6/17/2025
Drug Development Targeting Transcription Drivers in Cancer Dysregulation of gene expression is a hallmark of all cancers. It is critical for self-renewal and chemo-resistance of cancer cells which contributes to…
6/17/2025
Membranes and membrane proteins participate in some of the most important and interesting cellular processes. Energy transduction, cell signaling, membrane excitability, secretion and immune recognition are examples of a few…
6/17/2025
The Chalfant Laboratory has historically focused on two major, but diverse areas of basic science in regard to Biochemistry, Biophysics, and Molecular Biology. Specifically, the Chalfant Laboratory studies mechanisms of…
6/17/2025
Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate…
6/17/2025
Although I still determine structures using X-ray crystallography, I am currently primarily involved in the development of a new generation of Laboratory Information Management System (LIMS) to track experimental procedures…
6/17/2025
Background and Summary of Previous Findings: Neural development involves competition at many levels, whether it be axons innervating a target or synapses refining a connection. Over 50 years ago, Viktor…
6/17/2025
Current funded projects in the laboratory: (1) Elucidation of molecular mechanisms controlling smooth muscle contractility; (2) Development of drugs against the influenza and Ebola viruses; (3) Studies of the mechanism of protein crystallization…
6/17/2025
*Our perspective*: It is generally known that electrical signals lie at the very core of our beating hearts and thinking brains. It may however surprise you to know that the…
6/17/2025
In every human cell, dynamic cytoskeletal networks drive or enable critical processes such as cell division, motility, and secretion. Cytoskeletal dysregulation consequently results in cellular malfunction and several pathologies, ranging…
6/17/2025
Our research is focused on the structure and function of macromolecular assemblies, using the techniques of electron cryo-microscopy and three-dimensional reconstruction. Historically, we have been working in two different areas:…
