Pharmacology Professor Investigates Aging

July 6, 2023 by   |   Leave a Comment

Seen in the Medicine in Motion newsletter on July 6th, 2023:

Irina Bochkis, PhD, an associate professor of pharmacology, is studying the process of aging by looking at removing the wrinkles from our cells’ DNA. The nuclear membranes housing our cells’ DNA get crinkly over time, leading to decline in the body’s functioning through inflammation and metabolic syndrome, which can point to development of nonalcoholic fatty liver disease.

Aging goes hand in hand with increased inflammation and metabolic syndrome. In the liver, this can lead to nonalcoholic fatty liver disease. Bochkis’ research directly connects the integrity of the DNA’s envelope to that condition. She believes other aspects of aging may directly relate as well.

Eyleeen O’Rourke, PhD, an associate professor of biology and cell biology and member of the Robert M. Berne Cardiovascular Center, and her School of Medicine team of scientists are also investigating aging, studying two biological models involving yeast and roundworms. Her research aims to control aging by removing toxic byproducts of fat through a process called “AMAR” or “Alcohol and aldehyde-dehydrogenase Mediated Anti-aging Response.”

Read the full story here.



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