6/17/2025
The genomic DNA of eukaryotes is packaged into chromatin through a fundamental repeating unit known as the nucleosome. In this chromatin environment, our genomic DNA is constantly exposed to a…
6/17/2025
The primary focus of our work is to develop a fundamental understanding of the mechanisms that govern the formation of multinucleated cell types produced by cell-cell fusion – making one…
6/17/2025
Research in my lab focuses on advancing knowledge of how the human immune system responds to environmental triggers that worsen lung disease. The prevalence of asthma has risen dramatically in…
6/17/2025
MicroRNAs (miRNAs) are small , non-coding RNAs that post- transcriptionally control gene expression by directing either the degradation or translational repression of target mRNAs. miRNAs potentially regulate as many as…
6/17/2025
Analysis of the role of TGIFs during development. TGIF proteins are transcriptional repressors, which regulate TGFβ signaling and have been suggested to repress retinoid regulated gene expression. Mutations in human TGIF…
6/17/2025
6/17/2025
We study infectious disease pathogenesis and work to develop new therapies and diagnostics for infectious diseases and cancers using the new insights that we develop. In one set of projects we…
6/17/2025
During the development of chronic lung disease, repetitive environmental insults/injuries, such as cigarette smoke, respiratory viruses infection and allergy lead to ineffective repair in the genetically susceptible subjects. Molecular understanding on…
6/17/2025
Under certain conditions, all essential biopolymers, such as polypeptides, nucleic acids and polysaccharides, have to cross at least one membrane to reach their final destinations. Examples include the secretion of…
6/17/2025
We are using multi-scale approaches to understand mechanisms of how mitotic and meiotic spindles are assembled and function to segregate chromosomes in various model systems. Failure of these processes are…
