6/17/2025
The Agaisse Lab is associated with the Department of Microbiology, Immunology, and Cancer Biology (MIC). Our laboratory studies the bacterial pathogen Shigella flexneri, which causes approximately 270 million cases of…
6/17/2025
Alu RNA transcripts promote advanced dry age-related macular degeneration:Geographic atrophy (GA) is the advanced form of dry age-related macular degeneration and is a leading cause of blindness in the Unites…
6/17/2025
Research Projects Engineering T cells to overcome suppressive signals in the tumor microenvironment Engineered T cell therapy can effectively kill ovarian cancer cells, but there are still tumor-driven hurdles that T cells…
6/17/2025
The Arandjelovic laboratory research focus is on cell clearance in inflammatory disease, using rheumatoid arthritis (RA) and multiple sclerosis (MS) as model systems. Inflammatory states are associated with high rates…
6/17/2025
Genetically engineering T cells with a chimeric antigen receptor (CAR) allows for recognition and subsequent destruction of cancer cells. While this has been a revolutionary treatment for many patients with…
6/17/2025
Infection in the juvenile stage disrupts growth and metabolism, often with long-lasting effects. In young children and in fruit fly larvae, infections disrupt production of homologous hormones: insulin-like growth factor…
6/17/2025
The survival of organisms ranging from simple bacteria to complex metazoans relies on the ability of individual cells to sample the environment and respond appropriately. Understanding the molecular pathways involved…
6/17/2025
A main goal of research in the Brown Lab centers on the genetics of host resistance to viral infection, and the role of natural killer (NK) cells in viral immunity.…
6/17/2025
The focus of our work is on the use of costimulatory pathways, particularly the CD70-CD27 TNF-superfamily members, to promote immunotherapeutic T cell responses against melanoma and other malignancies, and as…
6/17/2025
Arf family GTPases and their function in membrane trafficking and cell motility Cell biology of bacterial infection The innate immune response to bacterial infection
