6/17/2025
Despite advancements in melanoma treatment with immune checkpoint blockade (ICB) and BRAF-targeted therapy, 40-65% of metastatic melanoma patients do not survive beyond five years. An observed 'obesity paradox' shows improved…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
6/17/2025
Analysis of the role of TGIFs during development. TGIF proteins are transcriptional repressors, which regulate TGFβ signaling and have been suggested to repress retinoid regulated gene expression. Mutations in human TGIF…
6/17/2025
During the development of chronic lung disease, repetitive environmental insults/injuries, such as cigarette smoke, respiratory viruses infection and allergy lead to ineffective repair in the genetically susceptible subjects. Molecular understanding on…
6/17/2025
Alloimmunity in Transfusion and Transplantation , Oxidant Stress Biology in Health and Disease
6/17/2025
We are using multi-scale approaches to understand mechanisms of how mitotic and meiotic spindles are assembled and function to segregate chromosomes in various model systems. Failure of these processes are…
