Yugesh Kharel

Kharel, Y., Huang, T., Dunnavant, K., Foster, D., Souza, G., Nimchuk, K. E., . . . Lynch, K. R. (2024). Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target.. bioRxiv. doi:10.1101/2024.03.26.586765

Tanaka, S., Zheng, S., Kharel, Y., Fritzemeier, R. G., Huang, T., Foster, D., . . . Okusa, M. D. (2022). Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. SCIENCE TRANSLATIONAL MEDICINE, 14(658). doi:10.1126/scitranslmed.abj2681

Oyewole, O. O., Dunnavant, K., Bhattarai, S., Kharel, Y., Lynch, K. R., Santos, W. L., & Reid, S. P. (2022). A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection. VIRUSES-BASEL, 14(6). doi:10.3390/v14061123

Fritzemeier, R., Foster, D., Peralta, A., Payette, M., Kharel, Y., Huang, T., . . . Santos, W. L. (2022). Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 65(11), 7656-7681. doi:10.1021/acs.jmedchem.1c02171

Congdon, M., Fritzemeier, R. G., Kharel, Y., Brown, A. M., Serbulea, V., Bevan, D. R., . . . Santos, W. L. (2021). Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 212. doi:10.1016/j.ejmech.2020.113121

Li, H., Sibley, C. D., Kharel, Y., Huang, T., Brown, A. M., Wonilowicz, L. G., . . . Santos, W. L. (2021). Lipophilic tail modifications of 2-(hydroxymethyl)pyrrolidine scaffold reveal dual sphingosine kinase 1 and 2 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, 30. doi:10.1016/j.bmc.2020.115941

Kharel, Y., Huang, T., Salamon, A., Harris, T. E., Santos, W. L., & Lynch, K. R. (2020). Mechanism of sphingosine 1-phosphate clearance from blood. BIOCHEMICAL JOURNAL, 477(5), 925-935. doi:10.1042/BCJ20190730

Sibley, C. D., Morris, E. A., Kharel, Y., Brown, A. M., Huang, T., Bevan, D. R., . . . Santos, W. L. (2020). Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. JOURNAL OF MEDICINAL CHEMISTRY, 63(3), 1178-1198. doi:10.1021/acs.jmedchem.9b01508

Cao, R., Li, J., Kharel, Y., Zhang, C., Morris, E., Santos, W. L., . . . Hu, S. (2018). Photoacoustic microscopy reveals the hemodynamic basis of sphingosine 1-phosphate-induced neuroprotection against ischemic stroke. THERANOSTICS, 8(22), 6111-6120. doi:10.7150/thno.29435

Kharel, Y., Agah, S., Huang, T., Mendelson, A. J., Eletu, O. T., Barkey-Bircannl, P., . . . Lynch, K. R. (2018). Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. PLOS ONE, 13(4). doi:10.1371/journal.pone.0192179

Childress, E. S., Kharel, Y., Brown, A. M., Bevan, D. R., Lynch, K. R., & Santos, W. L. (2017). Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity. JOURNAL OF MEDICINAL CHEMISTRY, 60(9), 3933-3957. doi:10.1021/acs.jmedchem.7b00233

Kharel, Y., Agah, S., Huang, T., Mendelson, A., Eletu, O., Barkey-Bircann, P., . . . Lynch, K. (2017). Saccharomyces cerevisiaeas a Platform for Assessing Sphingolipid Lipid Kinase Inhibitors. doi:10.1101/148858

Houck, J. D., Dawson, T. K., Kennedy, A. J., Kharel, Y., Naimon, N. D., Field, S. D., . . . Macdonald, T. L. (2016). Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. ACS MEDICINAL CHEMISTRY LETTERS, 7(5), 487-492. doi:10.1021/acsmedchemlett.6b00002

Congdon, M. D., Kharel, Y., Brown, A. M., Lewis, S. N., Bevan, D. R., Lynch, K. R., & Santos, W. L. (2016). Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS, 7(3), 229-234. doi:10.1021/acsmedchemlett.5b00304

Kharel, Y., Morris, E. A., Congdon, M. D., Thorpe, S. B., Tomsig, J. L., Santos, W. L., & Lynch, K. R. (2015). Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 355(1), 23-31. doi:10.1124/jpet.115.225862

Congdon, M. D., Childress, E. S., Patwardhan, N. N., Gumkowski, J., Morris, E. A., Kharel, Y., . . . Santos, W. L. (2015). Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4956-4960. doi:10.1016/j.bmcl.2015.03.041

Patwardhan, N. N., Morris, E. A., Kharel, Y., Raje, M. R., Gao, M., Tomsig, J. L., . . . Santos, W. L. (2015). Structure-Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1-and SphK2-Selective Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 58(4), 1879-1899. doi:10.1021/jm501760d

Kharel, Y., Raje, M., Gao, M., Gellett, A. M., Tomsig, J. L., Lynch, K. R., & Santos, W. L. (2012). Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. BIOCHEMICAL JOURNAL, 447, 149-157. doi:10.1042/BJ20120609

Gellett, A. M., Kharel, Y., Sunkara, M., Morris, A. J., & Lynch, K. R. (2012). Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 422(4), 758-763. doi:10.1016/j.bbrc.2012.05.077

Knott, K., Kharel, Y., Raje, M. R., Lynch, K. R., & Santos, W. L. (2012). Effect of alkyl chain length on sphingosine kinase 2 selectivity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(22), 6817-6820. doi:10.1016/j.bmcl.2012.01.050

Kharel, Y., Mathews, T. P., Gellett, A. M., Tomsig, J. L., Kennedy, P. C., Moyer, M. L., . . . Lynch, K. R. (2011). Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. BIOCHEMICAL JOURNAL, 440, 345-353. doi:10.1042/BJ20110817

Raje, M. R., Knott, K., Kharel, Y., Bissel, P., Lynch, K. R., & Santos, W. L. (2012). Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, 20(1), 183-194. doi:10.1016/j.bmc.2011.11.011

Kennedy, A. J., Mathews, T. P., Kharel, Y., Field, S. D., Moyer, M. L., East, J. E., . . . Macdonald, T. L. (2011). Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells. JOURNAL OF MEDICINAL CHEMISTRY, 54(10), 3524-3548. doi:10.1021/jm2001053

Kharel, Y., Mathews, T. P., Kennedy, A. J., Houck, J. D., Macdonald, T. L., & Lynch, K. R. (2011). A rapid assay for assessment of sphingosine kinase inhibitors and substrates. ANALYTICAL BIOCHEMISTRY, 411(2), 230-235. doi:10.1016/j.ab.2011.01.003

Mathews, T. P., Kennedy, A. J., Kharel, Y., Kennedy, P. C., Nicoara, O., Sunkara, M., . . . Macdonald, T. L. (2010). Discovery, Biological Evaluation, and Structure-Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, 53(7), 2766-2778. doi:10.1021/jm901860h

Raje, M. R., Kharel, Y., Lynch, K. R., & Santos, W. L. (2010). Structure-activity relationship studies of sphingosine kinase inhibitors. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 240. Retrieved from https://www.webofscience.com/