Research Facilities

Core faculty members and research scientists of the CIIR have available 13,000 square feet of recently renovated research space on the 4th and 5th floors of the University of Virginia Old Medical School building.

Shared Facilities

Zeiss Axioskop Photofluorescence Microscope
Diane Rosin
Zeiss Apotome Microscope
Diane Rosin
Jitendra Gautam
Real time PCR
Amandeep Bajwa
FACScan: two 5-color flow cytometers
Li Li
Jitendra Gautam
Applied Biosystems Genetic Analyzer
Mike Brown
Perkin Elmer LS50B Spectrofluorimeter
Bert Kinsey

Core Facilities & Centers

The UVA Health System has a number of shared instrumentation facilities available to investigators and trainees interested in research:

UVA Office of Research Core Administration

Advanced Microscopy
This facility provides access to electron and light microscopes, training in microscope use and sample preparation, a full range of TEM and SEM preparatory services, and consultation regarding microscopy applications in biomedical investigations.

Beirne B. Carter Center for Immunology Research
This center offers an outstanding Interdisciplinary Training Program in Immunology developed by internationally recognized faculty. Immunology research and training is focused in the areas of: allergy/atopic disease, antigen presentation, autoimmunity, host immune response to infection, innate immune mechanisms, lymphocyte development, and tumor immunology.

Biomolecular Analysis Facility (BAF)
The Biomolecular Analysis Facility (BAF) provides a centralized setting for a diverse but interactive suite of services, instrumentation, and expertise in the areas of proteomics, metabolomics, small molecules, and molecular interactions. Some instrumentation is available open-access while other services are provided by the staff.

Biomolecular Magnetic Resonance Facility (BMRF)
This facility facilitates and promotes research that utilizes NMR (nuclear magnetic resonance) spectroscopy to examine biologically important molecules, providing information on molecular structure and dynamics at atomic level resolution.

Biostatistics »
The Division of Biostatistics and Epidemiology in the Department of Public Health Sciences of the School of Medicine provides collaborative consulting in study design, conduct, analysis, and interpretation.

Center for Biomedical Ethics
This center’s mission is to advance education, research, and service concerning moral values in health care. The program is devoted to helping those in the public sector who are charged with making decisions to respond to the challenges facing health care systems.

Center for Cell Signaling
This multidisciplinary biomedical research center in the School of Medicine provides a vibrant atmosphere to study cellular and molecular mechanisms of signal transduction.

Center for Comparative Medicine
This center’s mission is to support biomedical research and teaching that utilizes laboratory animals. This is done in a manner that promotes the policies set by the Institutional Animal Care and Use Committee (IACUC) whose charge is to oversee compliance by UVA personnel with federal regulations and guidelines.

Flow Cytometry
The flow cytometry core provides state-of-the-art instrumentation such as the DIVA FACSVantage SE TurboSortT. Also offers 4 way high speed cell sorting and complex analytical services and has three dual laser FACSCaliburT benchtop analyzers. Recent additions include a Cyan ADP nine color benchtop cytometer, an Imagestream100 imaging flow cytometer and a Luminex 100 bead based multiplex analyzer.

Genomic Analysis and Technology Core
The Genome Analysis and Technology Core provides high throughput (Next Generation) sequencing services for both novice and experienced users alike, by providing timely assistance in all facets of experimentation from project design/execution to data analysis/reporting.

General Clinical Research Center (GCRC) »
This NIH-sponsored facility includes a ten-bed, inpatient and outpatient multidisciplinary human clinical investigative unit that can be used by any qualified investigator and has been used by faculty from almost every department within the University, encompassing over 250 research protocols. The center maintains an Informatics Core that provides clinical investigators with the latest computer tools to facilitate the analysis of data and subsequent publication process needed after the compilation of research data. The core laboratory performs multiple specific assays of research-oriented human samples and to perform high-volume, high-precision estimation of human hormones by radioimmunoassay and immunoradiometric and chemiluminescence assays. Assay results are electronically stored in CRC computers for subsequent analysis of biorhythms.

W.M. Keck Center for Cellular Imaging
This center is a state-of-the-art optical imaging facility that provides continual development and implementation of novel optical imaging methods that interface expertise in biology, optics and electronic engineering. The center has imaging systems to image from a single molecule to the whole animal, with specialized processing software including FRET and FLIM.

Molecular Imaging Core
This facility offers the latest advances in imaging/spectroscopy strategies for imaging in vivo of live animals, and excised human and animal organs.

Molmart Product Core
MolMart supplies molecular biology reagents to UVA researchers.

Research Histology Core
This facility provides a range of capabilities directed at correlative studies in basic, preclinical and clinical investigations. Services include: tissue fixation and processing, tissue sectioning, histology section staining, cell preparation for immunocytology, immunohistology and immunocytology, and laser capture microdissection. This core is closely tied to several others including the Genome Analysis & Technology Core, Protein Sciences Core, Tissue Procurement Facility, and Molecular Assessment and Preclinical Studies Core.

Tissue Culture Facility
This core facility is a central source of tissue culture media, reagents, sterile hood space, cell banking, cell culture consultation and specialized tissue culture cell services. The facility provides services to the UVA research community including cell culture and storage services, transfections, baculovirus transfections, viral titering, mycoplasma testing, and training in tissue culture techniques.

Biorepository and Tissue Research Facility
This facility is involved in procurement and processing of human tissue samples.

UVA Cancer Center
The UVA Cancer Center is a NCI designated cancer center that has several research programs. Six are basic/translational programs representing key scientific foci important for understanding cancer: 1) Cell Signaling, 2) Endocrinology, 3) lmmunology, 4) Migration and Metastasis, 5) Structural Biology, and 6) Molecular Genetics. One is a translational/clinical program, Developmental Therapeutics, with subprograms: 1) Immune Therapies, and 2) Targeted Therapies, Biomarkers, and Imaging.