-788. doi:10.1001/jamaneurol.2015.0582
Carty, C. L., Keene, K. L., Cheng, Y. -C., Meschia, J. F., Chen, W. -M., Nalls, M., . . . Fornage, M. (2015). Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. STROKE, 46(8), 2063-2068. doi:10.1161/STROKEAHA.115.009044
Hadley, D., Hagopian, W., Liu, E., She, J. -X., Simell, O., Akolkar, B., . . . Agardh, D. (2015). HLA-DPB1☆04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study. AMERICAN JOURNAL OF GASTROENTEROLOGY, 110(6), 915-920. doi:10.1038/ajg.2015.150
Brorsson, C. A., Onengut, S., Chen, W. -M., Wenzlau, J., Yu, L., Baker, P., . . . Pociot, F. (2015). Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes. DIABETES, 64(8), 3017-3027. doi:10.2337/db14-1730
Onengut-Gumuscu, S., Chen, W. -M., Burren, O., Cooper, N. J., Quinlan, A. R., Mychaleckyj, J. C., . . . Rich, S. S. (2015). Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. NATURE GENETICS, 47(4), 381-U199. doi:10.1038/ng.3245
Anaya, J., Reon, B., Chen, W. -M., Bekiranov, S., & Duna, A. (2016). A pan-cancer analysis of prognostic genesl. PEERJ, 4. doi:10.7717/peerj.1499
2014
Torn, C., Hadley, D., Lee, H. -S., Hagopian, W., Lernmark, A., Simell, O., . . . Krischer, J. (2015). Role of Type 1 Diabetes-Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study. DIABETES, 64(5), 1818-1829. doi:10.2337/db14-1497
Evangelou, M., Smyth, D. J., Fortune, M. D., Burren, O. S., Walker, N. M., Guo, H., . . . Wallace, C. (2014). A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations. GENETIC EPIDEMIOLOGY, 38(8), 661-670. doi:10.1002/gepi.21853
Ng, M. C. Y., Shriner, D., Chen, B. H., Li, J., Chen, W. -M., Guo, X., . . . Bowden, D. W. (2014). Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes. PLOS GENETICS, 10(8). doi:10.1371/journal.pgen.1004517
Tomlinson, M. J., Pitsillides, A., Pickin, R., Mika, M., Keene, K. L., Hou, X., . . . Onengut-Gumuscu, S. (2014). Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13. DIABETES, 63(12), 4360-4368. doi:10.2337/db13-1785
Fernandez, C. A., Smith, C., Yang, W., Date, M., Bashford, D., Larsen, E., . . . Relling, M. V. (2014). HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies. BLOOD, 124(8), 1266-1276. doi:10.1182/blood-2014-03-563742
Hu, X., Kim, H., Raj, T., Brennan, P. J., Trynka, G., Teslovich, N., . . . Raychaudhuri, S. (2014). Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells. PLOS GENETICS, 10(6). doi:10.1371/journal.pgen.1004404
Pontikos, N., Smyth, D. J., Schuilenburg, H., Howson, J. M. M., Walker, N. M., Burren, O. S., . . . Wallace, C. (2014). A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples. BMC GENOMICS, 15. doi:10.1186/1471-2164-15-274
Williams, S. R., Yang, Q., Chen, F., Liu, X., Keene, K. L., Jacques, P., . . . Sale, M. M. (2014). Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004214
Huang, J., Huffman, J. E., Yamkauchi, M., Trompet, S., Asselbergs, F. W., Sabater-Lleal, M., . . . O'Donnell, C. J. (2014). Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(5), 1093-1101. doi:10.1161/ATVBAHA.113.302088
Allen, E. K., Manichaikul, A., Chen, W. -M., Rich, S. S., Daly, K. A., & Sale, M. M. (2014). Evaluation of Replication of Variants Associated with Genetic Risk of Otitis Media. PLOS ONE, 9(8). doi:10.1371/journal.pone.0104212
Keene, K. L., Chen, W. -M., Chen, F., Williams, S. R., Elkhatib, S. D., Hsu, F. -C., . . . Sale, M. M. (2014). Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial. FRONTIERS IN PUBLIC HEALTH, 2. doi:10.3389/fpubh.2014.00112
2013
Allen, E. K., Chen, W. -M., Weeks, D. E., Chen, F., Hou, X., Mattos, J. L., . . . Sale, M. M. (2013). A Genome-Wide Association Study of Chronic Otitis Media with Effusion and Recurrent Otitis Media Identifies a Novel Susceptibility Locus on Chromosome 2. JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 14(6), 791-800. doi:10.1007/s10162-013-0411-2
