6/17/2025
Targeted therapy: by serendipity, we identified a novel oncogene, and found that multiple cancers are addicted to its activity. This oncogene addiction is evidenced in glioblastoma, pediatric sarcoma, and others.…
6/17/2025
The focus of my research has been the pharmacology and physiology of adenosine receptors. Various agonists and antagonists of adenosine receptors have therapeutic uses or potential for the treatment of…
6/17/2025
Dr. Loughran's current research includes: current research includes: • R01 grant from the NIH’s National Cancer Institute to identify and characterize the LGL leukemia virus and understand how it might cause leukemia; •…
6/17/2025
1. Wnt and PCP signaling in mechanosensory hair cell polarity. The actin-based hair bundle atop sensory hair cells is the mechanotransduction organelle essential for hearing and balance. A majority of sensorineural…
6/17/2025
Our laboratory is focused on understanding how immunological pathways contribute to neurodegenerative, neurodevelopmental, mental and behavior disorders. We are actively investigating the cellular and molecular pathways that contribute to neuroinflammation…
6/17/2025
Our research investigates the biology of the lipid mediator, sphingosine 1-phosphate (S1P). S1P concentration gradients are known to influence immune cell positioning. Indeed, S1P type 1 receptor agonist drugs are…
6/17/2025
Our research is in the field of human genetics. Specifically, we are studying the molecular genetics and biology of myotonic dystrophy (DM), the most common inherited neuromuscular disorder in adults.…
6/17/2025
I'm interested in translational science, economic, and computational methods that support evidence integration in precision medicine to allow patients, families, clinicians, and health systems to make decisions about novel therapeutics.…
6/17/2025
