GEMM has been using the CRISPR technology to create genome-edited mice since June 2013.  We have created many KO/KI mice using the CRISPR technology.  Our average KO mutation rate (mutants/pups) is about 40%.  For KI, we’ve generated mice with point mutations, loxP, HA and attP insertions.  Our average KI mutation rate (mutants/pups) is about 20%.  Our fees for CRISPR-based injections are very competitive.