Franceschini, N., Fox, E., Zhang, Z., Edwards, T. L., Nalls, M. A., Sung, Y. J., . . . Zhu, X. (2013). Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations. AMERICAN JOURNAL OF HUMAN GENETICS, 93(3), 545-554. doi:10.1016/j.ajhg.2013.07.010
Yadav, S., Cotlarciuc, I., Munroe, P. B., Khan, M. S., Nalls, M. A., Bevan, S., . . . Sharma, P. (2013). Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke. STROKE, 44(10), 2703-2709. doi:10.1161/STROKEAHA.113.002186
van Dongen, J., Willemsen, G., Chen, W. -M., de Geus, E. J. C., & Boomsma, D. I. (2013). Heritability of metabolic syndrome traits in a large population-based sample. JOURNAL OF LIPID RESEARCH, 54(10), 2914-2923. doi:10.1194/jlr.P041673
Hinks, A., Cobb, J., Marion, M. C., Prahalad, S., Sudman, M., Bowes, J., . . . Thompson, S. D. (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. NATURE GENETICS, 45(6), 664-+. doi:10.1038/ng.2614
Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., . . . Haiman, C. A. (2013). A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. NATURE GENETICS, 45(6), 690-+. doi:10.1038/ng.2608
Ferreira, R. C., Freitag, D. F., Cutler, A. J., Howson, J. M. M., Rainbow, D. B., Smyth, D. J., . . . Todd, J. A. (2013). Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases. PLOS GENETICS, 9(4). doi:10.1371/journal.pgen.1003444
Liu, C. -T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., . . . Fox, C. S. (2013). Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci. PLOS GENETICS, 9(8). doi:10.1371/journal.pgen.1003681
Langefeld, C. D., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., Chen, W. -M., . . . Ramos, P. S. (2013). Identification Of Autoimmune Disease Risk Alleles That Are Under Recent Selection In The Sea Island Gullah African Americans. ARTHRITIS AND RHEUMATISM, 65, S60-S61. Retrieved from https://www.webofscience.com/
Faraco, J., Lin, L., Kornum, B. R., Kenny, E. E., Trynka, G., Einen, M., . . . Mignot, E. (2013). ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy. PLOS GENETICS, 9(2). doi:10.1371/journal.pgen.1003270
Jia, X., Han, B., Onengut-Gumuscu, S., Chen, W. -M., Concannon, P. J., Rich, S. S., . . . de Bakker, P. I. W. (2013). Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens. PLOS ONE, 8(6). doi:10.1371/journal.pone.0064683
Ramos, P. S., Titus, N., Sajuthi, S., Divers, J., Huang, Y., Nayak, U., . . . Langefeld, C. D. (2013). Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina. ARTHRITIS AND RHEUMATISM, 65, S61. Retrieved from https://www.webofscience.com/
2012
Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y. -C., . . . Markus, H. S. (2012). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. LANCET NEUROLOGY, 11(11), 951-962. doi:10.1016/S1474-4422(12)70234-X
Cheng, Y. -C., Anderson, C. D., Bione, S., Keene, K., Maguire, J. M., Nalls, M., . . . Mitchell, B. D. (2012). Are Myocardial Infarction-Associated Single-Nucleotide Polymorphisms Associated With Ischemic Stroke?. STROKE, 43(4), 980-U143. doi:10.1161/STROKEAHA.111.632075
Chen, M. -H., Huang, J., Chen, W. -M., Larson, M. G., Fox, C. S., Vasan, R. S., . . . Yang, Q. (2012). Using Family-Based Imputation in Genome-Wide Association Studies with Large Complex Pedigrees: The Framingham Heart Study. PLOS ONE, 7(12). doi:10.1371/journal.pone.0051589
Manichaikul, A., Palmas, W., Rodriguez, C. J., Peralta, C. A., Divers, J., Guo, X., . . . Mychaleckyj, J. C. (2012). Population Structure of Hispanics in the United States: The Multi-Ethnic Study of Atherosclerosis. PLOS GENETICS, 8(4), 285-298. doi:10.1371/journal.pgen.1002640
Elbers, C. C., Guo, Y., Tragante, V., van Iperen, E. P. A., Lanktree, M. B., Castillo, B. A., . . . Keating, B. J. (2012). Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050198
2011
Stanton, C. M., Yates, J. R. W., den Hollander, A. I., Seddon, J. M., Swaroop, A., Stambolian, D., . . . Wright, A. F. (2011). Complement factor D in age-related macular degeneration.. Investigative ophthalmology & visual science, 52(12), 8828-8834. doi:10.1167/iovs.11-7933
