Chair of the Department of Molecular Physiology and Biological Physics, Molecular Physiology and Biological Physics
- BS, Microbiology, Fudan University
- PhD, Immunology, University of Maryland, Baltimore County
- Postdoctoral fellow, Telomere biology, Johns Hopkins University
- Research Associate, CREB and Metabolism, Salk Institute
Cell and Developmental Biology, Immunology, Metabolism, Molecular Physiology and Biological Physics, Neuroscience, Physiology
Delineate the physiological importance and structure-function relationship of ER-associated degradation in humans.
My laboratory aims to explore the physiological role of endoplasmic reticulum (ER) homeostasis (with a special focus on ER-associated degradation, ERAD) in the context of human diseases. We use genetic, immunological, molecular and cellular approaches to dissect the molecular processes of protein folding quality control and to produce new insights into disease pathogenesis. We have made significant contributions in the fields of ERAD in health and disease while maintaining a high standard of excellence at the levels of both individual scientist and whole laboratory. To date, the most significant contribution to the ERAD field is to bring new lights into the pathophysiological significance of ERAD in humans, with a recent identification of many patients carrying the mutations in SEL1L-HRD1 ERAD (ENDI patients).