Steven M. Powell, MD
PRIMARY APPOINTMENT
Associate Professor, Medicine: Gastroenterology and Hepatology
CONTACT
PO Box 800708
2nd Floor Multistory, 213
Telephone: 434-243-9309
Fax: 434-244-7527
EDUCATION
- Clinical Fellowship, Gastroenterology, Johns Hopkins Oncology Center
- Residency, Internal Medicine, Indiana University Medical Center
- BA, Mathematics, Depauw University
- MD, Medicine, Indiana Univ. School of Medicine, Indpls., IN
RESEARCH AREAS
Colorectal cancer risk assessment and molecular tumorigenesis of colon cancer, gastric cancer, and Barrett’s esophagus.
RESEARCH SUMMARY
Gastrointestinal cancers generate one of the largest health burdens on society. Thus, our team’s primary focus is advancing our current diagnostic, prognostic and therapeutic armamentarium to combat these lethal cancers.
Recent advances in the fields of molecular genetics and biology provide new avenues we are using to increase our understanding of the development of these gastrointestinal cancers. Investigations include molecular biologic analyses focused on familial and sporadic cases of these cancers, including colorectal and gastric cancers. In defining mechanisms of gastrointestinal tumorigenesis, we analyze tumor and normal specimens at the genetic and protein levels employing established and state-of-the-art molecular techniques.
We also are developing new methodologies to examine normal and tumor cells to identify critical changes in these cancers and new avenues to identify best those at higher risk for colorectal cancer and relaying recommendations appropriate to those at risk.
Uppal DS, Powell SM, Genetics/genomics/proteomics of gastric adenocarcinoma., 2013; Gastroenterology clinics of North America. 42(2) 241-60. PMID: 23639639
Peng D, Sheta EA, Powell SM, Moskaluk CA, Washington K, Goldknopf IL, El-Rifai W, Alterations in Barrett’s-related adenocarcinomas: a proteomic approach., 2008; Int J Cancer. 122(6) 1303-10. PMID:
Razvi MH, Peng D, Dar AA, Powell SM, Frierson Jr, Moskaluk CA, Washington K, El-Rifai W, Transcriptional oncogenomic hot spots in Barrett’s adenocarcinomas: serial analysis of gene expression., 2007; Genes Chromosomes Cancer. 0(46) 10.0. PMID:
Lee OJ, Hong SM, Razvi MH, Peng D, Powell SM, Smoklin M, Moskaluk CA, El-Rifai W, Expression of calcium-binding proteins S100A2 and S100A4 in Barrett’s adenocarcinomas., 2006; Neoplasia. 0(8) 10.0. PMID: | PMCID: PMC1715926
Sankpal NV, Moskaluk CA, Hampton GM, Powell SM, Overexpression of CEBPbeta correlates with decreased TFF1 in gastric cancer., 2005; Oncogene. 25(4) 643-9. PMID: 16247479
Sankpal NV, Mayo MW, Powell SM, Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta., 2005; Biochimica et biophysica acta. 1728(1) 1-10. PMID: 15777639
Fox CA, Sapinoso LM, Zhang H, Zhang W, McLeod HL, Petroni GR, Mullick T, Moskaluk CA, Frierson HF, Hampton GM, Powell SM, Altered expression of TFF-1 and CES-2 in Barrett’s Esophagus and associated adenocarcinomas., 2005; Neoplasia (New York, N.Y.). 7(4) 407-16. PMID: 15967118
French AJ, Petroni G, Thibideau SN, Smolkin M, Bissonette E, Roviello F, Harper JC, Koch BR, Anderson SA, Hebbring SJ, Powell SM, Allelic imbalance of 8p indicates poor survival in gastric cancer., 2004; The Journal of molecular diagnostics: JMD. 6(3) 243-52. PMID: 15269302
Morris LE, Bloom GS, Frierson HF, Powell SM, Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers., 2004; Genes, chromosomes & cancer. 42(3) 280-6. PMID: 15611933
Beckler AD, Roche JK, Harper JC, Petroni G, Frierson HF, Moskaluk CA, El-Rifai W, Powell SM, Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas., 2003; Cancer. 98(10) 2184-91. PMID: 14601088
El-Rifai W, Moskaluk CA, Abdrabbo MK, Harper J, Yoshida C, Riggins GJ, Frierson HF, Powell SM, Gastric cancers overexpress S100A calcium-binding proteins., 2002; Cancer research. 62(23) 6823-6. PMID: 12460893
El-Rifai W, Smith MF, Li G, Beckler A, Carl VS, Montgomery E, Knuutila S, Moskaluk CA, Frierson HF, Powell SM, Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP., 2002; Cancer research. 62(14) 4061-4. PMID: 12124342
Powell SM, Petersen GM, Krush AJ, Booker S, Jen J, Giardiello FM, Hamilton SR, Vogelstein B, Kinzler KW, Molecular diagnosis of familial adenomatous polyposis., 1993; The New England journal of medicine. 329(27) 1982-7. PMID: 8247073