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Lulu Jiang

Lulu Jiang

Assistant Professor, Neuroscience

Primary Location
409 Lane Road
Charlottesville, VA 22908
Primary Phone Number
434.924.8229
Email
[email protected]
Website
https://med.virginia.edu/neuroscience/faculty/primary-faculty/lulu-jiang-md-phd/

Bio & Overview

Our research focuses on several key areas that drive our scientific interests and contribute to the understanding and treatment of neurodegenerative diseases. These areas include: 1. Investigation of RNA modifications and epitranscriptomic mechanisms in the pathogenesis of Alzheimer’s disease (AD) and related dementias. By studying how RNA modifications impact disease progression, we aim to uncover novel therapeutic targets and diagnostic markers. 2. Exploration of neuron-glia interactions and neuroimmunological mechanisms underlying the progression of AD and Parkinson’s disease (PD). Understanding the complex interplay between neurons and glial cells will provide crucial insights into the underlying mechanisms and potential avenues for therapeutic intervention. 3. Utilization of iPSC-induced 3D human brain organoid models to study neurodegenerative diseases and enable precision medicine approaches. These advanced models allow us to recapitulate the complexity of the human brain, facilitating the identification of disease mechanisms and the development of personalized treatment strategies. 4. Elucidation of the molecular mechanisms driving prion-like propagation in the Braak stages of AD. Investigating the spread of pathological proteins in the brain will contribute to our understanding of disease progression and may lead to the development of interventions that disrupt this process. 5. Development of innovative genetic and small molecule therapeutics for neurodegenerative diseases. Our research aims to identify and optimize potential therapeutic targets, including genetic approaches and small molecules, with the goal of ultimately translating these findings into effective treatments for patients. These research directions represent our current focus and ongoing projects, which collectively contribute to the advancement of knowledge and the development of new strategies for the management and treatment of neurodegenerative diseases.

Academic Information

Department
Neuroscience

Primary Education

  • Ph.D., undefinedNational Institute of Environmental Health Sciencesnull
  • M.D., undefinedShandong Universitynull
  • MBBS, undefinedShandong Universitynull

Other Affiliations

  • MSTP

Research Interests

The Pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and other dementia-related disorders.

Research Disciplines

  • Development, Stem Cells & Regeneration
  • Molecular Pharmacology
  • Neuroimmunology
  • Neuroscience

Research Opportunities

  • Development, Stem Cells & Regeneration
  • Molecular Pharmacology
  • Neuroimmunology
  • Neuroscience
  • Physiological Basis of Human Disease

PhD Programs

  • Neuroscience

Selected Publications

2023

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Kilci, A., . . . Wolozin, B. (2023). Accumulation of m6A exhibits stronger correlation with MAPT than β-amyloid pathology in an APPNL-G-F /MAPTP301S mouse model of Alzheimer's disease. doi:10.21203/rs.3.rs-2745852/v1

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Kilci, A., . . . Wolozin, B. (2023). Accumulation of m6A exhibits stronger correlation with MAPT than β-amyloid pathology in an APPNL-G-F/MAPTP301Smouse model of Alzheimer’s disease. doi:10.1101/2023.03.28.534515

Jiang, L., Chakraborty, P., Zhang, L., Wong, M., Hill, S. E., Webber, C. J., . . . Zweckstetter, M. (2023). Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. SCIENCE ADVANCES, 9(5). doi:10.1126/sciadv.add9789

2022

Rickner, H. D., Jiang, L., Hong, R., O'Neill, N. K., Mojica, C. A., Snyder, B. J., . . . Cheng, C. S. (2022). Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34005-1

2021

Jiang, L., Lin, W., Zhang, C., Ash, P. E. A., Verma, M., Kwan, J., . . . Wolozin, B. (2021). Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. MOLECULAR CELL, 81(20), 4209-+. doi:10.1016/j.molcel.2021.07.038

Ash, P. E. A., Lei, S., Shattuck, J., Boudeau, S., Carlomagno, Y., Medalla, M., . . . Wolozin, B. (2021). TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(9). doi:10.1073/pnas.2014188118

2020

Li, X., Jiang, L., Yu, T., Li, M., Wang, Q., Liu, Z., & Xie, K. (2020). No-observed-adverse-effect level of hair pyrrole adducts in chronic n-hexane intoxication in rats. NEUROTOXICOLOGY, 78, 11-20. doi:10.1016/j.neuro.2020.02.002

Jiang, L., Zhao, J., Cheng, J. -X., & Wolozin, B. (2020). Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins. FRONTIERS IN NEUROLOGY, 11. doi:10.3389/fneur.2020.579434

2019

Apicco, D. J., Zhang, C., Maziuk, B., Jiang, L., Ballance, H. I., Boudeau, S., . . . Wolozin, B. (2019). Dysregulation of RNA Splicing in Tauopathies. CELL REPORTS, 29(13), 4377-+. doi:10.1016/j.celrep.2019.11.093

Song, S., Wang, Q., Jiang, L., Oyarzabal, E., Riddick, N. V., Wilson, B., . . . Hong, J. -S. (2019). Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions. BRAIN BEHAVIOR AND IMMUNITY, 81, 374-387. doi:10.1016/j.bbi.2019.06.034

2018

Jiang, L., Ash, P. E. A., Maziuk, B. F., Ballance, H. I., Boudeau, S., Al Abdullatif, A., . . . Wolozin, B. (2019). TIA1 regulates the generation and response to toxic tau oligomers. ACTA NEUROPATHOLOGICA, 137(2), 259-277. doi:10.1007/s00401-018-1937-5