Chen, W. -M., Manichaikul, A., & Rich, S. S. (2011). Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees.. BMC proceedings, 5 Suppl 9, S68. doi:10.1186/1753-6561-5-s9-s68
Hsu, F. -C., Sides, E. G., Mychaleckyj, J. C., Worrall, B. B., Elias, G. A., Liu, Y., . . . Sale, M. M. (2011). Transcobalamin 2 variant associated with poststroke homocysteine modifies recurrent stroke risk. NEUROLOGY, 77(16), 1543-1550. doi:10.1212/WNL.0b013e318233b1f9
Chen, W. -M., Allen, E. K., Mychaleckyj, J. C., Chen, F., Hou, X., Rich, S. S., . . . Sale, M. M. (2011). Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM). BMC MEDICAL GENETICS, 12. doi:10.1186/1471-2350-12-124
Manichaikul, A., Chen, W. -M., Williams, K., Wong, Q., Sale, M. M., Pankow, J. S., . . . Mychaleckyj, J. C. (2012). Analysis of family- and population-based samples in cohort genome-wide association studies. HUMAN GENETICS, 131(2), 275-287. doi:10.1007/s00439-011-1071-0
Morahan, G., Mehta, M., James, I., Chen, W. -M., Akolkar, B., Erlich, H. A., . . . Rich, S. S. (2011). Tests for Genetic Interactions in Type 1 Diabetes Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs. DIABETES, 60(3), 1030-1040. doi:10.2337/db10-1195
Sale, M. M., Chen, W. -M., Weeks, D. E., Mychaleckyj, J. C., Hou, X., Marion, M., . . . Daly, K. A. (2011). Evaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM). PLOS ONE, 6(8). doi:10.1371/journal.pone.0022297
Solorzano, G., Chen, F., Mychaleckyj, J. C., Chen, W. -M., Hsu, F. -C., Sale, M., & Worrall, B. B. (2011). Antihypertensive Class And Stroke Recurrence: An Analysis Of The VISP Trial. STROKE, 42(3), E348. Retrieved from https://www.webofscience.com/
2010
Ding, J., Gudjonsson, J. E., Liang, L., Stuart, P. E., Li, Y., Chen, W., . . . Abecasis, G. R. (2010). Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals.. American journal of human genetics, 87(6), 779-789. doi:10.1016/j.ajhg.2010.10.024
Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W. -M. (2010). Robust relationship inference in genome-wide association studies. BIOINFORMATICS, 26(22), 2867-2873. doi:10.1093/bioinformatics/btq559
Baratz, K. H., Tosakulwong, N., Ryu, E., Brown, W. L., Branham, K., Chen, W., . . . Edwards, A. O. (2010). E2-2 protein and Fuchs's corneal dystrophy.. The New England journal of medicine, 363(11), 1016-1024. doi:10.1056/nejmoa1007064
Kanda, A., Stambolian, D., Chen, W., Curcio, C. A., Abecasis, G. R., & Swaroop, A. (2010). Age-related macular degeneration-associated variants at chromosome 10q26 do not significantly alter ARMS2 and HTRA1 transcript levels in the human retina.. Molecular vision, 16, 1317-1323.
Strunnikova, N. V., Maminishkis, A., Barb, J. J., Wang, F., Zhi, C., Sergeev, Y., . . . Miller, S. S. (2010). Transcriptome analysis and molecular signature of human retinal pigment epithelium.. Human molecular genetics, 19(12), 2468-2486. doi:10.1093/hmg/ddq129
Scuteri, A., Sanna, S., Chen, W. -M., Uda, M., Albai, G., Strait, J., . . . Abecasis, G. R. (2010). Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits. PLOS GENETICS, 6(4). doi:10.1371/journal.pgen.0030115
Patel, R. K., Elias, G. A., Hsu, F. -C., Mychaleckyj, J. C., Chen, W. -M., Worrall, B. B., & Sale, M. M. (2010). Investigation of Recurrent Stroke Risk in the Vitamin Intervention for Stroke Prevention (VISP) Trial Suggests Different Genetic Influences on Prevalent and Incident Stroke. STROKE, 41(4), E335. Retrieved from https://www.webofscience.com/
Elias, G. A., Patel, R. K., Chen, W. -M., Mychaleckyj, J. C., Hsu, F. -C., Worrall, B. B., & Sale, M. M. (2010). Association of a Transcobalamin 2 (TCN2) Variant Located in the 3UTR With Post-stroke Homocysteine Level in Subjects From the Vitamin Intervention for Stroke Prevention Trial. STROKE, 41(4), E335. Retrieved from https://www.webofscience.com/