Peter Lobo, MD Lab
Professor of Medicine, Medicine: Nephrology
EDUCATION AND TRAINING:
- Fellowship, Nephrology, Immunology, Transplantation, University of Virginia
- MD, Makerere University
- Residency, Makerere University
Basic Transplant Immunology; Role of Naturally occurring IgM antibodies in Acute Kidney Injury and transplant rejection.
My basic research involves investigating the role of naturally occurring IgM autoantibodies that bind to receptors on inflammatory cells and endothelial cells. Thus far, we have shown that these antibodies regulate inflammatory cell functions and downregulate the inflammatory response that occurs after acute ischemic injury to the kidney, as well as after transplantation (i.e. rejection). A subset of normal individuals and patients awaiting transplantation (i.e. kidney, heart) have high levels of these natural antibodies. We and others have noted a strong association between the presence of high IgM anti-leukocyte natural antibodies and protection from rejection.
Currently, our basic research efforts are focused on 1) studying the mechanism by which IgM downregulates the inflammatory response; 2) determining if there is a role of IgM in inducing transplant tolerance, thus decreasing the use of immunosuppressive agents; and 3) evaluating strategies (e.g. vaccines) to increase levels of such antibodies especially in patients awaiting transplantation. Other clinical studies are aimed at determining if there is an association between levels of such antibodies and severity of renal failure (e.g. after cardiac surgery) and severity of glomerular inflammation (e.g. in SLE or IgA nephropathy).
My clinical research involves transplant immunobiology, primarily focusing on B cell regulation, alloantibodies, and desensitizing patients with donor specific antibodies.
- Lobo PI, Brayman KL, Okusa MD, Natural IgM anti-leucocyte autoantibodies (IgM-ALA) regulate inflammation induced by innate and adaptive immune mechanisms., 2014; Journal of clinical immunology. 34() S22-9. PMID: 24711004 | PMCID: PMC4096817
- Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD, Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury., 2012; Journal of immunology (Baltimore, Md. : 1950). 189(5) 2584-96. PMID: 22855711 | PMCID: PMC3433235
- Kinsey GR, Huang L, Jaworska K, Khutsishvili K, Becker DA, Ye H, Lobo PI, Okusa MD, Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection., 2012; Journal of the American Society of Nephrology : JASN. 23(9) 1528-37. PMID: 22835488 | PMCID: PMC3431416
- Chhabra P, Schlegel K, Okusa MD, Lobo PI, Brayman KL, Naturally occurring immunoglobulin M (nIgM) autoantibodies prevent autoimmune diabetes and mitigate inflammation after transplantation., 2012; Annals of surgery. 256(4) 634-41. PMID: 22964733 | PMCID: PMC3875377
- Lobo PI, Schlegal KH, Vengal J, Okusa MD, Pei H, Naturally occurring IgM anti-leukocyte autoantibodies inhibit T-cell activation and chemotaxis., 2010; Journal of clinical immunology. 30() S31-6. PMID: 20401525 | PMCID: PMC3518423
- Jones DG, Taylor AM, Enkiri SA, Lobo P, Brayman KL, Keeley EC, Lipson LC, Gimple LW, Ragosta M, Extent and severity of coronary disease and mortality in patients with end-stage renal failure evaluated for renal transplantation., 2009; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 9(8) 1846-52. PMID: 19538490 | PMCID: PMC2850065