Maziuk, B. F., Apicco, D. J., Cruz, A. L., Jiang, L., Ash, P. E. A., da Rocha, E. L., . . . Wolozin, B. (2018). RNA binding proteins co-localize with small tau inclusions in tauopathy. ACTA NEUROPATHOLOGICA COMMUNICATIONS, 6. doi:10.1186/s40478-018-0574-5

Li, M., Wang, S., Li, X., Jiang, L., Wang, X., Kou, R., . . . Xie, K. (2018). Diallyl sulfide protects against lipopolysaccharide/D-galactosamine-induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. FOOD AND CHEMICAL TOXICOLOGY, 120, 500-509. doi:10.1016/j.fct.2018.07.053

Song, S., Jiang, L., Oyarzabal, E. A., Wilson, B., Li, Z., Shih, Y. -Y. I., . . . Hong, J. -S. (2019). Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration. MOLECULAR NEUROBIOLOGY, 56(4), 2653-2669. doi:10.1007/s12035-018-1235-1

Han, W., Wang, S., Li, M., Jiang, L., Wang, X., & Xie, K. (2018). The protective effect of diallyl trisulfide on cytopenia induced by benzene through modulating benzene metabolism. FOOD AND CHEMICAL TOXICOLOGY, 112, 393-399. doi:10.1016/j.fct.2017.12.060

2017

Han, W., Wang, S., Jiang, L., Wang, H., Li, M., Wang, X., & Xie, K. (2017). Diallyl trisulfide (DATS) suppresses benzene-induced cytopenia by modulating haematopoietic cell apoptosis. ENVIRONMENTAL POLLUTION, 231, 301-310. doi:10.1016/j.envpol.2017.07.069

Wang, S., Li, M., Wang, X., Li, X., Yin, H., Jiang, L., . . . Xie, K. (2017). Diallyl trisulfide attenuated n-hexane induced neurotoxicity in rats by modulating P450 enzymes. CHEMICO-BIOLOGICAL INTERACTIONS, 265, 1-7. doi:10.1016/j.cbi.2017.01.013

2016

Wang, S., Li, X., Li, M., Jiang, L., Yuan, H., Han, W., . . . Xie, K. (2017). Cystamine attenuated behavioral deficiency via increasing the expression of BDNF and activating PI3K/Akt signaling in 2,5-hexanedione intoxicated rats. TOXICOLOGY RESEARCH, 6(2), 199-204. doi:10.1039/c6tx00409a

Wang, S., Irving, G., Jiang, L., Wang, H., Li, M., Wang, X., . . . Xie, K. (2017). Oxidative Stress Mediated Hippocampal Neuron Apoptosis Participated in Carbon Disulfide-Induced Rats Cognitive Dysfunction. NEUROCHEMICAL RESEARCH, 42(2), 583-594. doi:10.1007/s11064-016-2113-8

Wang, S., Chu, C. -H., Guo, M., Jiang, L., Nie, H., Zhang, W., . . . Zhang, J. (2016). Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. JOURNAL OF NEUROINFLAMMATION, 13. doi:10.1186/s12974-016-0606-7

Jiang, L., Wu, X., Wang, S., Chen, S. -H., Zhou, H., Wilson, B., . . . Hong, J. -S. (2016). Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. JOURNAL OF NEUROINFLAMMATION, 13. doi:10.1186/s12974-016-0573-z

Yang, Y., Jiang, L., Wang, S., Zeng, T., & Xie, K. (2016). Diallyl trisulfide protects the liver against hepatotoxicity induced by isoniazid and rifampin in mice by reducing oxidative stress and activating Kupffer cells. TOXICOLOGY RESEARCH, 5(3), 954-962. doi:10.1039/c5tx00440c

Xu, Y., Wang, S., Jiang, L., Wang, H., Yang, Y., Li, M., . . . Xie, K. (2016). Identify Melatonin as a Novel Therapeutic Reagent in the Treatment of 1-Bromopropane(1-BP) Intoxication. MEDICINE, 95(3). doi:10.1097/MD.0000000000002203

2015

An, L., Li, G., Si, J., Zhang, C., Han, X., Wang, S., . . . Xie, K. (2016). Acrylamide Retards the Slow Axonal Transport of Neurofilaments in Rat Cultured Dorsal Root Ganglia Neurons and the Corresponding Mechanisms. NEUROCHEMICAL RESEARCH, 41(5), 1000-1009. doi:10.1007/s11064-015-1782-z

Jiang, L., Chen, S. -H., Chu, C. -H., Wang, S. -J., Oyarzabal, E., Wilson, B., . . . Hong, J. -S. (2015). A Novel Role of Microglial NADPH Oxidase in Mediating Extra-Synaptic Function of Norepinephrine in Regulating Brain Immune Homeostasis. GLIA, 63(6), 1057-1072. doi:10.1002/glia.22801

2014

Guo, Y., Yuan, H., Jiang, L., Yang, J., Zeng, T., Xie, K., . . . Zhao, X. (2015). Involvement of decreased neuroglobin protein level in cognitive dysfunction induced by 1-bromopropane in rats. BRAIN RESEARCH, 1600, 1-16. doi:10.1016/j.brainres.2014.12.046

Wang, Q., Chu, C. -H., Qian, L., Chen, S. -H., Wilson, B., Oyarzabal, E., . . . Hong, J. -S. (2014). Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase. JOURNAL OF NEUROSCIENCE, 34(37), 12490-12503. doi:10.1523/JNEUROSCI.2238-14.2014

Wang, Q., Chu, C. -H., Oyarzabal, E., Jiang, L., Chen, S. -H., Wilson, B., . . . Hong, J. -S. (2014). Subpicomolar Diphenyleneiodonium Inhibits Microglial NADPH Oxidase with High Specificity and Shows Great Potential as a Therapeutic Agent for Neurodegenerative Diseases. GLIA, 62(12), 2034-2043. doi:10.1002/glia.22724