Stephen H. Caldwell, MD
Stephen H. Caldwell, MD
Director of Clinical Research
PRIMARY APPOINTMENT
Professor, Medicine: Gastroenterology and Hepatology
CONTACT
Box 800708
Hosp. West
Telephone: 434-924-2626
Fax: 434-244-7546
EDUCATION
- Fellowship, Gastroenterology, University of Virginia
- Fellowship, Hepatology, University of Miami
- MD, Wake Forest University School of Medicine
- Residency, Roanoke Memorial Hospital
RESEARCH AREAS
Steatohepatitis, cirrhosis, variceal bleeding, hepatocellular cancer, coagulopathy in liver disease, and viral hepatitis.
RESEARCH SUMMARY
Research Interests include non-alcoholic fatty liver disease and mitochondrial dysfunction, cyanoacrylates in variceal bleeding, ascites, coagulopathy in liver disease, liver assist devices, viral hepatitis, techniques in liver biopsy, and alcoholic liver disease.
Stein DJ, Salinas C, Sabri S, Onyeali R, Caldwell S, Henry Z, Balloon Retrograde Transvenous Obliteration Versus Endoscopic Cyanoacrylate in Bleeding Gastric Varices: Comparison of Rebleeding and Mortality with Extended Follow-up., 2019; Journal of vascular and interventional radiology: JVIR. 30(2) 187-194. PMID: 30717949
Intagliata NM, Caldwell SH, Tripodi A, Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis., 2019; Gastroenterology. () . PMID: 30771355
Violi F, Corazza GR, Caldwell SH, Talerico G, Romiti GF, Napoleone L, Perticone F, Bolondi L, Pietrangelo A, Vestri AR, Raparelli V, Basili S, Incidence and Recurrence of Portal Vein Thrombosis in Cirrhotic Patients., 2019; Thrombosis and haemostasis. 119(3) 496-499. PMID: 30616246
Stine JG, Wentworth BJ, Zimmet A, Rinella ME, Loomba R, Caldwell SH, Argo CK, Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases., 2018; Alimentary pharmacology & therapeutics. 48(7) 696-703. PMID: 30136293
Intagliata NM, Argo CK, Stine JG, Lisman T, Caldwell SH, Violi F, Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference., 2018; Thrombosis and haemostasis. 118(8) 1491-1506. PMID: 30060258 | PMCID: PMC6202935
Intagliata NM, Davis JPE, Caldwell SH, Coagulation Pathways, Hemostasis, and Thrombosis in Liver Failure., 2018; Seminars in respiratory and critical care medicine. 39(5) 598-608. PMID: 30485890
Jayakumar S, Middleton MS, Lawitz EJ, Mantry PS, Caldwell SH, Arnold H, Mae Diehl A, Ghalib R, Elkhashab M, Abdelmalek MF, Kowdley KV, Stephen Djedjos C, Xu R, Han L, Mani Subramanian G, Myers RP, Goodman ZD, Afdhal NH, Charlton MR, Sirlin CB, Loomba R, Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib., 2018; Journal of hepatology. 70(1) 133-141. PMID: 30291868
Byrne FL, Hargett SR, Lahiri S, Roy RJ, Berr SS, Caldwell SH, Hoehn KL, Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth., 2018; Cancers. 10(9) . PMID: 30189621 | PMCID: PMC6162796
Argo CK, Stine JG, Henry ZH, Lackner C, Patrie JT, Weltman AL, Caldwell SH, Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis., 2018; Alimentary pharmacology & therapeutics. 48(3) 290-299. PMID: 29797529
Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Aguilar-Olivos NE, Alva-López LF, Fajardo-Ordoñez E, Ponciano-Rodríguez G, Northup PG, Intagliata N, Caldwell SH, Qi X, Méndez-Sánchez N, Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients., 2018; Annals of hepatology. 17(3) 476-481. PMID: 29735798
Stine JG, Niccum BA, Zimmet AN, Intagliata N, Caldwell SH, Argo CK, Northup PG, Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis., 2018; Clinical and translational gastroenterology. 9(3) 140. PMID: 29511162 | PMCID: PMC5862151
