From UVA Medicine in Motion:
Norbert Leitinger, PhD, a professor of pharmacology and associate director of UVA’s Robert M. Berne Cardiovascular Research Center, was awarded a $2.5 million grant, for a project to study Acetyl CoA Carboxylase in the metabolic control of inflammation.
The project will use genetic approaches, bioenergetics analysis, metabolomics and lipidomics to determine the role of ACC isoforms in the inflammation-driven metabolic response and the production of pro-resolving lipid mediators by macrophages and in murine models of bacterial infection. Since ACC inhibitors are being tested in clinical trials in patients with fatty liver disease and certain cancers, it will be important to examine the role of ACC in host response to infections. The proposed research will also identify if separate inhibition of individual ACC isoforms will be beneficial.
Collaborators include James Casanova, PhD, in the Department of Cell Biology and Ku-Lung (Ken) Hsu, PhD, in the Department of Chemistry.