6/17/2025
Research Projects Engineering T cells to overcome suppressive signals in the tumor microenvironment Engineered T cell therapy can effectively kill ovarian cancer cells, but there are still tumor-driven hurdles that T cells…
6/17/2025
A main goal of research in the Brown Lab centers on the genetics of host resistance to viral infection, and the role of natural killer (NK) cells in viral immunity.…
6/17/2025
The Cowardin laboratory, located within the Child Health Research Center at the University of Virginia, focuses on understanding how the gut microbiota during pregnancy and early postnatal life set the…
6/17/2025
Our laboratory studies N. gonorrhoeae, an obligate human bacterial pathogen that causes the sexually transmitted infection gonorrhea. Gonorrhea has existed within the human population for all of recorded history and…
6/17/2025
The central objective of my lab is to understand how the host immune response is reprogrammed by tumors to promote growth and metastasis. Specifically, we focus on the role of…
6/17/2025
*Our perspective*: It is generally known that electrical signals lie at the very core of our beating hearts and thinking brains. It may however surprise you to know that the…
6/17/2025
The research focus in the Elliott Lab is to understand the function of tissue-resident macrophages as effectors of innate immunity in acute and chronic inflammation, and cancer. Macrophages are a…
6/17/2025
The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work…
6/17/2025
CURRENT PROJECTS: - Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production. - Defining the mechanisms by which autoimmune susceptibility elicits…
6/17/2025
OVERVIEW: How does the body recognize an infectious organism? During infection, how does it determine when to escalate inflammation for pathogen clearance versus dampen inflammation to prevent damage to self? What…