Stine JG, Wang J, Cornella SL, Behm BW, Henry Z, Shah NL, Caldwell SH, Northup PG, Treatment of Type-1 Hepatorenal Syndrome with Pentoxifylline: A Randomized Placebo-Controlled Clinical Trial., 2018; Annals of hepatology. 17(2) 300-306. PMID: 29469046
Davis JPE, Northup PG, Caldwell SH, Intagliata NM, Viscoelastic Testing in Liver Disease., 2018; Annals of hepatology. 17(2) 205-213. PMID: 29469043
Stine JG, Wynter JA, Niccum B, Kelly V, Caldwell SH, Shah NL, Effect of Treatment with Direct Acting Antiviral on Glycemic Control in Patients with Diabetes Mellitus and Chronic Hepatitis C., 2017; Annals of hepatology. 16(2) 215-220. PMID: 28233744
Stine JG, Argo CK, Pelletier SJ, Maluf DG, Caldwell SH, Northup PG, Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis., 2017; World journal of hepatology. 9(3) 139-146. PMID: 28217250 | PMCID: PMC5295147
Nelson ME, Lahiri S, Chow JD, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, Hoehn KL, Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defense and promoting cell survival., 2017; Nature communications. 8() 14689. PMID: 28290443 | PMCID: PMC5424065
Stine JG, Wang J, Shah PM, Argo CK, Intagliata N, Uflacker A, Caldwell SH, Northup PG, Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study., 2017; Liver international: official journal of the International Association for the Study of the Liver. 38(1) 94-101. PMID: 28632958
Loomba R, Lawitz E, Mantry PS, Jayakumar S, Caldwell SH, Arnold H, Diehl AM, Djedjos CS, Han L, Myers RP, Subramanian GM, McHutchison JG, Goodman ZD, Afdhal NH, Charlton MR, The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial., 2017; Hepatology (Baltimore, Md.). () . PMID: 28892558 | PMCID: PMC5814892
Younossi ZM, Loomba R, Rinella ME, Bugianesi E, Marchesini G, Neuschwander-Tetri BA, Serfaty L, Negro F, Caldwell SH, Ratziu V, Corey KE, Friedman SL, Abdelmalek MF, Harrison SA, Sanyal AJ, Lavine JE, Mathurin P, Charlton MR, Chalasani NP, Anstee QM, Kowdley KV, George J, Goodman ZD, Lindor K, Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis., 2017; Hepatology (Baltimore, Md.). 68(1) 361-371. PMID: 29222911
Younossi ZM, Loomba R, Anstee QM, Rinella ME, Bugianesi E, Marchesini G, Neuschwander-Tetri BA, Serfaty L, Negro F, Caldwell SH, Ratziu V, Corey KE, Friedman SL, Abdelmalek MF, Harrison SA, Sanyal AJ, Lavine JE, Mathurin P, Charlton MR, Goodman ZD, Chalasani NP, Kowdley KV, George J, Lindor K, Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis., 2017; Hepatology (Baltimore, Md.). 68(1) 349-360. PMID: 29222917
Stine JG, Wynter JA, Niccum B, Kelly V, Caldwell SH, Shah NL, Reply to “HbA1c levels as a parameter of glycemic control in patients with liver cirrhosis”., 2017; Annals of hepatology. 16(3) 471-472. PMID: 28425421
Stine JG, Intagliata N, Northup PG, Caldwell SH, Nonalcoholic Fatty Liver Disease, Portal Vein Thrombosis, and Coagulation: More Questions Than Answers?, 2017; Transplantation. 101(8) e281-e282. PMID: 28471888
DeAngelis GA, Khot R, Haskal ZJ, Maitland HS, Northup PG, Shah NL, Caldwell SH, Reply to: “Bleeding Risk and Management in Interventional Procedures in Chronic Liver Disease.”, 2017; Journal of vascular and interventional radiology: JVIR. 28(6) 922-923. PMID: 28532752
Smith EZ, Caldwell SH, The Reply., 2017; The American journal of medicine. 130(11) e513. PMID: 29073975
Intagliata NM, Caldwell SH, Changes in hemostasis in liver disease., 2017; Journal of hepatology. 67(6) 1332-1333. PMID: 29156209
