Charles E. Chalfant, PhD


Charles E. Chalfant, PhDProfessor of Medicine, Division of Hematology & Oncology
Secondary Appointment: Cell Biology

UVA School of Medicine
Aurbach Medical Research Building (Aurbach 2313)
450 Ray C. Hunt Drive
Charlottesville, VA 22903
Telephone: 434-982-1055

GS15 Research Microbiologist
Senior Research Career Scientist
Richmond Veterans Administration Medical Center
Central Virginia VA Health Care System
Research 151
1201 Broad Rock Blvd
Richmond, VA 23249
Telephone: 804-675-5000 Ext. 3862


  • PhD, University of South Florida College of Medicine, Tampa, FL
  • Postdoctoral Fellow, University of South Florida College of Medicine, Tampa, FL
  • Postdoctoral Fellow, Duke University Medical Center, Durham, NC
  • Postdoctoral Fellow, Medical University of South Carolina, Charleston, SC


  • Veteran’s Administration, 1IK6BX004603-01, (Senior Research Career Scientist Award) PI, 04/01/2009 -03/31/2026
  • Veteran’s Administration, MERIT I, BX001792, (The role of RNA Splicing in NSCLC) PI, 10/01/2001 -09/30/2024
  • National Institutes of Health, R01AI139072, (The roles of ceramide and its derivatives in A. phagocytophilum pathogenesis) PI (MPI) 06/01/18 – 05/01/23
  • National Institutes of General Medical Sciences, R01#R01GM137578, (The role of ceramide kinase in mitophagy) PI, 9/30/20 – 09/30/24
  • National Institutes of General Medical Sciences, R01#R01GM137394, (The role and mechanistic regulation of cPLA2a in eicosanoid biosynthesis and wound healing) Lead PI (MPI), 01/01/20 – 12/31/24
  • National Institutes of Health, NIDDK, R01# R01DK126444, (Lipid-regulated Bcl-x splicing and b-cell death: implications in type 1 diabetes) PI, 05/01/21 – 04/30/25
  • Juvenile Diabetes Research Foundation, 2-SRA-2022-1210-S-B, (Novel Combination Regimen Therapy to Modulate Pro-and Anti-inflammatory Lipid Signaling to Counter T1D) Co-Investigator,06/01/22 – 05/31/24
  • R01 DK085259 (Sphingolipids in Acute Kidney Injury and Disease Progression)
  • R01 DK123248 (Neuroimmune Regulation of Acute Kidney Injury)
  • T32 DK072922 (Kidney Disease and Inflammation)


Cancer Cell Signaling, biochemistry, molecular biology, cell biology.

Specific research areas: Bioactive Lipid signaling and RNA Biology related to disease states.


The Chalfant Laboratory has historically focused on two major but diverse areas of basic science Biochemistry, Biophysics, and Molecular Biology. Specifically, the Chalfant Laboratory studies mechanisms of cell signaling associated with both bioactive lipids and RNA splicing with a focus on both basic science mechanisms related to cancer, wound healing, and inflammation, in many cases, to clinical translation. Regarding our bioactive lipid research, these studies have recently exploded into numerous sectors with clinical applications.