6/17/2025
Mutations in any one of hundreds of genes cause neurodevelopmental disorders, like autism spectrum disorders and intellectual disability. For some unique genes, either an increase or decrease in their expression…
6/17/2025
The general research program in this laboratory deals with how cells can exhibit directed movements of plasma membrane glycoproteins. In particular, we are studying the role of cytoskeleton-plasma membrane interactions…
6/17/2025
Arf family GTPases and their function in membrane trafficking and cell motility Cell biology of bacterial infection The innate immune response to bacterial infection
6/17/2025
The longstanding interest of my laboratory is on the regulation of membrane trafficking in the secretory and endocytic pathways. A new direction that is a major focus of our research…
6/17/2025
The use of light and electron microscopy technologies to elucidate biological processes by virtue of imaging protein localization, interactions and structure.
6/17/2025
Research in the DeSimone laboratory centers on the problem of morphogenesis, which is the process biological systems use to generate form and develop increasingly complex structures needed to carry out…
6/17/2025
Development of the Cerebral Cortex Your cerebral cortex mediates your conscious sensory perceptions, thoughts, and behaviors. To perform these functions, the cortex must develop the proper structure and circuitry during…
6/17/2025
Why do some animals have the ability to regenerate certain tissues and organs, while others have lost this capacity? The study of regenerative biology and medicine have shown that the…
6/17/2025
Our laboratory is specifically interested in the regulation of vascular cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. We also aim to understand…
6/17/2025
WE USE FROGS TO STUDY DEVELOPMENT, DISEASE, AND REGENERATION PRECISION MEDICINE OF BIRTH DEFECTS Every parent that loses their baby to a birth defect wants to know why and if it will…