Tripodi A, Primignani M, Mannucci PM, Caldwell SH, Changing Concepts of Cirrhotic Coagulopathy., 2016; The American journal of gastroenterology. 112(2) 274-281. PMID: 27801884
Intagliata NM, Maitland H, Pellitier S, Caldwell SH, Reversal of direct oral anticoagulants for liver transplantation in cirrhosis: A step forward., 2016; Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(3) 396-397. PMID: 28026110
Henry ZH, Caldwell SH, Obesity and Hepatocellular Carcinoma: A Complex Relationship., 2015; Gastroenterology. 149(1) 18-20. PMID: 26008860
Caldwell SH, Argo CK, Reversing Advanced Hepatic Fibrosis in NASH: Clearly Possible, but Widely at Hand?, 2015; Digestive diseases and sciences. 60(4) 810-2. PMID: 25618312
Stine JG, Shah NL, Argo CK, Pelletier SJ, Caldwell SH, Northup PG, Increased risk of Portal Vein Thrombosis in Patients with Cirrhosis due to Non-Alcoholic Steatohepatitis (NASH)., 2015; Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. () . PMID: 25845711
Shah NL, Intagliata NM, Northup PG, Argo CK, Caldwell SH, Procoagulant therapeutics in liver disease: a critique and clinical rationale., 2014; Nature reviews. Gastroenterology & hepatology. 11(11) 675-82. PMID: 25023035
Ahuja NK, Ally WA, Caldwell SH, Direct acting inhibitors of ammonia genesis: a role in post-TIPS encephalopathy?, 2014; Annals of hepatology. 13(2) 179-86. PMID: 24552859
Caldwell SH, Management of coagulopathy in liver disease., 2014; Gastroenterology & hepatology. 10(5) 330-2. PMID: 24987319 | PMCID: PMC4076882
Northup PG, Caldwell SH, Coagulation in liver disease: a guide for the clinician., 2013; Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 11(9) 1064-74. PMID: 23506859
Shah NL, Northup PG, Caldwell SH, A clinical survey of bleeding, thrombosis, and blood product use in decompensated cirrhosis patients., 2012; Annals of hepatology. 11(5) 686-90. PMID: 22947530
Truesdale AE, Caldwell SH, Shah NL, Argo CK, Al-Osaimi AM, Schmitt TM, Northup PG, Sorafenib therapy for hepatocellular carcinoma prior to liver transplant is associated with increased complications after transplant., 2011; Transpl Int. 0(0) null. PMID:
Balogun RA, Turgut F, Caldwell S, Abdel-Rahman EM, Regional citrate anticoagulation in critically ill patients with liver and kidney failure., 2011; J Nephrol. 0(0) null. PMID:
Caldwell S, Ikura Y, Dias D, Isomoto K, Yabu A, Moskaluk C, Pramoonjago P, Simmons W, Scruggs H, Rosenbaum N, Wilkinson T, Toms P, Argo CK, Al-Osaimi AM, Redick JA, Hepatocellular ballooning in NASH., 2010; J Hepatol. 53(4) 719-23. PMID: | PMCID: PMC2930100
Reardon KA, McIntosh AF, Shilling AT, Hagspiel KD, Al-Osaimi A, Berg C, Caldwell SH, Northup PG, Angle F, Mulder R, Rich TA, Treatment of primary liver tumors with Yttrium-90 microspheres (TheraSphere) in high-risk patients: analysis of survival and toxicities., 2009; Technol Cancer Res Treat. 8(1) 71-7. PMID:
McIntosh A, Hagspiel KD, Al-Osaimi AM, Northup P, Caldwell S, Berg C, Angle JF, Argo C, Weiss G, Rich TA, Accelerated treatment using intensity-modulated radiation therapy plus concurrent capecitabine for unresectable hepatocellular carcinoma., 2009; Cancer. 115(21) 5117-25. PMID:
Sabri SS, Swee W, Turba UC, Saad WE, Park AW, Al-Osaimi AM, Caldwell SH, Matsumoto AH, Angle JF, Bleeding gastric varices obliteration with balloon-occluded retrograde transvenous obliteration using sodium tetradecyl sulfate foam.,; J Vasc Interv Radiol. 22(3) 309-16; quiz 316. PMID: