6/17/2025
Research description: Herpes simplex viruses type 1 and type 2 are significant human pathogens. Approximately 65% of the US population are infected with HSV-1 and 20% with HSV-2. The viruses persist…
6/17/2025
Membrane proteins facilitate the transfer of information across lipid bilayers, comprise approximately 25% of a typical proteome, and represent over half of all drug targets. The membrane proteins that mediate…
6/17/2025
Our laboratory studies N. gonorrhoeae, an obligate human bacterial pathogen that causes the sexually transmitted infection gonorrhea. Gonorrhea has existed within the human population for all of recorded history and…
6/17/2025
Background and Summary of Previous Findings: Neural development involves competition at many levels, whether it be axons innervating a target or synapses refining a connection. Over 50 years ago, Viktor…
6/17/2025
*Our perspective*: It is generally known that electrical signals lie at the very core of our beating hearts and thinking brains. It may however surprise you to know that the…
6/17/2025
Development of the Cerebral Cortex Your cerebral cortex mediates your conscious sensory perceptions, thoughts, and behaviors. To perform these functions, the cortex must develop the proper structure and circuitry during…
6/17/2025
Our research is focused on the structure and function of macromolecular assemblies, using the techniques of electron cryo-microscopy and three-dimensional reconstruction. Historically, we have been working in two different areas:…
6/17/2025
The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work…
6/17/2025
CURRENT PROJECTS: - Using mouse genetics to identify the susceptibility factors that control B cell tolerance, differentiation and survival, leading to autoantibody production. - Defining the mechanisms by which autoimmune susceptibility elicits…
