6/17/2025
Although I still determine structures using X-ray crystallography, I am currently primarily involved in the development of a new generation of Laboratory Information Management System (LIMS) to track experimental procedures…
6/17/2025
The Coutinho-Budd lab is interested in the cellular and molecular aspects of glial cell development and function. Glia are critical components of the nervous system—almost everything that neurons do requires…
6/17/2025
The research in my lab was directed toward understanding how complex sequences of differentiation are genetically regulated during development. Drosophila oogenesis is being used as a model system for characterizing…
6/17/2025
We study the molecular mechanisms underlying the interaction between pathogens and their mammalian host. In particular, we investigate how the obligate intracellular bacteria Chlamydia trachomatis manipulates the host and establishes…
6/17/2025
Overview. I work at the interface of virology and genetics to reveal core principles of viral and host gene expression. I seek to understand how viruses manipulate the transcriptional machinery…
6/17/2025
Development of the Cerebral Cortex Your cerebral cortex mediates your conscious sensory perceptions, thoughts, and behaviors. To perform these functions, the cortex must develop the proper structure and circuitry during…
6/17/2025
Genetics of complex disease Common diseases, such as osteoporosis, impart significant societal health burdens. These diseases are, in part, regulated by genetic determinants and understanding their genetic basis is critical to…
6/17/2025
They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly)…
6/17/2025
Ongoing work in my laboratory focuses on the role of an alternative splicing factor, the RNA helicase DDX39B, known to immunologists as BAT1, on immunity and autoimmunity. The connection to…
6/17/2025
My laboratory is investigating how the axial properties of vertebrate embryos are first established and then how particular tissues are determined within defined regions of the embryo. Research projects concerning…
