6/17/2025
Our research focus is to understand the structure and function of unusual DNA sequences in living cells, and how these sequences cause genome instability and lead to human diseases. Human…
6/17/2025
The genomic DNA of eukaryotes is packaged into chromatin through a fundamental repeating unit known as the nucleosome. In this chromatin environment, our genomic DNA is constantly exposed to a…
6/17/2025
The primary focus of our work is to develop a fundamental understanding of the mechanisms that govern the formation of multinucleated cell types produced by cell-cell fusion – making one…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
6/17/2025
Analysis of the role of TGIFs during development. TGIF proteins are transcriptional repressors, which regulate TGFβ signaling and have been suggested to repress retinoid regulated gene expression. Mutations in human TGIF…
6/17/2025
We forge collaborative efforts at the dynamic intersection of biology, chemistry, and medicine, propelling forward the boundaries of scientific exploration. Our work revolves around the development of cutting-edge imaging tools,…
6/17/2025
6/17/2025
My laboratory is interested in understanding the pathogenetic mechanism of Huntington's disease (HD). HD is a dominantly inherited neurodegenerative disorder that affects about 1 in 10,000 people in the United…
6/17/2025
Protein abundance and post-translational modifications (PTMs) are tightly regulated to control cellular activities and developmental processes. Dysregulated protein function, either through abnormal protein levels or PTMs, disrupts normal cellular activities…
6/17/2025
