6/17/2025
The primary focus of our work is to develop a fundamental understanding of the mechanisms that govern the formation of multinucleated cell types produced by cell-cell fusion – making one…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
6/17/2025
Analysis of the role of TGIFs during development. TGIF proteins are transcriptional repressors, which regulate TGFβ signaling and have been suggested to repress retinoid regulated gene expression. Mutations in human TGIF…
6/17/2025
We forge collaborative efforts at the dynamic intersection of biology, chemistry, and medicine, propelling forward the boundaries of scientific exploration. Our work revolves around the development of cutting-edge imaging tools,…
6/17/2025
6/17/2025
My laboratory is interested in understanding the pathogenetic mechanism of Huntington's disease (HD). HD is a dominantly inherited neurodegenerative disorder that affects about 1 in 10,000 people in the United…
6/17/2025
Protein abundance and post-translational modifications (PTMs) are tightly regulated to control cellular activities and developmental processes. Dysregulated protein function, either through abnormal protein levels or PTMs, disrupts normal cellular activities…
6/17/2025
6/17/2025
During the development of chronic lung disease, repetitive environmental insults/injuries, such as cigarette smoke, respiratory viruses infection and allergy lead to ineffective repair in the genetically susceptible subjects. Molecular understanding on…
6/17/2025
Under certain conditions, all essential biopolymers, such as polypeptides, nucleic acids and polysaccharides, have to cross at least one membrane to reach their final destinations. Examples include the secretion of…
